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Items: 1 to 50 of 68

1.

Nitro-fatty acids: New drug candidates for chronic inflammatory and fibrotic diseases.

Schopfer FJ, Vitturi DA, Jorkasky DK, Freeman BA.

Nitric Oxide. 2018 Jun 23;79:31-37. doi: 10.1016/j.niox.2018.06.006. [Epub ahead of print] Review.

PMID:
29944935
2.

The discovery of nitro-fatty acids as products of metabolic and inflammatory reactions and mediators of adaptive cell signaling.

Freeman BA, O'Donnell VB, Schopfer FJ.

Nitric Oxide. 2018 Jul 1;77:106-111. doi: 10.1016/j.niox.2018.05.002. Epub 2018 May 6. Review.

PMID:
29742447
3.

Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice.

Chartoumpekis DV, Yagishita Y, Fazzari M, Palliyaguru DL, Rao UN, Zaravinos A, Khoo NK, Schopfer FJ, Weiss KR, Michalopoulos GK, Sipula I, O'Doherty RM, Kensler TW, Wakabayashi N.

JCI Insight. 2018 Mar 8;3(5). pii: 97735. doi: 10.1172/jci.insight.97735. [Epub ahead of print]

4.

Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice.

Chartoumpekis DV, Palliyaguru DL, Wakabayashi N, Fazzari M, Khoo NK, Schopfer FJ, Sipula I, Yagishita Y, Michalopoulos GK, O'Doherty RM, Kensler TW.

Am J Physiol Endocrinol Metab. 2018 Feb 27. doi: 10.1152/ajpendo.00311.2017. [Epub ahead of print]

PMID:
29486138
5.

In situ generation, metabolism and immunomodulatory signaling actions of nitro-conjugated linoleic acid in a murine model of inflammation.

Villacorta L, Minarrieta L, Salvatore SR, Khoo NK, Rom O, Gao Z, Berman RC, Jobbagy S, Li L, Woodcock SR, Chen YE, Freeman BA, Ferreira AM, Schopfer FJ, Vitturi DA.

Redox Biol. 2018 May;15:522-531. doi: 10.1016/j.redox.2018.01.005. Epub 2018 Jan 12.

6.

Electrophilic fatty acid nitroalkenes regulate Nrf2 and NF-κB signaling:A medicinal chemistry investigation of structure-function relationships.

Khoo NKH, Li L, Salvatore SR, Schopfer FJ, Freeman BA.

Sci Rep. 2018 Feb 2;8(1):2295. doi: 10.1038/s41598-018-20460-8.

7.

CMPF, a Metabolite Formed Upon Prescription Omega-3-Acid Ethyl Ester Supplementation, Prevents and Reverses Steatosis.

Prentice KJ, Wendell SG, Liu Y, Eversley JA, Salvatore SR, Mohan H, Brandt SL, Adams AC, Serena Wang X, Wei D, FitzGerald GA, Durham TB, Hammond CD, Sloop KW, Skarke C, Schopfer FJ, Wheeler MB.

EBioMedicine. 2018 Jan;27:200-213. doi: 10.1016/j.ebiom.2017.12.019. Epub 2017 Dec 19.

8.

Topical electrophilic nitro-fatty acids potentiate cutaneous inflammation.

Mathers AR, Carey CD, Killeen ME, Salvatore SR, Ferris LK, Freeman BA, Schopfer FJ, Falo LD Jr.

Free Radic Biol Med. 2018 Feb 1;115:31-42. doi: 10.1016/j.freeradbiomed.2017.11.009. Epub 2017 Nov 10.

PMID:
29132974
9.

Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling.

Rahaman MM, Nguyen AT, Miller MP, Hahn SA, Sparacino-Watkins C, Jobbagy S, Carew NT, Cantu-Medellin N, Wood KC, Baty CJ, Schopfer FJ, Kelley EE, Gladwin MT, Martin E, Straub AC.

Circ Res. 2017 Jul 7;121(2):137-148. doi: 10.1161/CIRCRESAHA.117.310705. Epub 2017 Jun 5.

10.

