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Items: 43


Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation.

Brown EA, Neier SC, Neuhauser C, Schrum AG, Smith SEP.

J Vis Exp. 2019 Aug 21;(150). doi: 10.3791/60029.


Eosinophils downregulate lung alloimmunity by decreasing TCR signal transduction.

Onyema OO, Guo Y, Mahgoub B, Wang Q, Manafi A, Mei Z, Banerjee A, Li D, Stoler MH, Zaidi MT, Schrum AG, Kreisel D, Gelman AE, Jacobsen EA, Krupnick AS.

JCI Insight. 2019 Jun 6;4(11). pii: 128241. doi: 10.1172/jci.insight.128241. eCollection 2019 Jun 6.


The early proximal αβ TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network.

Neier SC, Ferrer A, Wilton KM, Smith SEP, Kelcher AMH, Pavelko KD, Canfield JM, Davis TR, Stiles RJ, Chen Z, McCluskey J, Burrows SR, Rossjohn J, Hebrink DM, Carmona EM, Limper AH, Kappes DJ, Wettstein PJ, Johnson AJ, Pease LR, Daniels MA, Neuhauser C, Gil D, Schrum AG.

Sci Immunol. 2019 Feb 15;4(32). pii: eaal2201. doi: 10.1126/sciimmunol.aal2201.


Breaking tolerance with engineered class I antigen-presenting molecules.

Parks CA, Henning KR, Pavelko KD, Hansen MJ, Van Keulen VP, Reed BK, Stone JD, Schrum AG, Gil D, Kranz DM, Bordner AJ, Barry MA, Pease LR.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3136-3145. doi: 10.1073/pnas.1807465116. Epub 2019 Feb 6.


Clustering the autisms using glutamate synapse protein interaction networks from cortical and hippocampal tissue of seven mouse models.

Brown EA, Lautz JD, Davis TR, Gniffke EP, VanSchoiack AAW, Neier SC, Tashbook N, Nicolini C, Fahnestock M, Schrum AG, Smith SEP.

Mol Autism. 2018 Sep 15;9:48. doi: 10.1186/s13229-018-0229-1. eCollection 2018.


iNKT cells ameliorate human autoimmunity: Lessons from alopecia areata.

Ghraieb A, Keren A, Ginzburg A, Ullmann Y, Schrum AG, Paus R, Gilhar A.

J Autoimmun. 2018 Jul;91:61-72. doi: 10.1016/j.jaut.2018.04.001. Epub 2018 Apr 18.


Innate lymphoid cells 3 induce psoriasis in xenotransplanted healthy human skin.

Keren A, Shemer A, Ginzburg A, Ullmann Y, Schrum AG, Paus R, Gilhar A.

J Allergy Clin Immunol. 2018 Jul;142(1):305-308.e6. doi: 10.1016/j.jaci.2018.02.015. Epub 2018 Mar 2. No abstract available.


IL-12 Signals through the TCR To Support CD8 Innate Immune Responses.

Goplen NP, Saxena V, Knudson KM, Schrum AG, Gil D, Daniels MA, Zamoyska R, Teixeiro E.

J Immunol. 2016 Sep 15;197(6):2434-43. doi: 10.4049/jimmunol.1600037. Epub 2016 Aug 12.


Multiplex matrix network analysis of protein complexes in the human TCR signalosome.

Smith SE, Neier SC, Reed BK, Davis TR, Sinnwell JP, Eckel-Passow JE, Sciallis GF, Wieland CN, Torgerson RR, Gil D, Neuhauser C, Schrum AG.

Sci Signal. 2016 Aug 2;9(439):rs7. doi: 10.1126/scisignal.aad7279.


Science Signaling Podcast for 2 August 2016: Patient-specific protein complexes.

Schrum AG, Neier SC, VanHook AM.

Sci Signal. 2016 Aug 2;9(439):c17. doi: 10.1126/scisignal.aah5912.


Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies.

