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IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression.

Thiem A, Hesbacher S, Kneitz H, di Primio T, Heppt MV, Hermanns HM, Goebeler M, Meierjohann S, Houben R, Schrama D.

J Exp Clin Cancer Res. 2019 Sep 11;38(1):397. doi: 10.1186/s13046-019-1403-9.


MCPyV Large T Antigen-Induced Atonal Homolog 1 Is a Lineage-Dependency Oncogene in Merkel Cell Carcinoma.

Fan K, Gravemeyer J, Ritter C, Rasheed K, Gambichler T, Moens U, Shuda M, Schrama D, Becker JC.

J Invest Dermatol. 2019 Jul 5. pii: S0022-202X(19)31853-6. doi: 10.1016/j.jid.2019.06.135. [Epub ahead of print]


Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review.

Kervarrec T, Samimi M, Guyétant S, Sarma B, Chéret J, Blanchard E, Berthon P, Schrama D, Houben R, Touzé A.

Front Oncol. 2019 Jun 10;9:451. doi: 10.3389/fonc.2019.00451. eCollection 2019. Review.


Morphologic and immunophenotypical features distinguishing Merkel cell polyomavirus-positive and negative Merkel cell carcinoma.

Kervarrec T, Tallet A, Miquelestorena-Standley E, Houben R, Schrama D, Gambichler T, Berthon P, Le Corre Y, Hainaut-Wierzbicka E, Aubin F, Bens G, Tabareau-Delalande F, Beneton N, Fromont G, Arbion F, Leteurtre E, Herfs M, Touzé A, Samimi M, Guyétant S.

Mod Pathol. 2019 Jun 14. doi: 10.1038/s41379-019-0288-7. [Epub ahead of print]


Dietary Creatine Supplementation in Gilthead Seabream (Sparus aurata) Increases Dorsal Muscle Area and the Expression of myod1 and capn1 Genes.

Ramos-Pinto L, Lopes G, Sousa V, Castro LFC, Schrama D, Rodrigues P, Valente LMP.

Front Endocrinol (Lausanne). 2019 Mar 28;10:161. doi: 10.3389/fendo.2019.00161. eCollection 2019.


Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells.

Wobser M, Weber A, Glunz A, Tauch S, Seitz K, Butelmann T, Hesbacher S, Goebeler M, Bartz R, Kohlhof H, Schrama D, Houben R.

J Hematol Oncol. 2019 Mar 18;12(1):30. doi: 10.1186/s13045-019-0719-4.


Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: Integration pattern suggest that large T antigen truncating events occur before or during integration.

Schrama D, Sarosi EM, Adam C, Ritter C, Kaemmerer U, Klopocki E, König EM, Utikal J, Becker JC, Houben R.

Int J Cancer. 2019 Aug 15;145(4):1020-1032. doi: 10.1002/ijc.32280. Epub 2019 Apr 4.


Dietary Creatine Supplementation in Gilthead Seabream (Sparus aurata): Comparative Proteomics Analysis on Fish Allergens, Muscle Quality, and Liver.

Schrama D, Cerqueira M, Raposo CS, Rosa da Costa AM, Wulff T, Gonçalves A, Camacho C, Colen R, Fonseca F, Rodrigues PM.

Front Physiol. 2018 Dec 21;9:1844. doi: 10.3389/fphys.2018.01844. eCollection 2018.


Use of Two-Dimensional Electrophoresis to Explore Foodborne Bacterial Pathogen Responses to Gastrointestinal Stress.

Schrama D, Faleiro ML.

Methods Mol Biol. 2019;1918:139-147. doi: 10.1007/978-1-4939-9000-9_11.


The identification of patient-specific mutations reveals dual pathway activation in most patients with melanoma and activated receptor tyrosine kinases in BRAF/NRAS wild-type melanomas.

Appenzeller S, Gesierich A, Thiem A, Hufnagel A, Jessen C, Kneitz H, Regensburger M, Schmidt C, Zirkenbach V, Bischler T, Schilling B, Siedel C, Goebeler ME, Houben R, Schrama D, Gehrig A, Rost S, Maurus K, Bargou R, Rosenwald A, Schartl M, Goebeler M, Meierjohann S.

