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Items: 1 to 50 of 55

1.

Global view of the RAF-MEK-ERK module and its immediate downstream effectors.

Santini CC, Longden J, Schoof EM, Simpson CD, Jeschke GR, Creixell P, Kim J, Wu X, Turk BE, Rosen N, Poulikakos PI, Linding R.

Sci Rep. 2019 Jul 26;9(1):10865. doi: 10.1038/s41598-019-47245-x.

2.

Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML.

Jakobsen JS, Laursen LG, Schuster MB, Pundhir S, Schoof E, Ge Y, d'Altri T, Vitting-Seerup K, Rapin N, Gentil C, Jendholm J, Theilgaard-Mönch K, Reckzeh K, Bullinger L, Döhner K, Hokland P, Fitzgibbon J, Porse BT.

Sci Adv. 2019 Jul 10;5(7):eaaw4304. doi: 10.1126/sciadv.aaw4304. eCollection 2019 Jul.

3.

Mesenchymal stromal cell activation by breast cancer secretomes in bioengineered 3D microenvironments.

Blache U, Horton ER, Xia T, Schoof EM, Blicher LH, Schönenberger A, Snedeker JG, Martin I, Erler JT, Ehrbar M.

Life Sci Alliance. 2019 Jun 3;2(3). pii: e201900304. doi: 10.26508/lsa.201900304. Print 2019 Jun.

4.

Two binding proteins of the ABC transporter that confers growth of Bifidobacterium animalis subsp. lactis ATCC27673 on β-mannan possess distinct manno-oligosaccharide-binding profiles.

Ejby M, Guskov A, Pichler MJ, Zanten GC, Schoof E, Saburi W, Slotboom DJ, Abou Hachem M.

Mol Microbiol. 2019 Jul;112(1):114-130. doi: 10.1111/mmi.14257. Epub 2019 Apr 25.

PMID:
30947380
5.

Glycoproteomic Analysis of MGL-Binding Proteins on Acute T-Cell Leukemia Cells.

Pirro M, Schoof E, van Vliet SJ, Rombouts Y, Stella A, de Ru A, Mohammed Y, Wuhrer M, van Veelen PA, Hensbergen PJ.

J Proteome Res. 2019 Mar 1;18(3):1125-1132. doi: 10.1021/acs.jproteome.8b00796. Epub 2019 Jan 9.

6.

Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia.

van Galen P, Mbong N, Kreso A, Schoof EM, Wagenblast E, Ng SWK, Krivdova G, Jin L, Nakauchi H, Dick JE.

Cell Rep. 2018 Oct 30;25(5):1109-1117.e5. doi: 10.1016/j.celrep.2018.10.021.

7.

Unravelling the GSK3β-related genotypic interaction network influencing hippocampal volume in recurrent major depressive disorder.

Inkster B, Simmons A, Cole JH, Schoof E, Linding R, Nichols T, Muglia P, Holsboer F, Sämann PG, McGuffin P, Fu CHY, Miskowiak K, Matthews PM, Zai G, Nicodemus K.

Psychiatr Genet. 2018 Oct;28(5):77-84. doi: 10.1097/YPG.0000000000000203.

8.

Enhancer and Transcription Factor Dynamics during Myeloid Differentiation Reveal an Early Differentiation Block in Cebpa null Progenitors.

Pundhir S, Bratt Lauridsen FK, Schuster MB, Jakobsen JS, Ge Y, Schoof EM, Rapin N, Waage J, Hasemann MS, Porse BT.

Cell Rep. 2018 May 29;23(9):2744-2757. doi: 10.1016/j.celrep.2018.05.012.

9.

Quantitative Proteomics of Intestinal Mucosa From Male Mice Lacking Intestinal Epithelial Insulin Receptors.

Jensen SR, Schoof EM, Wheeler SE, Hvid H, Ahnfelt-Rønne J, Hansen BF, Nishimura E, Olsen GS, Kislinger T, Brubaker PL.

Endocrinology. 2017 Aug 1;158(8):2470-2485. doi: 10.1210/en.2017-00194.

PMID:
28591806
10.

Global proteomics dataset of miR-126 overexpression in acute myeloid leukemia.

Schoof EM, Lechman ER, Dick JE.

Data Brief. 2016 Aug 24;9:57-61. doi: 10.1016/j.dib.2016.07.035. eCollection 2016 Dec.

11.

Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors.

Wojtowicz EE, Lechman ER, Hermans KG, Schoof EM, Wienholds E, Isserlin R, van Veelen PA, Broekhuis MJ, Janssen GM, Trotman-Grant A, Dobson SM, Krivdova G, Elzinga J, Kennedy J, Gan OI, Sinha A, Ignatchenko V, Kislinger T, Dethmers-Ausema B, Weersing E, Alemdehy MF, de Looper HW, Bader GD, Ritsema M, Erkeland SJ, Bystrykh LV, Dick JE, de Haan G.

