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Items: 1 to 50 of 53

1.

Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment.

Sulea T, Rohani N, Baardsnes J, Corbeil CR, Deprez C, Cepero-Donates Y, Robert A, Schrag JD, Parat M, Duchesne M, Jaramillo ML, Purisima EO, Zwaagstra JC.

MAbs. 2020 Jan-Dec;12(1):1682866. doi: 10.1080/19420862.2019.1682866.

2.

Binding symmetry and surface flexibility mediate antibody self-association.

Schrag JD, Picard MÈ, Gaudreault F, Gagnon LP, Baardsnes J, Manenda MS, Sheff J, Deprez C, Baptista C, Hogues H, Kelly JF, Purisima EO, Shi R, Sulea T.

MAbs. 2019 Oct;11(7):1300-1318. doi: 10.1080/19420862.2019.1632114. Epub 2019 Jul 18.

3.

Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human VH/VL Single-Domain Antibodies from In Vitro Display Libraries.

Henry KA, Kim DY, Kandalaft H, Lowden MJ, Yang Q, Schrag JD, Hussack G, MacKenzie CR, Tanha J.

Front Immunol. 2017 Dec 12;8:1759. doi: 10.3389/fimmu.2017.01759. eCollection 2017.

4.

Antibody light chain variable domains and their biophysically improved versions for human immunotherapy.

Kim DY, To R, Kandalaft H, Ding W, van Faassen H, Luo Y, Schrag JD, St-Amant N, Hefford M, Hirama T, Kelly JF, MacKenzie R, Tanha J.

MAbs. 2014 Jan-Feb;6(1):219-35. doi: 10.4161/mabs.26844.

5.

Structural and enzymatic characterization of NanS (YjhS), a 9-O-Acetyl N-acetylneuraminic acid esterase from Escherichia coli O157:H7.

Rangarajan ES, Ruane KM, Proteau A, Schrag JD, Valladares R, Gonzalez CF, Gilbert M, Yakunin AF, Cygler M.

Protein Sci. 2011 Jul;20(7):1208-19. doi: 10.1002/pro.649. Epub 2011 May 31.

6.

Different active-site loop orientation in serine hydrolases versus acyltransferases.

Jiang Y, Morley KL, Schrag JD, Kazlauskas RJ.

Chembiochem. 2011 Mar 21;12(5):768-76. doi: 10.1002/cbic.201000693. Epub 2011 Feb 23.

PMID:
21351219
7.

Switching catalysis from hydrolysis to perhydrolysis in Pseudomonas fluorescens esterase.

Yin DL, Bernhardt P, Morley KL, Jiang Y, Cheeseman JD, Purpero V, Schrag JD, Kazlauskas RJ.

Biochemistry. 2010 Mar 9;49(9):1931-42. doi: 10.1021/bi9021268.

8.

Structure of the noncatalytic domains and global fold of the protein disulfide isomerase ERp72.

Kozlov G, Määttänen P, Schrag JD, Hura GL, Gabrielli L, Cygler M, Thomas DY, Gehring K.

Structure. 2009 May 13;17(5):651-9. doi: 10.1016/j.str.2009.02.016.

9.

Molecular dynamics-solvated interaction energy studies of protein-protein interactions: the MP1-p14 scaffolding complex.

Cui Q, Sulea T, Schrag JD, Munger C, Hung MN, Naïm M, Cygler M, Purisima EO.

J Mol Biol. 2008 Jun 13;379(4):787-802. doi: 10.1016/j.jmb.2008.04.035. Epub 2008 Apr 20.

PMID:
18479705
10.

The crystal structure and dimerization interface of GADD45gamma.

Schrag JD, Jiralerspong S, Banville M, Jaramillo ML, O'Connor-McCourt MD.

Proc Natl Acad Sci U S A. 2008 May 6;105(18):6566-71. doi: 10.1073/pnas.0800086105. Epub 2008 Apr 29.

11.

Crystal structure of the bb' domains of the protein disulfide isomerase ERp57.

Kozlov G, Maattanen P, Schrag JD, Pollock S, Cygler M, Nagar B, Thomas DY, Gehring K.

Structure. 2006 Aug;14(8):1331-9.

12.

The structure of the exopolyphosphatase (PPX) from Escherichia coli O157:H7 suggests a binding mode for long polyphosphate chains.

Rangarajan ES, Nadeau G, Li Y, Wagner J, Hung MN, Schrag JD, Cygler M, Matte A.

J Mol Biol. 2006 Jun 23;359(5):1249-60. Epub 2006 Apr 27.

PMID:
16678853
13.

Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI.

Sivaraman J, Myers RS, Boju L, Sulea T, Cygler M, Jo Davisson V, Schrag JD.

Biochemistry. 2005 Aug 2;44(30):10071-80.

