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Items: 1 to 50 of 177

1.

Longitudinal proliferation mapping in vivo reveals NADPH oxidase-mediated dampening of Staphylococcus aureus growth rates within neutrophils.

Seiß EA, Krone A, Formaglio P, Goldmann O, Engelmann S, Schraven B, Medina E, Müller AJ.

Sci Rep. 2019 Apr 5;9(1):5703. doi: 10.1038/s41598-019-42129-6.

2.

Characterization of Mice with a Platelet-Specific Deletion of the Adapter Molecule ADAP.

Rudolph JM, Guttek K, Weitz G, Meinke CA, Kliche S, Reinhold D, Schraven B, Reinhold A.

Mol Cell Biol. 2019 Apr 16;39(9). pii: e00365-18. doi: 10.1128/MCB.00365-18. Print 2019 May 1.

PMID:
30833485
3.

Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of Kv1.3 potassium channels, AKT and ERK1/2 signaling.

Lowinus T, Heidel FH, Bose T, Nimmagadda SC, Schnöder T, Cammann C, Schmitz I, Seifert U, Fischer T, Schraven B, Bommhardt U.

Cell Commun Signal. 2019 Jan 16;17(1):5. doi: 10.1186/s12964-018-0317-z.

4.

Filamin A Phosphorylation at Serine 2152 by the Serine/Threonine Kinase Ndr2 Controls TCR-Induced LFA-1 Activation in T Cells.

Waldt N, Seifert A, Demiray YE, Devroe E, Turk BE, Reichardt P, Mix C, Reinhold A, Freund C, Müller AJ, Schraven B, Stork O, Kliche S.

Front Immunol. 2018 Dec 4;9:2852. doi: 10.3389/fimmu.2018.02852. eCollection 2018.

5.

CD11c-expressing Ly6C+CCR2+ monocytes constitute a reservoir for efficient Leishmania proliferation and cell-to-cell transmission.

Heyde S, Philipsen L, Formaglio P, Fu Y, Baars I, Höbbel G, Kleinholz CL, Seiß EA, Stettin J, Gintschel P, Dudeck A, Bousso P, Schraven B, Müller AJ.

PLoS Pathog. 2018 Oct 22;14(10):e1007374. doi: 10.1371/journal.ppat.1007374. eCollection 2018 Oct.

6.

Engulfment of mast cell secretory granules on skin inflammation boosts dendritic cell migration and priming efficiency.

Dudeck J, Froebel J, Kotrba J, Lehmann CHK, Dudziak D, Speier S, Nedospasov SA, Schraven B, Dudeck A.

J Allergy Clin Immunol. 2019 May;143(5):1849-1864.e4. doi: 10.1016/j.jaci.2018.08.052. Epub 2018 Oct 17.

PMID:
30339853
7.

JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation.

Edelmann B, Gupta N, Schnoeder TM, Oelschlegel AM, Shahzad K, Goldschmidt J, Philipsen L, Weinert S, Ghosh A, Saalfeld FC, Nimmagadda SC, Müller P, Braun-Dullaeus R, Mohr J, Wolleschak D, Kliche S, Amthauer H, Heidel FH, Schraven B, Isermann B, Müller AJ, Fischer T.

J Clin Invest. 2018 Oct 1;128(10):4359-4371. doi: 10.1172/JCI90312. Epub 2018 Jul 19.

8.

Beware the intruder: Real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo.

Neumann J, Henneberg S, von Kenne S, Nolte N, Müller AJ, Schraven B, Görtler MW, Reymann KG, Gunzer M, Riek-Burchardt M.

PLoS One. 2018 Mar 15;13(3):e0193970. doi: 10.1371/journal.pone.0193970. eCollection 2018.

9.

CD45 in human physiology and clinical medicine.

Rheinländer A, Schraven B, Bommhardt U.

Immunol Lett. 2018 Apr;196:22-32. doi: 10.1016/j.imlet.2018.01.009. Epub 2018 Jan 31. Review.

PMID:
29366662
10.

Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells.

Ranjan S, Goihl A, Kohli S, Gadi I, Pierau M, Shahzad K, Gupta D, Bock F, Wang H, Shaikh H, Kähne T, Reinhold D, Bank U, Zenclussen AC, Niemz J, Schnöder TM, Brunner-Weinzierl M, Fischer T, Kalinski T, Schraven B, Luft T, Huehn J, Naumann M, Heidel FH, Isermann B.

Nat Commun. 2017 Aug 21;8(1):311. doi: 10.1038/s41467-017-00169-4.

11.

HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience.

Raza SA, Albrecht A, Çalışkan G, Müller B, Demiray YE, Ludewig S, Meis S, Faber N, Hartig R, Schraven B, Lessmann V, Schwegler H, Stork O.

