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Items: 1 to 50 of 96

1.

Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients.

Deuse T, Hu X, Gravina A, Wang D, Tediashvili G, De C, Thayer WO, Wahl A, Garcia JV, Reichenspurner H, Davis MM, Lanier LL, Schrepfer S.

Nat Biotechnol. 2019 Mar;37(3):252-258. doi: 10.1038/s41587-019-0016-3. Epub 2019 Feb 18.

PMID:
30778232
2.

Exosomal profiling in cardiac allograft rejection: Best basic science article in 2018.

Kulkarni HS, Diamond JM, Schrepfer S, Cantu E.

J Heart Lung Transplant. 2019 Mar;38(3):334-336. doi: 10.1016/j.healun.2018.12.010. Epub 2018 Dec 21. No abstract available.

PMID:
30642798
3.

Dead space ventilation promotes alveolar hypocapnia reducing surfactant secretion by altering mitochondrial function.

Kiefmann M, Tank S, Tritt MO, Keller P, Heckel K, Schulte-Uentrop L, Olotu C, Schrepfer S, Goetz AE, Kiefmann R.

Thorax. 2019 Mar;74(3):219-228. doi: 10.1136/thoraxjnl-2018-211864. Epub 2019 Jan 12.

PMID:
30636196
4.

No effect of thymosin beta-4 on the expression of the transcription factor Islet-1 in the adult murine heart.

Weinberger F, Nicol P, Starbatty J, Stubbendorff M, Becher PM, Schrepfer S, Eschenhagen T.

Pharmacol Res Perspect. 2018 Jun;6(3):e00407. doi: 10.1002/prp2.407.

5.

Sphingosine-1-phosphate receptor 1 regulates neointimal growth in a humanized model for restenosis.

Braetz J, Becker A, Geissen M, Larena-Avellaneda A, Schrepfer S, Daum G.

J Vasc Surg. 2018 Dec;68(6S):201S-207S. doi: 10.1016/j.jvs.2018.02.053. Epub 2018 May 24.

PMID:
29804740
6.

Optimization of oxygenation during ex vivo lung perfusion-Best basic science article in 2017.

Shaver CM, Diamond JM, Schrepfer S, Cantu E.

J Heart Lung Transplant. 2018 Jun;37(6):800-802. doi: 10.1016/j.healun.2018.02.010. Epub 2018 Feb 21. No abstract available.

PMID:
29525103
7.

Balloon-based Injury to Induce Myointimal Hyperplasia in the Mouse Abdominal Aorta.

Tediashvili G, Wang D, Reichenspurner H, Deuse T, Schrepfer S.

J Vis Exp. 2018 Feb 7;(132). doi: 10.3791/56477.

PMID:
29443065
8.

Opportunities for Lung Repair and Regeneration: An Overview.

Schrepfer S.

Ann Am Thorac Soc. 2017 Sep;14(Suppl_3):S247-S250. doi: 10.1513/AnnalsATS.201610-794MG. Review. No abstract available.

PMID:
28945474
9.

Differences in Vascular Response between Balloon Overstretch and Stent Overexpansion in Nonatherosclerotic Porcine Coronary Arteries.

Mitsutake Y, Reifart J, Pyun WB, Lyons JK, Deuse T, Schrepfer S, Ikeno F.

Comp Med. 2017 Aug 1;67(4):350-355.

10.

Thalidomide treatment prevents chronic graft rejection after aortic transplantation in rats - an experimental study.

Miller KK, Wang D, Hu X, Hua X, Deuse T, Neofytou E, Renne T, Velden J, Reichenspurner H, Schrepfer S, Bernstein D.

Transpl Int. 2017 Nov;30(11):1181-1189. doi: 10.1111/tri.13004. Epub 2017 Aug 14.

11.

The ubiquitin-proteasome system: A potential therapeutic target for heart failure.

Barac YD, Emrich F, Krutzwakd-Josefson E, Schrepfer S, Sampaio LC, Willerson JT, Robbins RC, Ciechanover A, Mohr FW, Aravot D, Taylor DA.

J Heart Lung Transplant. 2017 Jul;36(7):708-714. doi: 10.1016/j.healun.2017.02.012. Epub 2017 Feb 20. Review.