PMID:
16042384
14.
15.

Crystal structure of N-succinylarginine dihydrolase AstB, bound to substrate and product, an enzyme from the arginine catabolic pathway of Escherichia coli.

Tocilj A, Schrag JD, Li Y, Schneider BL, Reitzer L, Matte A, Cygler M.

J Biol Chem. 2005 Apr 22;280(16):15800-8. Epub 2005 Feb 9.

16.

Crystal structures of Escherichia coli ATP-dependent glucokinase and its complex with glucose.

Lunin VV, Li Y, Schrag JD, Iannuzzi P, Cygler M, Matte A.

J Bacteriol. 2004 Oct;186(20):6915-27.

17.

Insights into function of PSI domains from structure of the Met receptor PSI domain.

Kozlov G, Perreault A, Schrag JD, Park M, Cygler M, Gehring K, Ekiel I.

Biochem Biophys Res Commun. 2004 Aug 13;321(1):234-40.

PMID:
15358240
18.

Structure of an aryl esterase from Pseudomonas fluorescens.

Cheeseman JD, Tocilj A, Park S, Schrag JD, Kazlauskas RJ.

Acta Crystallogr D Biol Crystallogr. 2004 Jul;60(Pt 7):1237-43. Epub 2004 Jun 22.

PMID:
15213385
19.

Defining substrate characteristics from 3D structure; perspective on EstA structure.

Schrag JD, Cygler M.

Structure. 2004 Apr;12(4):521-2. No abstract available.

20.

Lectin control of protein folding and sorting in the secretory pathway.

Schrag JD, Procopio DO, Cygler M, Thomas DY, Bergeron JJ.

Trends Biochem Sci. 2003 Jan;28(1):49-57. Review.

PMID:
12517452
21.

Mutational analysis of the gephyrin-related molybdenum cofactor biosynthetic gene cnxE from the lower eukaryote Aspergillus nidulans.

Heck IS, Schrag JD, Sloan J, Millar LJ, Kanan G, Kinghorn JR, Unkles SE.

Genetics. 2002 Jun;161(2):623-32.

22.

Structure of the 16S rRNA pseudouridine synthase RsuA bound to uracil and UMP.

Sivaraman J, Sauvé V, Larocque R, Stura EA, Schrag JD, Cygler M, Matte A.

Nat Struct Biol. 2002 May;9(5):353-8.

PMID:
11953756
23.

Mechanism of action and NAD+-binding mode revealed by the crystal structure of L-histidinol dehydrogenase.

Barbosa JA, Sivaraman J, Li Y, Larocque R, Matte A, Schrag JD, Cygler M.

Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1859-64. Epub 2002 Feb 12.

24.

The Structure of calnexin, an ER chaperone involved in quality control of protein folding.

Schrag JD, Bergeron JJ, Li Y, Borisova S, Hahn M, Thomas DY, Cygler M.

Mol Cell. 2001 Sep;8(3):633-44.

25.
26.

The crystal structure of Escherichia coli MoeA, a protein from the molybdopterin synthesis pathway.

Schrag JD, Huang W, Sivaraman J, Smith C, Plamondon J, Larocque R, Matte A, Cygler M.

J Mol Biol. 2001 Jul 6;310(2):419-31.

PMID:
11428898
27.

Three-dimensional structure of 2-amino-3-ketobutyrate CoA ligase from Escherichia coli complexed with a PLP-substrate intermediate: inferred reaction mechanism.

Schmidt A, Sivaraman J, Li Y, Larocque R, Barbosa JA, Smith C, Matte A, Schrag JD, Cygler M.

Biochemistry. 2001 May 1;40(17):5151-60.

PMID:
11318637
28.

Structure and conformational flexibility of Candida rugosa lipase.

Cygler M, Schrag JD.

Biochim Biophys Acta. 1999 Nov 23;1441(2-3):205-14. Review.

PMID:
10570248
29.

Identification and crystallization of a protease-resistant core of calnexin that retains biological activity.

Hahn M, Borisova S, Schrag JD, Tessier DC, Zapun A, Tom R, Kamen AA, Bergeron JJ, Thomas DY, Cygler M.

J Struct Biol. 1998 Nov;123(3):260-4.

PMID:
9878580
30.

Interaction of a G-protein beta-subunit with a conserved sequence in Ste20/PAK family protein kinases.

Leeuw T, Wu C, Schrag JD, Whiteway M, Thomas DY, Leberer E.

Nature. 1998 Jan 8;391(6663):191-5.

PMID:
9428767
31.

The open conformation of a Pseudomonas lipase.

Schrag JD, Li Y, Cygler M, Lang D, Burgdorf T, Hecht HJ, Schmid R, Schomburg D, Rydel TJ, Oliver JD, Strickland LC, Dunaway CM, Larson SB, Day J, McPherson A.