Cancer. 2019 Feb 15;125(4):586-600. doi: 10.1002/cncr.31843. Epub 2018 Dec 18.


VEGF-A Inhibition as a Potential Therapeutic Approach in Merkel Cell Carcinoma.

Kervarrec T, Gaboriaud P, Tallet A, Leblond V, Arnold F, Berthon P, Schweinitzer S, Larcher T, Guyétant S, Schrama D, Houben R, Samimi M, Touzé A.

J Invest Dermatol. 2019 Mar;139(3):736-739. doi: 10.1016/j.jid.2018.08.029. Epub 2018 Oct 22. No abstract available.


Diagnostic accuracy of a panel of immunohistochemical and molecular markers to distinguish Merkel cell carcinoma from other neuroendocrine carcinomas.

Kervarrec T, Tallet A, Miquelestorena-Standley E, Houben R, Schrama D, Gambichler T, Berthon P, Le Corre Y, Hainaut-Wierzbicka E, Aubin F, Bens G, Tabareau-Delalande F, Beneton N, Fromont G, Arbion F, Leteurtre E, Touzé A, Samimi M, Guyétant S.

Mod Pathol. 2019 Apr;32(4):499-510. doi: 10.1038/s41379-018-0155-y. Epub 2018 Oct 22.


Effects of dietary lipid sources on hepatic nutritive contents, fatty acid composition and proteome of Nile tilapia (Oreochromis niloticus).

Boonanuntanasarn S, Nakharuthai C, Schrama D, Duangkaew R, Rodrigues PM.

J Proteomics. 2019 Feb 10;192:208-222. doi: 10.1016/j.jprot.2018.09.003. Epub 2018 Sep 8.


Impacts of the combined exposure to seawater acidification and arsenic on the proteome of Crassostrea angulata and Crassostrea gigas.

Moreira A, Figueira E, Mestre NC, Schrama D, Soares AMVM, Freitas R, Bebianno MJ.

Aquat Toxicol. 2018 Oct;203:117-129. doi: 10.1016/j.aquatox.2018.07.021. Epub 2018 Jul 30.


Circulating Cell-Free miR-375 as Surrogate Marker of Tumor Burden in Merkel Cell Carcinoma.

Fan K, Ritter C, Nghiem P, Blom A, Verhaegen ME, Dlugosz A, Ødum N, Woetmann A, Tothill RW, Hicks RJ, Sand M, Schrama D, Schadendorf D, Ugurel S, Becker JC.

Clin Cancer Res. 2018 Dec 1;24(23):5873-5882. doi: 10.1158/1078-0432.CCR-18-1184. Epub 2018 Jul 30.


Early onset of diffuse melanosis cutis under pembrolizumab therapy illustrates the limitations of anti-PD-1 checkpoint inhibitors.

Thiem A, Schummer P, Ueberschaar S, Kerstan A, Kneitz H, Schrama D, Appenzeller S, Meierjohann S, Schilling B, Goebeler M, Gesierich A.

Melanoma Res. 2018 Oct;28(5):465-468. doi: 10.1097/CMR.0000000000000458.


Detection of the Merkel cell polyomavirus in the neuroendocrine component of combined Merkel cell carcinoma.

Kervarrec T, Samimi M, Gaboriaud P, Gheit T, Beby-Defaux A, Houben R, Schrama D, Fromont G, Tommasino M, Le Corre Y, Hainaut-Wierzbicka E, Aubin F, Bens G, Maillard H, Furudoï A, Michenet P, Touzé A, Guyétant S.

Virchows Arch. 2018 May;472(5):825-837. doi: 10.1007/s00428-018-2342-0. Epub 2018 Mar 28.


Merkel cell carcinomas infiltrated with CD33+ myeloid cells and CD8+ T cells are associated with improved outcome.