Evaluation of 10-Nitro Oleic Acid Bio-Elimination in Rats and Humans.

Salvatore SR, Vitturi DA, Fazzari M, Jorkasky DK, Schopfer FJ.

Sci Rep. 2017 Jan 5;7:39900. doi: 10.1038/srep39900.

11.

The Chemical Basis of Thiol Addition to Nitro-conjugated Linoleic Acid, a Protective Cell-signaling Lipid.

Turell L, Vitturi DA, Coitiño EL, Lebrato L, Möller MN, Sagasti C, Salvatore SR, Woodcock SR, Alvarez B, Schopfer FJ.

J Biol Chem. 2017 Jan 27;292(4):1145-1159. doi: 10.1074/jbc.M116.756288. Epub 2016 Dec 6.

12.

Nitro-fatty acid pharmacokinetics in the adipose tissue compartment.

Fazzari M, Khoo NK, Woodcock SR, Jorkasky DK, Li L, Schopfer FJ, Freeman BA.

J Lipid Res. 2017 Feb;58(2):375-385. doi: 10.1194/jlr.M072058. Epub 2016 Dec 2.

13.

Electrophilic nitro-fatty acids suppress allergic contact dermatitis in mice.

Mathers AR, Carey CD, Killeen ME, Diaz-Perez JA, Salvatore SR, Schopfer FJ, Freeman BA, Falo LD Jr.

Allergy. 2017 Apr;72(4):656-664. doi: 10.1111/all.13067. Epub 2016 Nov 11.

14.

Novel Roles for Peroxynitrite in Angiotensin II and CaMKII Signaling.

Zhou C, Ramaswamy SS, Johnson DE, Vitturi DA, Schopfer FJ, Freeman BA, Hudmon A, Levitan ES.

Sci Rep. 2016 Apr 15;6:23416. doi: 10.1038/srep23416.

15.

Fatty acid nitroalkenes induce resistance to ischemic cardiac injury by modulating mitochondrial respiration at complex II.

Koenitzer JR, Bonacci G, Woodcock SR, Chen CS, Cantu-Medellin N, Kelley EE, Schopfer FJ.

Redox Biol. 2016 Aug;8:1-10. doi: 10.1016/j.redox.2015.11.002. Epub 2015 Nov 17.

16.

Nitro-fatty acids in cardiovascular regulation and diseases: characteristics and molecular mechanisms.

Villacorta L, Gao Z, Schopfer FJ, Freeman BA, Chen YE.

Front Biosci (Landmark Ed). 2016 Jan 1;21:873-89. Review.

17.

Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes.

Delmastro-Greenwood M, Hughan KS, Vitturi DA, Salvatore SR, Grimes G, Potti G, Shiva S, Schopfer FJ, Gladwin MT, Freeman BA, Gelhaus Wendell S.

Free Radic Biol Med. 2015 Dec;89:333-41. doi: 10.1016/j.freeradbiomed.2015.07.149. Epub 2015 Sep 16.

18.

Generation and esterification of electrophilic fatty acid nitroalkenes in triacylglycerides.

Fazzari M, Khoo N, Woodcock SR, Li L, Freeman BA, Schopfer FJ.

Free Radic Biol Med. 2015 Oct;87:113-24. doi: 10.1016/j.freeradbiomed.2015.05.033. Epub 2015 Jun 9.

19.

Convergence of biological nitration and nitrosation via symmetrical nitrous anhydride.

Vitturi DA, Minarrieta L, Salvatore SR, Postlethwait EM, Fazzari M, Ferrer-Sueta G, Lancaster JR Jr, Freeman BA, Schopfer FJ.

Nat Chem Biol. 2015 Jul;11(7):504-10. doi: 10.1038/nchembio.1814. Epub 2015 May 25.

20.

Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives.

Cipollina C, Salvatore SR, Muldoon MF, Freeman BA, Schopfer FJ.

PLoS One. 2014 Apr 15;9(4):e94836. doi: 10.1371/journal.pone.0094836. eCollection 2014.

21.

Nitro-oleic acid and epoxyoleic acid are not altered in obesity and type 2 diabetes: reply.

Schopfer FJ, Freeman BA, Khoo NK.

