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Lack of multidrug resistance-associated protein 4 (Mrp4) alters the kinetics of acetaminophen toxicity.

Donepudi AC, Goedken MJ, Schuetz JD, E Manautou J.

Toxicol Rep. 2019 Aug 7;6:841-849. doi: 10.1016/j.toxrep.2019.08.005. eCollection 2019.


Corrigendum to "Metabolic switching in pluripotent stem cells reorganizes energy metabolism and subcellular organelles" [379 (2019) 55-64].

O'Reilly C, Cho JH, Qi Q, Peters JL, Fukuda Y, Frase S, Peng J, Schuetz JD, Cheng Y, Yoon SO, Han MJ.

Exp Cell Res. 2019 Aug 1;381(1):163. doi: 10.1016/j.yexcr.2019.05.002. Epub 2019 May 9. No abstract available.


Characterizing the cultural niches of North American birds.

Schuetz JG, Johnston A.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):10868-10873. doi: 10.1073/pnas.1820670116. Epub 2019 Apr 15.


Regulation of gene expression by miR-144/451 during mouse erythropoiesis.

Xu P, Palmer LE, Lechauve C, Zhao G, Yao Y, Luan J, Vourekas A, Tan H, Peng J, Schuetz JD, Mourelatos Z, Wu G, Weiss MJ, Paralkar VR.

Blood. 2019 Jun 6;133(23):2518-2528. doi: 10.1182/blood.2018854604. Epub 2019 Apr 10.


Metabolic switching in pluripotent stem cells reorganizes energy metabolism and subcellular organelles.

O'Reilly C, Cho JH, Qi Q, Peters JL, Fukuda Y, Frase S, Peng J, Schuetz JD, Cheng Y, Yoon SO, Han MJ.

Exp Cell Res. 2019 Jun 1;379(1):55-64. doi: 10.1016/j.yexcr.2019.03.028. Epub 2019 Mar 25. Erratum in: Exp Cell Res. 2019 Aug 1;381(1):163.


Genetic variants in genes related to inflammation, apoptosis and autophagy in breast cancer risk.

Schuetz JM, Grundy A, Lee DG, Lai AS, Kobayashi LC, Richardson H, Long J, Zheng W, Aronson KJ, Spinelli JJ, Brooks-Wilson AR.

PLoS One. 2019 Jan 2;14(1):e0209010. doi: 10.1371/journal.pone.0209010. eCollection 2019.


Influence of Multidrug Resistance-Associated Proteins on the Excretion of the ABCC1 Imaging Probe 6-Bromo-7-[11C]Methylpurine in Mice.

Zoufal V, Mairinger S, Krohn M, Wanek T, Filip T, Sauberer M, Stanek J, Traxl A, Schuetz JD, Kuntner C, Pahnke J, Langer O.

Mol Imaging Biol. 2019 Apr;21(2):306-316. doi: 10.1007/s11307-018-1230-y.


Beyond Competitive Inhibition: Regulation of ABC Transporters by Kinases and Protein-Protein Interactions as Potential Mechanisms of Drug-Drug Interactions.

Crawford RR, Potukuchi PK, Schuetz EG, Schuetz JD.

Drug Metab Dispos. 2018 May;46(5):567-580. doi: 10.1124/dmd.118.080663. Epub 2018 Mar 7. Review.


Climate vulnerability and resilience in the most valuable North American fishery.

Le Bris A, Mills KE, Wahle RA, Chen Y, Alexander MA, Allyn AJ, Schuetz JG, Scott JD, Pershing AJ.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1831-1836. doi: 10.1073/pnas.1711122115. Epub 2018 Jan 22.


ABCB6, an ABC Transporter Impacting Drug Response and Disease.

Boswell-Casteel RC, Fukuda Y, Schuetz JD.

AAPS J. 2017 Nov 30;20(1):8. doi: 10.1208/s12248-017-0165-6. Review.


Obstacles to Brain Tumor Therapy: Key ABC Transporters.

