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Items: 1 to 50 of 70


Introducing Multiple Screener: An unsupervised digital screening tool for cognitive deficits in MS.

van Dongen L, Westerik B, van der Hiele K, Visser LH, Schoonheim MM, Douw L, Twisk JWR, de Jong BA, Geurts JJG, Hulst HE.

Mult Scler Relat Disord. 2019 Oct 30;38:101479. doi: 10.1016/j.msard.2019.101479. [Epub ahead of print]


Long-range connections are more severely damaged and relevant for cognition in multiple sclerosis.

Meijer KA, Steenwijk MD, Douw L, Schoonheim MM, Geurts JJG.

Brain. 2020 Jan 1;143(1):150-160. doi: 10.1093/brain/awz355.


The road ahead in clinical network neuroscience.

Douw L, van Dellen E, Gouw AA, Griffa A, de Haan W, van den Heuvel M, Hillebrand A, Van Mieghem P, Nissen IA, Otte WM, Reijmer YD, Schoonheim MM, Senden M, van Straaten ECW, Tijms BM, Tewarie P, Stam CJ.

Netw Neurosci. 2019 Sep 1;3(4):969-993. doi: 10.1162/netn_a_00103. eCollection 2019. Review.


Cortical atrophy accelerates as cognitive decline worsens in multiple sclerosis.

Eijlers AJC, Dekker I, Steenwijk MD, Meijer KA, Hulst HE, Pouwels PJW, Uitdehaag BMJ, Barkhof F, Vrenken H, Schoonheim MM, Geurts JJG.

Neurology. 2019 Oct 1;93(14):e1348-e1359. doi: 10.1212/WNL.0000000000008198. Epub 2019 Sep 4.


Evaluation of the Central Vein Sign as a Diagnostic Imaging Biomarker in Multiple Sclerosis.

Sinnecker T, Clarke MA, Meier D, Enzinger C, Calabrese M, De Stefano N, Pitiot A, Giorgio A, Schoonheim MM, Paul F, Pawlak MA, Schmidt R, Kappos L, Montalban X, Rovira À, Evangelou N, Wuerfel J; MAGNIMS Study Group.

JAMA Neurol. 2019 Aug 19. doi: 10.1001/jamaneurol.2019.2478. [Epub ahead of print]


Plasma proteome in multiple sclerosis disease progression.

Malekzadeh A, Leurs C, van Wieringen W, Steenwijk MD, Schoonheim MM, Amann M, Naegelin Y, Kuhle J, Killestein J, Teunissen CE.

Ann Clin Transl Neurol. 2019 Sep;6(9):1582-1594. doi: 10.1002/acn3.771. Epub 2019 Jul 31.


A pilot study of the effects of running training on visuospatial memory in MS: A stronger functional embedding of the hippocampus in the default-mode network?

Huiskamp M, Moumdjian L, van Asch P, Popescu V, Schoonheim MM, Steenwijk MD, Vanzeir E, van Wijmeersch B, Geurts JJ, Feys P, Hulst HE.

Mult Scler. 2019 Jul 18:1352458519863644. doi: 10.1177/1352458519863644. [Epub ahead of print]


Functional Network Dynamics on Functional MRI: A Primer on an Emerging Frontier in Neuroscience.

Eijlers AJC, Wink AM, Meijer KA, Douw L, Geurts JJG, Schoonheim MM.

Radiology. 2019 Aug;292(2):460-463. doi: 10.1148/radiol.2019194009. Epub 2019 Jun 25. No abstract available.


Reduced Network Dynamics on Functional MRI Signals Cognitive Impairment in Multiple Sclerosis.

Eijlers AJC, Wink AM, Meijer KA, Douw L, Geurts JJG, Schoonheim MM.

Radiology. 2019 Aug;292(2):449-457. doi: 10.1148/radiol.2019182623. Epub 2019 Jun 25.


Predicting clinical progression in multiple sclerosis after 6 and 12 years.

