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CD70 expression correlates with a worse prognosis in malignant pleural mesothelioma patients via immune evasion and enhanced invasiveness.

Inaguma S, Lasota J, Czapiewski P, Langfort R, Rys J, Szpor J, Waloszczyk P, Okoń K, Biernat W, Schrump DS, Hassan R, Kasai K, Miettinen M, Ikeda H.

J Pathol. 2019 Oct 22. doi: 10.1002/path.5361. [Epub ahead of print]


Bile acid-induced "Minority MOMP" promotes esophageal carcinogenesis while maintaining apoptotic resistance via Mcl-1.

Xu Y, Surman DR, Diggs L, Xi S, Gao S, Gurusamy D, McLoughlin K, Drake J, Feingold P, Brown K, Wangsa D, Wangsa D, Zhang X, Ried T, Davis JL, Hernandez J, Hoang C, Souza RF, Schrump DS, Taylor Ripley R.

Oncogene. 2019 Sep 30. doi: 10.1038/s41388-019-1029-6. [Epub ahead of print]


MicroRNA-215-5p Treatment Suppresses Mesothelioma Progression via the MDM2-p53-Signaling Axis.

Singh A, Bhattacharyya N, Srivastava A, Pruett N, Ripley RT, Schrump DS, Hoang CD.

Mol Ther. 2019 Sep 4;27(9):1665-1680. doi: 10.1016/j.ymthe.2019.05.020. Epub 2019 Jun 4.


Severe Hepatotoxicity of Mithramycin Therapy Caused by Altered Expression of Hepatocellular Bile Transporters.

Sissung TM, Huang PA, Hauke RJ, McCrea EM, Peer CJ, Barbier RH, Strope JD, Ley AM, Zhang M, Hong JA, Venzon D, Jackson JP, Brouwer KR, Grohar P, Glod J, Widemann BC, Heller T, Schrump DS, Figg WD.

Mol Pharmacol. 2019 Aug;96(2):158-167. doi: 10.1124/mol.118.114827. Epub 2019 Jun 7.


Metadherin Is a Prognostic Apoptosis Modulator in Mesothelioma Induced via NF-κB-Mediated Signaling.

Zhang L, Singh A, Plaisier C, Pruett N, Ripley RT, Schrump DS, Hoang CD.

Transl Oncol. 2019 Jun;12(6):859-870. doi: 10.1016/j.tranon.2019.03.005. Epub 2019 May 1.


Inherited predisposition to malignant mesothelioma and overall survival following platinum chemotherapy.

Hassan R, Morrow B, Thomas A, Walsh T, Lee MK, Gulsuner S, Gadiraju M, Panou V, Gao S, Mian I, Khan J, Raffeld M, Patel S, Xi L, Wei JS, Hesdorffer M, Zhang J, Calzone K, Desai A, Padiernos E, Alewine C, Schrump DS, Steinberg SM, Kindler HL, King MC, Churpek JE.

Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):9008-9013. doi: 10.1073/pnas.1821510116. Epub 2019 Apr 11.


Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer.

Lo W, Parkhurst M, Robbins PF, Tran E, Lu YC, Jia L, Gartner JJ, Pasetto A, Deniger D, Malekzadeh P, Shelton TE, Prickett T, Ray S, Kivitz S, Paria BC, Kriley I, Schrump DS, Rosenberg SA.

Cancer Immunol Res. 2019 Apr;7(4):534-543. doi: 10.1158/2326-6066.CIR-18-0686. Epub 2019 Feb 1. Review.


Correction: Screening of cancer tissue arrays identifies CXCR4 on adrenocortical carcinoma: correlates with expression and quantification on metastases using 64Cu-plerixafor PET.

Weiss ID, Huff LM, Evbuomwan MO, Xu X, Dang HD, Velez DS, Singh SP, Zhang HH, Gardina PJ, Lee JH, Lindenberg L, Myers TG, Paik CH, Schrump DS, Pittaluga S, Choyke PL, Fojo T, Farber JM.

Oncotarget. 2018 Oct 2;9(77):34641. doi: 10.18632/oncotarget.26214. eCollection 2018 Oct 2.


Induction of Thioredoxin-Interacting Protein by a Histone Deacetylase Inhibitor, Entinostat, Is Associated with DNA Damage and Apoptosis in Esophageal Adenocarcinoma.

Feingold PL, Surman DR, Brown K, Xu Y, McDuffie LA, Shukla V, Reardon ES, Crooks DR, Trepel JB, Lee S, Lee MJ, Gao S, Xi S, McLoughlin KC, Diggs LP, Beer DG, Nancarrow DJ, Neckers LM, Davis JL, Hoang CD, Hernandez JM, Schrump DS, Ripley RT.

