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Items: 1 to 50 of 66

1.

The Kidney Contains Ontogenetically Distinct Dendritic Cell and Macrophage Subtypes throughout Development That Differ in Their Inflammatory Properties.

Salei N, Rambichler S, Salvermoser J, Papaioannou NE, Schuchert R, Pakalniškytė D, Li N, Marschner JA, Lichtnekert J, Stremmel C, Cernilogar FM, Salvermoser M, Walzog B, Straub T, Schotta G, Anders HJ, Schulz C, Schraml BU.

J Am Soc Nephrol. 2020 Jan 13. pii: ASN.2019040419. doi: 10.1681/ASN.2019040419. [Epub ahead of print]

PMID:
31932472
2.

Pre-marked chromatin and transcription factor co-binding shape the pioneering activity of Foxa2.

Cernilogar FM, Hasenöder S, Wang Z, Scheibner K, Burtscher I, Sterr M, Smialowski P, Groh S, Evenroed IM, Gilfillan GD, Lickert H, Schotta G.

Nucleic Acids Res. 2019 Sep 26;47(17):9069-9086. doi: 10.1093/nar/gkz627.

3.

Loss of KDM6A confers drug resistance in acute myeloid leukemia.

Stief SM, Hanneforth AL, Weser S, Mattes R, Carlet M, Liu WH, Bartoschek MD, Domínguez Moreno H, Oettle M, Kempf J, Vick B, Ksienzyk B, Tizazu B, Rothenberg-Thurley M, Quentmeier H, Hiddemann W, Vosberg S, Greif PA, Metzeler KH, Schotta G, Bultmann S, Jeremias I, Leonhardt H, Spiekermann K.

Leukemia. 2020 Jan;34(1):50-62. doi: 10.1038/s41375-019-0497-6. Epub 2019 Jun 14.

PMID:
31201358
4.

Point mutations in the PDX1 transactivation domain impair human β-cell development and function.

Wang X, Sterr M, Ansarullah, Burtscher I, Böttcher A, Beckenbauer J, Siehler J, Meitinger T, Häring HU, Staiger H, Cernilogar FM, Schotta G, Irmler M, Beckers J, Wright CVE, Bakhti M, Lickert H.

Mol Metab. 2019 Jun;24:80-97. doi: 10.1016/j.molmet.2019.03.006. Epub 2019 Mar 20.

5.

BZLF1 interacts with chromatin remodelers promoting escape from latent infections with EBV.

Schaeffner M, Mrozek-Gorska P, Buschle A, Woellmer A, Tagawa T, Cernilogar FM, Schotta G, Krietenstein N, Lieleg C, Korber P, Hammerschmidt W.

Life Sci Alliance. 2019 Mar 29;2(2). pii: e201800108. doi: 10.26508/lsa.201800108. Print 2019 Apr.

6.

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.

Garg G, Muschaweckh A, Moreno H, Vasanthakumar A, Floess S, Lepennetier G, Oellinger R, Zhan Y, Regen T, Hiltensperger M, Peter C, Aly L, Knier B, Palam LR, Kapur R, Kaplan MH, Waisman A, Rad R, Schotta G, Huehn J, Kallies A, Korn T.

Cell Rep. 2019 Feb 12;26(7):1854-1868.e5. doi: 10.1016/j.celrep.2019.01.070.

7.

The Aryl Hydrocarbon Receptor Pathway Defines the Time Frame for Restorative Neurogenesis.

Di Giaimo R, Durovic T, Barquin P, Kociaj A, Lepko T, Aschenbroich S, Breunig CT, Irmler M, Cernilogar FM, Schotta G, Barbosa JS, Trümbach D, Baumgart EV, Neuner AM, Beckers J, Wurst W, Stricker SH, Ninkovic J.

Cell Rep. 2018 Dec 18;25(12):3241-3251.e5. doi: 10.1016/j.celrep.2018.11.055.

8.

Genome-wide analysis of PDX1 target genes in human pancreatic progenitors.

Wang X, Sterr M, Burtscher I, Chen S, Hieronimus A, Machicao F, Staiger H, Häring HU, Lederer G, Meitinger T, Cernilogar FM, Schotta G, Irmler M, Beckers J, Hrabě de Angelis M, Ray M, Wright CVE, Bakhti M, Lickert H.

Mol Metab. 2018 Mar;9:57-68. doi: 10.1016/j.molmet.2018.01.011. Epub 2018 Jan 31.

9.

Mammalian HP1 Isoforms Have Specific Roles in Heterochromatin Structure and Organization.

Bosch-Presegué L, Raurell-Vila H, Thackray JK, González J, Casal C, Kane-Goldsmith N, Vizoso M, Brown JP, Gómez A, Ausió J, Zimmermann T, Esteller M, Schotta G, Singh PB, Serrano L, Vaquero A.