Dekker I, Eijlers AJC, Popescu V, Balk LJ, Vrenken H, Wattjes MP, Uitdehaag BMJ, Killestein J, Geurts JJG, Barkhof F, Schoonheim MM.

Eur J Neurol. 2019 Jun;26(6):893-902. doi: 10.1111/ene.13904. Epub 2019 Feb 2.


What Causes Deep Gray Matter Atrophy in Multiple Sclerosis?

Schoonheim MM, Geurts JJG.

AJNR Am J Neuroradiol. 2019 Jan;40(1):107-108. doi: 10.3174/ajnr.A5942. Epub 2018 Dec 27. No abstract available.


Acid sphingomyelinase: No potential as a biomarker for multiple sclerosis.

Leurs CE, Lopes Pinheiro MA, Wierts L, den Hoedt S, Mulder MT, Eijlers AJC, Schoonheim MM, Balk LJ, Uitdehaag BMJ, Killestein J, de Vries HE.

Mult Scler Relat Disord. 2019 Feb;28:44-49. doi: 10.1016/j.msard.2018.11.024. Epub 2018 Nov 30.


Structural network topology relates to tissue properties in multiple sclerosis.

Kiljan S, Meijer KA, Steenwijk MD, Pouwels PJW, Schoonheim MM, Schenk GJ, Geurts JJG, Douw L.

J Neurol. 2019 Jan;266(1):212-222. doi: 10.1007/s00415-018-9130-2. Epub 2018 Nov 22.


Resting-state MEG measurement of functional activation as a biomarker for cognitive decline in MS.

Schoonhoven DN, Fraschini M, Tewarie P, Uitdehaag BM, Eijlers AJ, Geurts JJ, Hillebrand A, Schoonheim MM, Stam CJ, Strijbis EM.

Mult Scler. 2019 Dec;25(14):1896-1906. doi: 10.1177/1352458518810260. Epub 2018 Nov 22.


No Plasmatic Proteomic Signature at Clinical Disease Onset Associated With 11 Year Clinical, Cognitive and MRI Outcomes in Relapsing-Remitting Multiple Sclerosis Patients.

Bridel C, Eijlers AJC, van Wieringen WN, Koel-Simmelink M, Leurs CE, Schoonheim MM, Killestein J, Teunissen CE.

Front Mol Neurosci. 2018 Oct 31;11:371. doi: 10.3389/fnmol.2018.00371. eCollection 2018.


Is impaired information processing speed a matter of structural or functional damage in MS?

Meijer KA, van Geest Q, Eijlers AJC, Geurts JJG, Schoonheim MM, Hulst HE.

Neuroimage Clin. 2018;20:844-850. doi: 10.1016/j.nicl.2018.09.021. Epub 2018 Sep 26.


Predicting cognitive decline in multiple sclerosis: a 5-year follow-up study.

Eijlers AJC, van Geest Q, Dekker I, Steenwijk MD, Meijer KA, Hulst HE, Barkhof F, Uitdehaag BMJ, Schoonheim MM, Geurts JJG.

Brain. 2018 Sep 1;141(9):2605-2618. doi: 10.1093/brain/awy202.


Determinants of Cognitive Impairment in Patients with Multiple Sclerosis with and without Atrophy.

Eijlers AJC, Meijer KA, van Geest Q, Geurts JJG, Schoonheim MM.

Radiology. 2018 Aug;288(2):544-551. doi: 10.1148/radiol.2018172808. Epub 2018 May 22.


The value of including thalamic atrophy as a clinical trial endpoint in multiple sclerosis.

Schoonheim MM, Ciccarelli O.

Neurology. 2018 Apr 10;90(15):677-678. doi: 10.1212/WNL.0000000000005279. Epub 2018 Mar 14. No abstract available.


Explaining the heterogeneity of functional connectivity findings in multiple sclerosis: An empirically informed modeling study.

Tewarie P, Steenwijk MD, Brookes MJ, Uitdehaag BMJ, Geurts JJG, Stam CJ, Schoonheim MM.

Hum Brain Mapp. 2018 Jun;39(6):2541-2548. doi: 10.1002/hbm.24020. Epub 2018 Feb 21.


