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Items: 34


Hyperbaric oxygen therapy accelerates wound healing in diabetic mice by decreasing active matrix metalloproteinase-9.

Nguyen TT, Jones JI, Wolter WR, Pérez RL, Schroeder VA, Champion MM, Hesek D, Lee M, Suckow MA, Mobashery S, Chang M.

Wound Repair Regen. 2019 Nov 17. doi: 10.1111/wrr.12782. [Epub ahead of print]


The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus.

Janardhanan J, Bouley R, Martínez-Caballero S, Peng Z, Batuecas-Mordillo M, Meisel JE, Ding D, Schroeder VA, Wolter WR, Mahasenan KV, Hermoso JA, Mobashery S, Chang M.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02637-18. doi: 10.1128/AAC.02637-18. Print 2019 May.


Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing.

Nguyen TT, Ding D, Wolter WR, Pérez RL, Champion MM, Mahasenan KV, Hesek D, Lee M, Schroeder VA, Jones JI, Lastochkin E, Rose MK, Peterson CE, Suckow MA, Mobashery S, Chang M.

J Med Chem. 2018 Oct 11;61(19):8825-8837. doi: 10.1021/acs.jmedchem.8b01005. Epub 2018 Sep 27.


In Search of Selectivity in Inhibition of ADAM10.

Mahasenan KV, Ding D, Gao M, Nguyen TT, Suckow MA, Schroeder VA, Wolter WR, Chang M, Mobashery S.

ACS Med Chem Lett. 2018 Jun 11;9(7):708-713. doi: 10.1021/acsmedchemlett.8b00163. eCollection 2018 Jul 12.


Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers.

Nguyen TT, Ding D, Wolter WR, Champion MM, Hesek D, Lee M, Pérez RL, Schroeder VA, Suckow MA, Mobashery S, Chang M.

Eur J Pharmacol. 2018 Sep 5;834:77-83. doi: 10.1016/j.ejphar.2018.07.014. Epub 2018 Jul 19.


Exploitation of Conformational Dynamics in Imparting Selective Inhibition for Related Matrix Metalloproteinases.

Mahasenan KV, Bastian M, Gao M, Frost E, Ding D, Zorina-Lichtenwalter K, Jacobs J, Suckow MA, Schroeder VA, Wolter WR, Chang M, Mobashery S.

ACS Med Chem Lett. 2017 May 1;8(6):654-659. doi: 10.1021/acsmedchemlett.7b00130. eCollection 2017 Jun 8.


Targeted Antibiotic Delivery: Selective Siderophore Conjugation with Daptomycin Confers Potent Activity against Multidrug Resistant Acinetobacter baumannii Both in Vitro and in Vivo.

Ghosh M, Miller PA, Möllmann U, Claypool WD, Schroeder VA, Wolter WR, Suckow M, Yu H, Li S, Huang W, Zajicek J, Miller MJ.

J Med Chem. 2017 Jun 8;60(11):4577-4583. doi: 10.1021/acs.jmedchem.7b00102. Epub 2017 Apr 1.


Selective Inhibition of MMP-2 Does Not Alter Neurological Recovery after Spinal Cord Injury.

Gao M, Zhang H, Trivedi A, Mahasenan KV, Schroeder VA, Wolter WR, Suckow MA, Mobashery S, Noble-Haeusslein LJ, Chang M.

ACS Chem Neurosci. 2016 Nov 16;7(11):1482-1487. Epub 2016 Aug 25.


In Vitro and In Vivo Synergy of the Oxadiazole Class of Antibacterials with β-Lactams.

Janardhanan J, Meisel JE, Ding D, Schroeder VA, Wolter WR, Mobashery S, Chang M.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5581-8. doi: 10.1128/AAC.00787-16. Print 2016 Sep.


Dual Carfilzomib and Doxorubicin-Loaded Liposomal Nanoparticles for Synergistic Efficacy in Multiple Myeloma.

Ashley JD, Quinlan CJ, Schroeder VA, Suckow MA, Pizzuti VJ, Kiziltepe T, Bilgicer B.

Mol Cancer Ther. 2016 Jul;15(7):1452-9. doi: 10.1158/1535-7163.MCT-15-0867. Epub 2016 Apr 19.


Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials.