Wijaya J, Fukuda Y, Schuetz JD.

Int J Mol Sci. 2017 Nov 27;18(12). pii: E2544. doi: 10.3390/ijms18122544. Review.


A novel role for OATP2A1/SLCO2A1 in a murine model of colon cancer.

Nakanishi T, Ohno Y, Aotani R, Maruyama S, Shimada H, Kamo S, Oshima H, Oshima M, Schuetz JD, Tamai I.

Sci Rep. 2017 Nov 29;7(1):16567. doi: 10.1038/s41598-017-16738-y.


An unexpected protein interaction promotes drug resistance in leukemia.

Pitre A, Ge Y, Lin W, Wang Y, Fukuda Y, Temirov J, Phillips AH, Peters JL, Fan Y, Ma J, Nourse A, Sinha C, Lin H, Kriwacki R, Downing JR, Gruber TA, Centonze VE, Naren AP, Chen T, Schuetz JD.

Nat Commun. 2017 Nov 16;8(1):1547. doi: 10.1038/s41467-017-01678-y.


Zebrafish abcb11b mutant reveals strategies to restore bile excretion impaired by bile salt export pump deficiency.

Ellis JL, Bove KE, Schuetz EG, Leino D, Valencia CA, Schuetz JD, Miethke A, Yin C.

Hepatology. 2018 Apr;67(4):1531-1545. doi: 10.1002/hep.29632. Epub 2018 Feb 23.


Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis.

Fukuda Y, Wang Y, Lian S, Lynch J, Nagai S, Fanshawe B, Kandilci A, Janke LJ, Neale G, Fan Y, Sorrentino BP, Roussel MF, Grosveld G, Schuetz JD.

JCI Insight. 2017 Aug 3;2(15). pii: 92409. doi: 10.1172/jci.insight.92409. eCollection 2017 Aug 3.


Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan in vivo.

Murray J, Valli E, Yu DMT, Truong AM, Gifford AJ, Eden GL, Gamble LD, Hanssen KM, Flemming CL, Tan A, Tivnan A, Allan S, Saletta F, Cheung L, Ruhle M, Schuetz JD, Henderson MJ, Byrne JA, Norris MD, Haber M, Fletcher JI.

Eur J Cancer. 2017 Sep;83:132-141. doi: 10.1016/j.ejca.2017.06.024. Epub 2017 Jul 20.


Differential effects of thiopurine methyltransferase (TPMT) and multidrug resistance-associated protein gene 4 (MRP4) on mercaptopurine toxicity.

Liu C, Janke LJ, Yang JJ, Evans WE, Schuetz JD, Relling MV.

Cancer Chemother Pharmacol. 2017 Aug;80(2):287-293. doi: 10.1007/s00280-017-3361-2. Epub 2017 Jun 16.


Investigation of the Importance of Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4) in the Active Efflux of Anionic Drugs Across the Blood-Brain Barrier.

Kanamitsu K, Kusuhara H, Schuetz JD, Takeuchi K, Sugiyama Y.

J Pharm Sci. 2017 Sep;106(9):2566-2575. doi: 10.1016/j.xphs.2017.04.040. Epub 2017 Apr 27.


Nonrandom occurrence of lymphoid cancer types in 140 families.

Jones SJ, Voong J, Thomas R, English A, Schuetz J, Slack GW, Graham J, Connors JM, Brooks-Wilson A.

Leuk Lymphoma. 2017 Sep;58(9):1-10. doi: 10.1080/10428194.2017.1281412. Epub 2017 Feb 21.


Genetic polymorphism at BCL2 as a predictor for rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone efficacy in patients with diffuse large B-cell lymphoma.

Bashash M, Connors JM, Gascoyne RD, Meissner B, Schuetz JM, Leach S, Slack GW, Berry BR, Hu H, Sehn LH, Brooks-Wilson AR, Spinelli JJ.

Haematologica. 2017 May;102(5):e199-e202. doi: 10.3324/haematol.2016.159087. Epub 2017 Feb 2. No abstract available.


