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Items: 41


LPS-neutralizing peptides reduce outer membrane vesicle-induced inflammatory responses.

Pfalzgraff A, Correa W, Heinbockel L, Schromm AB, Lübow C, Gisch N, Martinez-de-Tejada G, Brandenburg K, Weindl G.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1503-1513. doi: 10.1016/j.bbalip.2019.05.018. Epub 2019 Jun 1.


Antibacterial action of synthetic antilipopolysaccharide peptides (SALP) involves neutralization of both membrane-bound and free toxins.

Correa W, Heinbockel L, Behrends J, Kaconis Y, Barcena-Varela S, Gutsmann T, Mauss K, Schürholz T, Schromm AB, Martinez de Tejada G, Brandenburg K.

FEBS J. 2019 Apr;286(8):1576-1593. doi: 10.1111/febs.14805. Epub 2019 Mar 20.


Lipophilic Allergens, Different Modes of Allergen-Lipid Interaction and Their Impact on Asthma and Allergy.

Jappe U, Schwager C, Schromm AB, González Roldán N, Stein K, Heine H, Duda KA.

Front Immunol. 2019 Feb 14;10:122. doi: 10.3389/fimmu.2019.00122. eCollection 2019. Review.


Identification of novel target genes in human lung tissue involved in chronic obstructive pulmonary disease.

Heinbockel L, Marwitz S, Schromm AB, Watz H, Kugler C, Ammerpohl O, Schnepf K, Rabe KF, Droemann D, Goldmann T.

Int J Chron Obstruct Pulmon Dis. 2018 Jul 26;13:2255-2259. doi: 10.2147/COPD.S161958. eCollection 2018.


Structure-Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists.

Facchini FA, Zaffaroni L, Minotti A, Rapisarda S, Calabrese V, Forcella M, Fusi P, Airoldi C, Ciaramelli C, Billod JM, Schromm AB, Braun H, Palmer C, Beyaert R, Lapenta F, Jerala R, Pirianov G, Martin-Santamaria S, Peri F.

J Med Chem. 2018 Apr 12;61(7):2895-2909. doi: 10.1021/acs.jmedchem.7b01803. Epub 2018 Mar 12.


Novel therapeutic roles for surfactant-inositols and -phosphatidylglycerols in a neonatal piglet ARDS model: a translational study.

Spengler D, Winoto-Morbach S, Kupsch S, Vock C, Blöchle K, Frank S, Rintz N, Diekötter M, Janga H, Weckmann M, Fuchs S, Schromm AB, Fehrenbach H, Schütze S, Krause MF.

Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L32-L53. doi: 10.1152/ajplung.00128.2017. Epub 2017 Aug 31.


Lipopolysaccharide-binding protein is bound and internalized by host cells and colocalizes with LPS in the cytoplasm: Implications for a role of LBP in intracellular LPS-signaling.

Kopp F, Kupsch S, Schromm AB.

Biochim Biophys Acta. 2016 Apr;1863(4):660-72. doi: 10.1016/j.bbamcr.2016.01.015. Epub 2016 Jan 22.


Erratum to: Detoxifying Escherichia coli for endotoxin-free production of recombinant proteins.

Mamat U, Wilke K, Bramhill D, Schromm AB, Lindner B, Kohl TA, Corchero JL, Villaverde A, Schaffer L, Head SR, Souvignier C, Meredith TC, Woodard RW.

Microb Cell Fact. 2015 Jun 11;14:81. doi: 10.1186/s12934-015-0265-x. No abstract available.


Detoxifying Escherichia coli for endotoxin-free production of recombinant proteins.

Mamat U, Wilke K, Bramhill D, Schromm AB, Lindner B, Kohl TA, Corchero JL, Villaverde A, Schaffer L, Head SR, Souvignier C, Meredith TC, Woodard RW.

Microb Cell Fact. 2015 Apr 16;14:57. doi: 10.1186/s12934-015-0241-5. Erratum in: Microb Cell Fact. 2015;14:81.


Fusion of Legionella pneumophila outer membrane vesicles with eukaryotic membrane systems is a mechanism to deliver pathogen factors to host cell membranes.

Jäger J, Keese S, Roessle M, Steinert M, Schromm AB.

Cell Microbiol. 2015 May;17(5):607-20. doi: 10.1111/cmi.12392. Epub 2014 Dec 18.