Gilhar A, Schrum AG, Etzioni A, Waldmann H, Paus R.

Autoimmun Rev. 2016 Jul;15(7):726-35. doi: 10.1016/j.autrev.2016.03.008. Epub 2016 Mar 10. Review.


Maternal IL-6 can cause T-cell-mediated juvenile alopecia by non-scarring follicular dystrophy in mice.

Smith SE, Maus RL, Davis TR, Sundberg JP, Gil D, Schrum AG.

Exp Dermatol. 2016 Mar;25(3):223-8. doi: 10.1111/exd.12914. Epub 2016 Feb 10.


Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo.

Hoffmann MM, Molina-Mendiola C, Nelson AD, Parks CA, Reyes EE, Hansen MJ, Rajagopalan G, Pease LR, Schrum AG, Gil D.

Sci Adv. 2015 Oct 2;1(9):e1500415. doi: 10.1126/sciadv.1500415. eCollection 2015 Oct.


A Versatile Simple Capture Assay for Assessing the Structural Integrity of MHC Multimer Reagents.

Reed BK, Chopp LB, Malo CS, Renner DN, Van Keulen VS, Girtman MA, Nevala WN, Pavelko KD, Gil D, Schrum AG, Johnson AJ, Pease LR.

PLoS One. 2015 Sep 21;10(9):e0137984. doi: 10.1371/journal.pone.0137984. eCollection 2015.


Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression.

Southwell AL, Smith SE, Davis TR, Caron NS, Villanueva EB, Xie Y, Collins JA, Ye ML, Sturrock A, Leavitt BR, Schrum AG, Hayden MR.

Sci Rep. 2015 Jul 15;5:12166. doi: 10.1038/srep12166.


Combinatorial Immunoprofiling in Latent Tuberculosis Infection. Toward Better Risk Stratification.

Escalante P, Peikert T, Van Keulen VP, Erskine CL, Bornhorst CL, Andrist BR, McCoy K, Pease LR, Abraham RS, Knutson KL, Kita H, Schrum AG, Limper AH.

Am J Respir Crit Care Med. 2015 Sep 1;192(5):605-17. doi: 10.1164/rccm.201412-2141OC.


Detection of constant domain of human T cell antigen receptor alpha-chain via novel monoclonal antibody 7F18.

Reed BK, Lee KA, Bell MP, Gil D, Schrum AG.

Monoclon Antib Immunodiagn Immunother. 2014 Dec;33(6):386-92. doi: 10.1089/mab.2013.0086.


Signalling protein complexes isolated from primary human skin-resident T cells can be analysed by Multiplex IP-FCM.

Smith SE, Neier SC, Davis TR, Pittelkow MR, Gil D, Schrum AG.

Exp Dermatol. 2014 Apr;23(4):272-3. doi: 10.1111/exd.12362.


Toward T cell protein-protein interaction activity relevant to alopecia areata.

Neier SC, Smith SE, Davis TR, Gil D, Schrum AG.

J Investig Dermatol Symp Proc. 2013 Dec;16(1):S31-3. doi: 10.1038/jidsymp.2013.9.


Lifetime incidence risk of alopecia areata estimated at 2.1% by Rochester Epidemiology Project, 1990-2009.

Mirzoyev SA, Schrum AG, Davis MDP, Torgerson RR.

J Invest Dermatol. 2014 Apr;134(4):1141-1142. doi: 10.1038/jid.2013.464. Epub 2013 Nov 11. No abstract available.


Slow angled-descent forepaw grasping (SLAG): an innate behavioral task for identification of individual experimental mice possessing functional vision.

Gil-Pagés M, Stiles RJ, Parks CA, Neier SC, Radulovic M, Oliveros A, Ferrer A, Reed BK, Wilton KM, Schrum AG.

Behav Brain Funct. 2013 Aug 23;9(1):35. doi: 10.1186/1744-9081-9-35.