Nat Commun. 2017 Aug 4;8(1):189. doi: 10.1038/s41467-017-00205-3.

12.

A highly conserved redox-active Mx(2)CWx(6)R motif regulates Zap70 stability and activity.

Thurm C, Poltorak MP, Reimer E, Brinkmann MM, Leichert L, Schraven B, Simeoni L.

Oncotarget. 2017 May 9;8(19):30805-30816. doi: 10.18632/oncotarget.16486.

13.

JAK2-V617F activates β1-integrin-mediated adhesion of granulocytes to vascular cell adhesion molecule 1.

Gupta N, Edelmann B, Schnoeder TM, Saalfeld FC, Wolleschak D, Kliche S, Schraven B, Heidel FH, Fischer T.

Leukemia. 2017 May;31(5):1223-1226. doi: 10.1038/leu.2017.26. Epub 2017 Jan 18. No abstract available.

14.

De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling.

Philipsen L, Reddycherla AV, Hartig R, Gumz J, Kästle M, Kritikos A, Poltorak MP, Prokazov Y, Turbin E, Weber A, Zuschratter W, Schraven B, Simeoni L, Müller AJ.

Sci Signal. 2017 Jan 17;10(462). pii: eaaf4736. doi: 10.1126/scisignal.aaf4736.

PMID:
28096507
15.

D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes.

Witte A, Meineke B, Sticht J, Philipsen L, Kuropka B, Müller AJ, Freund C, Schraven B, Kliche S.

Mol Cell Biol. 2017 Mar 17;37(7). pii: e00509-16. doi: 10.1128/MCB.00509-16. Print 2017 Apr 1.

16.

Normal Development and Function of T Cells in Proline Rich 7 (Prr7) Deficient Mice.

Hrdinka M, Sudan K, Just S, Drobek A, Stepanek O, Schlüter D, Reinhold D, Jordan BA, Gintschel P, Schraven B, Kreutz MR.

PLoS One. 2016 Sep 22;11(9):e0162863. doi: 10.1371/journal.pone.0162863. eCollection 2016.

17.

ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens.

Parzmair GP, Gereke M, Haberkorn O, Annemann M, Podlasly L, Kliche S, Reinhold A, Schraven B, Bruder D.

J Leukoc Biol. 2017 Feb;101(2):407-419. doi: 10.1189/jlb.1A0216-090RR. Epub 2016 Sep 7.

PMID:
27605210
18.

Immunomodulation by memantine in therapy of Alzheimer's disease is mediated through inhibition of Kv1.3 channels and T cell responsiveness.

Lowinus T, Bose T, Busse S, Busse M, Reinhold D, Schraven B, Bommhardt UH.

Oncotarget. 2016 Aug 16;7(33):53797-53807. doi: 10.18632/oncotarget.10777.

19.

Early changes in the metabolic profile of activated CD8(+) T cells.

Cammann C, Rath A, Reichl U, Lingel H, Brunner-Weinzierl M, Simeoni L, Schraven B, Lindquist JA.

BMC Cell Biol. 2016 Jul 7;17(1):28. doi: 10.1186/s12860-016-0104-x.

20.

Tyrosine-phosphorylation of the scaffold protein ADAP and its role in T cell signaling.

Kuropka B, Schraven B, Kliche S, Krause E, Freund C.

Expert Rev Proteomics. 2016 Jun;13(6):545-54. doi: 10.1080/14789450.2016.1187565. Review.

PMID:
27258783
21.

Atypical IκB proteins in immune cell differentiation and function.

Annemann M, Plaza-Sirvent C, Schuster M, Katsoulis-Dimitriou K, Kliche S, Schraven B, Schmitz I.

Immunol Lett. 2016 Mar;171:26-35. doi: 10.1016/j.imlet.2016.01.006. Epub 2016 Jan 22. Review.

PMID:
26804211
22.

Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64(+) cells.

Vogel S, Grabski E, Buschjäger D, Klawonn F, Döring M, Wang J, Fletcher E, Bechmann I, Witte T, Durisin M, Schraven B, Mangsbo SM, Schönfeld K, Czeloth N, Kalinke U.

Sci Rep. 2015 Dec 16;5:18308. doi: 10.1038/srep18308.

23.

T cells and reactive oxygen species.

Belikov AV, Schraven B, Simeoni L.

J Biomed Sci. 2015 Oct 15;22:85. doi: 10.1186/s12929-015-0194-3. Review.

24.

Analysis of Phosphorylation-dependent Protein Interactions of Adhesion and Degranulation Promoting Adaptor Protein (ADAP) Reveals Novel Interaction Partners Required for Chemokine-directed T cell Migration.

Kuropka B, Witte A, Sticht J, Waldt N, Majkut P, Hackenberger CP, Schraven B, Krause E, Kliche S, Freund C.

