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Mammalian germ cells are determined after PGC colonization of the nascent gonad.

Nicholls PK, Schorle H, Naqvi S, Hu YC, Fan Y, Carmell MA, Dobrinski I, Watson AL, Carlson DF, Fahrenkrug SC, Page DC.

Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25677-25687. doi: 10.1073/pnas.1910733116. Epub 2019 Nov 21.


Unique and redundant roles of SOX2 and SOX17 in regulating the germ cell tumor fate.

Jostes SV, Fellermeyer M, Arévalo L, Merges GE, Kristiansen G, Nettersheim D, Schorle H.

Int J Cancer. 2019 Oct 3. doi: 10.1002/ijc.32714. [Epub ahead of print]


TCam-2 Cells Deficient for SOX2 and FOXA2 Are Blocked in Differentiation and Maintain a Seminoma-Like Cell Fate In Vivo.

Nettersheim D, Vadder S, Jostes S, Heimsoeth A, Schorle H.

Cancers (Basel). 2019 May 25;11(5). pii: E728. doi: 10.3390/cancers11050728.


Human sFLT1 Leads to Severe Changes in Placental Differentiation and Vascularization in a Transgenic hsFLT1/rtTA FGR Mouse Model.

Vogtmann R, Kühnel E, Dicke N, Verkaik-Schakel RN, Plösch T, Schorle H, Stojanovska V, Herse F, Köninger A, Kimmig R, Winterhager E, Gellhaus A.

Front Endocrinol (Lausanne). 2019 Mar 21;10:165. doi: 10.3389/fendo.2019.00165. eCollection 2019.


N6-Methyladenosine detected in RNA of testicular germ cell tumors is controlled by METTL3, ALKBH5, YTHDC1/F1/F2, and HNRNPC as writers, erasers, and readers.

Nettersheim D, Berger D, Jostes S, Kristiansen G, Lochnit G, Schorle H.

Andrology. 2019 Jul;7(4):498-506. doi: 10.1111/andr.12612. Epub 2019 Mar 23.


Epigenetic drugs and their molecular targets in testicular germ cell tumours.

Jostes S, Nettersheim D, Schorle H.

Nat Rev Urol. 2019 Apr;16(4):245-259. doi: 10.1038/s41585-019-0154-x. Review.


Deciphering the molecular effects of romidepsin on germ cell tumours: DHRS2 is involved in cell cycle arrest but not apoptosis or induction of romidepsin effectors.

Nettersheim D, Berger D, Jostes S, Skowron M, Schorle H.

J Cell Mol Med. 2019 Jan;23(1):670-679. doi: 10.1111/jcmm.13971. Epub 2018 Nov 20.


Placental insufficiency contributes to fatty acid metabolism alterations in aged female mouse offspring.

Stojanovska V, Sharma N, Dijkstra DJ, Scherjon SA, Jäger A, Schorle H, Plösch T.

Am J Physiol Regul Integr Comp Physiol. 2018 Dec 1;315(6):R1107-R1114. doi: 10.1152/ajpregu.00420.2017. Epub 2018 Sep 12.


Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming.

Schwarz BA, Cetinbas M, Clement K, Walsh RM, Cheloufi S, Gu H, Langkabel J, Kamiya A, Schorle H, Meissner A, Sadreyev RI, Hochedlinger K.

Cell Stem Cell. 2018 Aug 2;23(2):289-305.e5. doi: 10.1016/j.stem.2018.06.013. Epub 2018 Jul 12.


Signals and transcription factors for specification of human germ cells.

Jostes S, Schorle H.

Stem Cell Investig. 2018 Apr 29;5:13. doi: 10.21037/sci.2018.04.01. eCollection 2018. No abstract available.


Brentuximab vedotin exerts profound antiproliferative and pro-apoptotic efficacy in CD30-positive as well as cocultured CD30-negative germ cell tumour cell lines.