Gray matter networks and cognitive impairment in multiple sclerosis.

Rimkus CM, Schoonheim MM, Steenwijk MD, Vrenken H, Eijlers AJ, Killestein J, Wattjes MP, Leite CC, Barkhof F, Tijms BM.

Mult Scler. 2019 Mar;25(3):382-391. doi: 10.1177/1352458517751650. Epub 2018 Jan 11.


Staging of cortical and deep grey matter functional connectivity changes in multiple sclerosis.

Meijer KA, Eijlers AJC, Geurts JJG, Schoonheim MM.

J Neurol Neurosurg Psychiatry. 2018 Feb;89(2):205-210. doi: 10.1136/jnnp-2017-316329. Epub 2017 Oct 6.


Loss of Functional Connectivity in Patients with Parkinson Disease and Visual Hallucinations.

Hepp DH, Foncke EMJ, Olde Dubbelink KTE, van de Berg WDJ, Berendse HW, Schoonheim MM.

Radiology. 2017 Dec;285(3):896-903. doi: 10.1148/radiol.2017170438. Epub 2017 Sep 27.


Damaged fiber tracts of the nucleus basalis of Meynert in Parkinson's disease patients with visual hallucinations.

Hepp DH, Foncke EMJ, Berendse HW, Wassenaar TM, Olde Dubbelink KTE, Groenewegen HJ, D J van de Berg W, Schoonheim MM.

Sci Rep. 2017 Aug 31;7(1):10112. doi: 10.1038/s41598-017-10146-y.


Agreement of MSmetrix with established methods for measuring cross-sectional and longitudinal brain atrophy.

Steenwijk MD, Amiri H, Schoonheim MM, de Sitter A, Barkhof F, Pouwels PJW, Vrenken H.

Neuroimage Clin. 2017 Jun 30;15:843-853. doi: 10.1016/j.nicl.2017.06.034. eCollection 2017.


Increased connectivity of hub networks and cognitive impairment in multiple sclerosis.

Meijer KA, Eijlers AJC, Douw L, Uitdehaag BMJ, Barkhof F, Geurts JJG, Schoonheim MM.

Neurology. 2017 May 30;88(22):2107-2114. doi: 10.1212/WNL.0000000000003982. Epub 2017 May 3.


Altered eigenvector centrality is related to local resting-state network functional connectivity in patients with longstanding type 1 diabetes mellitus.

van Duinkerken E, Schoonheim MM, IJzerman RG, Moll AC, Landeira-Fernandez J, Klein M, Diamant M, Snoek FJ, Barkhof F, Wink AM.

Hum Brain Mapp. 2017 Jul;38(7):3623-3636. doi: 10.1002/hbm.23617. Epub 2017 Apr 21.


Metabolites predict lesion formation and severity in relapsing-remitting multiple sclerosis.

Klauser AM, Wiebenga OT, Eijlers AJ, Schoonheim MM, Uitdehaag BM, Barkhof F, Pouwels PJ, Geurts JJ.

Mult Scler. 2018 Apr;24(4):491-500. doi: 10.1177/1352458517702534. Epub 2017 Apr 13.


Cognitive impairment in patients with multiple sclerosis is associated with atrophy of the inner retinal layers.

Coric D, Balk LJ, Verrijp M, Eijlers A, Schoonheim MM, Killestein J, Uitdehaag BM, Petzold A.

Mult Scler. 2018 Feb;24(2):158-166. doi: 10.1177/1352458517694090. Epub 2017 Feb 1.


Increased default-mode network centrality in cognitively impaired multiple sclerosis patients.

Eijlers AJ, Meijer KA, Wassenaar TM, Steenwijk MD, Uitdehaag BM, Barkhof F, Wink AM, Geurts JJ, Schoonheim MM.

Neurology. 2017 Mar 7;88(10):952-960. doi: 10.1212/WNL.0000000000003689. Epub 2017 Feb 8.


Functional reorganization is a maladaptive response to injury - Commentary.

Schoonheim MM.