Mol Cancer Ther. 2018 Sep;17(9):2013-2023. doi: 10.1158/1535-7163.MCT-17-1240. Epub 2018 Jun 22.


Metabolomic and BH3 profiling of esophageal cancers: novel assessment methods for precision therapy.

Taylor Ripley R, Surman DR, Diggs LP, Trepel JB, Lee MJ, Ryan J, Davis JL, Steinberg SM, Hernandez JM, Hoang C, Kenney CM, Bond CD, Kunst TF, Letai A, Schrump DS.

BMC Gastroenterol. 2018 Jun 22;18(1):94. doi: 10.1186/s12876-018-0823-x.


Analysis of circulating tumor DNA: The next paradigm shift in detection and treatment of lung cancer.

Schrump DS, Hong JA.

J Thorac Cardiovasc Surg. 2018 Jun;155(6):2632-2633. doi: 10.1016/j.jtcvs.2018.01.060. Epub 2018 Feb 8. No abstract available.


IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways.

Song NY, Zhu F, Wang Z, Willette-Brown J, Xi S, Sun Z, Su L, Wu X, Ma B, Nussinov R, Xia X, Schrump DS, Johnson PF, Karin M, Hu Y.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E812-E821. doi: 10.1073/pnas.1717520115. Epub 2018 Jan 8.


Bile acid and cigarette smoke enhance the aggressive phenotype of esophageal adenocarcinoma cells by downregulation of the mitochondrial uncoupling protein-2.

Xu Y, Feingold PL, Surman DR, Brown K, Xi S, Davis JL, Hernandez J, Schrump DS, Ripley RT.

Oncotarget. 2017 Nov 10;8(60):101057-101071. doi: 10.18632/oncotarget.22380. eCollection 2017 Nov 24.


CD38 knockout suppresses tumorigenesis in mice and clonogenic growth of human lung cancer cells.

Bu X, Kato J, Hong JA, Merino MJ, Schrump DS, Lund FE, Moss J.

Carcinogenesis. 2018 Feb 9;39(2):242-251. doi: 10.1093/carcin/bgx137.


Screening of cancer tissue arrays identifies CXCR4 on adrenocortical carcinoma: correlates with expression and quantification on metastases using 64Cu-plerixafor PET.

Weiss ID, Huff LM, Evbuomwan MO, Xu X, Dang HD, Velez DS, Singh SP, Zhang HH, Gardina PJ, Lee JH, Lindenberg L, Myers TG, Paik CH, Schrump DS, Pittaluga S, Choyke PL, Fojo T, Farber JM.

Oncotarget. 2017 Aug 4;8(43):73387-73406. doi: 10.18632/oncotarget.19945. eCollection 2017 Sep 26. Erratum in: Oncotarget. 2018 Oct 2;9(77):34641.


ASXL3 Is a Novel Pluripotency Factor in Human Respiratory Epithelial Cells and a Potential Therapeutic Target in Small Cell Lung Cancer.

Shukla V, Rao M, Zhang H, Beers J, Wangsa D, Wangsa D, Buishand FO, Wang Y, Yu Z, Stevenson HS, Reardon ES, McLoughlin KC, Kaufman AS, Payabyab EC, Hong JA, Zhang M, Davis S, Edelman D, Chen G, Miettinen MM, Restifo NP, Ried T, Meltzer PA, Schrump DS.

Cancer Res. 2017 Nov 15;77(22):6267-6281. doi: 10.1158/0008-5472.CAN-17-0570. Epub 2017 Sep 21.


Expression of ALCAM (CD166) and PD-L1 (CD274) independently predicts shorter survival in malignant pleural mesothelioma.

Inaguma S, Lasota J, Wang Z, Czapiewski P, Langfort R, Rys J, Szpor J, Waloszczyk P, Okoń K, Biernat W, Ikeda H, Schrump DS, Hassan R, Miettinen M.

Hum Pathol. 2018 Jan;71:1-7. doi: 10.1016/j.humpath.2017.04.032. Epub 2017 Aug 12.


Targeting the epigenome in malignant pleural mesothelioma.

McLoughlin KC, Kaufman AS, Schrump DS.

Transl Lung Cancer Res. 2017 Jun;6(3):350-365. doi: 10.21037/tlcr.2017.06.06. Review.


Circulating tumor DNA: Solid data from liquid biopsies.

Schrump DS.

J Thorac Cardiovasc Surg. 2017 Sep;154(3):1132-1133. doi: 10.1016/j.jtcvs.2017.05.059. Epub 2017 May 25. No abstract available.


