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Items: 19


Microbiota and mucosal defense in IBD: an update.

Stange EF, Schroeder BO.

Expert Rev Gastroenterol Hepatol. 2019 Oct;13(10):963-976. doi: 10.1080/17474124.2019.1671822. Epub 2019 Oct 11.


The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function.

Volk JK, Nyström EEL, van der Post S, Abad BM, Schroeder BO, Johansson Å, Svensson F, Jäverfelt S, Johansson MEV, Hansson GC, Birchenough GMH.

J Exp Med. 2019 Nov 4;216(11):2602-2618. doi: 10.1084/jem.20190679. Epub 2019 Aug 16.


Proteolytic Degradation of reduced Human Beta Defensin 1 generates a Novel Antibiotic Octapeptide.

Wendler J, Schroeder BO, Ehmann D, Koeninger L, Mailänder-Sánchez D, Lemberg C, Wanner S, Schaller M, Stange EF, Malek NP, Weidenmaier C, LeibundGut-Landmann S, Wehkamp J.

Sci Rep. 2019 Mar 6;9(1):3640. doi: 10.1038/s41598-019-40216-2.


Fight them or feed them: how the intestinal mucus layer manages the gut microbiota.

Schroeder BO.

Gastroenterol Rep (Oxf). 2019 Feb;7(1):3-12. doi: 10.1093/gastro/goy052. Epub 2019 Feb 13. Review.


Dietary destabilisation of the balance between the microbiota and the colonic mucus barrier.

Birchenough G, Schroeder BO, Bäckhed F, Hansson GC.

Gut Microbes. 2019;10(2):246-250. doi: 10.1080/19490976.2018.1513765. Epub 2018 Sep 25.


Bacterial Periplasmic Oxidoreductases Control the Activity of Oxidized Human Antimicrobial β-Defensin 1.

Wendler J, Ehmann D, Courth L, Schroeder BO, Malek NP, Wehkamp J.

Infect Immun. 2018 Mar 22;86(4). pii: e00875-17. doi: 10.1128/IAI.00875-17. Print 2018 Apr.


Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration.

Schroeder BO, Birchenough GMH, Ståhlman M, Arike L, Johansson MEV, Hansson GC, Bäckhed F.

Cell Host Microbe. 2018 Jan 10;23(1):27-40.e7. doi: 10.1016/j.chom.2017.11.004. Epub 2017 Dec 21.


Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16.

Bergström JH, Birchenough GM, Katona G, Schroeder BO, Schütte A, Ermund A, Johansson ME, Hansson GC.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13833-13838. Epub 2016 Nov 14.


Signals from the gut microbiota to distant organs in physiology and disease.

Schroeder BO, Bäckhed F.

Nat Med. 2016 Oct;22(10):1079-1089. doi: 10.1038/nm.4185. Epub 2016 Oct 6. Review.


Disulphide-reduced psoriasin is a human apoptosis-inducing broad-spectrum fungicide.

Hein KZ, Takahashi H, Tsumori T, Yasui Y, Nanjoh Y, Toga T, Wu Z, Grötzinger J, Jung S, Wehkamp J, Schroeder BO, Schroeder JM, Morita E.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):13039-44. doi: 10.1073/pnas.1511197112. Epub 2015 Oct 5.


Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptide.

Schroeder BO, Ehmann D, Precht JC, Castillo PA, Küchler R, Berger J, Schaller M, Stange EF, Wehkamp J.

Mucosal Immunol. 2015 May;8(3):661-71. doi: 10.1038/mi.2014.100. Epub 2014 Nov 5.


Gastric antimicrobial peptides fail to eradicate Helicobacter pylori infection due to selective induction and resistance.

Nuding S, Gersemann M, Hosaka Y, Konietzny S, Schaefer C, Beisner J, Schroeder BO, Ostaff MJ, Saigenji K, Ott G, Schaller M, Stange EF, Wehkamp J.

PLoS One. 2013 Sep 11;8(9):e73867. doi: 10.1371/journal.pone.0073867. eCollection 2013.


Antimicrobial activity of high-mobility-group box 2: a new function to a well-known protein.

Küchler R, Schroeder BO, Jaeger SU, Stange EF, Wehkamp J.

Antimicrob Agents Chemother. 2013 Oct;57(10):4782-93. doi: 10.1128/AAC.00805-13. Epub 2013 Jul 22.


Cell-mediated reduction of human β-defensin 1: a major role for mucosal thioredoxin.

Jaeger SU, Schroeder BO, Meyer-Hoffert U, Courth L, Fehr SN, Gersemann M, Stange EF, Wehkamp J.

Mucosal Immunol. 2013 Nov;6(6):1179-90. doi: 10.1038/mi.2013.17. Epub 2013 Apr 10.


[Human beta-defensin 1: from defence to offence].

Schroeder BO, Stange EF, Wehkamp J.

Z Gastroenterol. 2012 Nov;50(11):1171-5. doi: 10.1055/s-0032-1312865. Epub 2012 Nov 13. Review. German.


More than a marine propeller--the flagellum of the probiotic Escherichia coli strain Nissle 1917 is the major adhesin mediating binding to human mucus.

Troge A, Scheppach W, Schroeder BO, Rund SA, Heuner K, Wehkamp J, Stange EF, Oelschlaeger TA.

Int J Med Microbiol. 2012 Dec;302(7-8):304-14. doi: 10.1016/j.ijmm.2012.09.004. Epub 2012 Nov 4.


Waking the wimp: redox-modulation activates human beta-defensin 1.

Schroeder BO, Stange EF, Wehkamp J.

Gut Microbes. 2011 Jul-Aug;2(4):262-6. doi: 10.4161/gmic.2.4.17692. Epub 2011 Jul 1. No abstract available.


Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1.

Schroeder BO, Wu Z, Nuding S, Groscurth S, Marcinowski M, Beisner J, Buchner J, Schaller M, Stange EF, Wehkamp J.

Nature. 2011 Jan 20;469(7330):419-23. doi: 10.1038/nature09674.


Probiotic E. coli treatment mediates antimicrobial human beta-defensin synthesis and fecal excretion in humans.

Möndel M, Schroeder BO, Zimmermann K, Huber H, Nuding S, Beisner J, Fellermann K, Stange EF, Wehkamp J.

Mucosal Immunol. 2009 Mar;2(2):166-72. doi: 10.1038/mi.2008.77. Epub 2008 Nov 26.


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