Cardiovasc Res. 2014 Jun 1;102(3):518. doi: 10.1093/cvr/cvu042. Epub 2014 Feb 21. No abstract available.

22.

Olives and olive oil are sources of electrophilic fatty acid nitroalkenes.

Fazzari M, Trostchansky A, Schopfer FJ, Salvatore SR, Sánchez-Calvo B, Vitturi D, Valderrama R, Barroso JB, Radi R, Freeman BA, Rubbo H.

PLoS One. 2014 Jan 14;9(1):e84884. doi: 10.1371/journal.pone.0084884. eCollection 2014.

23.

Biomimetic nitration of conjugated linoleic acid: formation and characterization of naturally occurring conjugated nitrodienes.

Woodcock SR, Salvatore SR, Bonacci G, Schopfer FJ, Freeman BA.

J Org Chem. 2014 Jan 3;79(1):25-33. doi: 10.1021/jo4021562. Epub 2013 Dec 19.

24.

Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase.

Vitturi DA, Chen CS, Woodcock SR, Salvatore SR, Bonacci G, Koenitzer JR, Stewart NA, Wakabayashi N, Kensler TW, Freeman BA, Schopfer FJ.

J Biol Chem. 2013 Aug 30;288(35):25626-37. doi: 10.1074/jbc.M113.486282. Epub 2013 Jul 22.

25.

Inhibition of Mycobacterium tuberculosis PknG by non-catalytic rubredoxin domain specific modification: reaction of an electrophilic nitro-fatty acid with the Fe-S center.

Gil M, Graña M, Schopfer FJ, Wagner T, Denicola A, Freeman BA, Alzari PM, Batthyány C, Durán R.

Free Radic Biol Med. 2013 Dec;65:150-61. doi: 10.1016/j.freeradbiomed.2013.06.021. Epub 2013 Jun 20.

26.

Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis.

Perez-Rosello T, Anderson CT, Schopfer FJ, Zhao Y, Gilad D, Salvatore SR, Freeman BA, Hershfinkel M, Aizenman E, Tzounopoulos T.

J Neurosci. 2013 May 29;33(22):9259-72. doi: 10.1523/JNEUROSCI.0237-13.2013. Erratum in: J Neurosci. 2014 May 21;34(21):7394.

27.

Characterization and quantification of endogenous fatty acid nitroalkene metabolites in human urine.

Salvatore SR, Vitturi DA, Baker PR, Bonacci G, Koenitzer JR, Woodcock SR, Freeman BA, Schopfer FJ.

J Lipid Res. 2013 Jul;54(7):1998-2009. doi: 10.1194/jlr.M037804. Epub 2013 Apr 25.

28.

Electrophilic nitro-fatty acids inhibit vascular inflammation by disrupting LPS-dependent TLR4 signalling in lipid rafts.

Villacorta L, Chang L, Salvatore SR, Ichikawa T, Zhang J, Petrovic-Djergovic D, Jia L, Carlsen H, Schopfer FJ, Freeman BA, Chen YE.

Cardiovasc Res. 2013 Apr 1;98(1):116-24. doi: 10.1093/cvr/cvt002. Epub 2013 Jan 17.

29.

Nitrated fatty acids: synthesis and measurement.

Woodcock SR, Bonacci G, Gelhaus SL, Schopfer FJ.

Free Radic Biol Med. 2013 Jun;59:14-26. doi: 10.1016/j.freeradbiomed.2012.11.015. Epub 2012 Nov 29.

30.

Conjugated linoleic acid is a preferential substrate for fatty acid nitration.

Bonacci G, Baker PR, Salvatore SR, Shores D, Khoo NK, Koenitzer JR, Vitturi DA, Woodcock SR, Golin-Bisello F, Cole MP, Watkins S, St Croix C, Batthyany CI, Freeman BA, Schopfer FJ.

J Biol Chem. 2012 Dec 28;287(53):44071-82. doi: 10.1074/jbc.M112.401356. Epub 2012 Nov 9.

31.

Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ.