A co-housing strategy to improve fecundity of mice in timed matings.

Stiles RJ, Schrum AG, Gil D.

Lab Anim (NY). 2013 Feb;42(2):62-5. doi: 10.1038/laban.161.


IgG Fab fragments forming bivalent complexes by a conformational mechanism that is reversible by osmolytes.

Nelson AD, Hoffmann MM, Parks CA, Dasari S, Schrum AG, Gil D.

J Biol Chem. 2012 Dec 14;287(51):42936-50. doi: 10.1074/jbc.M112.410217. Epub 2012 Oct 29.


IP-FCM measures physiologic protein-protein interactions modulated by signal transduction and small-molecule drug inhibition.

Smith SE, Bida AT, Davis TR, Sicotte H, Patterson SE, Gil D, Schrum AG.

PLoS One. 2012;7(9):e45722. doi: 10.1371/journal.pone.0045722. Epub 2012 Sep 21.


Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells.

Schrum AG, Gil D, Turka LA, Palmer E.

J Immunol. 2011 Jul 15;187(2):870-8. doi: 10.4049/jimmunol.1100538. Epub 2011 Jun 10.


Basal and antigen-induced exposure of the proline-rich sequence in CD3ε.

de la Cruz J, Kruger T, Parks CA, Silge RL, van Oers NS, Luescher IF, Schrum AG, Gil D.

J Immunol. 2011 Feb 15;186(4):2282-90. doi: 10.4049/jimmunol.1003225. Epub 2011 Jan 12.


IP-FCM: immunoprecipitation detected by flow cytometry.

Davis TR, Schrum AG.

J Vis Exp. 2010 Dec 2;(46). pii: 2066. doi: 10.3791/2066.


B7-H1 expression on old CD8+ T cells negatively regulates the activation of immune responses in aged animals.

Mirza N, Duque MA, Dominguez AL, Schrum AG, Dong H, Lustgarten J.

J Immunol. 2010 May 15;184(10):5466-5474. doi: 10.4049/jimmunol.0903561. Epub 2010 Apr 7.


Mechanism of T cell tolerance induced by myeloid-derived suppressor cells.

Nagaraj S, Schrum AG, Cho HI, Celis E, Gabrilovich DI.

J Immunol. 2010 Mar 15;184(6):3106-16. doi: 10.4049/jimmunol.0902661. Epub 2010 Feb 8.


Visualization of multiprotein complexes by flow cytometry.

Schrum AG.

Curr Protoc Immunol. 2009 Nov;Chapter 5:Unit5.9. doi: 10.1002/0471142735.im0509s87.


Different T cell receptor signals determine CD8+ memory versus effector development.

Teixeiro E, Daniels MA, Hamilton SE, Schrum AG, Bragado R, Jameson SC, Palmer E.

Science. 2009 Jan 23;323(5913):502-5. doi: 10.1126/science.1163612.


A role for CD8 in the developmental tuning of antigen recognition and CD3 conformational change.

Gil D, Schrum AG, Daniels MA, Palmer E.

J Immunol. 2008 Mar 15;180(6):3900-9.


High-sensitivity detection and quantitative analysis of native protein-protein interactions and multiprotein complexes by flow cytometry.

Schrum AG, Gil D, Dopfer EP, Wiest DL, Turka LA, Schamel WW, Palmer E.

Sci STKE. 2007 Jun 5;2007(389):pl2. Erratum in: Sci STKE. 2007 Jun 19;2007(391):er3.


T cell division and death are segregated by mutation of TCRbeta chain constant domains.

Teixeiro E, Daniels MA, Hausmann B, Schrum AG, Naeher D, Luescher I, Thome M, Bragado R, Palmer E.

Immunity. 2004 Oct;21(4):515-26.


Surface T-cell antigen receptor expression and availability for long-term antigenic signaling.

Schrum AG, Turka LA, Palmer E.

Immunol Rev. 2003 Dec;196:7-24. Review.


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