Kervarrec T, Gaboriaud P, Berthon P, Zaragoza J, Schrama D, Houben R, Le Corre Y, Hainaut-Wierzbicka E, Aubin F, Bens G, Domenech J, Guyétant S, Touzé A, Samimi M.

J Am Acad Dermatol. 2018 May;78(5):973-982.e8. doi: 10.1016/j.jaad.2017.12.029. Epub 2017 Dec 19.


Epidemiology, biology and therapy of Merkel cell carcinoma: conclusions from the EU project IMMOMEC.

Becker JC, Stang A, Hausen AZ, Fischer N, DeCaprio JA, Tothill RW, Lyngaa R, Hansen UK, Ritter C, Nghiem P, Bichakjian CK, Ugurel S, Schrama D.

Cancer Immunol Immunother. 2018 Mar;67(3):341-351. doi: 10.1007/s00262-017-2099-3. Epub 2017 Nov 30. Review.


Coincident Metastatic Melanoma and Merkel Cell Carcinoma with Complete Remission on Treatment with Pembrolizumab.

Thiem A, Kneitz H, Schummer P, Herz S, Schrama D, Houben R, Goebeler M, Schilling B, Gesierich A.

Acta Derm Venereol. 2017 Nov 15;97(10):1252-1254. doi: 10.2340/00015555-2757. No abstract available.


BIK is involved in BRAF/MEK inhibitor induced apoptosis in melanoma cell lines.

Borst A, Haferkamp S, Grimm J, Rösch M, Zhu G, Guo S, Li C, Gao T, Meierjohann S, Schrama D, Houben R.

Cancer Lett. 2017 Sep 28;404:70-78. doi: 10.1016/j.canlet.2017.07.005. Epub 2017 Jul 15.


Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma.

Ritter C, Fan K, Paschen A, Reker Hardrup S, Ferrone S, Nghiem P, Ugurel S, Schrama D, Becker JC.

Sci Rep. 2017 May 23;7(1):2290. doi: 10.1038/s41598-017-02608-0.


Physiological responses of reared sea bream (Sparus aurata Linnaeus, 1758) to an Amyloodinium ocellatum outbreak.

Moreira M, Schrama D, Soares F, Wulff T, Pousão-Ferreira P, Rodrigues P.

J Fish Dis. 2017 Nov;40(11):1545-1560. doi: 10.1111/jfd.12623. Epub 2017 Apr 27.


Membrane-enriched proteome changes and prion protein expression during neural differentiation and in neuroblastoma cells.

Macedo JA, Schrama D, Duarte I, Tavares E, Renaut J, Futschik ME, Rodrigues PM, Melo EP.

BMC Genomics. 2017 Apr 22;18(1):319. doi: 10.1186/s12864-017-3694-6.


MGMT promoter methylation status in Merkel cell carcinoma: in vitro versus invivo.

Improta G, Ritter C, Pettinato A, Vasta V, Schrama D, Fraggetta F, Becker JC.

J Cancer Res Clin Oncol. 2017 Aug;143(8):1489-1497. doi: 10.1007/s00432-017-2413-7. Epub 2017 Apr 12.


Non-reproducible sequence artifacts in FFPE tissue: an experience report.

Ofner R, Ritter C, Ugurel S, Cerroni L, Stiller M, Bogenrieder T, Solca F, Schrama D, Becker JC.

J Cancer Res Clin Oncol. 2017 Jul;143(7):1199-1207. doi: 10.1007/s00432-017-2399-1. Epub 2017 Mar 17.


T cell receptor repertoire usage in cancer as a surrogate marker for immune responses.

Schrama D, Ritter C, Becker JC.

Semin Immunopathol. 2017 Apr;39(3):255-268. doi: 10.1007/s00281-016-0614-9. Epub 2017 Jan 10. Review.


Distribution of TERT promoter mutations in primary and metastatic melanomas in Austrian patients.

Ofner R, Ritter C, Heidenreich B, Kumar R, Ugurel S, Schrama D, Becker JC.

J Cancer Res Clin Oncol. 2017 Apr;143(4):613-617. doi: 10.1007/s00432-016-2322-1. Epub 2016 Dec 18.


