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In vitro activity of Exebacase (CF-301) against clinical Staphylococcus aureus surveillance isolates from the United States, Europe, and Latin America, 2015-2017.

Traczewski M, Oh J, Cassino C, Schuch R.

Diagn Microbiol Infect Dis. 2019 Aug 1:114879. doi: 10.1016/j.diagmicrobio.2019.114879. [Epub ahead of print]


Exebacase in Addition to Daptomycin is More Active than Daptomycin or Exebacase Alone in Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats.

Karau MJ, Schmidt-Malan SM, Yan Q, Greenwood-Quaintance KE, Mandrekar J, Lehoux D, Schuch R, Cassino C, Patel R.

Antimicrob Agents Chemother. 2019 Jul 29. pii: AAC.01235-19. doi: 10.1128/AAC.01235-19. [Epub ahead of print]


Antimicrobial Activity of Exebacase (Lysin CF-301) Against the Most Common Causes of Infective Endocarditis.

Watson A, Oh JT, Sauve K, Bradford PA, Cassino C, Schuch R.

Antimicrob Agents Chemother. 2019 Jul 22. pii: AAC.01078-19. doi: 10.1128/AAC.01078-19. [Epub ahead of print]


Lysocins: Bioengineered Antimicrobials That Deliver Lysins across the Outer Membrane of Gram-Negative Bacteria.

Heselpoth RD, Euler CW, Schuch R, Fischetti VA.

Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e00342-19. doi: 10.1128/AAC.00342-19. Print 2019 Jun.


Postantibiotic and Sub-MIC Effects of Exebacase (Lysin CF-301) Enhance Antimicrobial Activity against Staphylococcus aureus.

Oh JT, Cassino C, Schuch R.

Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e02616-18. doi: 10.1128/AAC.02616-18. Print 2019 Jun.


The PlyB Endolysin of Bacteriophage vB_BanS_Bcp1 Exhibits Broad-Spectrum Bactericidal Activity against Bacillus cereus Sensu Lato Isolates.

Schuch R, Pelzek AJ, Nelson DC, Fischetti VA.

Appl Environ Microbiol. 2019 Apr 18;85(9). pii: e00003-19. doi: 10.1128/AEM.00003-19. Print 2019 May 1.


The Antistaphylococcal Lysin, CF-301, Activates Key Host Factors in Human Blood To Potentiate Methicillin-Resistant Staphylococcus aureus Bacteriolysis.

Indiani C, Sauve K, Raz A, Abdelhady W, Xiong YQ, Cassino C, Bayer AS, Schuch R.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02291-18. doi: 10.1128/AAC.02291-18. Print 2019 Apr.


LemA and Erp Y-like recombinant proteins from Leptospira interrogans protect hamsters from challenge using AddaVax™ as adjuvant.

Oliveira TL, Schuch RA, Inda GR, Roloff BC, Neto ACPS, Amaral M, Dellagostin OA, Hartwig DD.

Vaccine. 2018 May 3;36(19):2574-2580. doi: 10.1016/j.vaccine.2018.03.078. Epub 2018 Apr 3.


Design of an optical trap for storing femtosecond laser pulses.

Shehata A, Chvykov V, Schuch R, Mohamed T.

Appl Opt. 2018 Feb 10;57(5):1212-1217. doi: 10.1364/AO.57.001212.


DNA vaccines against leptospirosis: A literature review.

Silveira MM, Oliveira TL, Schuch RA, McBride AJA, Dellagostin OA, Hartwig DD.

Vaccine. 2017 Oct 9;35(42):5559-5567. doi: 10.1016/j.vaccine.2017.08.067. Epub 2017 Sep 4. Review.


Human and animal leptospirosis in Southern Brazil: A five-year retrospective study.

Jorge S, Schuch RA, de Oliveira NR, da Cunha CEP, Gomes CK, Oliveira TL, Rizzi C, Qadan AF, Pacce VD, Coelho Recuero AL, Soares Brod C, Dellagostin OA.

Travel Med Infect Dis. 2017 Jul - Aug;18:46-52. doi: 10.1016/j.tmaid.2017.07.010. Epub 2017 Jul 22.


The Use of Xanthan Gum as Vaccine Adjuvant: An Evaluation of Immunostimulatory Potential in BALB/c Mice and Cytotoxicity In Vitro.

Schuch RA, Oliveira TL, Collares TF, Monte LG, Inda GR, Dellagostin OA, Vendruscolo CT, Moreira ADS, Hartwig DD.