Cell Stem Cell. 2016 Sep 1;19(3):383-96. doi: 10.1016/j.stem.2016.06.008. Epub 2016 Jul 14.

12.

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.

Lechman ER, Gentner B, Ng SWK, Schoof EM, van Galen P, Kennedy JA, Nucera S, Ciceri F, Kaufmann KB, Takayama N, Dobson SM, Trotman-Grant A, Krivdova G, Elzinga J, Mitchell A, Nilsson B, Hermans KG, Eppert K, Marke R, Isserlin R, Voisin V, Bader GD, Zandstra PW, Golub TR, Ebert BL, Lu J, Minden M, Wang JCY, Naldini L, Dick JE.

Cancer Cell. 2016 Apr 11;29(4):602-606. doi: 10.1016/j.ccell.2016.03.015. No abstract available.

13.

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.

Lechman ER, Gentner B, Ng SW, Schoof EM, van Galen P, Kennedy JA, Nucera S, Ciceri F, Kaufmann KB, Takayama N, Dobson SM, Trotman-Grant A, Krivdova G, Elzinga J, Mitchell A, Nilsson B, Hermans KG, Eppert K, Marke R, Isserlin R, Voisin V, Bader GD, Zandstra PW, Golub TR, Ebert BL, Lu J, Minden M, Wang JC, Naldini L, Dick JE.

Cancer Cell. 2016 Feb 8;29(2):214-28. doi: 10.1016/j.ccell.2015.12.011. Epub 2016 Jan 28. Erratum in: Cancer Cell. 2016 Apr 11;29(4):602-6.

14.

Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism.

Cox TR, Schoof EM, Gartland A, Erler JT, Linding R.

Data Brief. 2015 Oct 23;5:621-5. doi: 10.1016/j.dib.2015.09.039. eCollection 2015 Dec.

15.

Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.

Creixell P, Schoof EM, Simpson CD, Longden J, Miller CJ, Lou HJ, Perryman L, Cox TR, Zivanovic N, Palmeri A, Wesolowska-Andersen A, Helmer-Citterich M, Ferkinghoff-Borg J, Itamochi H, Bodenmiller B, Erler JT, Turk BE, Linding R.

Cell. 2015 Sep 24;163(1):202-17. doi: 10.1016/j.cell.2015.08.056. Epub 2015 Sep 17.

16.

The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.

Cox TR, Rumney RMH, Schoof EM, Perryman L, Høye AM, Agrawal A, Bird D, Latif NA, Forrest H, Evans HR, Huggins ID, Lang G, Linding R, Gartland A, Erler JT.

Nature. 2015 Jun 4;522(7554):106-110. doi: 10.1038/nature14492. Epub 2015 May 27.

17.

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

So J, Pasculescu A, Dai AY, Williton K, James A, Nguyen V, Creixell P, Schoof EM, Sinclair J, Barrios-Rodiles M, Gu J, Krizus A, Williams R, Olhovsky M, Dennis JW, Wrana JL, Linding R, Jorgensen C, Pawson T, Colwill K.

Sci Signal. 2015 Apr 7;8(371):rs3. doi: 10.1126/scisignal.2005700.

PMID:
25852190
18.

KinomeXplorer: an integrated platform for kinome biology studies.

Horn H, Schoof EM, Kim J, Robin X, Miller ML, Diella F, Palma A, Cesareni G, Jensen LJ, Linding R.

Nat Methods. 2014 Jun;11(6):603-4. doi: 10.1038/nmeth.2968. No abstract available.

PMID:
24874572
19.

Modulation of the chromatin phosphoproteome by the Haspin protein kinase.

Maiolica A, de Medina-Redondo M, Schoof EM, Chaikuad A, Villa F, Gatti M, Jeganathan S, Lou HJ, Novy K, Hauri S, Toprak UH, Herzog F, Meraldi P, Penengo L, Turk BE, Knapp S, Linding R, Aebersold R.

Mol Cell Proteomics. 2014 Jul;13(7):1724-40. doi: 10.1074/mcp.M113.034819. Epub 2014 Apr 14.

20.

Identification of hypoxia-regulated proteins using MALDI-mass spectrometry imaging combined with quantitative proteomics.

Djidja MC, Chang J, Hadjiprocopis A, Schmich F, Sinclair J, Mršnik M, Schoof EM, Barker HE, Linding R, Jørgensen C, Erler JT.

J Proteome Res. 2014 May 2;13(5):2297-313. doi: 10.1021/pr401056c. Epub 2014 Apr 24.

PMID:
24702160
21.

Experimental and computational tools for analysis of signaling networks in primary cells.

Schoof EM, Linding R.