Cell Rep. 2017 Nov 21;21(8):2048-2057. doi: 10.1016/j.celrep.2017.10.092.

10.

Histone H4K20 tri-methylation at late-firing origins ensures timely heterochromatin replication.

Brustel J, Kirstein N, Izard F, Grimaud C, Prorok P, Cayrou C, Schotta G, Abdelsamie AF, Déjardin J, Méchali M, Baldacci G, Sardet C, Cadoret JC, Schepers A, Julien E.

EMBO J. 2017 Sep 15;36(18):2726-2741. doi: 10.15252/embj.201796541. Epub 2017 Aug 4.

11.

Silencing of endogenous retroviruses by heterochromatin.

Groh S, Schotta G.

Cell Mol Life Sci. 2017 Jun;74(11):2055-2065. doi: 10.1007/s00018-017-2454-8. Epub 2017 Feb 3. Review.

PMID:
28160052
12.

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.

Bromberg KD, Mitchell TR, Upadhyay AK, Jakob CG, Jhala MA, Comess KM, Lasko LM, Li C, Tuzon CT, Dai Y, Li F, Eram MS, Nuber A, Soni NB, Manaves V, Algire MA, Sweis RF, Torrent M, Schotta G, Sun C, Michaelides MR, Shoemaker AR, Arrowsmith CH, Brown PJ, Santhakumar V, Martin A, Rice JC, Chiang GG, Vedadi M, Barsyte-Lovejoy D, Pappano WN.

Nat Chem Biol. 2017 Mar;13(3):317-324. doi: 10.1038/nchembio.2282. Epub 2017 Jan 23.

PMID:
28114273
13.

Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration.

Ramesh V, Bayam E, Cernilogar FM, Bonapace IM, Schulze M, Riemenschneider MJ, Schotta G, Götz M.

Genes Dev. 2016 Oct 1;30(19):2199-2212.

14.

Production of Small Noncoding RNAs from the flamenco Locus Is Regulated by the gypsy Retrotransposon of Drosophila melanogaster.

Guida V, Cernilogar FM, Filograna A, De Gregorio R, Ishizu H, Siomi MC, Schotta G, Bellenchi GC, Andrenacci D.

Genetics. 2016 Oct;204(2):631-644. Epub 2016 Aug 24.

15.

Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability.

Nelson DM, Jaber-Hijazi F, Cole JJ, Robertson NA, Pawlikowski JS, Norris KT, Criscione SW, Pchelintsev NA, Piscitello D, Stong N, Rai TS, McBryan T, Otte GL, Nixon C, Clark W, Riethman H, Wu H, Schotta G, Garcia BA, Neretti N, Baird DM, Berger SL, Adams PD.

Genome Biol. 2016 Jul 25;17(1):158. doi: 10.1186/s13059-016-1017-x.

16.

Cross-species Analyses Unravel the Complexity of H3K27me3 and H4K20me3 in the Context of Neural Stem Progenitor Cells.

Rhodes CT, Sandstrom RS, Huang SA, Wang Y, Schotta G, Berger MS, Lin CA.

Neuroepigenetics. 2016 Jun;6:10-25. Epub 2016 May 3.

17.

A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination.

Rocha PP, Raviram R, Fu Y, Kim J, Luo VM, Aljoufi A, Swanzey E, Pasquarella A, Balestrini A, Miraldi ER, Bonneau R, Petrini J, Schotta G, Skok JA.

Cell Rep. 2016 Jun 28;16(1):48-55. doi: 10.1016/j.celrep.2016.05.073. Epub 2016 Jun 16.

18.

A spherical harmonics intensity model for 3D segmentation and 3D shape analysis of heterochromatin foci.

Eck S, Wörz S, Müller-Ott K, Hahn M, Biesdorf A, Schotta G, Rippe K, Rohr K.

Med Image Anal. 2016 Aug;32:18-31. doi: 10.1016/j.media.2016.03.001. Epub 2016 Mar 17.

PMID:
27037463
19.

Retrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro-B cells.

Pasquarella A, Ebert A, Pereira de Almeida G, Hinterberger M, Kazerani M, Nuber A, Ellwart J, Klein L, Busslinger M, Schotta G.

Development. 2016 May 15;143(10):1788-99. doi: 10.1242/dev.130203. Epub 2016 Mar 24.

20.

ε-globin expression is regulated by SUV4-20h1.

Wang Y, Rank G, Li Z, Wang Y, Ju J, Nuber A, Wu Y, Liu M, Nie M, Huang F, Cerruti L, Ma C, Tan R, Schotta G, Jane SM, Zeng CK, Zhao Q.

Haematologica. 2016 May;101(5):e168-72. doi: 10.3324/haematol.2015.139980. Epub 2016 Jan 22. No abstract available.

21.

