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Items: 29

1.

Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation.

Desai HR, Sivasubramaniyam T, Revelo XS, Schroer SA, Luk CT, Rikkala PR, Metherel AH, Dodington DW, Park YJ, Kim MJ, Rapps JA, Besla R, Robbins CS, Wagner KU, Bazinet RP, Winer DA, Woo M.

Sci Rep. 2017 Aug 9;7(1):7653. doi: 10.1038/s41598-017-07923-0.

2.

Hepatic JAK2 protects against atherosclerosis through circulating IGF-1.

Sivasubramaniyam T, Schroer SA, Li A, Luk CT, Shi SY, Besla R, Dodington DW, Metherel AH, Kitson AP, Brunt JJ, Lopes J, Wagner KU, Bazinet RP, Bendeck MP, Robbins CS, Woo M.

JCI Insight. 2017 Jul 20;2(14). pii: 93735. doi: 10.1172/jci.insight.93735. eCollection 2017 Jul 20.

3.

Type I Interferon Responses Drive Intrahepatic T cells to Promote Metabolic Syndrome.

Ghazarian M, Revelo XS, Nøhr MK, Luck H, Zeng K, Lei H, Tsai S, Schroer SA, Park YJ, Chng MHY, Shen L, D'Angelo JA, Horton P, Chapman WC, Brockmeier D, Woo M, Engleman EG, Adeyi O, Hirano N, Jin T, Gehring AJ, Winer S, Winer DA.

Sci Immunol. 2017 Apr 21;2(10). pii: eaai7616. doi: 10.1126/sciimmunol.aai7616.

4.

FAK signalling controls insulin sensitivity through regulation of adipocyte survival.

Luk CT, Shi SY, Cai EP, Sivasubramaniyam T, Krishnamurthy M, Brunt JJ, Schroer SA, Winer DA, Woo M.

Nat Commun. 2017 Feb 6;8:14360. doi: 10.1038/ncomms14360.

5.

Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice.

Shi SY, Luk CT, Schroer SA, Kim MJ, Dodington DW, Sivasubramaniyam T, Lin L, Cai EP, Lu SY, Wagner KU, Bazinet RP, Woo M.

J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.

6.

Methods for Assessing the In Vivo Role of PTEN in Glucose Homeostasis.

Luk CT, Schroer SA, Woo M.

Methods Mol Biol. 2016;1388:75-91. doi: 10.1007/978-1-4939-3299-3_7.

PMID:
27033072
7.

JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice.

Shi SY, Zhang W, Luk CT, Sivasubramaniyam T, Brunt JJ, Schroer SA, Desai HR, Majerski A, Woo M.

Diabetologia. 2016 Jan;59(1):187-196. doi: 10.1007/s00125-015-3786-2. Epub 2015 Oct 29.

PMID:
26515423
8.

DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice.

Shi SY, Lu SY, Sivasubramaniyam T, Revelo XS, Cai EP, Luk CT, Schroer SA, Patel P, Kim RH, Bombardier E, Quadrilatero J, Tupling AR, Mak TW, Winer DA, Woo M.

Nat Commun. 2015 Jun 16;6:7415. doi: 10.1038/ncomms8415.

9.

Overexpression of HIF-2α in pancreatic β cells does not alter glucose homeostasis.

Brunt JJ, Shi SY, Schroer SA, Sivasubramaniyam T, Cai EP, Woo M.

Islets. 2014;6(5-6):e1006075. doi: 10.1080/19382014.2015.1006075.

10.

SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes.

Gilbert RE, Thai K, Advani SL, Cummins CL, Kepecs DM, Schroer SA, Woo M, Zhang Y.

Diabetologia. 2015 Apr;58(4):819-27. doi: 10.1007/s00125-014-3485-4. Epub 2015 Jan 7.

PMID:
25563725
11.

Rb and p107 are required for alpha cell survival, beta cell cycle control and glucagon-like peptide-1 action.

Cai EP, Luk CT, Wu X, Schroer SA, Shi SY, Sivasubramaniyam T, Brunt JJ, Zacksenhaus E, Woo M.

Diabetologia. 2014 Dec;57(12):2555-65. doi: 10.1007/s00125-014-3381-y. Epub 2014 Sep 24.

PMID:
25249236
12.

PTEN deletion in pancreatic α-cells protects against high-fat diet-induced hyperglucagonemia and insulin resistance.

Wang L, Luk CT, Cai EP, Schroer SA, Allister EM, Shi SY, Wheeler MB, Gaisano HY, Woo M.

Diabetes. 2015 Jan;64(1):147-57. doi: 10.2337/db13-1715. Epub 2014 Aug 4.

13.

Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions.

Wang L, Luk CT, Schroer SA, Smith AM, Li X, Cai EP, Gaisano H, MacDonald PE, Hao Z, Mak TW, Woo M.

Diabetologia. 2014 Sep;57(9):1889-98. doi: 10.1007/s00125-014-3295-8. Epub 2014 Jul 1.

PMID:
24981769
14.

Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex.

Wang L, Opland D, Tsai S, Luk CT, Schroer SA, Allison MB, Elia AJ, Furlonger C, Suzuki A, Paige CJ, Mak TW, Winer DA, Myers MG Jr, Woo M.

Nat Med. 2014 May;20(5):484-92. doi: 10.1038/nm.3527. Epub 2014 Apr 20.

PMID:
24747746
15.

Adipocyte-specific deficiency of Janus kinase (JAK) 2 in mice impairs lipolysis and increases body weight, and leads to insulin resistance with ageing.

Shi SY, Luk CT, Brunt JJ, Sivasubramaniyam T, Lu SY, Schroer SA, Woo M.