Mol Cell Proteomics. 2015 Nov;14(11):2961-72. doi: 10.1074/mcp.M115.048249. Epub 2015 Aug 5.

25.

Specificity of JAK-kinase inhibition determines impact on human and murine T-cell function.

Perner F, Schnöder TM, Ranjan S, Wolleschak D, Ebert C, Pils MC, Frey S, Polanetzki A, Fahldieck C, Schönborn U, Schraven B, Isermann B, Fischer T, Heidel FH.

Leukemia. 2016 Apr;30(4):991-5. doi: 10.1038/leu.2015.218. Epub 2015 Aug 5. No abstract available.

PMID:
26242463
26.

miR-20a inhibits TCR-mediated signaling and cytokine production in human naïve CD4+ T cells.

Reddycherla AV, Meinert I, Reinhold A, Reinhold D, Schraven B, Simeoni L.

PLoS One. 2015 Apr 17;10(4):e0125311. doi: 10.1371/journal.pone.0125311. eCollection 2015.

27.

Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes.

Hasenberg A, Hasenberg M, Männ L, Neumann F, Borkenstein L, Stecher M, Kraus A, Engel DR, Klingberg A, Seddigh P, Abdullah Z, Klebow S, Engelmann S, Reinhold A, Brandau S, Seeling M, Waisman A, Schraven B, Göthert JR, Nimmerjahn F, Gunzer M.

Nat Methods. 2015 May;12(5):445-52. doi: 10.1038/nmeth.3322. Epub 2015 Mar 16.

PMID:
25775045
28.

The adhesion- and degranulation-promoting adaptor protein and its role in the modulation of experimental autoimmune encephalomyelitis.

Engelmann S, Togni M, Kliche S, Reinhold D, Schraven B, Reinhold A.

Crit Rev Immunol. 2015;35(1):1-14. Review.

PMID:
25746044
29.

Selective targeting of transforming growth factor-beta1 into TCR/CD28 signalling plasma membrane domains silences T cell activation.

Harder T, Guttek K, Philipsen L, Simeoni L, Schraven B, Reinhold D.

Cell Commun Signal. 2014 Dec 8;12:74. doi: 10.1186/s12964-014-0074-6.

30.

NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.

Simma N, Bose T, Kahlfuss S, Mankiewicz J, Lowinus T, Lühder F, Schüler T, Schraven B, Heine M, Bommhardt U.

Cell Commun Signal. 2014 Dec 5;12:75. doi: 10.1186/s12964-014-0075-5.

31.

Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke.

Neumann J, Riek-Burchardt M, Herz J, Doeppner TR, König R, Hütten H, Etemire E, Männ L, Klingberg A, Fischer T, Görtler MW, Heinze HJ, Reichardt P, Schraven B, Hermann DM, Reymann KG, Gunzer M.

Acta Neuropathol. 2015 Feb;129(2):259-77. doi: 10.1007/s00401-014-1355-2. Epub 2014 Nov 13.

PMID:
25391494
32.

TCR-triggered extracellular superoxide production is not required for T-cell activation.

Belikov AV, Schraven B, Simeoni L.

Cell Commun Signal. 2014 Aug 1;12:50. doi: 10.1186/s12964-014-0050-1.

33.

Hippocampus-dependent learning in SKAP-HOM deficient mice.

Fiedler A, Grecksch G, Reinhold A, Schraven B, Becker A.

Behav Brain Res. 2014 Aug 15;270:125-30. doi: 10.1016/j.bbr.2014.04.051. Epub 2014 May 9.

PMID:
24815314
34.

Tetanus toxoid-pulsed monocyte vaccination for augmentation of collateral vessel growth.

Herold J, Francke A, Weinert S, Schmeisser A, Hebel K, Schraven B, Roehl FW, Strasser RH, Braun-Dullaeus RC.

J Am Heart Assoc. 2014 Apr 14;3(2):e000611. doi: 10.1161/JAHA.113.000611.

35.

Clinically relevant doses of FLT3-kinase inhibitors quizartinib and midostaurin do not impair T-cell reactivity and function.

Wolleschak D, Mack TS, Perner F, Frey S, Schnöder TM, Wagner MC, Höding C, Pils MC, Parkner A, Kliche S, Schraven B, Hebel K, Brunner-Weinzierl M, Ranjan S, Isermann B, Lipka DB, Fischer T, Heidel FH.

Haematologica. 2014 Jun;99(6):e90-3. doi: 10.3324/haematol.2014.104331. Epub 2014 Mar 14. No abstract available.

36.

Sos1 regulates sustained TCR-mediated Erk activation.

Poltorak M, Meinert I, Stone JC, Schraven B, Simeoni L.

