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Items: 40

1.

Ventral midbrain astrocytes display unique physiological features and sensitivity to dopamine D2 receptor signaling.

Xin W, Schuebel KE, Jair KW, Cimbro R, De Biase LM, Goldman D, Bonci A.

Neuropsychopharmacology. 2019 Jan;44(2):344-355. doi: 10.1038/s41386-018-0151-4. Epub 2018 Jul 13.

2.

Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia.

De Biase LM, Schuebel KE, Fusfeld ZH, Jair K, Hawes IA, Cimbro R, Zhang HY, Liu QR, Shen H, Xi ZX, Goldman D, Bonci A.

Neuron. 2017 Jul 19;95(2):341-356.e6. doi: 10.1016/j.neuron.2017.06.020. Epub 2017 Jul 6.

3.

A Four-Gene Promoter Methylation Marker Panel Consisting of GREM1, NEURL, LAD1, and NEFH Predicts Survival of Clear Cell Renal Cell Cancer Patients.

van Vlodrop IJH, Joosten SC, De Meyer T, Smits KM, Van Neste L, Melotte V, Baldewijns MMLL, Schouten LJ, van den Brandt PA, Jeschke J, Yi JM, Schuebel KE, Ahuja N, Herman JG, Aarts MJ, Bosman FT, Van Criekinge W, van Engeland M.

Clin Cancer Res. 2017 Apr 15;23(8):2006-2018. doi: 10.1158/1078-0432.CCR-16-1236. Epub 2016 Oct 18.

4.

Epigenetic silencing of neurofilament genes promotes an aggressive phenotype in breast cancer.

Calmon MF, Jeschke J, Zhang W, Dhir M, Siebenkäs C, Herrera A, Tsai HC, O'Hagan HM, Pappou EP, Hooker CM, Fu T, Schuebel KE, Gabrielson E, Rahal P, Herman JG, Baylin SB, Ahuja N.

Epigenetics. 2015;10(7):622-32. doi: 10.1080/15592294.2015.1050173.

5.

Spectrin repeat containing nuclear envelope 1 and forkhead box protein E1 are promising markers for the detection of colorectal cancer in blood.

Melotte V, Yi JM, Lentjes MH, Smits KM, Van Neste L, Niessen HE, Wouters KA, Louwagie J, Schuebel KE, Herman JG, Baylin SB, van Criekinge W, Meijer GA, Ahuja N, van Engeland M.

Cancer Prev Res (Phila). 2015 Feb;8(2):157-64. doi: 10.1158/1940-6207.CAPR-14-0198. Epub 2014 Dec 23.

6.

Functional identification of cancer-specific methylation of CDO1, HOXA9, and TAC1 for the diagnosis of lung cancer.

Wrangle J, Machida EO, Danilova L, Hulbert A, Franco N, Zhang W, Glöckner SC, Tessema M, Van Neste L, Easwaran H, Schuebel KE, Licchesi J, Hooker CM, Ahuja N, Amano J, Belinsky SA, Baylin SB, Herman JG, Brock MV.

Clin Cancer Res. 2014 Apr 1;20(7):1856-64. doi: 10.1158/1078-0432.CCR-13-2109. Epub 2014 Jan 31.

7.

Frequent inactivation of cysteine dioxygenase type 1 contributes to survival of breast cancer cells and resistance to anthracyclines.

Jeschke J, O'Hagan HM, Zhang W, Vatapalli R, Calmon MF, Danilova L, Nelkenbrecher C, Van Neste L, Bijsmans IT, Van Engeland M, Gabrielson E, Schuebel KE, Winterpacht A, Baylin SB, Herman JG, Ahuja N.

Clin Cancer Res. 2013 Jun 15;19(12):3201-11. doi: 10.1158/1078-0432.CCR-12-3751. Epub 2013 Apr 29.

8.

Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen.

Jeschke J, Van Neste L, Glöckner SC, Dhir M, Calmon MF, Deregowski V, Van Criekinge W, Vlassenbroeck I, Koch A, Chan TA, Cope L, Hooker CM, Schuebel KE, Gabrielson E, Winterpacht A, Baylin SB, Herman JG, Ahuja N.

Epigenetics. 2012 Jul;7(7):701-9. doi: 10.4161/epi.20445. Epub 2012 Jul 1.

PMID:
22647880
9.

Genomic and epigenomic integration identifies a prognostic signature in colon cancer.

Yi JM, Dhir M, Van Neste L, Downing SR, Jeschke J, Glöckner SC, de Freitas Calmon M, Hooker CM, Funes JM, Boshoff C, Smits KM, van Engeland M, Weijenberg MP, Iacobuzio-Donahue CA, Herman JG, Schuebel KE, Baylin SB, Ahuja N.

Clin Cancer Res. 2011 Mar 15;17(6):1535-45. doi: 10.1158/1078-0432.CCR-10-2509. Epub 2011 Jan 28.