The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6.

Fukuda Y, Cheong PL, Lynch J, Brighton C, Frase S, Kargas V, Rampersaud E, Wang Y, Sankaran VG, Yu B, Ney PA, Weiss MJ, Vogel P, Bond PJ, Ford RC, Trent RJ, Schuetz JD.

Nat Commun. 2016 Aug 10;7:12353. doi: 10.1038/ncomms12353.


Polymorphisms of Insulin-Like Growth Factor 1 Pathway Genes and Breast Cancer Risk.

Shi J, Aronson KJ, Grundy A, Kobayashi LC, Burstyn I, Schuetz JM, Lohrisch CA, SenGupta SK, Lai AS, Brooks-Wilson A, Spinelli JJ, Richardson H.

Front Oncol. 2016 Jun 8;6:136. doi: 10.3389/fonc.2016.00136. eCollection 2016.


DNA repair variants and breast cancer risk.

Grundy A, Richardson H, Schuetz JM, Burstyn I, Spinelli JJ, Brooks-Wilson A, Aronson KJ.

Environ Mol Mutagen. 2016 May;57(4):269-81. doi: 10.1002/em.22013. Epub 2016 Apr 9.


ABCC4 Is a Determinant of Cytarabine-Induced Cytotoxicity and Myelosuppression.

Drenberg CD, Hu S, Li L, Buelow DR, Orwick SJ, Gibson AA, Schuetz JD, Sparreboom A, Baker SD.

Clin Transl Sci. 2016 Feb;9(1):51-9. doi: 10.1111/cts.12366. Epub 2016 Feb 4.


Papillomavirus-Associated Tumor Formation Critically Depends on c-Fos Expression Induced by Viral Protein E2 and Bromodomain Protein Brd4.

Delcuratolo M, Fertey J, Schneider M, Schuetz J, Leiprecht N, Hudjetz B, Brodbeck S, Corall S, Dreer M, Schwab RM, Grimm M, Wu SY, Stubenrauch F, Chiang CM, Iftner T.

PLoS Pathog. 2016 Jan 4;12(1):e1005366. doi: 10.1371/journal.ppat.1005366. eCollection 2016 Jan.


Genetic variation in vitamin D-related genes and risk of breast cancer among women of European and East Asian descent.

Shi J, Grundy A, Richardson H, Burstyn I, Schuetz JM, Lohrisch CA, SenGupta SK, Lai AS, Brooks-Wilson A, Spinelli JJ, Aronson KJ.

Tumour Biol. 2016 May;37(5):6379-87. doi: 10.1007/s13277-015-4417-8. Epub 2015 Dec 2.


Making spatial prioritizations robust to climate change uncertainties: a case study with North American birds.

Schuetz JG, Langham GM, Soykan CU, Wilsey CB, Auer T, Sanchez CC.

Ecol Appl. 2015 Oct;25(7):1819-31.


Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death.

Morgan JA, Lynch J, Panetta JC, Wang Y, Frase S, Bao J, Zheng J, Opferman JT, Janke L, Green DM, Chemaitilly W, Schuetz JD.

Sci Rep. 2015 Nov 18;5:16488. doi: 10.1038/srep16488.


Maternal bile acid transporter deficiency promotes neonatal demise.

Zhang Y, Li F, Wang Y, Pitre A, Fang ZZ, Frank MW, Calabrese C, Krausz KW, Neale G, Frase S, Vogel P, Rock CO, Gonzalez FJ, Schuetz JD.

Nat Commun. 2015 Sep 29;6:8186. doi: 10.1038/ncomms9186.


The ABCC4 membrane transporter modulates platelet aggregation.

Cheepala SB, Pitre A, Fukuda Y, Takenaka K, Zhang Y, Wang Y, Frase S, Pestina T, Gartner TK, Jackson C, Schuetz JD.

Blood. 2015 Nov 12;126(20):2307-19. doi: 10.1182/blood-2014-08-595942. Epub 2015 Sep 24.