Curr Protoc Immunol. 2014 Feb 4;104:11.11.1-11.11.23. doi: 10.1002/0471142735.im1111s104.

PMID:
24510617
22.

CoreFlow: a computational platform for integration, analysis and modeling of complex biological data.

Pasculescu A, Schoof EM, Creixell P, Zheng Y, Olhovsky M, Tian R, So J, Vanderlaan RD, Pawson T, Linding R, Colwill K.

J Proteomics. 2014 Apr 4;100:167-73. doi: 10.1016/j.jprot.2014.01.023. Epub 2014 Feb 3.

PMID:
24503186
23.

In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis.

Zanivan S, Meves A, Behrendt K, Schoof EM, Neilson LJ, Cox J, Tang HR, Kalna G, van Ree JH, van Deursen JM, Trempus CS, Machesky LM, Linding R, Wickström SA, Fässler R, Mann M.

Cell Rep. 2013 Feb 21;3(2):552-66. doi: 10.1016/j.celrep.2013.01.003. Epub 2013 Jan 31.

24.

Navigating cancer network attractors for tumor-specific therapy.

Creixell P, Schoof EM, Erler JT, Linding R.

Nat Biotechnol. 2012 Sep;30(9):842-8. doi: 10.1038/nbt.2345.

PMID:
22965061
25.

Mutational properties of amino acid residues: implications for evolvability of phosphorylatable residues.

Creixell P, Schoof EM, Tan CS, Linding R.

Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19;367(1602):2584-93. doi: 10.1098/rstb.2012.0076. Erratum in: Philos Trans R Soc Lond B Biol Sci. 2012 Nov 5;367(1602):3058.

26.

Brief adrenomedullin inhalation leads to sustained reduction of pulmonary artery pressure.

von der Hardt K, Kandler MA, Chada M, Cubra A, Schoof E, Amann K, Rascher W, Dötsch J.

Eur Respir J. 2004 Oct;24(4):615-23.

27.

Comparison of aerosol therapy with different perfluorocarbons in surfactant-depleted animals.

von der Hardt K, Kandler MA, Brenn G, Scheuerer K, Schoof E, Dötsch J, Rascher W.

Crit Care Med. 2004 May;32(5):1200-6.

PMID:
15190973
28.

Comparison of leptin gene expression in different adipose tissues in children and adults.

Schoof E, Stuppy A, Harig F, Carbon R, Horbach T, Stöhr W, Rascher W, Dötsch J.

Eur J Endocrinol. 2004 Apr;150(4):579-84.

PMID:
15080789
29.

Five-year follow-up of a 13-year-old boy with a pituitary adenoma causing gigantism--effect of octreotide therapy.

Schoof E, Dörr HG, Kiess W, Lüdecke DK, Freitag E, Zindel V, Rascher W, Dötsch J.

Horm Res. 2004;61(4):184-9. Epub 2004 Jan 23.

PMID:
14739526
30.

High frequency oscillatory ventilation suppresses inflammatory response in lung tissue and microdissected alveolar macrophages in surfactant depleted piglets.

von der Hardt K, Kandler MA, Fink L, Schoof E, Dötsch J, Brandenstein O, Bohle RM, Rascher W.

Pediatr Res. 2004 Feb;55(2):339-46. Epub 2003 Dec 8.

PMID:
14663153
31.

Cardiopulmonary bypass surgery does not further increase elevated serum leptin concentrations after major surgery.

Dötsch J, Wagner R, Gröschl M, Schoof E, Harig F, Scharf J, Singer H, Katz N, Blum WF, Dörr HG, Rascher W.

Pediatr Crit Care Med. 2001 Jan;2(1):36-39.

PMID:
12797886
32.

Pilot intervention: aerosolized adrenomedullin reduces pulmonary hypertension.

Kandler MA, Von Der Hardt K, Mahfoud S, Chada M, Schoof E, Papadopoulos T, Rascher W, Dötsch J.

J Pharmacol Exp Ther. 2003 Sep;306(3):1021-6. Epub 2003 May 15.

PMID:
12750441
33.

No influence of surgical stress on postoperative leptin gene expression in different adipose tissues and soluble leptin receptor plasma levels.

Schoof E, Stuppy A, Harig F, Singer H, Carbon R, Horbach T, Kratzsch J, Rascher W, Dötsch J.

Horm Res. 2003;59(4):184-90.

PMID:
12649572
34.

Laser-assisted microdissection and real-time PCR detect anti-inflammatory effect of perfluorocarbon.

von der Hardt K, Kandler MA, Fink L, Schoof E, Dotsch J, Bohle RM, Rascher W.

Am J Physiol Lung Cell Mol Physiol. 2003 Jul;285(1):L55-62. Epub 2003 Feb 21.

35.
36.

Aerosolized perfluorocarbon reduces adhesion molecule gene expression and neutrophil sequestration in acute respiratory distress.