Enhanced dietary formulation to mitigate winter thermal stress in gilthead sea bream (Sparus aurata): a 2D-DIGE plasma proteome study.

Schrama D, Richard N, Silva TS, Figueiredo FA, Conceição LE, Burchmore R, Eckersall D, Rodrigues PM.

Fish Physiol Biochem. 2017 Apr;43(2):603-617. doi: 10.1007/s10695-016-0315-2. Epub 2016 Nov 24.


Nutritional mitigation of winter thermal stress in gilthead seabream: Associated metabolic pathways and potential indicators of nutritional state.

Richard N, Silva TS, Wulff T, Schrama D, Dias JP, Rodrigues PM, Conceição LE.

J Proteomics. 2016 Jun 16;142:1-14. doi: 10.1016/j.jprot.2016.04.037. Epub 2016 Apr 26.


RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells.

Hesbacher S, Pfitzer L, Wiedorfer K, Angermeyer S, Borst A, Haferkamp S, Scholz CJ, Wobser M, Schrama D, Houben R.

Oncotarget. 2016 May 31;7(22):32956-68. doi: 10.18632/oncotarget.8793.


Combination with γ-secretase inhibitor prolongs treatment efficacy of BRAF inhibitor in BRAF-mutated melanoma cells.

Zhu G, Yi X, Haferkamp S, Hesbacher S, Li C, Goebeler M, Gao T, Houben R, Schrama D.

Cancer Lett. 2016 Jun 28;376(1):43-52. doi: 10.1016/j.canlet.2016.03.028. Epub 2016 Mar 18.


Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma.

Ritter C, Fan K, Paulson KG, Nghiem P, Schrama D, Becker JC.

Sci Rep. 2016 Feb 23;6:21678. doi: 10.1038/srep21678.


SERPINB1 expression is predictive for sensitivity and outcome of cisplatin-based chemotherapy in melanoma.

Willmes C, Kumar R, Becker JC, Fried I, Rachakonda PS, Poppe LM, Hesbacher S, Schadendorf D, Sucker A, Schrama D, Ugurel S.

Oncotarget. 2016 Mar 1;7(9):10117-32. doi: 10.18632/oncotarget.6956.


Serine 220 phosphorylation of the Merkel cell polyomavirus large T antigen crucially supports growth of Merkel cell carcinoma cells.

Schrama D, Hesbacher S, Angermeyer S, Schlosser A, Haferkamp S, Aue A, Adam C, Weber A, Schmidt M, Houben R.

Int J Cancer. 2016 Mar 1;138(5):1153-62. doi: 10.1002/ijc.29862. Epub 2015 Oct 5.


STAT3 Single Nucleotide Polymorphism rs4796793 SNP Does Not Correlate with Response to Adjuvant IFNα Therapy in Stage III Melanoma Patients.

Schrama D, Ugurel S, Sucker A, Ritter C, Zapatka M, Schadendorf D, Becker JC.

Front Med (Lausanne). 2014 Nov 28;1:47. doi: 10.3389/fmed.2014.00047. eCollection 2014.


Characterization of functional domains in the Merkel cell polyoma virus Large T antigen.

Houben R, Angermeyer S, Haferkamp S, Aue A, Goebeler M, Schrama D, Hesbacher S.

Int J Cancer. 2015 Mar 1;136(5):E290-300. doi: 10.1002/ijc.29200. Epub 2014 Sep 19.


Downregulation of MHC-I expression is prevalent but reversible in Merkel cell carcinoma.

Paulson KG, Tegeder A, Willmes C, Iyer JG, Afanasiev OK, Schrama D, Koba S, Thibodeau R, Nagase K, Simonson WT, Seo A, Koelle DM, Madeleine M, Bhatia S, Nakajima H, Sano S, Hardwick JS, Disis ML, Cleary MA, Becker JC, Nghiem P.

Cancer Immunol Res. 2014 Nov;2(11):1071-9. doi: 10.1158/2326-6066.CIR-14-0005. Epub 2014 Aug 12.


