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Items: 42

1.

Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation.

Dumas SJ, Meta E, Borri M, Goveia J, Rohlenova K, Conchinha NV, Falkenberg K, Teuwen LA, de Rooij L, Kalucka J, Chen R, Khan S, Taverna F, Lu W, Parys M, De Legher C, Vinckier S, Karakach TK, Schoonjans L, Lin L, Bolund L, Dewerchin M, Eelen G, Rabelink TJ, Li X, Luo Y, Carmeliet P.

J Am Soc Nephrol. 2019 Dec 9. pii: ASN.2019080832. doi: 10.1681/ASN.2019080832. [Epub ahead of print]

PMID:
31818909
2.

Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation.

Jain IH, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz GR, Ast T, Wang H, Schleifer G, Stepanova A, Brepoels K, Schoonjans L, Carmeliet P, Galkin A, Ichinose F, Zapol WM, Mootha VK.

Cell Metab. 2019 Oct 1;30(4):824-832.e3. doi: 10.1016/j.cmet.2019.07.006. Epub 2019 Aug 8.

PMID:
31402314
3.

EndoDB: a database of endothelial cell transcriptomics data.

Khan S, Taverna F, Rohlenova K, Treps L, Geldhof V, de Rooij L, Sokol L, Pircher A, Conradi LC, Kalucka J, Schoonjans L, Eelen G, Dewerchin M, Karakach T, Li X, Goveia J, Carmeliet P.

Nucleic Acids Res. 2019 Jan 8;47(D1):D736-D744. doi: 10.1093/nar/gky997.

4.

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis.

Eelen G, Dubois C, Cantelmo AR, Goveia J, Brüning U, DeRan M, Jarugumilli G, van Rijssel J, Saladino G, Comitani F, Zecchin A, Rocha S, Chen R, Huang H, Vandekeere S, Kalucka J, Lange C, Morales-Rodriguez F, Cruys B, Treps L, Ramer L, Vinckier S, Brepoels K, Wyns S, Souffreau J, Schoonjans L, Lamers WH, Wu Y, Haustraete J, Hofkens J, Liekens S, Cubbon R, Ghesquière B, Dewerchin M, Gervasio FL, Li X, van Buul JD, Wu X, Carmeliet P.

Nature. 2018 Sep;561(7721):63-69. doi: 10.1038/s41586-018-0466-7. Epub 2018 Aug 29.

5.

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation.

Bruning U, Morales-Rodriguez F, Kalucka J, Goveia J, Taverna F, Queiroz KCS, Dubois C, Cantelmo AR, Chen R, Loroch S, Timmerman E, Caixeta V, Bloch K, Conradi LC, Treps L, Staes A, Gevaert K, Tee A, Dewerchin M, Semenkovich CF, Impens F, Schilling B, Verdin E, Swinnen JV, Meier JL, Kulkarni RA, Sickmann A, Ghesquière B, Schoonjans L, Li X, Mazzone M, Carmeliet P.

Cell Metab. 2018 Dec 4;28(6):866-880.e15. doi: 10.1016/j.cmet.2018.07.019. Epub 2018 Aug 23.

6.

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells.

Vandekeere S, Dubois C, Kalucka J, Sullivan MR, García-Caballero M, Goveia J, Chen R, Diehl FF, Bar-Lev L, Souffreau J, Pircher A, Kumar S, Vinckier S, Hirabayashi Y, Furuya S, Schoonjans L, Eelen G, Ghesquière B, Keshet E, Li X, Vander Heiden MG, Dewerchin M, Carmeliet P.

Cell Metab. 2018 Oct 2;28(4):573-587.e13. doi: 10.1016/j.cmet.2018.06.009. Epub 2018 Jul 12.

7.

Role of glutamine and interlinked asparagine metabolism in vessel formation.