Atrx promotes heterochromatin formation at retrotransposons.

Sadic D, Schmidt K, Groh S, Kondofersky I, Ellwart J, Fuchs C, Theis FJ, Schotta G.

EMBO Rep. 2015 Jul;16(7):836-50. doi: 10.15252/embr.201439937. Epub 2015 May 26.

22.

Comparative computational analysis of pluripotency in human and mouse stem cells.

Ernst M, Abu Dawud R, Kurtz A, Schotta G, Taher L, Fuellen G.

Sci Rep. 2015 Jan 21;5:7927. doi: 10.1038/srep07927.

23.

Emergence of cancer stem cells in hepatocellular carcinoma.

Pilz S, Schotta G.

EMBO J. 2015 Feb 12;34(4):425-6. doi: 10.15252/embj.201490785. Epub 2015 Jan 8. No abstract available.

24.

Heterochromatin-mediated gene silencing facilitates the diversification of olfactory neurons.

Lyons DB, Magklara A, Goh T, Sampath SC, Schaefer A, Schotta G, Lomvardas S.

Cell Rep. 2014 Nov 6;9(3):884-92. doi: 10.1016/j.celrep.2014.10.001. Epub 2014 Oct 30.

25.

Specificity, propagation, and memory of pericentric heterochromatin.

Müller-Ott K, Erdel F, Matveeva A, Mallm JP, Rademacher A, Hahn M, Bauer C, Zhang Q, Kaltofen S, Schotta G, Höfer T, Rippe K.

Mol Syst Biol. 2014 Aug 18;10:746. doi: 10.15252/msb.20145377.

26.

Concerted activities of distinct H4K20 methyltransferases at DNA double-strand breaks regulate 53BP1 nucleation and NHEJ-directed repair.

Tuzon CT, Spektor T, Kong X, Congdon LM, Wu S, Schotta G, Yokomori K, Rice JC.

Cell Rep. 2014 Jul 24;8(2):430-8. doi: 10.1016/j.celrep.2014.06.013. Epub 2014 Jul 4.

27.

Quiescence-induced LncRNAs trigger H4K20 trimethylation and transcriptional silencing.

Bierhoff H, Dammert MA, Brocks D, Dambacher S, Schotta G, Grummt I.

Mol Cell. 2014 May 22;54(4):675-82. doi: 10.1016/j.molcel.2014.03.032. Epub 2014 Apr 24.

28.

Comment on "Biomolecular dynamics and binding studies in the living cell" by Stephan Diekmann and Christian Hoischen.

Pilz S, Schotta G.

Phys Life Rev. 2014 Mar;11(1):31-2; discussion 38. doi: 10.1016/j.plrev.2013.11.010. Epub 2013 Nov 22. No abstract available.

PMID:
24315387
29.

Dynamic changes of the epigenetic landscape during cellular differentiation.

Dambacher S, de Almeida GP, Schotta G.

Epigenomics. 2013 Dec;5(6):701-13. doi: 10.2217/epi.13.67. Review.

PMID:
24283883
30.

Epigenetics of eu- and heterochromatin in inverted and conventional nuclei from mouse retina.

Eberhart A, Feodorova Y, Song C, Wanner G, Kiseleva E, Furukawa T, Kimura H, Schotta G, Leonhardt H, Joffe B, Solovei I.

Chromosome Res. 2013 Aug;21(5):535-54. doi: 10.1007/s10577-013-9375-7. Epub 2013 Aug 31.

PMID:
23996328
31.

The compact view on heterochromatin.

Dambacher S, Hahn M, Schotta G.

Cell Cycle. 2013 Sep 15;12(18):2925-6. doi: 10.4161/cc.26179. Epub 2013 Aug 23. No abstract available.

32.

Wnt/β-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse.

Engert S, Burtscher I, Liao WP, Dulev S, Schotta G, Lickert H.

Development. 2013 Aug;140(15):3128-38. doi: 10.1242/dev.088765. Epub 2013 Jul 3.

33.

FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis.

Neguembor MV, Xynos A, Onorati MC, Caccia R, Bortolanza S, Godio C, Pistoni M, Corona DF, Schotta G, Gabellini D.

J Mol Cell Biol. 2013 Oct;5(5):294-307. doi: 10.1093/jmcb/mjt018. Epub 2013 May 29.

PMID:
23720823
34.

Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin.

Hahn M, Dambacher S, Dulev S, Kuznetsova AY, Eck S, Wörz S, Sadic D, Schulte M, Mallm JP, Maiser A, Debs P, von Melchner H, Leonhardt H, Schermelleh L, Rohr K, Rippe K, Storchova Z, Schotta G.

Genes Dev. 2013 Apr 15;27(8):859-72. doi: 10.1101/gad.210377.112. Epub 2013 Apr 18.

35.

H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization.

