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Items: 18


Dissecting Therapeutic Resistance to ERK Inhibition.

Jha S, Morris EJ, Hruza A, Mansueto MS, Schroeder GK, Arbanas J, McMasters D, Restaino CR, Dayananth P, Black S, Elsen NL, Mannarino A, Cooper A, Fawell S, Zawel L, Jayaraman L, Samatar AA.

Mol Cancer Ther. 2016 Apr;15(4):548-59. doi: 10.1158/1535-7163.MCT-15-0172. Epub 2016 Feb 1.


Reactions of Cg10062, a cis-3-Chloroacrylic Acid Dehalogenase Homologue, with Acetylene and Allene Substrates: Evidence for a Hydration-Dependent Decarboxylation.

Huddleston JP, Johnson WH Jr, Schroeder GK, Whitman CP.

Biochemistry. 2015 May 19;54(19):3009-23. doi: 10.1021/acs.biochem.5b00240. Epub 2015 May 1.


A mutational analysis of the active site loop residues in cis-3-Chloroacrylic acid dehalogenase.

Schroeder GK, Huddleston JP, Johnson WH Jr, Whitman CP.

Biochemistry. 2013 Jun 18;52(24):4204-16. doi: 10.1021/bi4004414. Epub 2013 Jun 5.


A pre-steady state kinetic analysis of the αY60W mutant of trans-3-chloroacrylic acid dehalogenase: implications for the mechanism of the wild-type enzyme.

Huddleston JP, Schroeder GK, Johnson KA, Whitman CP.

Biochemistry. 2012 Nov 20;51(46):9420-35. doi: 10.1021/bi3010686. Epub 2012 Nov 8.


Flight of a cytidine deaminase complex with an imperfect transition state analogue inhibitor: mass spectrometric evidence for the presence of a trapped water molecule.

Schroeder GK, Zhou L, Snider MJ, Chen X, Wolfenden R.

Biochemistry. 2012 Aug 14;51(32):6476-86. Epub 2012 Aug 2.


Reaction of cis-3-chloroacrylic acid dehalogenase with an allene substrate, 2,3-butadienoate: hydration via an enamine.

Schroeder GK, Johnson WH Jr, Huddleston JP, Serrano H, Johnson KA, Whitman CP.

J Am Chem Soc. 2012 Jan 11;134(1):293-304. doi: 10.1021/ja206873f. Epub 2011 Dec 19.


Kinetic, crystallographic, and mechanistic characterization of TomN: elucidation of a function for a 4-oxalocrotonate tautomerase homologue in the tomaymycin biosynthetic pathway.

Burks EA, Yan W, Johnson WH Jr, Li W, Schroeder GK, Min C, Gerratana B, Zhang Y, Whitman CP.

Biochemistry. 2011 Sep 6;50(35):7600-11. doi: 10.1021/bi200947w. Epub 2011 Aug 15.


The rate of spontaneous cleavage of the glycosidic bond of adenosine.

Stockbridge RB, Schroeder GK, Wolfenden R.

Bioorg Chem. 2010 Oct;38(5):224-8. doi: 10.1016/j.bioorg.2010.05.003. Epub 2010 Jun 4.


Contrasting behavior of conformationally locked carbocyclic nucleosides of adenosine and cytidine as substrates for deaminases.

Marquez VE, Schroeder GK, Ludek OR, Siddiqui MA, Ezzitouni A, Wolfenden R.

Nucleosides Nucleotides Nucleic Acids. 2009 May;28(5):614-32. doi: 10.1080/15257770903091904.


Pre-steady-state kinetic analysis of cis-3-chloroacrylic acid dehalogenase: analysis and implications.

Robertson BA, Schroeder GK, Jin Z, Johnson KA, Whitman CP.

Biochemistry. 2009 Dec 15;48(49):11737-44. doi: 10.1021/bi901349z.


Synthesis and conformational analysis of locked carbocyclic analogues of 1,3-diazepinone riboside, a high-affinity cytidine deaminase inhibitor.

Ludek OR, Schroeder GK, Liao C, Russ PL, Wolfenden R, Marquez VE.

J Org Chem. 2009 Aug 21;74(16):6212-23. doi: 10.1021/jo901127a.


Synthesis of conformationally locked carbocyclic 1,3-diazepinone nucleosides as inhibitors of cytidine deaminase.

Ludek OR, Schroeder GK, Wolfenden R, Marquez VE.

Nucleic Acids Symp Ser (Oxf). 2008;(52):659-60. doi: 10.1093/nass/nrn333.


Free-flow electrophoresis for top-down proteomics by Fourier transform ion cyclotron resonance mass spectrometry.

Ouvry-Patat SA, Torres MP, Quek HH, Gelfand CA, O'Mullan P, Nissum M, Schroeder GK, Han J, Elliott M, Dryhurst D, Ausio J, Wolfenden R, Borchers CH.

Proteomics. 2008 Jul;8(14):2798-808. doi: 10.1002/pmic.200800079.


Rates of spontaneous disintegration of DNA and the rate enhancements produced by DNA glycosylases and deaminases.

Schroeder GK, Wolfenden R.

Biochemistry. 2007 Nov 27;46(47):13638-47. Epub 2007 Nov 1.


The rate enhancement produced by the ribosome: an improved model.

Schroeder GK, Wolfenden R.

Biochemistry. 2007 Apr 3;46(13):4037-44. Epub 2007 Mar 13.


The time required for water attack at the phosphorus atom of simple phosphodiesters and of DNA.

Schroeder GK, Lad C, Wyman P, Williams NH, Wolfenden R.

Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4052-5. Epub 2006 Mar 6.


Fourier transform ion cyclotron resonance MS reveals the presence of a water molecule in an enzyme transition-state analogue complex.

Borchers CH, Marquez VE, Schroeder GK, Short SA, Snider MJ, Speir JP, Wolfenden R.

Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15341-5. Epub 2004 Oct 19.


Mnd2 and Swm1 are core subunits of the Saccharomyces cerevisiae anaphase-promoting complex.

Hall MC, Torres MP, Schroeder GK, Borchers CH.

J Biol Chem. 2003 May 9;278(19):16698-705. Epub 2003 Feb 27.

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