10.

Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells.

Ohm JE, Mali P, Van Neste L, Berman DM, Liang L, Pandiyan K, Briggs KJ, Zhang W, Argani P, Simons B, Yu W, Matsui W, Van Criekinge W, Rassool FV, Zambidis E, Schuebel KE, Cope L, Yen J, Mohammad HP, Cheng L, Baylin SB.

Cancer Res. 2010 Oct 1;70(19):7662-73. doi: 10.1158/0008-5472.CAN-10-1361. Epub 2010 Sep 14.

11.

Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleus.

Easwaran HP, Van Neste L, Cope L, Sen S, Mohammad HP, Pageau GJ, Lawrence JB, Herman JG, Schuebel KE, Baylin SB.

Cancer Res. 2010 Oct 15;70(20):8015-24. doi: 10.1158/0008-5472.CAN-10-0765. Epub 2010 Aug 24.

12.

Prognostic significance of Gremlin1 (GREM1) promoter CpG island hypermethylation in clear cell renal cell carcinoma.

van Vlodrop IJ, Baldewijns MM, Smits KM, Schouten LJ, van Neste L, van Criekinge W, van Poppel H, Lerut E, Schuebel KE, Ahuja N, Herman JG, de Bruïne AP, van Engeland M.

Am J Pathol. 2010 Feb;176(2):575-84. doi: 10.2353/ajpath.2010.090442. Epub 2009 Dec 30.

13.

Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers.

Tessema M, Yu YY, Stidley CA, Machida EO, Schuebel KE, Baylin SB, Belinsky SA.

Carcinogenesis. 2009 Jul;30(7):1132-8. doi: 10.1093/carcin/bgp114. Epub 2009 May 12.

14.

Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer.

Glöckner SC, Dhir M, Yi JM, McGarvey KE, Van Neste L, Louwagie J, Chan TA, Kleeberger W, de Bruïne AP, Smits KM, Khalid-de Bakker CA, Jonkers DM, Stockbrügger RW, Meijer GA, Oort FA, Iacobuzio-Donahue C, Bierau K, Herman JG, Baylin SB, Van Engeland M, Schuebel KE, Ahuja N.

Cancer Res. 2009 Jun 1;69(11):4691-9. doi: 10.1158/0008-5472.CAN-08-0142. Epub 2009 May 12.

15.

Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors.

Yi JM, Tsai HC, Glöckner SC, Lin S, Ohm JE, Easwaran H, James CD, Costello JF, Riggins G, Eberhart CG, Laterra J, Vescovi AL, Ahuja N, Herman JG, Schuebel KE, Baylin SB.

Cancer Res. 2008 Oct 1;68(19):8094-103. doi: 10.1158/0008-5472.CAN-07-6208.

16.

Epigenetic regulation of WNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia.

Dhir M, Montgomery EA, Glöckner SC, Schuebel KE, Hooker CM, Herman JG, Baylin SB, Gearhart SL, Ahuja N.

J Gastrointest Surg. 2008 Oct;12(10):1745-53. doi: 10.1007/s11605-008-0633-5. Epub 2008 Aug 21.

17.

Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells.

McGarvey KM, Van Neste L, Cope L, Ohm JE, Herman JG, Van Criekinge W, Schuebel KE, Baylin SB.

Cancer Res. 2008 Jul 15;68(14):5753-9. doi: 10.1158/0008-5472.CAN-08-0700.

18.

Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis.

Chan TA, Glockner S, Yi JM, Chen W, Van Neste L, Cope L, Herman JG, Velculescu V, Schuebel KE, Ahuja N, Baylin SB.

PLoS Med. 2008 May 27;5(5):e114. doi: 10.1371/journal.pmed.0050114.

19.

Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer.

Zhang W, Glöckner SC, Guo M, Machida EO, Wang DH, Easwaran H, Van Neste L, Herman JG, Schuebel KE, Watkins DN, Ahuja N, Baylin SB.

Cancer Res. 2008 Apr 15;68(8):2764-72. doi: 10.1158/0008-5472.CAN-07-6349. Erratum in: Cancer Res. 2008 Jul 15;68(14):6030.

20.

A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells.

Ting AH, Suzuki H, Cope L, Schuebel KE, Lee BH, Toyota M, Imai K, Shinomura Y, Tokino T, Baylin SB.

Cancer Res. 2008 Apr 15;68(8):2570-5. doi: 10.1158/0008-5472.CAN-07-6405.

21.

Comparing the DNA hypermethylome with gene mutations in human colorectal cancer.

Schuebel KE, Chen W, Cope L, Glöckner SC, Suzuki H, Yi JM, Chan TA, Van Neste L, Van Criekinge W, van den Bosch S, van Engeland M, Ting AH, Jair K, Yu W, Toyota M, Imai K, Ahuja N, Herman JG, Baylin SB.