Comprehensive immunohistochemical study of mesothelin (MSLN) using different monoclonal antibodies 5B2 and MN-1 in 1562 tumors with evaluation of its prognostic value in malignant pleural mesothelioma.

Inaguma S, Wang Z, Lasota J, Onda M, Czapiewski P, Langfort R, Rys J, Szpor J, Waloszczyk P, Okoń K, Biernat W, Ikeda H, Schrump DS, Hassan R, Pastan I, Miettinen M.

Oncotarget. 2017 Apr 18;8(16):26744-26754. doi: 10.18632/oncotarget.15814.


Genomic profiling of multiple sequentially acquired tumor metastatic sites from an "exceptional responder" lung adenocarcinoma patient reveals extensive genomic heterogeneity and novel somatic variants driving treatment response.

Biswas R, Gao S, Cultraro CM, Maity TK, Venugopalan A, Abdullaev Z, Shaytan AK, Carter CA, Thomas A, Rajan A, Song Y, Pitts S, Chen K, Bass S, Boland J, Hanada KI, Chen J, Meltzer PS, Panchenko AR, Yang JC, Pack S, Giaccone G, Schrump DS, Khan J, Guha U.

Cold Spring Harb Mol Case Stud. 2016 Nov;2(6):a001263.


Whole-Cell Cancer Vaccines Induce Large Antibody Responses to Carbohydrates and Glycoproteins.

Xia L, Schrump DS, Gildersleeve JC.

Cell Chem Biol. 2016 Dec 22;23(12):1515-1525. doi: 10.1016/j.chembiol.2016.10.012. Epub 2016 Nov 23.


Expression of mesothelin in thymic carcinoma and its potential therapeutic significance.

Thomas A, Chen Y, Berman A, Schrump DS, Giaccone G, Pastan I, Venzon DJ, Liewehr DJ, Steinberg SM, Miettinen M, Hassan R, Rajan A.

Lung Cancer. 2016 Nov;101:104-110. doi: 10.1016/j.lungcan.2016.09.015. Epub 2016 Sep 28.


Role of Local Ablative Therapy in Patients with Oligometastatic and Oligoprogressive Non-Small Cell Lung Cancer.

Kim C, Hoang CD, Kesarwala AH, Schrump DS, Guha U, Rajan A.

J Thorac Oncol. 2017 Feb;12(2):179-193. doi: 10.1016/j.jtho.2016.10.012. Epub 2016 Oct 22. Review.


Metastasectomy Following Immunotherapy with Adoptive Cell Transfer for Patients with Advanced Melanoma.

Klemen ND, Feingold PL, Goff SL, Hughes MS, Kammula US, Yang JC, Schrump DS, Rosenberg SA, Sherry RM.

Ann Surg Oncol. 2017 Jan;24(1):135-141. doi: 10.1245/s10434-016-5537-0. Epub 2016 Sep 16.


Ionic immune suppression within the tumour microenvironment limits T cell effector function.

Eil R, Vodnala SK, Clever D, Klebanoff CA, Sukumar M, Pan JH, Palmer DC, Gros A, Yamamoto TN, Patel SJ, Guittard GC, Yu Z, Carbonaro V, Okkenhaug K, Schrump DS, Linehan WM, Roychoudhuri R, Restifo NP.

Nature. 2016 Sep 22;537(7621):539-543. doi: 10.1038/nature19364. Epub 2016 Sep 14.


Thoracic Surgery in Chronic Granulomatous Disease: a 25-Year Single-Institution Experience.

Feingold PL, Quadri HS, Steinberg SM, Malech HL, Gallin JI, Zerbe CS, Zarember KA, Marciano BE, Holland SM, Schrump DS, Ripley RT.

J Clin Immunol. 2016 Oct;36(7):677-83. doi: 10.1007/s10875-016-0319-9. Epub 2016 Aug 6.


Rapidly Growing Chest Wall Mass in a Case of Sporadic Metastatic Paraganglioma: Imaging With 4 Different PET Radiopharmaceuticals.

Janssen I, Xekouki P, Nambuba J, Chen CC, Herscovitch P, Millo CM, Schrump DS, Pacak K.

Clin Nucl Med. 2016 May;41(5):399-400. doi: 10.1097/RLU.0000000000001116.


Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.

Sukumar M, Liu J, Mehta GU, Patel SJ, Roychoudhuri R, Crompton JG, Klebanoff CA, Ji Y, Li P, Yu Z, Whitehill GD, Clever D, Eil RL, Palmer DC, Mitra S, Rao M, Keyvanfar K, Schrump DS, Wang E, Marincola FM, Gattinoni L, Leonard WJ, Muranski P, Finkel T, Restifo NP.