Biomed Res Int. 2017;2017:3925024. doi: 10.1155/2017/3925024. Epub 2017 May 7.


Bacteriophage Lysin CF-301, a Potent Antistaphylococcal Biofilm Agent.

Schuch R, Khan BK, Raz A, Rotolo JA, Wittekind M.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e02666-16. doi: 10.1128/AAC.02666-16. Print 2017 Jul.


Reverse Vaccinology: An Approach for Identifying Leptospiral Vaccine Candidates.

Dellagostin OA, Grassmann AA, Rizzi C, Schuch RA, Jorge S, Oliveira TL, McBride AJ, Hartwig DD.

Int J Mol Sci. 2017 Jan 14;18(1). pii: E158. doi: 10.3390/ijms18010158. Review.


Immune response in hamsters immunised with a recombinant fragment of LigA from Leptospira interrogans, associated with carrier molecules.

Oliveira TL, Bacelo KL, Schuch RA, Seixas FK, Collares T, Rodrigues OE, Vargas J, Nascimento RO, Dellagostin OA, Hartwig DD.

Mem Inst Oswaldo Cruz. 2016 Nov;111(11):712-716. doi: 10.1590/0074-02760160214. Epub 2016 Oct 13.


Cell wall hydrolases and antibiotics: exploiting synergy to create efficacious new antimicrobial treatments.

Wittekind M, Schuch R.

Curr Opin Microbiol. 2016 Oct;33:18-24. doi: 10.1016/j.mib.2016.05.006. Epub 2016 May 31. Review.


DNA prime-protein boost based vaccination with a conserved region of leptospiral immunoglobulin-like A and B proteins enhances protection against leptospirosis.

Forster KM, Hartwig DD, Oliveira TL, Bacelo KL, Schuch R, Amaral MG, Dellagostin OA.

Mem Inst Oswaldo Cruz. 2015 Dec;110(8):989-95. doi: 10.1590/0074-02760150222. Epub 2015 Dec 11.


Evaluation of the Leptospira interrogans Outer Membrane Protein OmpL37 as a Vaccine Candidate.

Oliveira TL, Grassmann AA, Schuch RA, Seixas Neto AC, Mendonça M, Hartwig DD, McBride AJ, Dellagostin OA.

PLoS One. 2015 Nov 20;10(11):e0142821. doi: 10.1371/journal.pone.0142821. eCollection 2015.


The use of halloysite clay and carboxyl-functionalised multi-walled carbon nanotubes for recombinant LipL32 antigen delivery enhanced the IgG response.

Hartwig DD, Bacelo KL, Oliveira TL, Schuch R, Seixas FK, Collares T, Rodrigues O, Hartleben CP, Dellagostin OA.

Mem Inst Oswaldo Cruz. 2015 Feb;110(1):134-7. doi: 10.1590/0074-02760140276. Epub 2015 Jan 23.


A linear optical trap with active medium for experiments with high power laser pulses.

Mohamed T, Andler G, Schuch R.

Rev Sci Instrum. 2015 Feb;86(2):023113. doi: 10.1063/1.4913534.


Novel phage lysin capable of killing the multidrug-resistant gram-negative bacterium Acinetobacter baumannii in a mouse bacteremia model.

Lood R, Winer BY, Pelzek AJ, Diez-Martinez R, Thandar M, Euler CW, Schuch R, Fischetti VA.

Antimicrob Agents Chemother. 2015 Apr;59(4):1983-91. doi: 10.1128/AAC.04641-14. Epub 2015 Jan 20.


Beyond the chromosome: the prevalence of unique extra-chromosomal bacteriophages with integrated virulence genes in pathogenic Staphylococcus aureus.

Utter B, Deutsch DR, Schuch R, Winer BY, Verratti K, Bishop-Lilly K, Sozhamannan S, Fischetti VA.

PLoS One. 2014 Jun 25;9(6):e100502. doi: 10.1371/journal.pone.0100502. eCollection 2014.


Complete Genome Sequence of Bacillus cereus Sensu Lato Bacteriophage Bcp1.

Schuch R, Pelzek AJ, Fazzini MM, Nelson DC, Fischetti VA.

Genome Announc. 2014 Jun 12;2(3). pii: e00334-14. doi: 10.1128/genomeA.00334-14.


Xanthan gum as an adjuvant in a subunit vaccine preparation against leptospirosis.

