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Items: 1 to 50 of 63

1.

Analysis of Plasma Tenascin-C in Post-HCV Cirrhosis: A Prospective Study.

Benbow JH, Elam AD, Bossi KL, Massengill DL, Brandon-Warner E, Anderson WE, Culberson CR, Russo MW, deLemos AS, Schrum LW.

Dig Dis Sci. 2018 Mar;63(3):653-664. doi: 10.1007/s10620-017-4860-z. Epub 2018 Jan 12.

PMID:
29330728
2.

Adeno-Associated Virus Serotype 2 Vector-Mediated Reintroduction of microRNA-19b Attenuates Hepatic Fibrosis.

Brandon-Warner E, Benbow JH, Swet JH, Feilen NA, Culberson CR, McKillop IH, deLemos AS, Russo MW, Schrum LW.

Hum Gene Ther. 2018 Jun;29(6):674-686. doi: 10.1089/hum.2017.035. Epub 2018 Mar 1.

3.

Dietary fructose augments ethanol-induced liver pathology.

Thomes PG, Benbow JH, Brandon-Warner E, Thompson KJ, Jacobs C, Donohue TM Jr, Schrum LW.

J Nutr Biochem. 2017 May;43:141-150. doi: 10.1016/j.jnutbio.2017.02.008. Epub 2017 Mar 6.

PMID:
28315617
4.

Alcohol, microbiome, life style influence alcohol and non-alcoholic organ damage.

Neuman MG, French SW, Zakhari S, Malnick S, Seitz HK, Cohen LB, Salaspuro M, Voinea-Griffin A, Barasch A, Kirpich IA, Thomes PG, Schrum LW, Donohue TM Jr, Kharbanda KK, Cruz M, Opris M.

Exp Mol Pathol. 2017 Feb;102(1):162-180. doi: 10.1016/j.yexmp.2017.01.003. Epub 2017 Jan 7. Review.

PMID:
28077318
5.

Data on the effect of pro-fibrotic cytokine TGF-β on hepatic stellate cell autophagy.

Thomes PG, Brandon-Warner E, Li T, Donohue TM Jr, Schrum LW.

Data Brief. 2016 Dec 8;10:312-314. eCollection 2017 Feb.

6.

Rev-erb agonist and TGF-β similarly affect autophagy but differentially regulate hepatic stellate cell fibrogenic phenotype.

Thomes PG, Brandon-Warner E, Li T, Donohue TM Jr, Schrum LW.

Int J Biochem Cell Biol. 2016 Dec;81(Pt A):137-147. doi: 10.1016/j.biocel.2016.11.007. Epub 2016 Nov 10.

PMID:
27840152
7.

Processing of miR17-92 Cluster in Hepatic Stellate Cells Promotes Hepatic Fibrogenesis During Alcohol-Induced Injury.

Brandon-Warner E, Feilen NA, Culberson CR, Field CO, deLemos AS, Russo MW, Schrum LW.

Alcohol Clin Exp Res. 2016 Jul;40(7):1430-42. doi: 10.1111/acer.13116. Epub 2016 Jun 13.

8.

Mitigation of myocardial fibrosis by molecular cardiac surgery-mediated gene overexpression.

Katz MG, Brandon-Warner E, Fargnoli AS, Williams RD, Kendle AP, Hajjar RJ, Schrum LW, Bridges CR.

J Thorac Cardiovasc Surg. 2016 Apr;151(4):1191-200.e3. doi: 10.1016/j.jtcvs.2015.11.031. Epub 2015 Nov 25.

9.

Role of alcohol in the development and progression of hepatocellular carcinoma.

McKillop IH, Schrum LW, Thompson KJ.

Hepat Oncol. 2016 Jan;3(1):29-43. doi: 10.2217/hep.15.40. Epub 2015 Nov 30. Review.

10.

Diet-Induced Obesity Enhances Progression of Hepatocellular Carcinoma through Tenascin-C/Toll-Like Receptor 4 Signaling.

Benbow JH, Thompson KJ, Cope HL, Brandon-Warner E, Culberson CR, Bossi KL, Li T, Russo MW, Gersin KS, McKillop IH, deLemos AS, Schrum LW.