Cell Metab. 2016 Jan 12;23(1):63-76. doi: 10.1016/j.cmet.2015.11.002. Epub 2015 Dec 8.


Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells.

Rao M, Atay SM, Shukla V, Hong Y, Upham T, Ripley RT, Hong JA, Zhang M, Reardon E, Fetsch P, Miettinen M, Li X, Peer CJ, Sissung T, Figg WD, De Rienzo A, Bueno R, Schrump DS.

Clin Cancer Res. 2016 Mar 1;22(5):1197-210. doi: 10.1158/1078-0432.CCR-14-3379. Epub 2015 Oct 12.


Pulmonary Metastases Exhibit Epigenetic Clonality: Implications for Precision Cancer Therapy.

Reardon ES, Hong JA, Straughan DM, Azoury SC, Zhang M, Schrump DS.

Ann Thorac Surg. 2015 Nov;100(5):1839-48; discussion 1848. doi: 10.1016/j.athoracsur.2015.05.089. Epub 2015 Aug 20.


Pulmonary mucosa-associated lymphoma in a patient with von Hippel-Lindau disease.

Straughan DM, Kerkar S, Azoury SC, Reardon ES, Schrump DS.

J Surg Case Rep. 2015 Jul 14;2015(7). pii: rjv080. doi: 10.1093/jscr/rjv080.


Precision Therapy for Lung Cancer: Tyrosine Kinase Inhibitors and Beyond.

Rajan A, Schrump DS.

Semin Thorac Cardiovasc Surg. 2015 Spring;27(1):36-48. doi: 10.1053/j.semtcvs.2015.04.002. Epub 2015 Apr 8. Review.


Cigarette smoke mediates epigenetic repression of miR-217 during esophageal adenocarcinogenesis.

Xi S, Inchauste S, Guo H, Shan J, Xiao Z, Xu H, Miettenen M, Zhang MR, Hong JA, Raiji MT, Altorki NK, Casson AG, Beer DG, Robles AI, Bowman ED, Harris CC, Steinberg SM, Schrump DS.

Oncogene. 2015 Oct 29;34(44):5548-59. doi: 10.1038/onc.2015.10. Epub 2015 Feb 23.


Extended resections of non-small cell lung cancers invading the aorta, pulmonary artery, left atrium, or esophagus: can they be justified?

Reardon ES, Schrump DS.

Thorac Surg Clin. 2014 Nov;24(4):457-64. doi: 10.1016/j.thorsurg.2014.07.012. Epub 2014 Sep 11. Review.


Ectopic adrenocorticotropic hormone and corticotropin-releasing hormone co-secreting tumors in children and adolescents causing cushing syndrome: a diagnostic dilemma and how to solve it.

Karageorgiadis AS, Papadakis GZ, Biro J, Keil MF, Lyssikatos C, Quezado MM, Merino M, Schrump DS, Kebebew E, Patronas NJ, Hunter MK, Alwazeer MR, Karaviti LP, Balazs AE, Lodish MB, Stratakis CA.

J Clin Endocrinol Metab. 2015 Jan;100(1):141-8. doi: 10.1210/jc.2014-2945.


A phase I/II trial of belinostat in combination with cisplatin, doxorubicin, and cyclophosphamide in thymic epithelial tumors: a clinical and translational study.

Thomas A, Rajan A, Szabo E, Tomita Y, Carter CA, Scepura B, Lopez-Chavez A, Lee MJ, Redon CE, Frosch A, Peer CJ, Chen Y, Piekarz R, Steinberg SM, Trepel JB, Figg WD, Schrump DS, Giaccone G.

Clin Cancer Res. 2014 Nov 1;20(21):5392-402. doi: 10.1158/1078-0432.CCR-14-0968. Epub 2014 Sep 4.


Malignant mesothelioma and central nervous system metastases. Report of two cases, pooled analysis, and systematic review.

Miller AC, Miettinen M, Schrump DS, Hassan R.

Ann Am Thorac Soc. 2014 Sep;11(7):1075-81. doi: 10.1513/AnnalsATS.201404-165BC. Review.


Telomerase variant A279T induces telomere dysfunction and inhibits non-canonical telomerase activity in esophageal carcinomas.

Zhang Y, Calado R, Rao M, Hong JA, Meeker AK, Dumitriu B, Atay S, McCormick PJ, Garfield SH, Wangsa D, Padilla-Nash HM, Burkett S, Zhang M, Kunst TF, Peterson NR, Xi S, Inchauste S, Altorki NK, Casson AG, Beer DG, Harris CC, Ried T, Young NS, Schrump DS.