Schönberger S, van Beekum C, Götz B, Nettersheim D, Schorle H, Schneider DT, Casati A, Craveiro RB, Calaminus G, Dilloo D.

J Cell Mol Med. 2018 Jan;22(1):568-575. doi: 10.1111/jcmm.13344. Epub 2017 Sep 22.


MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy.

Reinhardt J, Landsberg J, Schmid-Burgk JL, Ramis BB, Bald T, Glodde N, Lopez-Ramos D, Young A, Ngiow SF, Nettersheim D, Schorle H, Quast T, Kolanus W, Schadendorf D, Long GV, Madore J, Scolyer RA, Ribas A, Smyth MJ, Tumeh PC, Tüting T, Hölzel M.

Cancer Res. 2017 Sep 1;77(17):4697-4709. doi: 10.1158/0008-5472.CAN-17-0395. Epub 2017 Jun 26.


The plasticity of germ cell cancers and its dependence on the cellular microenvironment.

Nettersheim D, Schorle H.

J Cell Mol Med. 2017 Aug;21(8):1463-1467. doi: 10.1111/jcmm.13082. Epub 2017 Feb 28. Review.


The spleen microenvironment influences disease transformation in a mouse model of KITD816V-dependent myeloproliferative neoplasm.

Pelusi N, Kosanke M, Riedt T, Rösseler C, Seré K, Li J, Gütgemann I, Zenke M, Janzen V, Schorle H.

Sci Rep. 2017 Jan 27;7:41427. doi: 10.1038/srep41427.


Breaking the first lineage barrier - many roads to trophoblast stem cell fate.

Kubaczka C, Kaiser F, Schorle H.

Placenta. 2017 Dec;60 Suppl 1:S52-S56. doi: 10.1016/j.placenta.2016.12.025. Epub 2016 Dec 23. Review.


The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo.

Jostes S, Nettersheim D, Fellermeyer M, Schneider S, Hafezi F, Honecker F, Schumacher V, Geyer M, Kristiansen G, Schorle H.

J Cell Mol Med. 2017 Jul;21(7):1300-1314. doi: 10.1111/jcmm.13059. Epub 2016 Dec 27.


Abrogation of Gap Junctional Communication in ES Cells Results in a Disruption of Primitive Endoderm Formation in Embryoid Bodies.

Wörsdörfer P, Bosen F, Gebhardt M, Russ N, Zimmermann K, Komla Kessie D, Sekaran T, Egert A, Ergün S, Schorle H, Pfeifer A, Edenhofer F, Willecke K.

Stem Cells. 2017 Apr;35(4):859-871. doi: 10.1002/stem.2545. Epub 2016 Dec 20.


Re-visiting the Protamine-2 locus: deletion, but not haploinsufficiency, renders male mice infertile.

Schneider S, Balbach M, Jan F Jikeli, Fietz D, Nettersheim D, Jostes S, Schmidt R, Kressin M, Bergmann M, Wachten D, Steger K, Schorle H.

Sci Rep. 2016 Nov 11;6:36764. doi: 10.1038/srep36764.


AP2γ controls adult hippocampal neurogenesis and modulates cognitive, but not anxiety or depressive-like behavior.

Mateus-Pinheiro A, Alves ND, Patrício P, Machado-Santos AR, Loureiro-Campos E, Silva JM, Sardinha VM, Reis J, Schorle H, Oliveira JF, Ninkovic J, Sousa N, Pinto L.

Mol Psychiatry. 2017 Dec;22(12):1725-1734. doi: 10.1038/mp.2016.169. Epub 2016 Oct 25.


Overexpression of histone demethylase Fbxl10 leads to enhanced migration in mouse embryonic fibroblasts.

Rohde M, Sievers E, Janzer A, Willmann D, Egert A, Schorle H, Schüle R, Kirfel J.

Exp Cell Res. 2016 Nov 1;348(2):123-131. doi: 10.1016/j.yexcr.2016.08.026. Epub 2016 Sep 17.