Bouley R, Ding D, Peng Z, Bastian M, Lastochkin E, Song W, Suckow MA, Schroeder VA, Wolter WR, Mobashery S, Chang M.

J Med Chem. 2016 May 26;59(10):5011-21. doi: 10.1021/acs.jmedchem.6b00372. Epub 2016 May 5.


Early Gelatinase Activity Is Not a Determinant of Long-Term Recovery after Traumatic Brain Injury in the Immature Mouse.

Semple BD, Noble-Haeusslein LJ, Gooyit M, Tercovich KG, Peng Z, Nguyen TT, Schroeder VA, Suckow MA, Chang M, Raber J, Trivedi A.

PLoS One. 2015 Nov 20;10(11):e0143386. doi: 10.1371/journal.pone.0143386. eCollection 2015.


Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA.

Gonzales PR, Pesesky MW, Bouley R, Ballard A, Biddy BA, Suckow MA, Wolter WR, Schroeder VA, Burnham CA, Mobashery S, Chang M, Dantas G.

Nat Chem Biol. 2015 Nov;11(11):855-61. doi: 10.1038/nchembio.1911. Epub 2015 Sep 14.


Water-Soluble MMP-9 Inhibitor Reduces Lesion Volume after Severe Traumatic Brain Injury.

Lee M, Chen Z, Tomlinson BN, Gooyit M, Hesek D, Juárez MR, Nizam R, Boggess B, Lastochkin E, Schroeder VA, Wolter WR, Suckow MA, Cui J, Mobashery S, Gu Z, Chang M.

ACS Chem Neurosci. 2015 Oct 21;6(10):1658-64. doi: 10.1021/acschemneuro.5b00140. Epub 2015 Aug 14.


Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one.

Bouley R, Kumarasiri M, Peng Z, Otero LH, Song W, Suckow MA, Schroeder VA, Wolter WR, Lastochkin E, Antunes NT, Pi H, Vakulenko S, Hermoso JA, Chang M, Mobashery S.

J Am Chem Soc. 2015 Feb 11;137(5):1738-41. doi: 10.1021/jacs.5b00056. Epub 2015 Feb 2.


Structure-activity relationship for the oxadiazole class of antibiotics.

Spink E, Ding D, Peng Z, Boudreau MA, Leemans E, Lastochkin E, Song W, Lichtenwalter K, O'Daniel PI, Testero SA, Pi H, Schroeder VA, Wolter WR, Antunes NT, Suckow MA, Vakulenko S, Chang M, Mobashery S.

J Med Chem. 2015 Feb 12;58(3):1380-9. doi: 10.1021/jm501661f. Epub 2015 Jan 30.


Liposomal carfilzomib nanoparticles effectively target multiple myeloma cells and demonstrate enhanced efficacy in vivo.

Ashley JD, Stefanick JF, Schroeder VA, Suckow MA, Alves NJ, Suzuki R, Kikuchi S, Hideshima T, Anderson KC, Kiziltepe T, Bilgicer B.

J Control Release. 2014 Dec 28;196:113-21. doi: 10.1016/j.jconrel.2014.10.005. Epub 2014 Oct 12.


Liposomal bortezomib nanoparticles via boronic ester prodrug formulation for improved therapeutic efficacy in vivo.

Ashley JD, Stefanick JF, Schroeder VA, Suckow MA, Kiziltepe T, Bilgicer B.

J Med Chem. 2014 Jun 26;57(12):5282-92. doi: 10.1021/jm500352v. Epub 2014 Jun 13.


Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity.

O'Daniel PI, Peng Z, Pi H, Testero SA, Ding D, Spink E, Leemans E, Boudreau MA, Yamaguchi T, Schroeder VA, Wolter WR, Llarrull LI, Song W, Lastochkin E, Kumarasiri M, Antunes NT, Espahbodi M, Lichtenwalter K, Suckow MA, Vakulenko S, Mobashery S, Chang M.

J Am Chem Soc. 2014 Mar 5;136(9):3664-72. doi: 10.1021/ja500053x. Epub 2014 Feb 21.


Combined obstructive hypertrophic cardiomyopathy and double outlet right ventricle in an infant with Down syndrome.

Ghimire L, Tawffik O, Schroeder VA.

Am J Case Rep. 2013 Nov 1;14:453-8. doi: 10.12659/AJCR.889581. eCollection 2013.