PMID:
28341100
12.

Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency.

Wang D, Tediashvili G, Pecha S, Reichenspurner H, Deuse T, Schrepfer S.

J Vis Exp. 2017 Jan 15;(119). doi: 10.3791/54839.

13.

miR-126: a potential new key player in hypoxia and reperfusion?

Guenther SP, Schrepfer S.

Ann Transl Med. 2016 Oct;4(19):377. No abstract available.

14.

Orthotopic tracheal transplantation using human bronchus: an original xenotransplant model of obliterative airway disorder.

Guihaire J, Itagaki R, Stubbendorff M, Hua X, Deuse T, Ullrich S, Fadel E, Dorfmüller P, Robbins RC, Reichenspurner H, Schumacher U, Schrepfer S.

Transpl Int. 2016 Dec;29(12):1337-1348. doi: 10.1111/tri.12854. Epub 2016 Oct 4.

15.

"Bioengineered lungs" Best science paper in JHLT 2014-2015.

Schrepfer S, Cantu E, Gandy K, Baan CC, West LJ.

J Heart Lung Transplant. 2016 Apr;35(4):544-6. doi: 10.1016/j.healun.2016.03.009. Epub 2016 Mar 17. No abstract available.

PMID:
27044534
16.

The Selective JAK1/3-Inhibitor R507 Mitigates Obliterative Airway Disease Both With Systemic Administration and Aerosol Inhalation.

Deuse T, Hua X, Stubbendorff M, Spin JM, Neofytou E, Taylor V, Chen Y, Park G, Fink JB, Renne T, Kiefmann M, Kiefmann R, Reichenspurner H, Robbins RC, Schrepfer S.

Transplantation. 2016 May;100(5):1022-31. doi: 10.1097/TP.0000000000001110.

PMID:
26910327
17.

miR-21 promotes fibrosis in an acute cardiac allograft transplantation model.

Gupta SK, Itagaki R, Zheng X, Batkai S, Thum S, Ahmad F, Van Aelst LN, Sharma A, Piccoli MT, Weinberger F, Fiedler J, Heuser M, Heymans S, Falk CS, Förster R, Schrepfer S, Thum T.

Cardiovasc Res. 2016 May 15;110(2):215-26. doi: 10.1093/cvr/cvw030. Epub 2016 Feb 9.

PMID:
26865549
18.

Sex Differences in Immunology: More Severe Development of Experimental Pulmonary Hypertension in Male Rats Exposed to Vascular Endothelial Growth Factor Receptor Blockade.

Guihaire J, Deuse T, Wang D, Fadel E, Reichenspurner H, Schrepfer S.

Biomed Res Int. 2015;2015:765292. doi: 10.1155/2015/765292. Epub 2015 Sep 1.

19.

Distal Airway Stem Cells are Essential for Lung Regeneration.

Deuse T, Schrepfer S.

Transplantation. 2015 Aug;99(8):1540-1. doi: 10.1097/TP.0000000000000794. No abstract available.

PMID:
26308298
20.

Alagebrium inhibits neointimal hyperplasia and restores distributions of wall shear stress by reducing downstream vascular resistance in obese and diabetic rats.

Wang H, Weihrauch D, Kersten JR, Toth JM, Passerini AG, Rajamani A, Schrepfer S, LaDisa JF Jr.

Am J Physiol Heart Circ Physiol. 2015 Oct;309(7):H1130-40. doi: 10.1152/ajpheart.00123.2014. Epub 2015 Aug 7.

21.

Advancing knowledge of right ventricular pathophysiology in chronic pressure overload: Insights from experimental studies.

Guihaire J, Noly PE, Schrepfer S, Mercier O.

Arch Cardiovasc Dis. 2015 Oct;108(10):519-29. doi: 10.1016/j.acvd.2015.05.008. Epub 2015 Jul 13. Review.

22.

Local MicroRNA Modulation Using a Novel Anti-miR-21-Eluting Stent Effectively Prevents Experimental In-Stent Restenosis.