Bacelo KL, Hartwig DD, Seixas FK, Schuch R, Moreira Ada S, Amaral M, Collares T, Vendrusculo CT, McBride AJ, Dellagostin OA.

Biomed Res Int. 2014;2014:636491. doi: 10.1155/2014/636491. Epub 2014 May 7.


Discovery of Novel Putative Inhibitors of UDP-GlcNAc 2-Epimerase as Potent Antibacterial Agents.

Xu Y, Brenning B, Clifford A, Vollmer D, Bearss J, Jones C, McCarthy V, Shi C, Wolfe B, Aavula B, Warner S, Bearss DJ, McCullar MV, Schuch R, Pelzek A, Bhaskaran SS, Stebbins CE, Goldberg AR, Fischetti VA, Vankayalapati H.

ACS Med Chem Lett. 2013 Dec 12;4(12):1142-1147.


Combination therapy with lysin CF-301 and antibiotic is superior to antibiotic alone for treating methicillin-resistant Staphylococcus aureus-induced murine bacteremia.

Schuch R, Lee HM, Schneider BC, Sauve KL, Law C, Khan BK, Rotolo JA, Horiuchi Y, Couto DE, Raz A, Fischetti VA, Huang DB, Nowinski RC, Wittekind M.

J Infect Dis. 2014 May 1;209(9):1469-78. doi: 10.1093/infdis/jit637. Epub 2013 Nov 28.


Identification of a ligand on the Wip1 bacteriophage highly specific for a receptor on Bacillus anthracis.

Kan S, Fornelos N, Schuch R, Fischetti VA.

J Bacteriol. 2013 Oct;195(19):4355-64. doi: 10.1128/JB.00655-13. Epub 2013 Jul 26.


Lysins: the arrival of pathogen-directed anti-infectives.

Pastagia M, Schuch R, Fischetti VA, Huang DB.

J Med Microbiol. 2013 Oct;62(Pt 10):1506-16. doi: 10.1099/jmm.0.061028-0. Epub 2013 Jun 27. Review.


Anthrax SET protein: a potential virulence determinant that epigenetically represses NF-κB activation in infected macrophages.

Mujtaba S, Winer BY, Jaganathan A, Patel J, Sgobba M, Schuch R, Gupta YK, Haider S, Wang R, Fischetti VA.

J Biol Chem. 2013 Aug 9;288(32):23458-72. doi: 10.1074/jbc.M113.467696. Epub 2013 May 29.


Use of a bacteriophage lysin to identify a novel target for antimicrobial development.

Schuch R, Pelzek AJ, Raz A, Euler CW, Ryan PA, Winer BY, Farnsworth A, Bhaskaran SS, Stebbins CE, Xu Y, Clifford A, Bearss DJ, Vankayalapati H, Goldberg AR, Fischetti VA.

PLoS One. 2013 Apr 10;8(4):e60754. doi: 10.1371/journal.pone.0060754. Print 2013.


Development of a high throughput assay for indirectly measuring phage growth using the OmniLog(TM) system.

Henry M, Biswas B, Vincent L, Mokashi V, Schuch R, Bishop-Lilly KA, Sozhamannan S.

Bacteriophage. 2012 Jul 1;2(3):159-167.


Tailoring of keV-ion beams by image charge when transmitting through rhombic and rectangular shaped nanocapillaries.

Zhang HQ, Akram N, Skog P, Soroka IL, Trautmann C, Schuch R.

Phys Rev Lett. 2012 May 11;108(19):193202. Epub 2012 May 7.


Site-specific chromatin immunoprecipitation: a selective method to individually analyze neighboring transcription factor binding sites in vivo.

Schuch R, Agelopoulos K, Neumann A, Brandt B, Bürger H, Korsching E.

BMC Res Notes. 2012 Feb 20;5:109. doi: 10.1186/1756-0500-5-109.


Evaporative cooling and coherent axial oscillations of highly charged ions in a penning trap.

Hobein M, Solders A, Suhonen M, Liu Y, Schuch R.

Phys Rev Lett. 2011 Jan 7;106(1):013002. Epub 2011 Jan 7.


Crowd control: Bacillus anthracis and quorum sensing.

Rollins SM, Schuch R.

Virulence. 2010 Mar-Apr;1(2):57-9. doi: 10.4161/viru.1.2.11051.


Identifying active phage lysins through functional viral metagenomics.