Hammond VJ, Morgan AH, Lauder S, Thomas CP, Brown S, Freeman BA, Lloyd CM, Davies J, Bush A, Levonen AL, Kansanen E, Villacorta L, Chen YE, Porter N, Garcia-Diaz YM, Schopfer FJ, O'Donnell VB.

J Biol Chem. 2012 Dec 7;287(50):41651-66. doi: 10.1074/jbc.M112.405407. Epub 2012 Oct 11.

32.

A retrospective mathematical analysis of controlled release design and experimentation.

Rothstein SN, Kay JE, Schopfer FJ, Freeman BA, Little SR.

Mol Pharm. 2012 Nov 5;9(11):3003-11. doi: 10.1021/mp300388w. Epub 2012 Oct 10.

PMID:
23009671
33.

Gas-phase fragmentation analysis of nitro-fatty acids.

Bonacci G, Asciutto EK, Woodcock SR, Salvatore SR, Freeman BA, Schopfer FJ.

J Am Soc Mass Spectrom. 2011 Sep;22(9):1534-51. doi: 10.1007/s13361-011-0185-x. Epub 2011 Jul 13.

34.

Formation and signaling actions of electrophilic lipids.

Schopfer FJ, Cipollina C, Freeman BA.

Chem Rev. 2011 Oct 12;111(10):5997-6021. doi: 10.1021/cr200131e. Epub 2011 Sep 20. Review. No abstract available.

35.

Atypical PKCζ transduces electrophilic fatty acid signaling in pulmonary epithelial cells.

Guo CJ, Schopfer FJ, Gonzales L, Wang P, Freeman BA, Gow AJ.

Nitric Oxide. 2011 Oct 30;25(3):366-72. doi: 10.1016/j.niox.2011.07.003. Epub 2011 Aug 19.

36.

Nitro-oleic acid targets transient receptor potential (TRP) channels in capsaicin sensitive afferent nerves of rat urinary bladder.

Artim DE, Bazely F, Daugherty SL, Sculptoreanu A, Koronowski KB, Schopfer FJ, Woodcock SR, Freeman BA, de Groat WC.

Exp Neurol. 2011 Nov;232(1):90-9. doi: 10.1016/j.expneurol.2011.08.007. Epub 2011 Aug 16.

37.

Electrophilic fatty acids regulate matrix metalloproteinase activity and expression.

Bonacci G, Schopfer FJ, Batthyany CI, Rudolph TK, Rudolph V, Khoo NK, Kelley EE, Freeman BA.

J Biol Chem. 2011 May 6;286(18):16074-81. doi: 10.1074/jbc.M111.225029. Epub 2011 Mar 15.

38.

Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism.

Kansanen E, Bonacci G, Schopfer FJ, Kuosmanen SM, Tong KI, Leinonen H, Woodcock SR, Yamamoto M, Carlberg C, Ylä-Herttuala S, Freeman BA, Levonen AL.

J Biol Chem. 2011 Apr 22;286(16):14019-27. doi: 10.1074/jbc.M110.190710. Epub 2011 Feb 25.

39.

Nitro-oleic acid inhibits angiotensin II-induced hypertension.

Zhang J, Villacorta L, Chang L, Fan Z, Hamblin M, Zhu T, Chen CS, Cole MP, Schopfer FJ, Deng CX, Garcia-Barrio MT, Feng YH, Freeman BA, Chen YE.

Circ Res. 2010 Aug 20;107(4):540-8. doi: 10.1161/CIRCRESAHA.110.218404. Epub 2010 Jun 17.

40.

Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids.

Groeger AL, Cipollina C, Cole MP, Woodcock SR, Bonacci G, Rudolph TK, Rudolph V, Freeman BA, Schopfer FJ.

Nat Chem Biol. 2010 Jun;6(6):433-41. doi: 10.1038/nchembio.367. Epub 2010 May 2.

41.

Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice.

Rudolph TK, Rudolph V, Edreira MM, Cole MP, Bonacci G, Schopfer FJ, Woodcock SR, Franek A, Pekarova M, Khoo NK, Hasty AH, Baldus S, Freeman BA.