Xenografting of Cancer Cell Lines for In Vivo Screening of the Therapeutic Potential of HDAC Inhibitors.

Nettersheim D, Jostes S, Schorle H.

Methods Mol Biol. 2017;1510:211-215.


A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment.

Nettersheim D, Jostes S, Fabry M, Honecker F, Schumacher V, Kirfel J, Kristiansen G, Schorle H.

Oncotarget. 2016 Nov 15;7(46):74931-74946. doi: 10.18632/oncotarget.11647.


Elucidating human male germ cell development by studying germ cell cancer.

Nettersheim D, Jostes S, Schneider S, Schorle H.

Reproduction. 2016 Oct;152(4):R101-13. doi: 10.1530/REP-16-0114. Review.


Protocol for the Direct Conversion of Murine Embryonic Fibroblasts into Trophoblast Stem Cells.

Kubaczka C, Schorle H.

J Vis Exp. 2016 Jul 25;(113). doi: 10.3791/54277.


The cancer/testis-antigen PRAME supports the pluripotency network and represses somatic and germ cell differentiation programs in seminomas.

Nettersheim D, Arndt I, Sharma R, Riesenberg S, Jostes S, Schneider S, Hölzel M, Kristiansen G, Schorle H.

Br J Cancer. 2016 Aug 9;115(4):454-64. doi: 10.1038/bjc.2016.187. Epub 2016 Jul 21.


SOX2 is essential for in vivo reprogramming of seminoma-like TCam-2 cells to an embryonal carcinoma-like fate.

Nettersheim D, Heimsoeth A, Jostes S, Schneider S, Fellermeyer M, Hofmann A, Schorle H.

Oncotarget. 2016 Jul 26;7(30):47095-47110. doi: 10.18632/oncotarget.9903.


Tpbpa-Cre-mediated deletion of TFAP2C leads to deregulation of Cdkn1a, Akt1 and the ERK pathway, causing placental growth arrest.

Sharma N, Kubaczka C, Kaiser S, Nettersheim D, Mughal SS, Riesenberg S, Hölzel M, Winterhager E, Schorle H.

Development. 2016 Mar 1;143(5):787-98. doi: 10.1242/dev.128553. Epub 2016 Jan 25.


Direct Induction of Trophoblast Stem Cells from Murine Fibroblasts.

Kubaczka C, Senner CE, Cierlitza M, Araúzo-Bravo MJ, Kuckenberg P, Peitz M, Hemberger M, Schorle H.

Cell Stem Cell. 2015 Nov 5;17(5):557-68. doi: 10.1016/j.stem.2015.08.005. Epub 2015 Sep 24.


BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma.

Nettersheim D, Jostes S, Sharma R, Schneider S, Hofmann A, Ferreira HJ, Hoffmann P, Kristiansen G, Esteller MB, Schorle H.

PLoS Genet. 2015 Jul 30;11(7):e1005415. doi: 10.1371/journal.pgen.1005415. eCollection 2015 Jul.


Reduced Gene Dosage of Tfap2c Impairs Trophoblast Lineage Differentiation and Alters Maternal Blood Spaces in the Mouse Placenta.

Kaiser S, Koch Y, Kühnel E, Sharma N, Gellhaus A, Kuckenberg P, Schorle H, Winterhager E.

Biol Reprod. 2015 Aug;93(2):31. doi: 10.1095/biolreprod.114.126474. Epub 2015 Jun 10.


Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71.

Mitschka S, Ulas T, Goller T, Schneider K, Egert A, Mertens J, Brüstle O, Schorle H, Beyer M, Klee K, Xue J, Günther P, Bassler K, Schultze JL, Kolanus W.

Sci Rep. 2015 Jun 9;5:11126. doi: 10.1038/srep11126.


Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics.

Belin S, Nawabi H, Wang C, Tang S, Latremoliere A, Warren P, Schorle H, Uncu C, Woolf CJ, He Z, Steen JA.