Huang H, Vandekeere S, Kalucka J, Bierhansl L, Zecchin A, Brüning U, Visnagri A, Yuldasheva N, Goveia J, Cruys B, Brepoels K, Wyns S, Rayport S, Ghesquière B, Vinckier S, Schoonjans L, Cubbon R, Dewerchin M, Eelen G, Carmeliet P.

EMBO J. 2017 Aug 15;36(16):2334-2352. doi: 10.15252/embj.201695518. Epub 2017 Jun 28.

8.

The role of fatty acid β-oxidation in lymphangiogenesis.

Wong BW, Wang X, Zecchin A, Thienpont B, Cornelissen I, Kalucka J, García-Caballero M, Missiaen R, Huang H, Brüning U, Blacher S, Vinckier S, Goveia J, Knobloch M, Zhao H, Dierkes C, Shi C, Hägerling R, Moral-Dardé V, Wyns S, Lippens M, Jessberger S, Fendt SM, Luttun A, Noel A, Kiefer F, Ghesquière B, Moons L, Schoonjans L, Dewerchin M, Eelen G, Lambrechts D, Carmeliet P.

Nature. 2017 Feb 2;542(7639):49-54. doi: 10.1038/nature21028. Epub 2016 Dec 26.

PMID:
28024299
9.

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy.

Cantelmo AR, Conradi LC, Brajic A, Goveia J, Kalucka J, Pircher A, Chaturvedi P, Hol J, Thienpont B, Teuwen LA, Schoors S, Boeckx B, Vriens J, Kuchnio A, Veys K, Cruys B, Finotto L, Treps L, Stav-Noraas TE, Bifari F, Stapor P, Decimo I, Kampen K, De Bock K, Haraldsen G, Schoonjans L, Rabelink T, Eelen G, Ghesquière B, Rehman J, Lambrechts D, Malik AB, Dewerchin M, Carmeliet P.

Cancer Cell. 2016 Dec 12;30(6):968-985. doi: 10.1016/j.ccell.2016.10.006. Epub 2016 Nov 17.

10.

Tumour hypoxia causes DNA hypermethylation by reducing TET activity.

Thienpont B, Steinbacher J, Zhao H, D'Anna F, Kuchnio A, Ploumakis A, Ghesquière B, Van Dyck L, Boeckx B, Schoonjans L, Hermans E, Amant F, Kristensen VN, Peng Koh K, Mazzone M, Coleman M, Carell T, Carmeliet P, Lambrechts D.

Nature. 2016 Sep 1;537(7618):63-68. doi: 10.1038/nature19081. Epub 2016 Aug 17.

11.

Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism.

Quaegebeur A, Segura I, Schmieder R, Verdegem D, Decimo I, Bifari F, Dresselaers T, Eelen G, Ghosh D, Davidson SM, Schoors S, Broekaert D, Cruys B, Govaerts K, De Legher C, Bouché A, Schoonjans L, Ramer MS, Hung G, Bossaert G, Cleveland DW, Himmelreich U, Voets T, Lemmens R, Bennett CF, Robberecht W, De Bock K, Dewerchin M, Ghesquière B, Fendt SM, Carmeliet P.

Cell Metab. 2016 Feb 9;23(2):280-91. doi: 10.1016/j.cmet.2015.12.007. Epub 2016 Jan 7.

12.

Extra-intestinal calcium handling contributes to normal serum calcium levels when intestinal calcium absorption is suboptimal.

Lieben L, Verlinden L, Masuyama R, Torrekens S, Moermans K, Schoonjans L, Carmeliet P, Carmeliet G.

Bone. 2015 Dec;81:502-512. doi: 10.1016/j.bone.2015.08.023. Epub 2015 Aug 28.

PMID:
26319498
13.

Corrigendum: Fatty acid carbon is essential for dNTP synthesis in endothelial cells.

Schoors S, Bruning U, Missiaen R, Queiroz KC, Borgers G, Elia I, Zecchin A, Cantelmo AR, Christen S, Goveia J, Heggermont W, Goddë L, Vinckier S, Van Veldhoven PP, Eelen G, Schoonjans L, Gerhardt H, Dewerchin M, Baes M, De Bock K, Ghesquière B, Lunt SY, Fendt SM, Carmeliet P.