PLoS One. 2014 Jul 1;9(7):e101010. doi: 10.1371/journal.pone.0101010. eCollection 2014.


Invited commentary.

Schrump DS.

Ann Thorac Surg. 2014 Mar;97(3):1045. doi: 10.1016/j.athoracsur.2013.12.031. No abstract available.


A systematic review and pooled analysis of CPR-associated cardiovascular and thoracic injuries.

Miller AC, Rosati SF, Suffredini AF, Schrump DS.

Resuscitation. 2014 Jun;85(6):724-31. doi: 10.1016/j.resuscitation.2014.01.028. Epub 2014 Feb 10. Review.


The pivotal role of IKKα in the development of spontaneous lung squamous cell carcinomas.

Xiao Z, Jiang Q, Willette-Brown J, Xi S, Zhu F, Burkett S, Back T, Song NY, Datla M, Sun Z, Goldszmid R, Lin F, Cohoon T, Pike K, Wu X, Schrump DS, Wong KK, Young HA, Trinchieri G, Wiltrout RH, Hu Y.

Cancer Cell. 2013 Apr 15;23(4):527-40. doi: 10.1016/j.ccr.2013.03.009.


Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis.

Xi S, Xu H, Shan J, Tao Y, Hong JA, Inchauste S, Zhang M, Kunst TF, Mercedes L, Schrump DS.

J Clin Invest. 2013 Mar;123(3):1241-61. doi: 10.1172/JCI61271. Epub 2013 Feb 15.


A rapid ultra HPLC-MS/MS method for the quantitation and pharmacokinetic analysis of 3-deazaneplanocin A in mice.

Peer CJ, Rao M, Spencer SD, Shahbazi S, Steeg PS, Schrump DS, Figg WD.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 May 15;927:142-6. doi: 10.1016/j.jchromb.2013.01.003. Epub 2013 Jan 9.


Characterization and management of cardiac involvement of thymic epithelial tumors.

Thomas A, Shanbhag S, Haglund K, Berman A, Jakopovic M, Szabo E, Arai A, Schrump DS, Kwong KF, Rajan A, Giaccone G.

J Thorac Oncol. 2013 Feb;8(2):246-9. doi: 10.1097/JTO.0b013e31827bd931.


Aryl hydrocarbon receptor-induced adrenomedullin mediates cigarette smoke carcinogenicity in humans and mice.

Portal-Nuñez S, Shankavaram UT, Rao M, Datrice N, Atay S, Aparicio M, Camphausen KA, Fernández-Salguero PM, Chang H, Lin P, Schrump DS, Garantziotis S, Cuttitta F, Zudaire E.

Cancer Res. 2012 Nov 15;72(22):5790-800. doi: 10.1158/0008-5472.CAN-12-0818. Epub 2012 Sep 19.


Mithramycin represses basal and cigarette smoke-induced expression of ABCG2 and inhibits stem cell signaling in lung and esophageal cancer cells.

Zhang M, Mathur A, Zhang Y, Xi S, Atay S, Hong JA, Datrice N, Upham T, Kemp CD, Ripley RT, Wiegand G, Avital I, Fetsch P, Mani H, Zlott D, Robey R, Bates SE, Li X, Rao M, Schrump DS.

Cancer Res. 2012 Aug 15;72(16):4178-92. doi: 10.1158/0008-5472.CAN-11-3983. Epub 2012 Jul 2.


Levels of peripheral CD4(+)FoxP3(+) regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer.

Yao X, Ahmadzadeh M, Lu YC, Liewehr DJ, Dudley ME, Liu F, Schrump DS, Steinberg SM, Rosenberg SA, Robbins PF.

Blood. 2012 Jun 14;119(24):5688-96. doi: 10.1182/blood-2011-10-386482. Epub 2012 May 3.


Targeting epigenetic mediators of gene expression in thoracic malignancies.

Schrump DS.

Biochim Biophys Acta. 2012 Jul;1819(7):836-45. doi: 10.1016/j.bbagrm.2012.03.009. Epub 2012 Apr 9. Review.


Operative management for recurrent and metastatic adrenocortical carcinoma.

Datrice NM, Langan RC, Ripley RT, Kemp CD, Steinberg SM, Wood BJ, Libutti SK, Fojo T, Schrump DS, Avital I.

J Surg Oncol. 2012 Jun 1;105(7):709-13. doi: 10.1002/jso.23015. Epub 2011 Dec 20.

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