Jack AP, Bussemer S, Hahn M, Pünzeler S, Snyder M, Wells M, Csankovszki G, Solovei I, Schotta G, Hake SB.

PLoS One. 2013;8(2):e51765. doi: 10.1371/journal.pone.0051765. Epub 2013 Feb 22.

36.

Suv4-20h histone methyltransferases promote neuroectodermal differentiation by silencing the pluripotency-associated Oct-25 gene.

Nicetto D, Hahn M, Jung J, Schneider TD, Straub T, David R, Schotta G, Rupp RA.

PLoS Genet. 2013;9(1):e1003188. doi: 10.1371/journal.pgen.1003188. Epub 2013 Jan 31.

37.

Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic integrity.

Jørgensen S, Schotta G, Sørensen CS.

Nucleic Acids Res. 2013 Mar 1;41(5):2797-806. doi: 10.1093/nar/gkt012. Epub 2013 Jan 23. Review.

38.

Maternal diet supplementation with methyl donors and increased parity affect the incidence of craniofacial defects in the offspring of twisted gastrulation mutant mice.

Billington CJ Jr, Schmidt B, Zhang L, Hodges JS, Georgieff MK, Schotta G, Gopalakrishnan R, Petryk A.

J Nutr. 2013 Mar;143(3):332-9. doi: 10.3945/jn.112.168906. Epub 2013 Jan 23.

39.

Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks.

Hartlerode AJ, Guan Y, Rajendran A, Ura K, Schotta G, Xie A, Shah JV, Scully R.

PLoS One. 2012;7(11):e49211. doi: 10.1371/journal.pone.0049211. Epub 2012 Nov 28.

40.

CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin.

Dambacher S, Deng W, Hahn M, Sadic D, Fröhlich J, Nuber A, Hoischen C, Diekmann S, Leonhardt H, Schotta G.

Nucleus. 2012 Jan-Feb;3(1):101-10. doi: 10.4161/nucl.18955.

41.

Suv4-20h abrogation enhances telomere elongation during reprogramming and confers a higher tumorigenic potential to iPS cells.

Marión RM, Schotta G, Ortega S, Blasco MA.

PLoS One. 2011;6(10):e25680. doi: 10.1371/journal.pone.0025680. Epub 2011 Oct 12.

42.

The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice.

Billington CJ Jr, Ng B, Forsman C, Schmidt B, Bagchi A, Symer DE, Schotta G, Gopalakrishnan R, Sarver AL, Petryk A.

Dev Biol. 2011 Jul 1;355(1):21-31. doi: 10.1016/j.ydbio.2011.04.026. Epub 2011 Apr 28.

43.

H4K20 monomethylation faces the WNT.

Schotta G.

Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3097-8. doi: 10.1073/pnas.1100147108. Epub 2011 Feb 11. Review. No abstract available.

44.

Epigenetic regulation of development by histone lysine methylation.

Dambacher S, Hahn M, Schotta G.

Heredity (Edinb). 2010 Jul;105(1):24-37. doi: 10.1038/hdy.2010.49. Epub 2010 May 5. Review.

45.

Heterochromatin dysregulation in human diseases.

Hahn M, Dambacher S, Schotta G.

J Appl Physiol (1985). 2010 Jul;109(1):232-42. doi: 10.1152/japplphysiol.00053.2010. Epub 2010 Apr 1. Review.

46.

PR-SET7 and SUV4-20H regulate H4 lysine-20 methylation at imprinting control regions in the mouse.

Pannetier M, Julien E, Schotta G, Tardat M, Sardet C, Jenuwein T, Feil R.

EMBO Rep. 2008 Oct;9(10):998-1005. doi: 10.1038/embor.2008.147. Epub 2008 Aug 22.

47.

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.

Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callén E, Celeste A, Pagani M, Opravil S, De La Rosa-Velazquez IA, Espejo A, Bedford MT, Nussenzweig A, Busslinger M, Jenuwein T.

Genes Dev. 2008 Aug 1;22(15):2048-61. doi: 10.1101/gad.476008.

48.

Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination.

Benetti R, Gonzalo S, Jaco I, Schotta G, Klatt P, Jenuwein T, Blasco MA.

J Cell Biol. 2007 Sep 10;178(6):925-36.

49.

Active and repressive chromatin are interspersed without spreading in an imprinted gene cluster in the mammalian genome.

Regha K, Sloane MA, Huang R, Pauler FM, Warczok KE, Melikant B, Radolf M, Martens JH, Schotta G, Jenuwein T, Barlow DP.

Mol Cell. 2007 Aug 3;27(3):353-66.

50.

Histone modification and the control of heterochromatic gene silencing in Drosophila.

Ebert A, Lein S, Schotta G, Reuter G.

Chromosome Res. 2006;14(4):377-92. Review.

PMID:
16821134

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