Wang D, Deuse T, Stubbendorff M, Chernogubova E, Erben RG, Eken SM, Jin H, Li Y, Busch A, Heeger CH, Behnisch B, Reichenspurner H, Robbins RC, Spin JM, Tsao PS, Schrepfer S, Maegdefessel L.

Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1945-53. doi: 10.1161/ATVBAHA.115.305597. Epub 2015 Jul 16. Erratum in: Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):e51.

23.

Effective Apical Infection of Differentiated Human Bronchial Epithelial Cells and Induction of Proinflammatory Chemokines by the Highly Pneumotropic Human Adenovirus Type 14p1.

Lam E, Ramke M, Warnecke G, Schrepfer S, Kopfnagel V, Dobner T, Heim A.

PLoS One. 2015 Jul 13;10(7):e0131201. doi: 10.1371/journal.pone.0131201. eCollection 2015.

24.

Mesenchymal stromal cell therapy: different sources exhibit different immunobiological properties.

Neofytou E, Deuse T, Beygui RE, Schrepfer S.

Transplantation. 2015 Jun;99(6):1113-8. doi: 10.1097/TP.0000000000000734. Review. No abstract available.

PMID:
26035274
25.

Immunobiology of fibrin-based engineered heart tissue.

Conradi L, Schmidt S, Neofytou E, Deuse T, Peters L, Eder A, Hua X, Hansen A, Robbins RC, Beygui RE, Reichenspurner H, Eschenhagen T, Schrepfer S.

Stem Cells Transl Med. 2015 Jun;4(6):625-31. doi: 10.5966/sctm.2013-0202. Epub 2015 May 6.

26.

Impaired Endothelial Regeneration Through Human Parvovirus B19-Infected Circulating Angiogenic Cells in Patients With Cardiomyopathy.

Schmidt-Lucke C, Zobel T, Schrepfer S, Kuhl U, Wang D, Klingel K, Becher PM, Fechner H, Pozzuto T, Van Linthout S, Lassner D, Spillmann F, Escher F, Holinski S, Volk HD, Schultheiss HP, Tschope C.

J Infect Dis. 2015 Oct 1;212(7):1070-81. doi: 10.1093/infdis/jiv178. Epub 2015 Mar 24.

PMID:
25805750
27.

Erratum: miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development.

Maegdefessel L, Spin JM, Raaz U, Eken SM, Toh R, Azuma J, Adam M, Nakagami F, Heymann HM, Chernogubova E, Jin H, Roy J, Hultgren R, Caidahl K, Schrepfer S, Hamsten A, Eriksson P, McConnell MV, Dalman RL, Tsao PS.

Nat Commun. 2015 Feb 26;6:6506. doi: 10.1038/ncomms7506. No abstract available.

28.

SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts.

Deuse T, Wang D, Stubbendorff M, Itagaki R, Grabosch A, Greaves LC, Alawi M, Grünewald A, Hu X, Hua X, Velden J, Reichenspurner H, Robbins RC, Jaenisch R, Weissman IL, Schrepfer S.

Cell Stem Cell. 2015 Jan 8;16(1):33-8. doi: 10.1016/j.stem.2014.11.003. Epub 2014 Nov 20.

29.

miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development.

Maegdefessel L, Spin JM, Raaz U, Eken SM, Toh R, Azuma J, Adam M, Nakagami F, Heymann HM, Chernogubova E, Jin H, Roy J, Hultgren R, Caidahl K, Schrepfer S, Hamsten A, Eriksson P, McConnell MV, Dalman RL, Tsao PS.

Nat Commun. 2014 Oct 31;5:5214. doi: 10.1038/ncomms6214. Erratum in: Nat Commun. 2015;6:6506. Nagakami, Futoshi [corrected to Nakagami, Futoshi]; Chernugobova, Ekaterina [corrected to Chernogubova, Ekaterina].

30.

Inducing myointimal hyperplasia versus atherosclerosis in mice: an introduction of two valid models.

Stubbendorff M, Hua X, Deuse T, Ali Z, Reichenspurner H, Maegdefessel L, Robbins RC, Schrepfer S.

J Vis Exp. 2014 May 14;(87). doi: 10.3791/51459.

31.

Dichloroacetate prevents restenosis in preclinical animal models of vessel injury.