Eur J Immunol. 2014 May;44(5):1535-40. doi: 10.1002/eji.201344046. Epub 2014 Feb 20.

37.

Negative interactions and feedback regulations are required for transient cellular response.

Mobashir M, Madhusudhan T, Isermann B, Beyer T, Schraven B.

Sci Rep. 2014 Jan 16;4:3718. doi: 10.1038/srep03718.

38.

Immunosuppression by N-methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells.

Kahlfuß S, Simma N, Mankiewicz J, Bose T, Lowinus T, Klein-Hessling S, Sprengel R, Schraven B, Heine M, Bommhardt U.

Mol Cell Biol. 2014 Mar;34(5):820-31. doi: 10.1128/MCB.01273-13. Epub 2013 Dec 16.

39.

T cell-independent modulation of experimental autoimmune encephalomyelitis in ADAP-deficient mice.

Engelmann S, Togni M, Thielitz A, Reichardt P, Kliche S, Reinhold D, Schraven B, Reinhold A.

J Immunol. 2013 Nov 15;191(10):4950-9. doi: 10.4049/jimmunol.1203340. Epub 2013 Oct 7.

40.

Multimolecular analysis of stable immunological synapses reveals sustained recruitment and sequential assembly of signaling clusters.

Philipsen L, Engels T, Schilling K, Gurbiel S, Fischer KD, Tedford K, Schraven B, Gunzer M, Reichardt P.

Mol Cell Proteomics. 2013 Sep;12(9):2551-67. doi: 10.1074/mcp.M112.025205. Epub 2013 Jun 10.

41.

PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells.

Smida M, Cammann C, Gurbiel S, Kerstin N, Lingel H, Lindquist S, Simeoni L, Brunner-Weinzierl MC, Suchanek M, Schraven B, Lindquist JA.

Cell Commun Signal. 2013 Apr 19;11(1):28. doi: 10.1186/1478-811X-11-28.

42.

T cell activation results in conformational changes in the Src family kinase Lck to induce its activation.

Stirnweiss A, Hartig R, Gieseler S, Lindquist JA, Reichardt P, Philipsen L, Simeoni L, Poltorak M, Merten C, Zuschratter W, Prokazov Y, Paster W, Stockinger H, Harder T, Gunzer M, Schraven B.

Sci Signal. 2013 Feb 19;6(263):ra13. doi: 10.1126/scisignal.2003607.

PMID:
23423439
43.

TCR activation kinetics and feedback regulation in primary human T cells.

Poltorak M, Arndt B, Kowtharapu BS, Reddycherla AV, Witte V, Lindquist JA, Schraven B, Simeoni L.

Cell Commun Signal. 2013 Jan 14;11:4. doi: 10.1186/1478-811X-11-4.

44.

Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX.

Arndt B, Kalinski T, Reinhold D, Thielitz A, Roessner A, Schraven B, Simeoni L.

J Leukoc Biol. 2013 Mar;93(3):353-62. doi: 10.1189/jlb.0312152. Epub 2013 Jan 10.

PMID:
23307938
45.

Discrete, qualitative models of interaction networks.

Ballerstein K, Haus UU, Lindquist JA, Beyer T, Schraven B, Weismantel R.

Front Biosci (Schol Ed). 2013 Jan 1;5:149-66. Review.

PMID:
23277042
46.

Simulated evolution of signal transduction networks.

Mobashir M, Schraven B, Beyer T.

PLoS One. 2012;7(12):e50905. doi: 10.1371/journal.pone.0050905. Epub 2012 Dec 12.

47.

Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation.

Arndt B, Poltorak M, Kowtharapu BS, Reichardt P, Philipsen L, Lindquist JA, Schraven B, Simeoni L.

J Immunol Methods. 2013 Jan 31;387(1-2):276-83. doi: 10.1016/j.jim.2012.11.006. Epub 2012 Nov 22.

PMID:
23178863
48.

Constitutive Akt1 signals attenuate B-cell receptor signaling and proliferation, but enhance B-cell migration and effector function.

Pierau M, Na SY, Simma N, Lowinus T, Marx A, Schraven B, Bommhardt UH.

Eur J Immunol. 2012 Dec;42(12):3381-93. doi: 10.1002/eji.201242397.

49.

First insight into the kinome of human regulatory T cells.

König S, Probst-Kepper M, Reinl T, Jeron A, Huehn J, Schraven B, Jänsch L.

PLoS One. 2012;7(7):e40896. doi: 10.1371/journal.pone.0040896. Epub 2012 Jul 16.

50.

The adapter protein ADAP is required for selected dendritic cell functions.

Togni M, Engelmann S, Reinhold D, Schraven B, Reinhold A.

Cell Commun Signal. 2012 Jun 6;10(1):14. doi: 10.1186/1478-811X-10-14.

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