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Items: 41

1.

Repurposing HAMI3379 to Block GPR17 and Promote Rodent and Human Oligodendrocyte Differentiation.

Merten N, Fischer J, Simon K, Zhang L, Schröder R, Peters L, Letombe AG, Hennen S, Schrage R, Bödefeld T, Vermeiren C, Gillard M, Mohr K, Lu QR, Brüstle O, Gomeza J, Kostenis E.

Cell Chem Biol. 2018 Jun 21;25(6):775-786.e5. doi: 10.1016/j.chembiol.2018.03.012. Epub 2018 Apr 26.

PMID:
29706593
2.

Allosteric modulators targeting CNS muscarinic receptors.

Bock A, Schrage R, Mohr K.

Neuropharmacology. 2018 Jul 1;136(Pt C):427-437. doi: 10.1016/j.neuropharm.2017.09.024. Epub 2017 Sep 18. Review.

PMID:
28935216
3.

The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes.

Simon K, Merten N, Schröder R, Hennen S, Preis P, Schmitt NK, Peters L, Schrage R, Vermeiren C, Gillard M, Mohr K, Gomeza J, Kostenis E.

Mol Pharmacol. 2017 May;91(5):518-532. doi: 10.1124/mol.116.107904. Epub 2017 Mar 2. Erratum in: Mol Pharmacol. 2017 Jul;92 (1):100.

PMID:
28254957
4.

A New Molecular Mechanism To Engineer Protean Agonism at a G Protein-Coupled Receptor.

De Min A, Matera C, Bock A, Holze J, Kloeckner J, Muth M, Traenkle C, De Amici M, Kenakin T, Holzgrabe U, Dallanoce C, Kostenis E, Mohr K, Schrage R.

Mol Pharmacol. 2017 Apr;91(4):348-356. doi: 10.1124/mol.116.107276. Epub 2017 Feb 6.

PMID:
28167741
5.

Engineered Context-Sensitive Agonism: Tissue-Selective Drug Signaling through a G Protein-Coupled Receptor.

Seemann WK, Wenzel D, Schrage R, Etscheid J, Bödefeld T, Bartol A, Warnken M, Sasse P, Klöckner J, Holzgrabe U, DeAmici M, Schlicker E, Racké K, Kostenis E, Meyer R, Fleischmann BK, Mohr K.

J Pharmacol Exp Ther. 2017 Feb;360(2):289-299. doi: 10.1124/jpet.116.237149. Epub 2016 Nov 15.

PMID:
28082514
6.

Functional selectivity and dualsteric/bitopic GPCR targeting.

Schrage R, Kostenis E.

Curr Opin Pharmacol. 2017 Feb;32:85-90. doi: 10.1016/j.coph.2016.12.001. Epub 2016 Dec 24. Review.

PMID:
28027487
7.

The experimental power of FR900359 to study Gq-regulated biological processes.

Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis E.

Nat Commun. 2015 Dec 14;6:10156. doi: 10.1038/ncomms10156.

8.

Superagonism at G protein-coupled receptors and beyond.

Schrage R, De Min A, Hochheiser K, Kostenis E, Mohr K.

Br J Pharmacol. 2016 Oct;173(20):3018-27. doi: 10.1111/bph.13278. Epub 2015 Oct 24. Review.

9.

Rational design of partial agonists for the muscarinic m1 acetylcholine receptor.

Chen X, Klöckner J, Holze J, Zimmermann C, Seemann WK, Schrage R, Bock A, Mohr K, Tränkle C, Holzgrabe U, Decker M.

J Med Chem. 2015 Jan 22;58(2):560-76. doi: 10.1021/jm500860w. Epub 2014 Dec 19.

PMID:
25478907
10.

Dualsteric muscarinic antagonists--orthosteric binding pose controls allosteric subtype selectivity.

Schmitz J, van der Mey D, Bermudez M, Klöckner J, Schrage R, Kostenis E, Tränkle C, Wolber G, Mohr K, Holzgrabe U.