Deuse T, Hua X, Wang D, Maegdefessel L, Heeren J, Scheja L, Bolaños JP, Rakovic A, Spin JM, Stubbendorff M, Ikeno F, Länger F, Zeller T, Schulte-Uentrop L, Stoehr A, Itagaki R, Haddad F, Eschenhagen T, Blankenberg S, Kiefmann R, Reichenspurner H, Velden J, Klein C, Yeung A, Robbins RC, Tsao PS, Schrepfer S.

Nature. 2014 May 29;509(7502):641-4. doi: 10.1038/nature13232. Epub 2014 Apr 20.

32.

The Ca²⁺-activated K⁺ channel KCa3.1 as a potential new target for the prevention of allograft vasculopathy.

Chen YJ, Lam J, Gregory CR, Schrepfer S, Wulff H.

PLoS One. 2013 Nov 29;8(11):e81006. doi: 10.1371/journal.pone.0081006. eCollection 2013.

33.

Granulocyte colony-stimulating factor therapy is associated with a reduced incidence of acute rejection episodes or allograft vasculopathy in heart transplant recipients.

Vrtovec B, Haddad F, Pham M, Deuse T, Fearon WF, Schrepfer S, Leon S, Vu T, Valantine H, Hunt SA.

Transplant Proc. 2013 Jul-Aug;45(6):2406-9. doi: 10.1016/j.transproceed.2013.01.106.

PMID:
23953556
34.

Immunological properties of extraembryonic human mesenchymal stromal cells derived from gestational tissue.

Stubbendorff M, Deuse T, Hua X, Phan TT, Bieback K, Atkinson K, Eiermann TH, Velden J, Schröder C, Reichenspurner H, Robbins RC, Volk HD, Schrepfer S.

Stem Cells Dev. 2013 Oct 1;22(19):2619-29. doi: 10.1089/scd.2013.0043. Epub 2013 Jun 29.

PMID:
23711207
35.

Small animal models of experimental obliterative bronchiolitis.

Jungraithmayr W, Jang JH, Schrepfer S, Inci I, Weder W.

Am J Respir Cell Mol Biol. 2013 Jun;48(6):675-84. doi: 10.1165/rcmb.2012-0379TR. Review.

PMID:
23392572
36.

The potassium channel KCa3.1 as new therapeutic target for the prevention of obliterative airway disease.

Hua X, Deuse T, Chen YJ, Wulff H, Stubbendorff M, Köhler R, Miura H, Länger F, Reichenspurner H, Robbins RC, Schrepfer S.

Transplantation. 2013 Jan 27;95(2):285-92. doi: 10.1097/TP.0b013e318275a2f4.

37.

Effects of intracoronary CD34+ stem cell transplantation in nonischemic dilated cardiomyopathy patients: 5-year follow-up.

Vrtovec B, Poglajen G, Lezaic L, Sever M, Domanovic D, Cernelc P, Socan A, Schrepfer S, Torre-Amione G, Haddad F, Wu JC.

Circ Res. 2013 Jan 4;112(1):165-73. doi: 10.1161/CIRCRESAHA.112.276519. Epub 2012 Oct 12.

PMID:
23065358
38.

Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545.

Deuse T, Hua X, Taylor V, Stubbendorff M, Baluom M, Chen Y, Park G, Velden J, Streichert T, Reichenspurner H, Robbins RC, Schrepfer S.

Transplantation. 2012 Oct 15;94(7):695-702. doi: 10.1097/TP.0b013e3182660496.

PMID:
22971540
39.

Human internal mammary artery (IMA) transplantation and stenting: a human model to study the development of in-stent restenosis.

Hua X, Deuse T, Michelakis ED, Haromy A, Tsao PS, Maegdefessel L, Erben RG, Bergow C, Behnisch BB, Reichenspurner H, Robbins RC, Schrepfer S.

J Vis Exp. 2012 May 9;(63):e3663. doi: 10.3791/3663.

40.

Localization of Islet-1-positive cells in the healthy and infarcted adult murine heart.

Weinberger F, Mehrkens D, Friedrich FW, Stubbendorff M, Hua X, Müller JC, Schrepfer S, Evans SM, Carrier L, Eschenhagen T.