Nature. 2015 Oct 1;526(7571):144. doi: 10.1038/nature14624. Epub 2015 Aug 5. No abstract available.

PMID:
26245368
14.

Fatty acid carbon is essential for dNTP synthesis in endothelial cells.

Schoors S, Bruning U, Missiaen R, Queiroz KC, Borgers G, Elia I, Zecchin A, Cantelmo AR, Christen S, Goveia J, Heggermont W, Goddé L, Vinckier S, Van Veldhoven PP, Eelen G, Schoonjans L, Gerhardt H, Dewerchin M, Baes M, De Bock K, Ghesquière B, Lunt SY, Fendt SM, Carmeliet P.

Nature. 2015 Apr 9;520(7546):192-197. doi: 10.1038/nature14362. Epub 2015 Apr 1. Erratum in: Nature. 2015 Oct 1;526(7571):144.

15.

Incomplete and transitory decrease of glycolysis: a new paradigm for anti-angiogenic therapy?

Schoors S, Cantelmo AR, Georgiadou M, Stapor P, Wang X, Quaegebeur A, Cauwenberghs S, Wong BW, Bifari F, Decimo I, Schoonjans L, De Bock K, Dewerchin M, Carmeliet P.

Cell Cycle. 2014;13(1):16-22. doi: 10.4161/cc.27519. Epub 2013 Dec 13.

16.

Role of PFKFB3-driven glycolysis in vessel sprouting.

De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong BW, Cantelmo AR, Quaegebeur A, Ghesquière B, Cauwenberghs S, Eelen G, Phng LK, Betz I, Tembuyser B, Brepoels K, Welti J, Geudens I, Segura I, Cruys B, Bifari F, Decimo I, Blanco R, Wyns S, Vangindertael J, Rocha S, Collins RT, Munck S, Daelemans D, Imamura H, Devlieger R, Rider M, Van Veldhoven PP, Schuit F, Bartrons R, Hofkens J, Fraisl P, Telang S, Deberardinis RJ, Schoonjans L, Vinckier S, Chesney J, Gerhardt H, Dewerchin M, Carmeliet P.

Cell. 2013 Aug 1;154(3):651-63. doi: 10.1016/j.cell.2013.06.037.

17.

Sustained function of alginate-encapsulated human islet cell implants in the peritoneal cavity of mice leading to a pilot study in a type 1 diabetic patient.

Jacobs-Tulleneers-Thevissen D, Chintinne M, Ling Z, Gillard P, Schoonjans L, Delvaux G, Strand BL, Gorus F, Keymeulen B, Pipeleers D; Beta Cell Therapy Consortium EU-FP7.

Diabetologia. 2013 Jul;56(7):1605-14. doi: 10.1007/s00125-013-2906-0. Epub 2013 Apr 26.

PMID:
23620058
18.

Telomere length homeostasis and telomere position effect on a linear human artificial chromosome are dictated by the genetic background.

Weuts A, Voet T, Verbeeck J, Lambrechts N, Wirix E, Schoonjans L, Danloy S, Marynen P, Froyen G.

Nucleic Acids Res. 2012 Dec;40(22):11477-89. doi: 10.1093/nar/gks926. Epub 2012 Oct 11.

19.

Neurons generated from APP/APLP1/APLP2 triple knockout embryonic stem cells behave normally in vitro and in vivo: lack of evidence for a cell autonomous role of the amyloid precursor protein in neuronal differentiation.

Bergmans BA, Shariati SA, Habets RL, Verstreken P, Schoonjans L, Müller U, Dotti CG, De Strooper B.

Stem Cells. 2010 Mar 31;28(3):399-406. doi: 10.1002/stem.296.

20.

Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice.