Mult Scler. 2017 Feb;23(2):194-196. doi: 10.1177/1352458516677593. Epub 2016 Dec 8. No abstract available.


Disrupted topological organization of structural and functional brain connectomes in clinically isolated syndrome and multiple sclerosis.

Shu N, Duan Y, Xia M, Schoonheim MM, Huang J, Ren Z, Sun Z, Ye J, Dong H, Shi FD, Barkhof F, Li K, Liu Y.

Sci Rep. 2016 Jul 12;6:29383. doi: 10.1038/srep29383.


Subgenual Cingulate Cortex Functional Connectivity in Relation to Depressive Symptoms and Cognitive Functioning in Type 1 Diabetes Mellitus Patients.

van Duinkerken E, Ryan CM, Schoonheim MM, Barkhof F, Klein M, Moll AC, Diamant M, IJzerman RG, Snoek FJ.

Psychosom Med. 2016 Jul-Aug;78(6):740-9. doi: 10.1097/PSY.0000000000000335.


White Matter Diffusion Changes during the First Year of Natalizumab Treatment in Relapsing-Remitting Multiple Sclerosis.

Wiebenga OT, Schoonheim MM, Hulst HE, Nagtegaal GJ, Strijbis EM, Steenwijk MD, Polman CH, Pouwels PJ, Barkhof F, Geurts JJ.

AJNR Am J Neuroradiol. 2016 Jun;37(6):1030-7. doi: 10.3174/ajnr.A4690. Epub 2016 Mar 10.


Grey Matter Atrophy in Multiple Sclerosis: Clinical Interpretation Depends on Choice of Analysis Method.

Popescu V, Schoonheim MM, Versteeg A, Chaturvedi N, Jonker M, Xavier de Menezes R, Gallindo Garre F, Uitdehaag BM, Barkhof F, Vrenken H.

PLoS One. 2016 Jan 8;11(1):e0143942. doi: 10.1371/journal.pone.0143942. eCollection 2016.


Structural MRI substrates of cognitive impairment in neuromyelitis optica.

Liu Y, Fu Y, Schoonheim MM, Zhang N, Fan M, Su L, Shen Y, Yan Y, Yang L, Wang Q, Zhang N, Yu C, Barkhof F, Shi FD.

Neurology. 2015 Oct 27;85(17):1491-9. doi: 10.1212/WNL.0000000000002067. Epub 2015 Sep 30.


Multi-parametric structural magnetic resonance imaging in relation to cognitive dysfunction in long-standing multiple sclerosis.

Daams M, Steenwijk MD, Schoonheim MM, Wattjes MP, Balk LJ, Tewarie PK, Killestein J, Uitdehaag BM, Geurts JJ, Barkhof F.

Mult Scler. 2016 Apr;22(5):608-19. doi: 10.1177/1352458515596598. Epub 2015 Jul 24.


Network collapse and cognitive impairment in multiple sclerosis.

Schoonheim MM, Meijer KA, Geurts JJ.

Front Neurol. 2015 Apr 14;6:82. doi: 10.3389/fneur.2015.00082. eCollection 2015. Review. No abstract available.


Enhanced axonal metabolism during early natalizumab treatment in relapsing-remitting multiple sclerosis.

Wiebenga OT, Klauser AM, Schoonheim MM, Nagtegaal GJ, Steenwijk MD, van Rossum JA, Polman CH, Barkhof F, Pouwels PJ, Geurts JJ.

AJNR Am J Neuroradiol. 2015 Jun;36(6):1116-23. doi: 10.3174/ajnr.A4252. Epub 2015 Mar 5.


Memory impairment in multiple sclerosis: Relevance of hippocampal activation and hippocampal connectivity.

Hulst HE, Schoonheim MM, Van Geest Q, Uitdehaag BM, Barkhof F, Geurts JJ.

Mult Scler. 2015 Nov;21(13):1705-12. doi: 10.1177/1352458514567727. Epub 2015 Feb 13.


Thalamus structure and function determine severity of cognitive impairment in multiple sclerosis.