J Med Chem. 2014 Aug 14;57(15):6739-50. doi: 10.1021/jm500790x. Epub 2014 Aug 4.

PMID:
25051097
11.

A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation.

Schmitz AL, Schrage R, Gaffal E, Charpentier TH, Wiest J, Hiltensperger G, Morschel J, Hennen S, Häußler D, Horn V, Wenzel D, Grundmann M, Büllesbach KM, Schröder R, Brewitz HH, Schmidt J, Gomeza J, Galés C, Fleischmann BK, Tüting T, Imhof D, Tietze D, Gütschow M, Holzgrabe U, Sondek J, Harden TK, Mohr K, Kostenis E.

Chem Biol. 2014 Jul 17;21(7):890-902. doi: 10.1016/j.chembiol.2014.06.003.

12.

New insight into active muscarinic receptors with the novel radioagonist [³H]iperoxo.

Schrage R, Holze J, Klöckner J, Balkow A, Klause AS, Schmitz AL, De Amici M, Kostenis E, Tränkle C, Holzgrabe U, Mohr K.

Biochem Pharmacol. 2014 Aug 1;90(3):307-19. doi: 10.1016/j.bcp.2014.05.012. Epub 2014 May 23.

PMID:
24863257
13.

Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist.

Hennen S, Wang H, Peters L, Merten N, Simon K, Spinrath A, Blättermann S, Akkari R, Schrage R, Schröder R, Schulz D, Vermeiren C, Zimmermann K, Kehraus S, Drewke C, Pfeifer A, König GM, Mohr K, Gillard M, Müller CE, Lu QR, Gomeza J, Kostenis E.

Sci Signal. 2013 Oct 22;6(298):ra93. doi: 10.1126/scisignal.2004350.

14.

Molecular alliance-from orthosteric and allosteric ligands to dualsteric/bitopic agonists at G protein coupled receptors.

Mohr K, Schmitz J, Schrage R, Tränkle C, Holzgrabe U.

Angew Chem Int Ed Engl. 2013 Jan 7;52(2):508-16. doi: 10.1002/anie.201205315. Epub 2012 Dec 6. Review.

PMID:
23225228
15.

Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor.

Schrage R, Seemann WK, Klöckner J, Dallanoce C, Racké K, Kostenis E, De Amici M, Holzgrabe U, Mohr K.

Br J Pharmacol. 2013 May;169(2):357-70. doi: 10.1111/bph.12003.

16.

The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling.

Bock A, Merten N, Schrage R, Dallanoce C, Bätz J, Klöckner J, Schmitz J, Matera C, Simon K, Kebig A, Peters L, Müller A, Schrobang-Ley J, Tränkle C, Hoffmann C, De Amici M, Holzgrabe U, Kostenis E, Mohr K.

Nat Commun. 2012;3:1044. doi: 10.1038/ncomms2028.

17.

[Psammoma bodies in cytological vaginal smears in metastatic ovarian carcinoma].

Erz W, Stoll P, Schrage R.

Geburtshilfe Frauenheilkd. 1995 Apr;55(4):229-30. German.

PMID:
7789713
18.

[The value of colposcopy and portio biopsy in preventive examination].

Geppert M, Smyczek-Gargya B, Blum S, Schrage R, Menton M.

Geburtshilfe Frauenheilkd. 1994 Jul;54(7):394-6. German.

PMID:
7926570
19.

[Attitude of patients to chorionic villi biopsy: motivation for the decision and perception].

Menton M, Chalkiadakis G, Wiest E, Schneider M, Schrage R.

Zentralbl Gynakol. 1993;115(8):370-3. German.

PMID:
8212943
20.
21.

[Cancer register problems--modified reporting law model for the improvement of data protection].

Schrage R.

Offentl Gesundheitswes. 1991 Nov;53(11):746-52. German.

PMID:
1837342
22.

[A pregnancy calendar as a computer program].