Circ Res. 2012 May 11;110(10):1303-10. doi: 10.1161/CIRCRESAHA.111.259630. Epub 2012 Mar 15.

41.

Human leukocyte antigen I knockdown human embryonic stem cells induce host ignorance and achieve prolonged xenogeneic survival.

Deuse T, Seifert M, Phillips N, Fire A, Tyan D, Kay M, Tsao PS, Hua X, Velden J, Eiermann T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S.

Circulation. 2011 Sep 13;124(11 Suppl):S3-9. doi: 10.1161/CIRCULATIONAHA.111.020727.

PMID:
21911816
42.

Assessment of physiologic natural killer cell cytotoxicity in vitro.

Duske H, Sputtek A, Binder T, Kröger N, Schrepfer S, Eiermann T.

Hum Immunol. 2011 Nov;72(11):1007-12. doi: 10.1016/j.humimm.2011.08.006. Epub 2011 Aug 10.

PMID:
21924314
43.

Immunobiology of naïve and genetically modified HLA-class-I-knockdown human embryonic stem cells.

Deuse T, Seifert M, Tyan D, Tsao PS, Hua X, Velden J, Eiermann T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S.

J Cell Sci. 2011 Sep 1;124(Pt 17):3029-37. doi: 10.1242/jcs.087718. Erratum in: J Cell Sci. 2011 Dec 1;124(Pt 23):4127-8. Phillips, Neil [removed]; Fire, Andrew [removed]; Kay, Mark [removed].

44.

Peptide ligands incorporated into the threefold spike capsid domain to re-direct gene transduction of AAV8 and AAV9 in vivo.

Michelfelder S, Varadi K, Raupp C, Hunger A, Körbelin J, Pahrmann C, Schrepfer S, Müller OJ, Kleinschmidt JA, Trepel M.

PLoS One. 2011;6(8):e23101. doi: 10.1371/journal.pone.0023101. Epub 2011 Aug 5.

45.

Bioluminescence imaging for assessment of immune responses following implantation of engineered heart tissue (EHT).

Conradi L, Pahrmann C, Schmidt S, Deuse T, Hansen A, Eder A, Reichenspurner H, Robbins RC, Eschenhagen T, Schrepfer S.

J Vis Exp. 2011 Jun 1;(52). pii: 2605. doi: 10.3791/2605.

46.

Prevention of transplant coronary artery disease by prenylation inhibitors.

Stein W, Schrepfer S, Itoh S, Kimura N, Velotta J, Palmer O, Bartos J, Wang X, Robbins RC, Fischbein MP.

J Heart Lung Transplant. 2011 Jul;30(7):761-9. doi: 10.1016/j.healun.2011.01.720. Epub 2011 Mar 31.

PMID:
21458297
47.

Orthotopic aortic transplantation: a rat model to study the development of chronic vasculopathy.

Stubbendorff M, Deuse T, Hammel A, Robbins RC, Reichenspurner H, Schrepfer S.

J Vis Exp. 2010 Dec 4;(46). pii: 1989. doi: 10.3791/1989.

48.

Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells.

Deuse T, Stubbendorff M, Tang-Quan K, Phillips N, Kay MA, Eiermann T, Phan TT, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S.

Cell Transplant. 2011;20(5):655-67. doi: 10.3727/096368910X536473. Epub 2010 Nov 5.

PMID:
21054940
49.

Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting.

Deuse T, Koyanagi T, Erben RG, Hua X, Velden J, Ikeno F, Reichenspurner H, Robbins RC, Mochly-Rosen D, Schrepfer S.

Circulation. 2010 Sep 14;122(11 Suppl):S170-8. doi: 10.1161/CIRCULATIONAHA.109.927640.

PMID:
20837910
50.

Non-volume-loaded heart provides a more relevant heterotopic transplantation model.

Tang-Quan KR, Bartos J, Deuse T, Churchill E, Schäfer H, Reichenspurner H, Mochly-Rosen D, Robbins RC, Schrepfer S.

Transpl Immunol. 2010 May;23(1-2):65-70. doi: 10.1016/j.trim.2010.04.005. Epub 2010 Apr 18.

PMID:
20403439

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