Neuron. 2015 May 20;86(4):1000-1014. doi: 10.1016/j.neuron.2015.03.060. Epub 2015 Apr 30.


Reference gene validation for RT-qPCR, a note on different available software packages.

De Spiegelaere W, Dern-Wieloch J, Weigel R, Schumacher V, Schorle H, Nettersheim D, Bergmann M, Brehm R, Kliesch S, Vandekerckhove L, Fink C.

PLoS One. 2015 Mar 31;10(3):e0122515. doi: 10.1371/journal.pone.0122515. eCollection 2015.


Kit transduced signals counteract erythroid maturation by MAPK-dependent modulation of erythropoietin signaling and apoptosis induction in mouse fetal liver.

Haas N, Riedt T, Labbaf Z, Baßler K, Gergis D, Fröhlich H, Gütgemann I, Janzen V, Schorle H.

Cell Death Differ. 2015 May;22(5):790-800. doi: 10.1038/cdd.2014.172. Epub 2014 Oct 17.


Are testicular mast cells involved in the regulation of germ cells in man?

Windschüttl S, Nettersheim D, Schlatt S, Huber A, Welter H, Schwarzer JU, Köhn FM, Schorle H, Mayerhofer A.

Andrology. 2014 Jul;2(4):615-22. doi: 10.1111/j.2047-2927.2014.00227.x. Epub 2014 Jun 12.


Derivation and maintenance of murine trophoblast stem cells under defined conditions.

Kubaczka C, Senner C, Araúzo-Bravo MJ, Sharma N, Kuckenberg P, Becker A, Zimmer A, Brüstle O, Peitz M, Hemberger M, Schorle H.

Stem Cell Reports. 2014 Jan 30;2(2):232-42. doi: 10.1016/j.stemcr.2013.12.013. eCollection 2014 Feb 11.


Analysis of TET expression/activity and 5mC oxidation during normal and malignant germ cell development.

Nettersheim D, Heukamp LC, Fronhoffs F, Grewe MJ, Haas N, Waha A, Honecker F, Waha A, Kristiansen G, Schorle H.

PLoS One. 2013 Dec 26;8(12):e82881. doi: 10.1371/journal.pone.0082881. eCollection 2013.


Transcription factor TFAP2C regulates major programs required for murine fetal germ cell maintenance and haploinsufficiency predisposes to teratomas in male mice.

Schemmer J, Araúzo-Bravo MJ, Haas N, Schäfer S, Weber SN, Becker A, Eckert D, Zimmer A, Nettersheim D, Schorle H.

PLoS One. 2013 Aug 13;8(8):e71113. doi: 10.1371/journal.pone.0071113. eCollection 2013. Erratum in: PLoS One. 2013;8(8). doi:10.1371/annotation/579ac618-0ed0-4451-a4fc-10bad989024b.


Fetuin-B, a liver-derived plasma protein is essential for fertilization.

Dietzel E, Wessling J, Floehr J, Schäfer C, Ensslen S, Denecke B, Rösing B, Neulen J, Veitinger T, Spehr M, Tropartz T, Tolba R, Renné T, Egert A, Schorle H, Gottenbusch Y, Hildebrand A, Yiallouros I, Stöcker W, Weiskirchen R, Jahnen-Dechent W.

Dev Cell. 2013 Apr 15;25(1):106-12. doi: 10.1016/j.devcel.2013.03.001. Epub 2013 Apr 4.


Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach.

Moschidou D, Mukherjee S, Blundell MP, Drews K, Jones GN, Abdulrazzak H, Nowakowska B, Phoolchund A, Lay K, Ramasamy TS, Cananzi M, Nettersheim D, Sullivan M, Frost J, Moore G, Vermeesch JR, Fisk NM, Thrasher AJ, Atala A, Adjaye J, Schorle H, De Coppi P, Guillot PV.