Schrage R.

Biomed Tech (Berl). 1989;34 Suppl:237. German. No abstract available.

PMID:
2819180
23.

[Thermoregulation and the performance of rabbits at high environmental temperatures].

Schrage R, Petersen J.

Dtsch Tierarztl Wochenschr. 1986 Mar 7;93(3):121-5. German. No abstract available.

PMID:
3519162
24.

[Chlamydia trachomatis--studies on the reliability of its detection in Papanicolaou preparations].

Donath EM, Schrage R, Hoyme UB.

Geburtshilfe Frauenheilkd. 1985 Jun;45(6):402-5. German.

PMID:
4018517
25.

[Chlamydia trachomatis--cytologic findings in infections of the uterine cervix].

Hoyme UB, Donath EM, Schrage R.

Geburtshilfe Frauenheilkd. 1983 Jun;43(6):370-2. German.

PMID:
6554209
26.

Amniotic fluid cells in the second trimester of pregnancy.

Schrage R, Bögelspacher HR, Wurster KG.

Acta Cytol. 1982 Jul-Aug;26(4):407-16.

PMID:
6957090
27.

[Epidemiology of vulvar cancer].

Schrage R, Schmid H.

Arch Gynecol. 1979 Jul 20;228(1-4):442-3. German. No abstract available.

PMID:
485422
28.

[Problems of current diagnosis of neoplasms in women].

Schrage R.

Fortschr Med. 1978 May 18;96(19):1023-6. German.

PMID:
417987
29.

[Evaluation of screening results for the early diagnosis of cancer in females (proceedings)].

Schrage R.

Arch Gynakol. 1977 Jul 29;224(1-4):299. German. No abstract available.

PMID:
579830
30.

[Prevention of neoplastic diseases in women].

Schrage R.

Schwest Rev. 1976 Oct 15;14(10):18-21. German. No abstract available.

PMID:
1050835
31.

[Phase contrast microscopy and imprint cytology for rapid intraoperative diagnosis].

Schrage R.

Med Welt. 1976 Aug 20;27(34):1570-4. German. No abstract available.

PMID:
781461
32.

[Results of cancer screening in women (author's transl)].

Schrage R.

Dtsch Med Wochenschr. 1976 May 14;101(20):774-9. German.

PMID:
1261424
33.

[Are more girls than boys born in breech presentation compared with head presentation?].

Schrage R.

Z Geburtshilfe Perinatol. 1976 Apr;180(2):145-8. German.

PMID:
936711
34.
35.

[Cytological picture of urine sediment in gynecologic radiotherapy, endoxan and bleomycin therapy].

Schrage R.

Arch Gynakol. 1975 Nov 18;219(1-4):70-1. German. No abstract available.

PMID:
55112
36.

[The timing of tubal ligation (Author's transl)].

Schrage R.

Geburtshilfe Frauenheilkd. 1975 Feb;35(2):141-6. German.

PMID:
1140550
37.

[Urocytogram in the treatment with bleomycin].

Schrage R.

Zentralbl Gynakol. 1975;97(21):1298-303. German.

PMID:
55014
38.

[The etiology of breech presentation (author's transl)].

Schrage R.

Z Geburtshilfe Perinatol. 1973 Dec;177(6):437-45. German. No abstract available.

PMID:
4595931
39.

[Gross, et al, differential blood sedimentation in gynecologic patients].

Schrage R.

Med Welt. 1973 Sep 21;24(38):1449-50. German. No abstract available.

PMID:
4766311
40.

[Vaginal hysterectomy in descensus].

Schrage R.

Med Welt. 1973 Jan 12;24(2):75-8. German. No abstract available.

PMID:
4803300
41.

[Urocytogram in the treatment of cervical and ovarian carcinoma. Differential diagnosis and clinical consequences].

Schrage R, König PA.

Med Welt. 1972 Dec 16;23(51):1938-43. German. No abstract available.

PMID:
4661516

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