Structure. 1997 Feb 15;5(2):187-202.

32.

Lipases and alpha/beta hydrolase fold.

Schrag JD, Cygler M.

Methods Enzymol. 1997;284:85-107. Review. No abstract available.

PMID:
9379946
33.

Structure as basis for understanding interfacial properties of lipases.

Cygler M, Schrag JD.

Methods Enzymol. 1997;284:3-27. Review. No abstract available.

PMID:
9379943
34.

Purification and characterization of a Penicillium sp. lipase which discriminates against diglycerides.

Gulomova K, Ziomek E, Schrag JD, Davranov K, Cygler M.

Lipids. 1996 Apr;31(4):379-84.

PMID:
8743049
35.

Redesigning the active site of Geotrichum candidum lipase.

Schrag JD, Vernet T, Laramée L, Thomas DY, Recktenwald A, Okoniewska M, Ziomek E, Cygler M.

Protein Eng. 1995 Aug;8(8):835-42.

PMID:
8637854
36.

Expression and characterization of Geotrichum candidum lipase I gene. Comparison of specificity profile with lipase II.

Bertolini MC, Schrag JD, Cygler M, Ziomek E, Thomas DY, Vernet T.

Eur J Biochem. 1995 Mar 15;228(3):863-9.

37.

Structural determinants defining common stereoselectivity of lipases toward secondary alcohols.

Cygler M, Grochulski P, Schrag JD.

Can J Microbiol. 1995;41 Suppl 1:289-96. Review.

PMID:
7606666
38.

Analogs of reaction intermediates identify a unique substrate binding site in Candida rugosa lipase.

Grochulski P, Bouthillier F, Kazlauskas RJ, Serreqi AN, Schrag JD, Ziomek E, Cygler M.

Biochemistry. 1994 Mar 29;33(12):3494-500.

PMID:
8142346
39.

Polymorphism in the lipase genes of Geotrichum candidum strains.

Bertolini MC, Laramée L, Thomas DY, Cygler M, Schrag JD, Vernet T.

Eur J Biochem. 1994 Jan 15;219(1-2):119-25.

40.

Two conformational states of Candida rugosa lipase.

Grochulski P, Li Y, Schrag JD, Cygler M.

Protein Sci. 1994 Jan;3(1):82-91.

41.

Cloning and expression of Geotrichum candidum lipase II gene in yeast. Probing of the enzyme active site by site-directed mutagenesis.

Vernet T, Ziomek E, Recktenwald A, Schrag JD, de Montigny C, Tessier DC, Thomas DY, Cygler M.

J Biol Chem. 1993 Dec 15;268(35):26212-9.

42.

Insights into interfacial activation from an open structure of Candida rugosa lipase.

Grochulski P, Li Y, Schrag JD, Bouthillier F, Smith P, Harrison D, Rubin B, Cygler M.

J Biol Chem. 1993 Jun 15;268(17):12843-7.

43.

1.8 A refined structure of the lipase from Geotrichum candidum.

Schrag JD, Cygler M.

J Mol Biol. 1993 Mar 20;230(2):575-91.

PMID:
8464065
44.

Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins.

Cygler M, Schrag JD, Sussman JL, Harel M, Silman I, Gentry MK, Doctor BP.

Protein Sci. 1993 Mar;2(3):366-82. Review.

45.

Pancreatic lipases: evolutionary intermediates in a positional change of catalytic carboxylates?

Schrag JD, Winkler FK, Cygler M.

J Biol Chem. 1992 Mar 5;267(7):4300-3.

46.

Advances in structural understanding of lipases.

Cygler M, Schrag JD, Ergan F.

Biotechnol Genet Eng Rev. 1992;10:143-84. Review. No abstract available.

PMID:
1301738
47.

Multiple crystal forms of lipases from Geotrichum candidum.

Schrag JD, Li Y, Wu S, Cygler M.

J Mol Biol. 1991 Aug 5;220(3):541-3.

PMID:
1870119
48.

Ser-His-Glu triad forms the catalytic site of the lipase from Geotrichum candidum.

Schrag JD, Li YG, Wu S, Cygler M.

Nature. 1991 Jun 27;351(6329):761-4.

PMID:
2062369
49.

Three-dimensional structure of the HSV1 nucleocapsid.

Schrag JD, Prasad BV, Rixon FJ, Chiu W.

Cell. 1989 Feb 24;56(4):651-60.

PMID:
2537151
50.

Crystallization and preliminary X-ray diffraction analysis of 11 S acetylcholinesterase.

Schrag JD, Schmid MF, Morgan DG, Phillips GN Jr, Chiu W, Tang L.

J Biol Chem. 1988 Jul 15;263(20):9795-800.

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