Mol Ther. 2012 Oct;20(10):1953-67. doi: 10.1038/mt.2012.117. Epub 2012 Jul 3.


Connexin 31 (GJB3) deficiency in mouse trophoblast stem cells alters giant cell differentiation and leads to loss of oxygen sensing.

Koch Y, van Fürden B, Kaiser S, Klein D, Kibschull M, Schorle H, Carpinteiro A, Gellhaus A, Winterhager E.

Biol Reprod. 2012 Aug 23;87(2):37. doi: 10.1095/biolreprod.111.098079. Print 2012 Aug.


The role of transcription factor Tcfap2c/TFAP2C in trophectoderm development.

Kuckenberg P, Kubaczka C, Schorle H.

Reprod Biomed Online. 2012 Jul;25(1):12-20. doi: 10.1016/j.rbmo.2012.02.015. Epub 2012 Mar 3. Review.


Establishment of a versatile seminoma model indicates cellular plasticity of germ cell tumor cells.

Nettersheim D, Westernströer B, Haas N, Leinhaas A, Brüstle O, Schlatt S, Schorle H.

Genes Chromosomes Cancer. 2012 Jul;51(7):717-26. doi: 10.1002/gcc.21958. Epub 2012 Apr 5.


MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells.

Schulte JH, Lindner S, Bohrer A, Maurer J, De Preter K, Lefever S, Heukamp L, Schulte S, Molenaar J, Versteeg R, Thor T, Künkele A, Vandesompele J, Speleman F, Schorle H, Eggert A, Schramm A.

Oncogene. 2013 Feb 21;32(8):1059-65. doi: 10.1038/onc.2012.106. Epub 2012 Apr 9.


PDGF signalling controls age-dependent proliferation in pancreatic β-cells.

Chen H, Gu X, Liu Y, Wang J, Wirt SE, Bottino R, Schorle H, Sage J, Kim SK.

Nature. 2011 Oct 12;478(7369):349-55. doi: 10.1038/nature10502.


The seminoma cell line TCam-2 is sensitive to HDAC inhibitor depsipeptide but tolerates various other chemotherapeutic drugs and loss of NANOG expression.

Nettersheim D, Gillis A, Biermann K, Looijenga LH, Schorle H.

Genes Chromosomes Cancer. 2011 Dec;50(12):1033-42. doi: 10.1002/gcc.20918. Epub 2011 Aug 24.


Lactogenic differentiation of HC11 cells is not accompanied by downregulation of AP-2 transcription factor genes.

Jäger R, Pappas L, Schorle H.

BMC Res Notes. 2011 Sep 9;4:345. doi: 10.1186/1756-0500-4-345. No abstract available.


Transgenic overexpression of Tcfap2c/AP-2gamma results in liver failure and intestinal dysplasia.

Holl D, Kuckenberg P, Woynecki T, Egert A, Becker A, Huss S, Stabenow D, Zimmer A, Knolle P, Tolba R, Fischer HP, Schorle H.

PLoS One. 2011;6(7):e22034. doi: 10.1371/journal.pone.0022034. Epub 2011 Jul 13.


TGF-β1, EGF and FGF4 synergistically induce differentiation of the seminoma cell line TCam-2 into a cell type resembling mixed non-seminoma.

Nettersheim D, Gillis AJ, Looijenga LH, Schorle H.

Int J Androl. 2011 Aug;34(4 Pt 2):e189-203. doi: 10.1111/j.1365-2605.2011.01172.x. Epub 2011 Jun 8.


The role of BLIMP1 and its putative downstream target TFAP2C in germ cell development and germ cell tumours.

Schäfer S, Anschlag J, Nettersheim D, Haas N, Pawig L, Schorle H.

Int J Androl. 2011 Aug;34(4 Pt 2):e152-8; discussion e158-9. doi: 10.1111/j.1365-2605.2011.01167.x. Epub 2011 May 12. Review.


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