Am J Pathol. 2016 Jan;186(1):145-58. doi: 10.1016/j.ajpath.2015.09.015. Epub 2015 Nov 18.

PMID:
26603137
11.

The effects of over expressing aquaporins on the cryopreservation of hepatocytes.

Kumar BK, Coger RN, Schrum LW, Lee CY.

Cryobiology. 2015 Oct;71(2):273-8. doi: 10.1016/j.cryobiol.2015.07.010. Epub 2015 Aug 4.

PMID:
26247402
12.

MiR-122 decreases HCV entry into hepatocytes through binding to the 3' UTR of OCLN mRNA.

Sendi H, Mehrab-Mohseni M, Foureau DM, Ghosh S, Walling TL, Steuerwald N, Zamor PJ, Kaplan KJ, Jacobs C, Ahrens WA, Russo MW, Clemens MG, Schrum LW, Bonkovsky HL.

Liver Int. 2015 Apr;35(4):1315-23. doi: 10.1111/liv.12698. Epub 2014 Oct 28.

PMID:
25302477
13.

Novel role of nuclear receptor Rev-erbα in hepatic stellate cell activation: potential therapeutic target for liver injury.

Li T, Eheim AL, Klein S, Uschner FE, Smith AC, Brandon-Warner E, Ghosh S, Bonkovsky HL, Trebicka J, Schrum LW.

Hepatology. 2014 Jun;59(6):2383-96. doi: 10.1002/hep.27049. Epub 2014 Apr 29.

PMID:
24497272
14.

Cytoskeletal proteins: shaping progression of hepatitis C virus-induced liver disease.

Ghosh S, Kaplan KJ, Schrum LW, Bonkovsky HL.

Int Rev Cell Mol Biol. 2013;302:279-319. doi: 10.1016/B978-0-12-407699-0.00005-4. Review.

PMID:
23351713
15.

Rodent models of alcoholic liver disease: of mice and men.

Brandon-Warner E, Schrum LW, Schmidt CM, McKillop IH.

Alcohol. 2012 Dec;46(8):715-25. doi: 10.1016/j.alcohol.2012.08.004. Epub 2012 Sep 7. Review.

16.

[Not Available].

Lakner AM, Steuerwald NM, Schrum LW.

Hepatology. 2013 Mar;57(3):1286-7. doi: 10.1002/hep.25997. Epub 2013 Feb 15. No abstract available.

PMID:
22886552
17.

Silibinin (Milk Thistle) potentiates ethanol-dependent hepatocellular carcinoma progression in male mice.

Brandon-Warner E, Eheim AL, Foureau DM, Walling TL, Schrum LW, McKillop IH.

Cancer Lett. 2012 Dec 29;326(1):88-95. doi: 10.1016/j.canlet.2012.07.028. Epub 2012 Aug 1.

18.

The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes.

Hou W, Tian Q, Steuerwald NM, Schrum LW, Bonkovsky HL.

Biochim Biophys Acta. 2012 Nov-Dec;1819(11-12):1113-22. doi: 10.1016/j.bbagrm.2012.06.001. Epub 2012 Jun 12.

19.

Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis.

Lakner AM, Steuerwald NM, Walling TL, Ghosh S, Li T, McKillop IH, Russo MW, Bonkovsky HL, Schrum LW.

Hepatology. 2012 Jul;56(1):300-10. doi: 10.1002/hep.25613. Epub 2012 Jun 18.

20.

Neonatal androgenization exacerbates alcohol-induced liver injury in adult rats, an effect abrogated by estrogen.

Ellefson WM, Lakner AM, Hamilton A, McKillop IH, Bonkovsky HL, Steuerwald NM, Huet YM, Schrum LW.

PLoS One. 2011;6(12):e29463. doi: 10.1371/journal.pone.0029463. Epub 2011 Dec 20.

21.

Chronic ethanol feeding accelerates hepatocellular carcinoma progression in a sex-dependent manner in a mouse model of hepatocarcinogenesis.

Brandon-Warner E, Walling TL, Schrum LW, McKillop IH.

Alcohol Clin Exp Res. 2012 Apr;36(4):641-53. doi: 10.1111/j.1530-0277.2011.01660.x. Epub 2011 Oct 21.