Pokreisz P, Vandenwijngaert S, Bito V, Van den Bergh A, Lenaerts I, Busch C, Marsboom G, Gheysens O, Vermeersch P, Biesmans L, Liu X, Gillijns H, Pellens M, Van Lommel A, Buys E, Schoonjans L, Vanhaecke J, Verbeken E, Sipido K, Herijgers P, Bloch KD, Janssens SP.

Circulation. 2009 Jan 27;119(3):408-16. doi: 10.1161/CIRCULATIONAHA.108.822072. Epub 2009 Jan 12.

21.

Caspase-14 protects against epidermal UVB photodamage and water loss.

Denecker G, Hoste E, Gilbert B, Hochepied T, Ovaere P, Lippens S, Van den Broecke C, Van Damme P, D'Herde K, Hachem JP, Borgonie G, Presland RB, Schoonjans L, Libert C, Vandekerckhove J, Gevaert K, Vandenabeele P, Declercq W.

Nat Cell Biol. 2007 Jun;9(6):666-74. Epub 2007 May 21.

PMID:
17515931
22.

Apoptosis affects integration frequency: adult stem cells injected in blastocysts show high caspase-3 activity.

Koestenbauer S, Vanderzwalmen P, Hammer A, Schoonjans L, Danloy S, Zech H, Dohr G, Zech NH.

Cell Biol Int. 2007 May;31(5):489-93. Epub 2006 Nov 29.

PMID:
17198755
23.

Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels.

Bosman EA, Lawson KA, Debruyn J, Beek L, Francis A, Schoonjans L, Huylebroeck D, Zwijsen A.

Development. 2006 Sep;133(17):3399-409. Epub 2006 Aug 3.

24.

Culturing in vitro produced blastocysts in sequential media promotes ES cell derivation.

Liu J, Schoonjans L, Tielens S, Speleman F, Cornelissen M, De Sutter P, Dhont M, Van der Elst J.

Mol Reprod Dev. 2006 Aug;73(8):1017-21.

PMID:
16700070
25.

Embryonic stem cells: similarities and differences between human and murine embryonic stem cells.

Koestenbauer S, Zech NH, Juch H, Vanderzwalmen P, Schoonjans L, Dohr G.

Am J Reprod Immunol. 2006 Mar;55(3):169-80. Review.

PMID:
16451351
26.

Salivary gland tumors in transgenic mice with targeted PLAG1 proto-oncogene overexpression.

Declercq J, Van Dyck F, Braem CV, Van Valckenborgh IC, Voz M, Wassef M, Schoonjans L, Van Damme B, Fiette L, Van de Ven WJ.

Cancer Res. 2005 Jun 1;65(11):4544-53.

27.

Paraffin-embedded manipulated blastocysts: a tool to demonstrate stem cell plasticity?

Zech NH, Koestenbauer S, Vanderzwalmen P, Schoonjans L, Danloy S, Zech H, Blaschitz A, Dohr G.

Reprod Biomed Online. 2005 Mar;10(3):406-14.

PMID:
15820055
28.

Breaking the species barrier: derivation of germline-competent embryonic stem cells from Mus spretus x C57BL/6 hybrids.

Hochepied T, Schoonjans L, Staelens J, Kreemers V, Danloy S, Puimège L, Collen D, Van Roy F, Libert C.

Stem Cells. 2004;22(4):441-7.

29.

The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation.

Van Eynde A, Nuytten M, Dewerchin M, Schoonjans L, Keppens S, Beullens M, Moons L, Carmeliet P, Stalmans W, Bollen M.

Mol Cell Biol. 2004 Jul;24(13):5863-74.

30.

Cardiomyocyte-specific overexpression of nitric oxide synthase 3 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction.

Janssens S, Pokreisz P, Schoonjans L, Pellens M, Vermeersch P, Tjwa M, Jans P, Scherrer-Crosbie M, Picard MH, Szelid Z, Gillijns H, Van de Werf F, Collen D, Bloch KD.