Conservation Status of North American Birds in the Face of Future Climate Change.

Langham GM, Schuetz JG, Distler T, Soykan CU, Wilsey C.

PLoS One. 2015 Sep 2;10(9):e0135350. doi: 10.1371/journal.pone.0135350. eCollection 2015.


ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy.

Morfouace M, Cheepala S, Jackson S, Fukuda Y, Patel YT, Fatima S, Kawauchi D, Shelat AA, Stewart CF, Sorrentino BP, Schuetz JD, Roussel MF.

Cancer Res. 2015 Sep 15;75(18):3879-89. doi: 10.1158/0008-5472.CAN-15-0030. Epub 2015 Jul 21.


PKA and actin play critical roles as downstream effectors in MRP4-mediated regulation of fibroblast migration.

Sinha C, Ren A, Arora K, Moon CS, Yarlagadda S, Woodrooffe K, Lin S, Schuetz JD, Ziady AG, Naren AP.

Cell Signal. 2015 Jul;27(7):1345-55. doi: 10.1016/j.cellsig.2015.03.022. Epub 2015 Apr 2.


Compartmentalized accumulation of cAMP near complexes of multidrug resistance protein 4 (MRP4) and cystic fibrosis transmembrane conductance regulator (CFTR) contributes to drug-induced diarrhea.

Moon C, Zhang W, Ren A, Arora K, Sinha C, Yarlagadda S, Woodrooffe K, Schuetz JD, Valasani KR, de Jonge HR, Shanmukhappa SK, Shata MT, Buddington RK, Parthasarathi K, Naren AP.

J Biol Chem. 2015 May 1;290(18):11246-57. doi: 10.1074/jbc.M114.605410. Epub 2015 Mar 11.


ABC transporters and cancer. Preface.

Schuetz JD, Ishikawa T.

Adv Cancer Res. 2015;125:xv-xvii. doi: 10.1016/S0065-230X(15)00010-X. No abstract available.


Leukemia and ABC transporters.

Fukuda Y, Lian S, Schuetz JD.

Adv Cancer Res. 2015;125:171-96. doi: 10.1016/bs.acr.2014.10.006. Epub 2015 Jan 8. Review.


The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism.

Demetz E, Schroll A, Auer K, Heim C, Patsch JR, Eller P, Theurl M, Theurl I, Theurl M, Seifert M, Lener D, Stanzl U, Haschka D, Asshoff M, Dichtl S, Nairz M, Huber E, Stadlinger M, Moschen AR, Li X, Pallweber P, Scharnagl H, Stojakovic T, März W, Kleber ME, Garlaschelli K, Uboldi P, Catapano AL, Stellaard F, Rudling M, Kuba K, Imai Y, Arita M, Schuetz JD, Pramstaller PP, Tietge UJF, Trauner M, Norata GD, Claudel T, Hicks AA, Weiss G, Tancevski I.

Cell Metab. 2014 Nov 4;20(5):787-798. doi: 10.1016/j.cmet.2014.09.004.


Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice.

Li-Harms X, Milasta S, Lynch J, Wright C, Joshi A, Iyengar R, Neale G, Wang X, Wang YD, Prolla TA, Thompson JE, Opferman JT, Green DR, Schuetz J, Kundu M.

Blood. 2015 Jan 1;125(1):162-74. doi: 10.1182/blood-2014-07-586396. Epub 2014 Nov 19.


Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport.

Jin D, Ni TT, Sun J, Wan H, Amack JD, Yu G, Fleming J, Chiang C, Li W, Papierniak A, Cheepala S, Conseil G, Cole SP, Zhou B, Drummond IA, Schuetz JD, Malicki J, Zhong TP.

Nat Cell Biol. 2014 Sep;16(9):841-51. doi: 10.1038/ncb3029. Epub 2014 Aug 31.


The role of transporters in toxicity and disease.

Schuetz JD, Swaan PW, Tweedie DJ.