Diabetologia. 2014 May;57(5):1016-26. doi: 10.1007/s00125-014-3185-0. Epub 2014 Feb 16.

PMID:
24531222
16.

Retinoblastoma tumor suppressor protein in pancreatic progenitors controls α- and β-cell fate.

Cai EP, Wu X, Schroer SA, Elia AJ, Nostro MC, Zacksenhaus E, Woo M.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14723-8. doi: 10.1073/pnas.1303386110. Epub 2013 Aug 14.

17.

In vivo knockdown of adipocyte erythropoietin receptor does not alter glucose or energy homeostasis.

Luk CT, Shi SY, Choi D, Cai EP, Schroer SA, Woo M.

Endocrinology. 2013 Oct;154(10):3652-9. doi: 10.1210/en.2013-1113. Epub 2013 Jul 24.

PMID:
23885016
18.

Dual role of VAMP8 in regulating insulin exocytosis and islet β cell growth.

Zhu D, Zhang Y, Lam PP, Dolai S, Liu Y, Cai EP, Choi D, Schroer SA, Kang Y, Allister EM, Qin T, Wheeler MB, Wang CC, Hong WJ, Woo M, Gaisano HY.

Cell Metab. 2012 Aug 8;16(2):238-49. doi: 10.1016/j.cmet.2012.07.001. Epub 2012 Jul 26.

19.

In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule trafficking.

Cai EP, Casimir M, Schroer SA, Luk CT, Shi SY, Choi D, Dai XQ, Hajmrle C, Spigelman AF, Zhu D, Gaisano HY, MacDonald PE, Woo M.

Diabetes. 2012 Jul;61(7):1708-18. doi: 10.2337/db11-1344. Epub 2012 Apr 12.

20.

Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance.

Shi SY, Martin RG, Duncan RE, Choi D, Lu SY, Schroer SA, Cai EP, Luk CT, Hopperton KE, Domenichiello AF, Tang C, Naples M, Dekker MJ, Giacca A, Adeli K, Wagner KU, Bazinet RP, Woo M.

J Biol Chem. 2012 Mar 23;287(13):10277-88. doi: 10.1074/jbc.M111.317453. Epub 2012 Jan 24.

21.

Redundant role of the cytochrome c-mediated intrinsic apoptotic pathway in pancreatic β-cells.

Choi D, Schroer SA, Lu SY, Cai EP, Hao Z, Woo M.

J Endocrinol. 2011 Sep;210(3):285-92. doi: 10.1530/JOE-11-0073. Epub 2011 Jun 30.

PMID:
21719578
22.

Vhl is required for normal pancreatic β cell function and the maintenance of β cell mass with age in mice.

Choi D, Cai EP, Schroer SA, Wang L, Woo M.

Lab Invest. 2011 Apr;91(4):527-38. doi: 10.1038/labinvest.2010.207. Epub 2011 Jan 17.

23.

Erythropoietin protects against diabetes through direct effects on pancreatic beta cells.

Choi D, Schroer SA, Lu SY, Wang L, Wu X, Liu Y, Zhang Y, Gaisano HY, Wagner KU, Wu H, Retnakaran R, Woo M.

J Exp Med. 2010 Dec 20;207(13):2831-42. doi: 10.1084/jem.20100665. Epub 2010 Dec 13.

24.

Deletion of Pten in pancreatic ß-cells protects against deficient ß-cell mass and function in mouse models of type 2 diabetes.

Wang L, Liu Y, Yan Lu S, Nguyen KT, Schroer SA, Suzuki A, Mak TW, Gaisano H, Woo M.

Diabetes. 2010 Dec;59(12):3117-26. doi: 10.2337/db09-1805. Epub 2010 Sep 17.

25.

Deletion of Fas in the pancreatic beta-cells leads to enhanced insulin secretion.

Choi D, Radziszewska A, Schroer SA, Liadis N, Liu Y, Zhang Y, Lam PP, Sheu L, Hao Z, Gaisano HY, Woo M.

Am J Physiol Endocrinol Metab. 2009 Dec;297(6):E1304-12. doi: 10.1152/ajpendo.00217.2009. Epub 2009 Sep 15.

26.

Absence of caspase-3 protects pancreatic {beta}-cells from c-Myc-induced apoptosis without leading to tumor formation.

Radziszewska A, Schroer SA, Choi D, Tajmir P, Radulovich N, Ho JC, Wang L, Liadis N, Hakem R, Tsao MS, Penn LZ, Evan GI, Woo M.

J Biol Chem. 2009 Apr 17;284(16):10947-56. doi: 10.1074/jbc.M806960200. Epub 2009 Feb 12.

27.

PTEN deletion and concomitant c-Myc activation do not lead to tumor formation in pancreatic beta cells.

Radziszewska A, Choi D, Nguyen KT, Schroer SA, Tajmir P, Wang L, Suzuki A, Mak TW, Evan GI, Woo M.

J Biol Chem. 2009 Jan 30;284(5):2917-22. doi: 10.1074/jbc.M805183200. Epub 2008 Dec 4.

28.

Partial deletion of Pten in the hypothalamus leads to growth defects that cannot be rescued by exogenous growth hormone.

Choi D, Nguyen KT, Wang L, Schroer SA, Suzuki A, Mak TW, Woo M.

Endocrinology. 2008 Sep;149(9):4382-6. doi: 10.1210/en.2007-1761. Epub 2008 May 22.

PMID:
18499759
29.

Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models.

Liadis N, Salmena L, Kwan E, Tajmir P, Schroer SA, Radziszewska A, Li X, Sheu L, Eweida M, Xu S, Gaisano HY, Hakem R, Woo M.

Diabetes. 2007 Sep;56(9):2302-11. Epub 2007 Jun 11.

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