Selective inhibition of matrix metalloproteinase-9 attenuates secondary damage resulting from severe traumatic brain injury.

Hadass O, Tomlinson BN, Gooyit M, Chen S, Purdy JJ, Walker JM, Zhang C, Giritharan AB, Purnell W, Robinson CR 2nd, Shin D, Schroeder VA, Suckow MA, Simonyi A, Sun GY, Mobashery S, Cui J, Chang M, Gu Z.

PLoS One. 2013 Oct 23;8(10):e76904. doi: 10.1371/journal.pone.0076904. eCollection 2013.


O-phenyl carbamate and phenyl urea thiiranes as selective matrix metalloproteinase-2 inhibitors that cross the blood-brain barrier.

Gooyit M, Song W, Mahasenan KV, Lichtenwalter K, Suckow MA, Schroeder VA, Wolter WR, Mobashery S, Chang M.

J Med Chem. 2013 Oct 24;56(20):8139-50. doi: 10.1021/jm401217d. Epub 2013 Oct 8.


Water-soluble mmp-9 inhibitor prodrug generates active metabolites that cross the blood-brain barrier.

Song W, Peng Z, Gooyit M, Suckow MA, Schroeder VA, Wolter WR, Lee M, Ikejiri M, Cui J, Gu Z, Chang M.

ACS Chem Neurosci. 2013 Aug 21;4(8):1168-73. doi: 10.1021/cn400077d. Epub 2013 May 30.


Effects of lactose-containing vs lactose-free infant formula on postprandial superior mesenteric artery flow in term infants.

Schroeder VA, Mattioli LF, Kilkenny TA, Belmont JM.

JPEN J Parenter Enteral Nutr. 2014 Feb;38(2):236-42. doi: 10.1177/0148607113478442. Epub 2013 Mar 11.


Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier.

Gooyit M, Suckow MA, Schroeder VA, Wolter WR, Mobashery S, Chang M.

ACS Chem Neurosci. 2012 Oct 17;3(10):730-6. doi: 10.1021/cn300062w. Epub 2012 Jul 30.


Selective water-soluble gelatinase inhibitor prodrugs.

Gooyit M, Lee M, Schroeder VA, Ikejiri M, Suckow MA, Mobashery S, Chang M.

J Med Chem. 2011 Oct 13;54(19):6676-90. doi: 10.1021/jm200566e. Epub 2011 Sep 6.


Left coronary artery arteriovenous malformation presenting as a diastolic murmur with exercise intolerance in a child with a suspected familial vascular malformation syndrome.

Schroeder VA, Lee EY, Douglas WI, Cottrill CM.

Congenit Heart Dis. 2007 May-Jun;2(3):203-7. doi: 10.1111/j.1747-0803.2007.00099.x.


Coincidence of long QT syndrome and propionic acidemia.

Kakavand B, Schroeder VA, Di Sessa TG.

Pediatr Cardiol. 2006 Jan-Feb;27(1):160-161. doi: 10.1007/s00246-005-1129-7.


Postoperative fluid balance influences the need for antihypertensive therapy following coarctation repair.

Schroeder VA, DiSessa TG, Douglas WI.

Pediatr Crit Care Med. 2004 Nov;5(6):539-41.


Usefulness of the mitral valve Z score in predicting the need to close moderate- to large-sized atrial septal defects in infants with aortic coarctation.

Schroeder VA, Pearl JM, Beekman RH, Cripe L, Khoury P, Manning PB, Nelson DP.

Am J Cardiol. 2003 Aug 15;92(4):480-3.


Combined steroid treatment for congenital heart surgery improves oxygen delivery and reduces postbypass inflammatory mediator expression.

Schroeder VA, Pearl JM, Schwartz SM, Shanley TP, Manning PB, Nelson DP.

Circulation. 2003 Jun 10;107(22):2823-8. Epub 2003 May 19.


Surgical emergencies during pediatric interventional catheterization.

Schroeder VA, Shim D, Spicer RL, Pearl JM, Manning PJ, Beekman RH 3rd.

J Pediatr. 2002 May;140(5):570-5.


A milking device for rats.

Stewart KL, Schroeder VA.

Contemp Top Lab Anim Sci. 1995 Mar;34(2):80-1. No abstract available.


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