Schmitz JE, Schuch R, Fischetti VA.

Appl Environ Microbiol. 2010 Nov;76(21):7181-7. doi: 10.1128/AEM.00732-10. Epub 2010 Sep 17.


A novel spore protein, ExsM, regulates formation of the exosporium in Bacillus cereus and Bacillus anthracis and affects spore size and shape.

Fazzini MM, Schuch R, Fischetti VA.

J Bacteriol. 2010 Aug;192(15):4012-21. doi: 10.1128/JB.00197-10. Epub 2010 Jun 11.


Prevalence of Bacillus anthracis-like organisms and bacteriophages in the intestinal tract of the earthworm Eisenia fetida.

Schuch R, Pelzek AJ, Kan S, Fischetti VA.

Appl Environ Microbiol. 2010 Apr;76(7):2286-94. doi: 10.1128/AEM.02518-09. Epub 2010 Jan 29.


The secret life of the anthrax agent Bacillus anthracis: bacteriophage-mediated ecological adaptations.

Schuch R, Fischetti VA.

PLoS One. 2009 Aug 12;4(8):e6532. doi: 10.1371/journal.pone.0006532.


Contributions to microbiology. Bacterial sensing and signaling. Foreword.

Collin M, Schuch R.

Contrib Microbiol. 2009;16:VII-VIII. No abstract available.


Two-center double-capture interference in fast He2+ + H2 collisions.

Misra D, Schmidt HT, Gudmundsson M, Fischer D, Haag N, Johansson HA, Källberg A, Najjari B, Reinhed P, Schuch R, Schöffler M, Simonsson A, Voitkiv AB, Cederquist H.

Phys Rev Lett. 2009 Apr 17;102(15):153201. Epub 2009 Apr 15.


Evidence of sequentially formed charge patches guiding ions through nanocapillaries.

Skog P, Zhang H, Schuch R.

Phys Rev Lett. 2008 Nov 28;101(22):223202. Epub 2008 Nov 26.


A genetic screen to identify bacteriophage lysins.

Schuch R, Fischetti VA, Nelson DC.

Methods Mol Biol. 2009;502:307-19. doi: 10.1007/978-1-60327-565-1_18.


Evidence of wave-particle duality for single fast hydrogen atoms.

Schmidt HT, Fischer D, Berenyi Z, Cocke CL, Gudmundsson M, Haag N, Johansson HA, Källberg A, Levin SB, Reinhed P, Sassenberg U, Schuch R, Simonsson A, Støchkel K, Cederquist H.

Phys Rev Lett. 2008 Aug 22;101(8):083201. Epub 2008 Aug 19.


A structural basis for the allosteric regulation of non-hydrolysing UDP-GlcNAc 2-epimerases.

Velloso LM, Bhaskaran SS, Schuch R, Fischetti VA, Stebbins CE.

EMBO Rep. 2008 Feb;9(2):199-205. doi: 10.1038/sj.embor.7401154. Epub 2008 Jan 11.


Rapid DNA library construction for functional genomic and metagenomic screening.

Schmitz JE, Daniel A, Collin M, Schuch R, Fischetti VA.

Appl Environ Microbiol. 2008 Mar;74(5):1649-52. Epub 2007 Dec 14.


Novel algorithms reveal streptococcal transcriptomes and clues about undefined genes.

Ryan PA, Kirk BW, Euler CW, Schuch R, Fischetti VA.

PLoS Comput Biol. 2007 Jul;3(7):e132.


nadA and nadB of Shigella flexneri 5a are antivirulence loci responsible for the synthesis of quinolinate, a small molecule inhibitor of Shigella pathogenicity.

Prunier AL, Schuch R, Fernández RE, Mumy KL, Kohler H, McCormick BA, Maurelli AT.

Microbiology. 2007 Jul;153(Pt 7):2363-72.


Genetic structure of the nadA and nadB antivirulence loci in Shigella spp.

Prunier AL, Schuch R, Fernández RE, Maurelli AT.

J Bacteriol. 2007 Sep;189(17):6482-6. Epub 2007 Jun 22.


The 1.6 A crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis.

Porter CJ, Schuch R, Pelzek AJ, Buckle AM, McGowan S, Wilce MC, Rossjohn J, Russell R, Nelson D, Fischetti VA, Whisstock JC.

J Mol Biol. 2007 Feb 16;366(2):540-50. Epub 2006 Nov 18.


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