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Items: 7

1.

mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance.

Haller S, Kapuria S, Riley RR, O'Leary MN, Schreiber KH, Andersen JK, Melov S, Que J, Rando TA, Rock J, Kennedy BK, Rodgers JT, Jasper H.

Cell Stem Cell. 2017 Dec 7;21(6):806-818.e5. doi: 10.1016/j.stem.2017.11.008.

2.

Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins.

Schreiber KH, Ortiz D, Academia EC, Anies AC, Liao CY, Kennedy BK.

Aging Cell. 2015 Apr;14(2):265-73. doi: 10.1111/acel.12313. Epub 2015 Feb 4.

3.

Nitric oxide induces ataxia telangiectasia mutated (ATM) protein-dependent γH2AX protein formation in pancreatic β cells.

Oleson BJ, Broniowska KA, Schreiber KH, Tarakanova VL, Corbett JA.

J Biol Chem. 2014 Apr 18;289(16):11454-64. doi: 10.1074/jbc.M113.531228. Epub 2014 Mar 7.

4.

The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1.

O'Leary MN, Schreiber KH, Zhang Y, Duc AC, Rao S, Hale JS, Academia EC, Shah SR, Morton JF, Holstein CA, Martin DB, Kaeberlein M, Ladiges WC, Fink PJ, Mackay VL, Wiest DL, Kennedy BK.

PLoS Genet. 2013;9(8):e1003708. doi: 10.1371/journal.pgen.1003708. Epub 2013 Aug 22.

5.

Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo.

Garelick MG, Mackay VL, Yanagida A, Academia EC, Schreiber KH, Ladiges WC, Kennedy BK.

Cell Cycle. 2013 Aug 1;12(15):2493-504. doi: 10.4161/cc.25512. Epub 2013 Jul 1.

6.

When lamins go bad: nuclear structure and disease.

Schreiber KH, Kennedy BK.

Cell. 2013 Mar 14;152(6):1365-75. doi: 10.1016/j.cell.2013.02.015. Review.

7.

Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

Ramos FJ, Chen SC, Garelick MG, Dai DF, Liao CY, Schreiber KH, MacKay VL, An EH, Strong R, Ladiges WC, Rabinovitch PS, Kaeberlein M, Kennedy BK.

Sci Transl Med. 2012 Jul 25;4(144):144ra103. doi: 10.1126/scitranslmed.3003802.

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