22.

Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes.

Ghosh S, Ahrens WA, Phatak SU, Hwang S, Schrum LW, Bonkovsky HL.

J Viral Hepat. 2011 Oct;18(10):e568-77. doi: 10.1111/j.1365-2893.2011.01487.x. Epub 2011 Jul 1.

PMID:
21914078
23.

Effects of a single dose of oral iron on hepcidin concentrations in human urine and serum analyzed by a robust LC-MS/MS method.

Hwang SI, Lee YY, Park JO, Norton HJ, Clemens E, Schrum LW, Bonkovsky HL.

Clin Chim Acta. 2011 Nov 20;412(23-24):2241-7. doi: 10.1016/j.cca.2011.08.014. Epub 2011 Aug 16.

24.

Nonmuscle myosin II regulates migration but not contraction in rat hepatic stellate cells.

Moore CC, Lakner AM, Yengo CM, Schrum LW.

World J Hepatol. 2011 Jul 27;3(7):184-97. doi: 10.4254/wjh.v3.i7.184.

25.

Lon peptidase 1 (LONP1)-dependent breakdown of mitochondrial 5-aminolevulinic acid synthase protein by heme in human liver cells.

Tian Q, Li T, Hou W, Zheng J, Schrum LW, Bonkovsky HL.

J Biol Chem. 2011 Jul 29;286(30):26424-30. doi: 10.1074/jbc.M110.215772. Epub 2011 Jun 9.

26.

S-adenosyl-L-methionine inhibits collagen secretion in hepatic stellate cells via increased ubiquitination.

Thompson KJ, Lakner AM, Cross BW, Tsukada S, Rippe RA, McKillop IH, Schrum LW.

Liver Int. 2011 Jul;31(6):891-901. doi: 10.1111/j.1478-3231.2011.02512.x. Epub 2011 Mar 21.

PMID:
21645221
27.

microRNAs: fad or future of liver disease.

Lakner AM, Bonkovsky HL, Schrum LW.

World J Gastroenterol. 2011 May 28;17(20):2536-42. doi: 10.3748/wjg.v17.i20.2536. Review.

28.

Targeting collagen expression in alcoholic liver disease.

Thompson KJ, McKillop IH, Schrum LW.

World J Gastroenterol. 2011 May 28;17(20):2473-81. doi: 10.3748/wjg.v17.i20.2473. Review.

29.

Altered expression and function of regulator of G-protein signaling-17 (RGS17) in hepatocellular carcinoma.

Sokolov E, Iannitti DA, Schrum LW, McKillop IH.

Cell Signal. 2011 Oct;23(10):1603-10. doi: 10.1016/j.cellsig.2011.05.012. Epub 2011 May 18.

30.

Legalon-SIL downregulates HCV core and NS5A in human hepatocytes expressing full-length HCV.

Mehrab-Mohseni M, Sendi H, Steuerwald N, Ghosh S, Schrum LW, Bonkovsky HL.

World J Gastroenterol. 2011 Apr 7;17(13):1694-700. doi: 10.3748/wjg.v17.i13.1694.

31.

Opioid-like compound exerts anti-fibrotic activity via decreased hepatic stellate cell activation and inflammation.

Day SA, Lakner AM, Moore CC, Yen MH, Clemens MG, Wu ES, Schrum LW.

Biochem Pharmacol. 2011 Apr 15;81(8):996-1003. doi: 10.1016/j.bcp.2011.01.015. Epub 2011 Feb 1.

PMID:
21291870
32.

Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation.

Lakner AM, Moore CC, Gulledge AA, Schrum LW.

World J Gastroenterol. 2010 Oct 28;16(40):5047-56.

33.

Altered aquaporin expression and role in apoptosis during hepatic stellate cell activation.

Lakner AM, Walling TL, McKillop IH, Schrum LW.

Liver Int. 2011 Jan;31(1):42-51. doi: 10.1111/j.1478-3231.2010.02356.x. Epub 2010 Oct 19.

PMID:
20958918
34.

Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in an in vitro model of hepatocellular carcinoma.

Brandon-Warner E, Sugg JA, Schrum LW, McKillop IH.