Arterioscler Thromb Vasc Biol. 2010 May;30(5):938-45. doi: 10.1161/ATVBAHA.109.201582. Epub 2010 Feb 18.

42.

Covalent peroxisome proliferator-activated receptor gamma adduction by nitro-fatty acids: selective ligand activity and anti-diabetic signaling actions.

Schopfer FJ, Cole MP, Groeger AL, Chen CS, Khoo NK, Woodcock SR, Golin-Bisello F, Motanya UN, Li Y, Zhang J, Garcia-Barrio MT, Rudolph TK, Rudolph V, Bonacci G, Baker PR, Xu HE, Batthyany CI, Chen YE, Hallis TM, Freeman BA.

J Biol Chem. 2010 Apr 16;285(16):12321-33. doi: 10.1074/jbc.M109.091512. Epub 2010 Jan 22.

43.

Activation of vascular endothelial nitric oxide synthase and heme oxygenase-1 expression by electrophilic nitro-fatty acids.

Khoo NK, Rudolph V, Cole MP, Golin-Bisello F, Schopfer FJ, Woodcock SR, Batthyany C, Freeman BA.

Free Radic Biol Med. 2010 Jan 15;48(2):230-9. doi: 10.1016/j.freeradbiomed.2009.10.046. Epub 2009 Oct 24.

44.

Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid.

Kansanen E, Jyrkkänen HK, Volger OL, Leinonen H, Kivelä AM, Häkkinen SK, Woodcock SR, Schopfer FJ, Horrevoets AJ, Ylä-Herttuala S, Freeman BA, Levonen AL.

J Biol Chem. 2009 Nov 27;284(48):33233-41. doi: 10.1074/jbc.M109.064873. Epub 2009 Oct 5.

45.

Nitro-fatty acid inhibition of neointima formation after endoluminal vessel injury.

Cole MP, Rudolph TK, Khoo NK, Motanya UN, Golin-Bisello F, Wertz JW, Schopfer FJ, Rudolph V, Woodcock SR, Bolisetty S, Ali MS, Zhang J, Chen YE, Agarwal A, Freeman BA, Bauer PM.

Circ Res. 2009 Nov 6;105(10):965-72. doi: 10.1161/CIRCRESAHA.109.199075. Epub 2009 Sep 24.

46.

Endogenous generation and protective effects of nitro-fatty acids in a murine model of focal cardiac ischaemia and reperfusion.

Rudolph V, Rudolph TK, Schopfer FJ, Bonacci G, Woodcock SR, Cole MP, Baker PR, Ramani R, Freeman BA.

Cardiovasc Res. 2010 Jan 1;85(1):155-66. doi: 10.1093/cvr/cvp275.

47.

Detection and quantification of protein adduction by electrophilic fatty acids: mitochondrial generation of fatty acid nitroalkene derivatives.

Schopfer FJ, Batthyany C, Baker PR, Bonacci G, Cole MP, Rudolph V, Groeger AL, Rudolph TK, Nadtochiy S, Brookes PS, Freeman BA.

Free Radic Biol Med. 2009 May 1;46(9):1250-9. doi: 10.1016/j.freeradbiomed.2008.12.025.

48.

Convergence of nitric oxide and lipid signaling: anti-inflammatory nitro-fatty acids.

Baker PR, Schopfer FJ, O'Donnell VB, Freeman BA.

Free Radic Biol Med. 2009 Apr 15;46(8):989-1003. doi: 10.1016/j.freeradbiomed.2008.11.021. Epub 2008 Dec 10. Review.

49.

Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway.

Iles KE, Wright MM, Cole MP, Welty NE, Ware LB, Matthay MA, Schopfer FJ, Baker PR, Agarwal A, Freeman BA.

Free Radic Biol Med. 2009 Apr 1;46(7):866-75. doi: 10.1016/j.freeradbiomed.2008.12.001. Epub 2008 Dec 14.

50.

PPARgamma and its ligands: therapeutic implications in cardiovascular disease.

Villacorta L, Schopfer FJ, Zhang J, Freeman BA, Chen YE.

Clin Sci (Lond). 2009 Feb;116(3):205-18. doi: 10.1042/CS20080195. Review.

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