Presence of human polyomavirus 6 in mutation-specific BRAF inhibitor-induced epithelial proliferations.

Schrama D, Groesser L, Ugurel S, Hafner C, Pastrana DV, Buck CB, Cerroni L, Theiler A, Becker JC.

JAMA Dermatol. 2014 Nov;150(11):1180-6. doi: 10.1001/jamadermatol.2014.1116.


Fluorescence in situ hybridization and qPCR to detect Merkel cell polyomavirus physical status and load in Merkel cell carcinomas.

Haugg AM, Rennspiess D, zur Hausen A, Speel EJ, Cathomas G, Becker JC, Schrama D.

Int J Cancer. 2014 Dec 15;135(12):2804-15. doi: 10.1002/ijc.28931. Epub 2014 May 9.


The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma.

Adam C, Baeurle A, Brodsky JL, Wipf P, Schrama D, Becker JC, Houben R.

PLoS One. 2014 Apr 2;9(4):e92041. doi: 10.1371/journal.pone.0092041. eCollection 2014.


T-cell responses to oncogenic merkel cell polyomavirus proteins distinguish patients with merkel cell carcinoma from healthy donors.

Lyngaa R, Pedersen NW, Schrama D, Thrue CA, Ibrani D, Met O, Thor Straten P, Nghiem P, Becker JC, Hadrup SR.

Clin Cancer Res. 2014 Apr 1;20(7):1768-78. doi: 10.1158/1078-0432.CCR-13-2697. Epub 2014 Feb 13.


Response to Shuda et al.

Angermeyer S, Hesbacher S, Becker JC, Schrama D, Houben R.

J Invest Dermatol. 2014 May;134(5):1481-1482. doi: 10.1038/jid.2013.486. Epub 2013 Nov 12. No abstract available.


Clinical remission of Merkel cell carcinoma after treatment with imatinib.

Loader DE, Feldmann R, Baumgartner M, Breier F, Schrama D, Becker JC, Steiner A.

J Am Acad Dermatol. 2013 Oct;69(4):e181-3. doi: 10.1016/j.jaad.2013.03.042. No abstract available.


The dark side of cyclophosphamide: cyclophosphamide-mediated ablation of regulatory T cells.

Becker JC, Schrama D.

J Invest Dermatol. 2013 Jun;133(6):1462-5. doi: 10.1038/jid.2013.67.


Immune-suppressive properties of the tumor microenvironment.

Becker JC, Andersen MH, Schrama D, Thor Straten P.

Cancer Immunol Immunother. 2013 Jul;62(7):1137-48. doi: 10.1007/s00262-013-1434-6. Epub 2013 May 11. Review.


Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.

Houben R, Dreher C, Angermeyer S, Borst A, Utikal J, Haferkamp S, Peitsch WK, Schrama D, Hesbacher S.

J Invest Dermatol. 2013 Oct;133(10):2453-2460. doi: 10.1038/jid.2013.169. Epub 2013 Apr 5.


Listeria monocytogenes dairy isolates show a different proteome response to sequential exposure to gastric and intestinal fluids.

Melo J, Schrama D, Hussey S, Andrew PW, Faleiro ML.

Int J Food Microbiol. 2013 May 15;163(2-3):51-63. doi: 10.1016/j.ijfoodmicro.2013.03.001. Epub 2013 Mar 14.


Adaptation of Listeria monocytogenes in a simulated cheese medium: effects on virulence using the Galleria mellonella infection model.

Schrama D, Helliwell N, Neto L, Faleiro ML.

Lett Appl Microbiol. 2013 Jun;56(6):421-7. doi: 10.1111/lam.12064. Epub 2013 Mar 25.


Proteomic analysis shows that individual Listeria monocytogenes strains use different strategies in response to gastric stress.

Melo J, Schrama D, Andrew PW, Faleiro ML.

Foodborne Pathog Dis. 2013 Feb;10(2):107-19. doi: 10.1089/fpd.2012.1297.


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