Pulmonary surfactant protein A-induced changes in the molecular conformation of bacterial deep-rough LPS lead to reduced activity on human macrophages.

Keese SP, Brandenburg K, Roessle M, Schromm AB.

Innate Immun. 2014 Nov;20(8):787-98. doi: 10.1177/1753425913506269. Epub 2013 Oct 11.


Interactions between lipid A and serum proteins.

Andrä J, Gutsmann T, Müller M, Schromm AB.

Adv Exp Med Biol. 2010;667:39-51. doi: 10.1007/978-1-4419-1603-7_4.


Endotoxins: relationship between structure, function, and activity.

Brandenburg K, Schromm AB, Gutsmann T.

Subcell Biochem. 2010;53:53-67. doi: 10.1007/978-90-481-9078-2_3. Review.


Influence of serum on the immune recognition of a synthetic lipopeptide mimetic of the 19-kDa lipoprotein from Mycobacterium tuberculosis.

Schromm AB, Reiling N, Howe J, Wiesmüller KH, Roessle M, Brandenburg K.

Innate Immun. 2010 Aug;16(4):213-25. doi: 10.1177/1753425909339232. Epub 2009 Aug 26.


Structural prerequisites for endotoxic activity in the Limulus test as compared to cytokine production in mononuclear cells.

Gutsmann T, Howe J, Zähringer U, Garidel P, Schromm AB, Koch MH, Fujimoto Y, Fukase K, Moriyon I, Martínez-de-Tejada G, Brandenburg K.

Innate Immun. 2010 Feb;16(1):39-47. doi: 10.1177/1753425909106447. Epub 2009 Jun 30.


Surfactant protein A activation of atypical protein kinase C zeta in IkappaB-alpha-dependent anti-inflammatory immune regulation.

Moulakakis C, Adam S, Seitzer U, Schromm AB, Leitges M, Stamme C.

J Immunol. 2007 Oct 1;179(7):4480-91.


The physicochemistry of endotoxins in relation to bioactivity.

Gutsmann T, Schromm AB, Brandenburg K.

Int J Med Microbiol. 2007 Sep;297(5):341-52. Epub 2007 Apr 23. Review.


Physicochemical and biological analysis of synthetic bacterial lipopeptides: validity of the concept of endotoxic conformation.

Schromm AB, Howe J, Ulmer AJ, Wiesmüller KH, Seyberth T, Jung G, Rössle M, Koch MH, Gutsmann T, Brandenburg K.

J Biol Chem. 2007 Apr 13;282(15):11030-7. Epub 2007 Feb 17.


Biophysical characterization of synthetic rhamnolipids.

Howe J, Bauer J, Andrä J, Schromm AB, Ernst M, Rössle M, Zähringer U, Rademann J, Brandenburg K.

FEBS J. 2006 Nov;273(22):5101-12. Epub 2006 Oct 24.


MaxiK blockade selectively inhibits the lipopolysaccharide-induced I kappa B-alpha /NF-kappa B signaling pathway in macrophages.

Papavlassopoulos M, Stamme C, Thon L, Adam D, Hillemann D, Seydel U, Schromm AB.

J Immunol. 2006 Sep 15;177(6):4086-93.


Cell activation of human macrophages by lipoteichoic acid is strongly attenuated by lipopolysaccharide-binding protein.

Mueller M, Stamme C, Draing C, Hartung T, Seydel U, Schromm AB.

J Biol Chem. 2006 Oct 20;281(42):31448-56. Epub 2006 Aug 23.


Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages.

Scheel O, Papavlassopoulos M, Blunck R, Gebert A, Hartung T, Zähringer U, Seydel U, Schromm AB.

Infect Immun. 2006 Jul;74(7):4354-6.


Endotoxin: physical requirements for cell activation.

Mueller M, Lindner B, Dedrick R, Schromm AB, Seydel U.

J Endotoxin Res. 2005;11(5):299-303.


Divalent cations affect chain mobility and aggregate structure of lipopolysaccharide from Salmonella minnesota reflected in a decrease of its biological activity.

Garidel P, Rappolt M, Schromm AB, Howe J, Lohner K, Andrä J, Koch MH, Brandenburg K.

Biochim Biophys Acta. 2005 Sep 15;1715(2):122-31.


Physicochemical characterization of carboxymethyl lipid A derivatives in relation to biological activity.