Schoonheim MM, Hulst HE, Brandt RB, Strik M, Wink AM, Uitdehaag BM, Barkhof F, Geurts JJ.

Neurology. 2015 Feb 24;84(8):776-83. doi: 10.1212/WNL.0000000000001285. Epub 2015 Jan 23.


Functional connectivity and cognitive decline over 3 years in Parkinson disease.

Olde Dubbelink KT, Schoonheim MM, Deijen JB, Twisk JW, Barkhof F, Berendse HW.

Neurology. 2014 Nov 25;83(22):2046-53. doi: 10.1212/WNL.0000000000001020. Epub 2014 Oct 29.


Functional brain networks: linking thalamic atrophy to clinical disability in multiple sclerosis, a multimodal fMRI and MEG study.

Tewarie P, Schoonheim MM, Schouten DI, Polman CH, Balk LJ, Uitdehaag BM, Geurts JJ, Hillebrand A, Barkhof F, Stam CJ.

Hum Brain Mapp. 2015 Feb;36(2):603-18. doi: 10.1002/hbm.22650. Epub 2014 Oct 8.


Ventral striatum, but not cortical volume loss, is related to cognitive dysfunction in type 1 diabetic patients with and without microangiopathy.

van Duinkerken E, Schoonheim MM, Steenwijk MD, Klein M, IJzerman RG, Moll AC, Heymans MW, Snoek FJ, Barkhof F, Diamant M.

Diabetes Care. 2014 Sep;37(9):2483-90. doi: 10.2337/dc14-0016. Epub 2014 Jun 27.


Structural degree predicts functional network connectivity: a multimodal resting-state fMRI and MEG study.

Tewarie P, Hillebrand A, van Dellen E, Schoonheim MM, Barkhof F, Polman CH, Beaulieu C, Gong G, van Dijk BW, Stam CJ.

Neuroimage. 2014 Aug 15;97:296-307. doi: 10.1016/j.neuroimage.2014.04.038. Epub 2014 Apr 23.


Differential impact of subclinical carotid artery disease on cerebral structure and functioning in type 1 diabetes patients with versus those without proliferative retinopathy.

van Duinkerken E, Ijzerman RG, van der Zijl NJ, Barkhof F, Pouwels PJ, Schoonheim MM, Moll AC, Boerop J, Wessels AM, Klein M, Snoek FJ, Diamant M.

Cardiovasc Diabetol. 2014 Mar 12;13:58. doi: 10.1186/1475-2840-13-58.


Longitudinal absolute metabolite quantification of white and gray matter regions in healthy controls using proton MR spectroscopic imaging.

Wiebenga OT, Klauser AM, Nagtegaal GJ, Schoonheim MM, Barkhof F, Geurts JJ, Pouwels PJ.

NMR Biomed. 2014 Mar;27(3):304-11. doi: 10.1002/nbm.3063. Epub 2014 Jan 7.


Changes in functional network centrality underlie cognitive dysfunction and physical disability in multiple sclerosis.

Schoonheim MM, Geurts J, Wiebenga OT, De Munck JC, Polman CH, Stam CJ, Barkhof F, Wink AM.

Mult Scler. 2014 Jul;20(8):1058-65. doi: 10.1177/1352458513516892. Epub 2013 Dec 17.


Cognition in MS correlates with resting-state oscillatory brain activity: An explorative MEG source-space study.

Van der Meer ML, Tewarie P, Schoonheim MM, Douw L, Barkhof F, Polman CH, Stam CJ, Hillebrand A.

Neuroimage Clin. 2013 May 13;2:727-34. doi: 10.1016/j.nicl.2013.05.003. eCollection 2013.


Functional brain network analysis using minimum spanning trees in Multiple Sclerosis: an MEG source-space study.

Tewarie P, Hillebrand A, Schoonheim MM, van Dijk BW, Geurts JJ, Barkhof F, Polman CH, Stam CJ.

Neuroimage. 2014 Mar;88:308-18. doi: 10.1016/j.neuroimage.2013.10.022. Epub 2013 Oct 22.


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