Circ Res. 2004 May 14;94(9):1256-62. Epub 2004 Mar 25.

PMID:
15044322
31.

A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis.

De Gendt K, Swinnen JV, Saunders PT, Schoonjans L, Dewerchin M, Devos A, Tan K, Atanassova N, Claessens F, Lécureuil C, Heyns W, Carmeliet P, Guillou F, Sharpe RM, Verhoeven G.

Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1327-32. Epub 2004 Jan 26.

32.

[Cardiovascular stem cell research in interactions between the university and industry].

Collen D, Carmeliet P, Brunaud C, Schoonjans L.

Verh K Acad Geneeskd Belg. 2003;65(5):281-2. Dutch. No abstract available.

PMID:
14671842
33.

Neuronal migration depends on intact peroxisomal function in brain and in extraneuronal tissues.

Janssen A, Gressens P, Grabenbauer M, Baumgart E, Schad A, Vanhorebeek I, Brouwers A, Declercq PE, Fahimi D, Evrard P, Schoonjans L, Collen D, Carmeliet P, Mannaerts G, Van Veldhoven P, Baes M.

J Neurosci. 2003 Oct 29;23(30):9732-41.

34.

Impaired neuronal migration and endochondral ossification in Pex7 knockout mice: a model for rhizomelic chondrodysplasia punctata.

Brites P, Motley AM, Gressens P, Mooyer PA, Ploegaert I, Everts V, Evrard P, Carmeliet P, Dewerchin M, Schoonjans L, Duran M, Waterham HR, Wanders RJ, Baes M.

Hum Mol Genet. 2003 Sep 15;12(18):2255-67. Epub 2003 Jul 15.

PMID:
12915479
35.

Improved generation of germline-competent embryonic stem cell lines from inbred mouse strains.

Schoonjans L, Kreemers V, Danloy S, Moreadith RW, Laroche Y, Collen D.

Stem Cells. 2003;21(1):90-7.

36.

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

Herreman A, Serneels L, Annaert W, Collen D, Schoonjans L, De Strooper B.

Nat Cell Biol. 2000 Jul;2(7):461-2. No abstract available.

PMID:
10878813
37.

Mice lacking factor VII develop normally but suffer fatal perinatal bleeding.

Rosen ED, Chan JC, Idusogie E, Clotman F, Vlasuk G, Luther T, Jalbert LR, Albrecht S, Zhong L, Lissens A, Schoonjans L, Moons L, Collen D, Castellino FJ, Carmeliet P.

Nature. 1997 Nov 20;390(6657):290-4.

PMID:
9384381
38.

Pluripotential rabbit embryonic stem (ES) cells are capable of forming overt coat color chimeras following injection into blastocysts.

Schoonjans L, Albright GM, Li JL, Collen D, Moreadith RW.

Mol Reprod Dev. 1996 Dec;45(4):439-43.

PMID:
8956281
39.

Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways.

Huang YY, Bach ME, Lipp HP, Zhuo M, Wolfer DP, Hawkins RD, Schoonjans L, Kandel ER, Godfraind JM, Mulligan R, Collen D, Carmeliet P.

Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8699-704.

40.

Physiological consequences of loss of plasminogen activator gene function in mice.

Carmeliet P, Schoonjans L, Kieckens L, Ream B, Degen J, Bronson R, De Vos R, van den Oord JJ, Collen D, Mulligan RC.

Nature. 1994 Mar 31;368(6470):419-24.

PMID:
8133887
41.

Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis.

Carmeliet P, Stassen JM, Schoonjans L, Ream B, van den Oord JJ, De Mol M, Mulligan RC, Collen D.

J Clin Invest. 1993 Dec;92(6):2756-60.

42.

Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization.

Carmeliet P, Kieckens L, Schoonjans L, Ream B, van Nuffelen A, Prendergast G, Cole M, Bronson R, Collen D, Mulligan RC.

J Clin Invest. 1993 Dec;92(6):2746-55.

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