Seydel U, Schromm AB, Brade L, Gronow S, Andrä J, Müller M, Koch MH, Fukase K, Kataoka M, Hashimoto M, Kusumoto S, Brandenburg K.

FEBS J. 2005 Jan;272(2):327-40.


Phospholipids inhibit lipopolysaccharide (LPS)-induced cell activation: a role for LPS-binding protein.

Mueller M, Brandenburg K, Dedrick R, Schromm AB, Seydel U.

J Immunol. 2005 Jan 15;174(2):1091-6.


Investigation into the interaction of the bacterial protease OmpT with outer membrane lipids and biological activity of OmpT:lipopolysaccharide complexes.

Brandenburg K, Garidel P, Schromm AB, Andrä J, Kramer A, Egmond M, Wiese A.

Eur Biophys J. 2005 Feb;34(1):28-41. Epub 2004 Jul 6.


Aggregates are the biologically active units of endotoxin.

Mueller M, Lindner B, Kusumoto S, Fukase K, Schromm AB, Seydel U.

J Biol Chem. 2004 Jun 18;279(25):26307-13. Epub 2004 Apr 19.


The generalized endotoxic principle.

Seydel U, Hawkins L, Schromm AB, Heine H, Scheel O, Koch MH, Brandenburg K.

Eur J Immunol. 2003 Jun;33(6):1586-92.


Novel engagement of CD14 and multiple toll-like receptors by group B streptococci.

Henneke P, Takeuchi O, van Strijp JA, Guttormsen HK, Smith JA, Schromm AB, Espevik TA, Akira S, Nizet V, Kasper DL, Golenbock DT.

J Immunol. 2001 Dec 15;167(12):7069-76.


Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.

Schromm AB, Lien E, Henneke P, Chow JC, Yoshimura A, Heine H, Latz E, Monks BG, Schwartz DA, Miyake K, Golenbock DT.

J Exp Med. 2001 Jul 2;194(1):79-88.


Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses.

Means TK, Jones BW, Schromm AB, Shurtleff BA, Smith JA, Keane J, Golenbock DT, Vogel SN, Fenton MJ.

J Immunol. 2001 Mar 15;166(6):4074-82.


Biological activities of lipopolysaccharides are determined by the shape of their lipid A portion.

Schromm AB, Brandenburg K, Loppnow H, Moran AP, Koch MH, Rietschel ET, Seydel U.

Eur J Biochem. 2000 Apr;267(7):2008-13.


Chemical structure, molecular conformation, and bioactivity of endotoxins.

Seydel U, Schromm AB, Blunck R, Brandenburg K.

Chem Immunol. 2000;74:5-24. Review. No abstract available.


The charge of endotoxin molecules influences their conformation and IL-6-inducing capacity.

Schromm AB, Brandenburg K, Loppnow H, Zähringer U, Rietschel ET, Carroll SF, Koch MH, Kusumoto S, Seydel U.

J Immunol. 1998 Nov 15;161(10):5464-71.


Hypothermia enhances the biological activity of lipopolysaccharide by altering its fluidity state.

Luhm J, Schromm AB, Seydel U, Brandenburg K, Wellinghausen N, Riedel E, Schumann RR, Rink L.

Eur J Biochem. 1998 Sep 1;256(2):325-33.


Mechanisms of action of the bactericidal/permeability-increasing protein BPI on endotoxin and phospholipid monolayers and aggregates.

Wiese A, Brandenburg K, Lindner B, Schromm AB, Carroll SF, Rietschel ET, Seydel U.

Biochemistry. 1997 Aug 19;36(33):10301-10.


Lipopolysaccharide-binding protein mediates CD14-independent intercalation of lipopolysaccharide into phospholipid membranes.

Schromm AB, Brandenburg K, Rietschel ET, Flad HD, Carroll SF, Seydel U.

FEBS Lett. 1996 Dec 16;399(3):267-71.


Zinc enhances lipopolysaccharide-induced monokine secretion by alteration of fluidity state of lipopolysaccharide.

Wellinghausen N, Schromm AB, Seydel U, Brandenburg K, Luhm J, Kirchner H, Rink L.

J Immunol. 1996 Oct 1;157(7):3139-45.


Conformation and fluidity of endotoxins as determinants of biological activity.

Brandenburg K, Schromm AB, Koch MH, Seydel U.

Prog Clin Biol Res. 1995;392:167-82. No abstract available.


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