Schoof E, von der Hardt K, Kandler MA, Abendroth F, Papadopoulos T, Rascher W, Dötsch J.

Eur J Pharmacol. 2002 Dec 20;457(2-3):195-200.

PMID:
12464366
37.

Aerosolized adrenomedullin suppresses pulmonary transforming growth factor-beta1 and interleukin-1 beta gene expression in vivo.

von der Hardt K, Kandler MA, Popp K, Schoof E, Chada M, Rascher W, Dötsch J.

Eur J Pharmacol. 2002 Dec 13;457(1):71-6.

PMID:
12460645
38.

Adrenomedullin gene expression in human placental tIssue and leukocytes: a potential marker of severe tIssue hypoxia in neonates with birth asphyxia.

Trollmann R, Schoof E, Beinder E, Wenzel D, Rascher W, Dotsch J.

Eur J Endocrinol. 2002 Nov;147(5):711-6.

PMID:
12444904
39.

Nitric oxide increases adrenomedullin receptor function in rat mesangial cells.

Dötsch J, Schoof E, Schöcklmann HO, Brüne B, Knerr I, Repp R, Rascher W.

Kidney Int. 2002 May;61(5):1707-13.

40.

Nitric oxide stimulates adrenomedullin secretion and gene expression in endothelial cells.

Dötsch J, Schoof E, Hänze J, Dittrich K, Opherk P, Dumke K, Rascher W.

Pharmacology. 2002;64(3):135-9.

PMID:
11834889
41.

Aerosolized perfluorocarbon suppresses early pulmonary inflammatory response in a surfactant-depleted piglet model.

von der Hardt K, Schoof E, Kandler MA, Dötsch J, Rascher W.

Pediatr Res. 2002 Feb;51(2):177-82.

PMID:
11809911
42.

Inflammatory cytokines stimulate adrenomedullin expression through nitric oxide-dependent and -independent pathways.

Hofbauer KH, Schoof E, Kurtz A, Sandner P.

Hypertension. 2002 Jan;39(1):161-7.

PMID:
11799096
43.

Identification of leptin in human saliva.

Gröschl M, Rauh M, Wagner R, Neuhuber W, Metzler M, Tamgüney G, Zenk J, Schoof E, Dörr HG, Blum WF, Rascher W, Dötsch J.

J Clin Endocrinol Metab. 2001 Nov;86(11):5234-9.

PMID:
11701683
44.

Gene expression of adrenomedullin, leptin, their receptors and neuropeptide Y in hormone-secreting and non-functioning pituitary adenomas, meningiomas and malignant intracranial tumours in humans.

Knerr I, Schuster S, Nomikos P, Buchfelder M, Dötsch J, Schoof E, Fahlbusch R, Rascher W.

Neuropathol Appl Neurobiol. 2001 Jun;27(3):215-22.

PMID:
11489141
45.

Course of placental 11beta-hydroxysteroid dehydrogenase type 2 and 15-hydroxyprostaglandin dehydrogenase mRNA expression during human gestation.

Schoof E, Girstl M, Frobenius W, Kirschbaum M, Repp R, Knerr I, Rascher W, Dötsch J.

Eur J Endocrinol. 2001 Aug;145(2):187-92.

PMID:
11454515
46.

Persistent improvement of gas exchange and lung mechanics by aerosolized perfluorocarbon.

Kandler MA, von der Hardt K, Schoof E, Dötsch J, Rascher W.

Am J Respir Crit Care Med. 2001 Jul 1;164(1):31-5.

PMID:
11435235
47.

Decreased gene expression of 11beta-hydroxysteroid dehydrogenase type 2 and 15-hydroxyprostaglandin dehydrogenase in human placenta of patients with preeclampsia.

Schoof E, Girstl M, Frobenius W, Kirschbaum M, Dörr HG, Rascher W, Dötsch J.

J Clin Endocrinol Metab. 2001 Mar;86(3):1313-7.

PMID:
11238526
48.

Growth hormone deficiency in one of two siblings with Fanconi's anaemia complementation group FA-D.

Schoof E, Beck JD, Joenje H, Doerr HG.

Growth Horm IGF Res. 2000 Oct;10(5):290-4.

PMID:
11042025
49.

Anorexia nervosa in congenital adrenal hyperplasia: long-term follow-up of 4 cases.

Brand M, Schoof E, Partsch C-J, Peter M, Hoepffner W, Dörr HG, Sippell WG.

Exp Clin Endocrinol Diabetes. 2000;108(6):430-5.

PMID:
11026757
50.

The endocrine spectrum of arachnoid cysts in childhood.

Mohn A, Schoof E, Fahlbusch R, Wenzel D, Dörr HG.

Pediatr Neurosurg. 1999 Dec;31(6):316-21. Review.

PMID:
10702732

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