Drug Metab Dispos. 2014 Apr;42(4):541-5. doi: 10.1124/dmd.114.057539. Review.


Deficiency of ATP-binding cassette transporter B6 in megakaryocyte progenitors accelerates atherosclerosis in mice.

Murphy AJ, Sarrazy V, Wang N, Bijl N, Abramowicz S, Westerterp M, Welch CB, Schuetz JD, Yvan-Charvet L.

Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):751-8. doi: 10.1161/ATVBAHA.113.302613. Epub 2014 Feb 6.


Protection against chemotherapy-induced alopecia: targeting ATP-binding cassette transporters in the hair follicle?

Haslam IS, Pitre A, Schuetz JD, Paus R.

Trends Pharmacol Sci. 2013 Nov;34(11):599-604. doi: 10.1016/ Epub 2013 Oct 4.


Non-Hodgkin lymphoma risk and variants in genes controlling lymphocyte development.

Schuetz JM, Daley D, Leach S, Conde L, Berry BR, Gallagher RP, Connors JM, Gascoyne RD, Bracci PM, Skibola CF, Spinelli JJ, Brooks-Wilson AR.

PLoS One. 2013 Sep 30;8(9):e75170. doi: 10.1371/journal.pone.0075170. eCollection 2013.


Sex- and subtype-specific analysis of H2AFX polymorphisms in non-Hodgkin lymphoma.

Bretherick KL, Schuetz JM, Morton LM, Purdue MP, Conde L, Gallagher RP, Connors JM, Gascoyne RD, Berry BR, Armstrong B, Kricker A, Vajdic CM, Grulich A, Hjalgrim H, Smedby KE, Skibola CF, Rothman N, Spinelli JJ, Brooks-Wilson AR.

PLoS One. 2013 Sep 17;8(9):e74619. doi: 10.1371/journal.pone.0074619. eCollection 2013.


Contribution of ABCC4-mediated gastric transport to the absorption and efficacy of dasatinib.

Furmanski BD, Hu S, Fujita KI, Li L, Gibson AA, Janke LJ, Williams RT, Schuetz JD, Sparreboom A, Baker SD.

Clin Cancer Res. 2013 Aug 15;19(16):4359-4370. doi: 10.1158/1078-0432.CCR-13-0980. Epub 2013 Jun 21.


Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction.

Wang X, Bathina M, Lynch J, Koss B, Calabrese C, Frase S, Schuetz JD, Rehg JE, Opferman JT.

Genes Dev. 2013 Jun 15;27(12):1351-64. doi: 10.1101/gad.215855.113.


Human immunodeficiency virus protease inhibitors interact with ATP binding cassette transporter 4/multidrug resistance protein 4: a basis for unanticipated enhanced cytotoxicity.

Fukuda Y, Takenaka K, Sparreboom A, Cheepala SB, Wu CP, Ekins S, Ambudkar SV, Schuetz JD.

Mol Pharmacol. 2013 Sep;84(3):361-71. doi: 10.1124/mol.113.086967. Epub 2013 Jun 17.


Crucial role for phylogenetically conserved cytoplasmic loop 3 in ABCC4 protein expression.

Cheepala SB, Bao J, Nachagari D, Sun D, Wang Y, Zhong TP, Naren AP, Zheng J, Schuetz JD.

J Biol Chem. 2013 Aug 2;288(31):22207-18. doi: 10.1074/jbc.M113.476218. Epub 2013 Jun 13. Erratum in: J Biol Chem. 2013 Sep 13;288(37):26821. Zhong, Tao [corrected to Zhong, Tao P].


Shift work, circadian gene variants and risk of breast cancer.

Grundy A, Schuetz JM, Lai AS, Janoo-Gilani R, Leach S, Burstyn I, Richardson H, Brooks-Wilson A, Spinelli JJ, Aronson KJ.

Cancer Epidemiol. 2013 Oct;37(5):606-12. doi: 10.1016/j.canep.2013.04.006. Epub 2013 May 28.


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