Cancer Lett. 2010 May 1;291(1):120-9. doi: 10.1016/j.canlet.2009.10.004. Epub 2009 Nov 8.

35.

Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis.

Son G, Hines IN, Lindquist J, Schrum LW, Rippe RA.

Hepatology. 2009 Nov;50(5):1512-23. doi: 10.1002/hep.23186.

36.

Role of alcohol in liver carcinogenesis.

McKillop IH, Schrum LW.

Semin Liver Dis. 2009 May;29(2):222-32. doi: 10.1055/s-0029-1214377. Epub 2009 Apr 22. Review.

PMID:
19387921
37.

Tissue-specific expression of ALA synthase-1 and heme oxygenase-1 and their expression in livers of rats chronically exposed to ethanol.

Zheng J, Tian Q, Hou W, Watts JA, Schrum LW, Bonkovsky HL.

FEBS Lett. 2008 Jun 11;582(13):1829-34. doi: 10.1016/j.febslet.2008.04.047. Epub 2008 May 8.

38.

S-adenosyl-L-methionine attenuates oxidative stress and hepatic stellate cell activation in an ethanol-LPS-induced fibrotic rat model.

Karaa A, Thompson KJ, McKillop IH, Clemens MG, Schrum LW.

Shock. 2008 Aug;30(2):197-205. doi: 10.1097/shk.0b013e318160f417.

PMID:
18180699
39.

Hepatocyte and kupffer cells co-cultured on micropatterned surfaces to optimize hepatocyte function.

Zinchenko YS, Schrum LW, Clemens M, Coger RN.

Tissue Eng. 2006 Apr;12(4):751-61.

PMID:
16674289
40.

Alcohol and liver cancer.

McKillop IH, Schrum LW.

Alcohol. 2005 Apr;35(3):195-203. Review.

PMID:
16054981
41.

LPS inhibits endothelin-1-mediated eNOS translocation to the cell membrane in sinusoidal endothelial cells.

Merkel SM, Kamoun W, Karaa A, Korneszczuk K, Schrum LW, Clemens MG.

Microcirculation. 2005 Jul-Aug;12(5):433-42.

PMID:
16020391
42.

The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation.

Gäbele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW, Brenner DA, Rippe RA.

J Biol Chem. 2005 Apr 8;280(14):13374-82. Epub 2005 Jan 26.

43.

TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein.

Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA, Brenner DA, Behrns KE.

Surgery. 2004 Jun;135(6):619-28.

PMID:
15179368
44.

Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism.

Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ, Brenner DA, Rippe RA, Behrns KE.

J Hepatol. 2004 Jun;40(6):942-51.

PMID:
15158334
45.

Bacterial infection induces expression of functional MHC class II molecules in murine and human osteoblasts.

Schrum LW, Bost KL, Hudson MC, Marriott I.

Bone. 2003 Nov;33(5):812-21.

PMID:
14623057
46.

Functional CD40 expression induced following bacterial infection of mouse and human osteoblasts.

Schrum LW, Marriott I, Butler BR, Thomas EK, Hudson MC, Bost KL.

Infect Immun. 2003 Mar;71(3):1209-16.

47.

Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism.

Samson CM, Schrum LW, Bird MA, Lange PA, Brenner DA, Rippe RA, Behrns KE.

Surgery. 2002 Sep;132(3):441-9.

PMID:
12324757
48.

Bacterium-induced CXCL10 secretion by osteoblasts can be mediated in part through toll-like receptor 4.

Gasper NA, Petty CC, Schrum LW, Marriott I, Bost KL.

Infect Immun. 2002 Aug;70(8):4075-82.

49.

Cholestasis induces murine hepatocyte apoptosis and DNA synthesis with preservation of the immediate-early gene response.

Bird MA, Lange PA, Schrum LW, Grisham JW, Rippe RA, Behrns KE.

Surgery. 2002 May;131(5):556-63.

PMID:
12019410
50.

Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathway.

Faouzi S, Burckhardt BE, Hanson JC, Campe CB, Schrum LW, Rippe RA, Maher JJ.

J Biol Chem. 2001 Dec 28;276(52):49077-82. Epub 2001 Oct 15.

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