PLoS Genet. 2007 Sep;3(9):1709-23. Epub 2007 Jul 31.

22.

Genomic biology: the epigenomic era opens.

Baylin SB, Schuebel KE.

Nature. 2007 Aug 2;448(7153):548-9. No abstract available.

23.

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing.

Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L, Mohammad HP, Chen W, Daniel VC, Yu W, Berman DM, Jenuwein T, Pruitt K, Sharkis SJ, Watkins DN, Herman JG, Baylin SB.

Nat Genet. 2007 Feb;39(2):237-42. Epub 2007 Jan 9.

24.
25.

De novo CpG island methylation in human cancer cells.

Jair KW, Bachman KE, Suzuki H, Ting AH, Rhee I, Yen RW, Baylin SB, Schuebel KE.

Cancer Res. 2006 Jan 15;66(2):682-92.

26.

Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation.

Ting AH, Schuebel KE, Herman JG, Baylin SB.

Nat Genet. 2005 Aug;37(8):906-10. Epub 2005 Jul 17.

27.

Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling.

Nakakura EK, Sriuranpong VR, Kunnimalaiyaan M, Hsiao EC, Schuebel KE, Borges MW, Jin N, Collins BJ, Nelkin BD, Chen H, Ball DW.

J Clin Endocrinol Metab. 2005 Jul;90(7):4350-6. Epub 2005 May 3.

PMID:
15870121
28.

Mammalian DNA methyltransferase 1: inspiration for new directions.

Ting AH, Jair KW, Suzuki H, Yen RW, Baylin SB, Schuebel KE.

Cell Cycle. 2004 Aug;3(8):1024-6. Epub 2004 Aug 2. Review.

PMID:
15280656
29.

CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1.

Ting AH, Jair KW, Suzuki H, Yen RW, Baylin SB, Schuebel KE.

Nat Genet. 2004 Jun;36(6):582-4. Epub 2004 May 23.

PMID:
15156141
30.

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer.

Suzuki H, Watkins DN, Jair KW, Schuebel KE, Markowitz SD, Chen WD, Pretlow TP, Yang B, Akiyama Y, Van Engeland M, Toyota M, Tokino T, Hinoda Y, Imai K, Herman JG, Baylin SB.

Nat Genet. 2004 Apr;36(4):417-22. Epub 2004 Mar 14.

PMID:
15034581
31.

Epigenetic inactivation of CHFR in human tumors.

Toyota M, Sasaki Y, Satoh A, Ogi K, Kikuchi T, Suzuki H, Mita H, Tanaka N, Itoh F, Issa JP, Jair KW, Schuebel KE, Imai K, Tokino T.

Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7818-23. Epub 2003 Jun 16.

32.

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells.

Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, Schuebel KE, Cui H, Feinberg AP, Lengauer C, Kinzler KW, Baylin SB, Vogelstein B.

Nature. 2002 Apr 4;416(6880):552-6.

PMID:
11932749
33.

Mammalian Scratch: a neural-specific Snail family transcriptional repressor.

Nakakura EK, Watkins DN, Schuebel KE, Sriuranpong V, Borges MW, Nelkin BD, Ball DW.

Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4010-5. Epub 2001 Mar 13.

34.

CpG methylation is maintained in human cancer cells lacking DNMT1.

Rhee I, Jair KW, Yen RW, Lengauer C, Herman JG, Kinzler KW, Vogelstein B, Baylin SB, Schuebel KE.

Nature. 2000 Apr 27;404(6781):1003-7.

PMID:
10801130
35.

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2.

Schuebel KE, Movilla N, Rosa JL, Bustelo XR.

EMBO J. 1998 Nov 16;17(22):6608-21.

36.

S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells.

Hardt WD, Chen LM, Schuebel KE, Bustelo XR, Galán JE.

Cell. 1998 May 29;93(5):815-26.

37.

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product.

Crespo P, Schuebel KE, Ostrom AA, Gutkind JS, Bustelo XR.

Nature. 1997 Jan 9;385(6612):169-72.

PMID:
8990121
38.

Limitations imposed by heteroduplex formation on quantitative RT-PCR.

Henley WN, Schuebel KE, Nielsen DA.

Biochem Biophys Res Commun. 1996 Sep 4;226(1):113-7.

PMID:
8806600
39.

Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes.

Schuebel KE, Bustelo XR, Nielsen DA, Song BJ, Barbacid M, Goldman D, Lee IJ.

Oncogene. 1996 Jul 18;13(2):363-71.

PMID:
8710375
40.

A quantitative assay for mouse granulocyte (CFU-g) and macrophage (CFU-m) precursors using plasma clots.

Iizuka Y, Noguchi K, Schuebel KE, Miyake T, Murphy MJ Jr.

J Histochem Cytochem. 1985 Jul;33(7):617-23.

PMID:
4008915

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