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Items: 21

1.

JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function.

Adam S, Simon N, Steffen U, Andes FT, Scholtysek C, Müller DIH, Weidner D, Andreev D, Kleyer A, Culemann S, Hahn M, Schett G, Krönke G, Frey S, Hueber AJ.

Sci Transl Med. 2020 Feb 12;12(530). pii: eaay4447. doi: 10.1126/scitranslmed.aay4447.

PMID:
32051226
2.

Environmental arginine controls multinuclear giant cell metabolism and formation.

Brunner JS, Vulliard L, Hofmann M, Kieler M, Lercher A, Vogel A, Russier M, Brüggenthies JB, Kerndl M, Saferding V, Niederreiter B, Junza A, Frauenstein A, Scholtysek C, Mikami Y, Klavins K, Krönke G, Bergthaler A, O'Shea JJ, Weichhart T, Meissner F, Smolen JS, Cheng P, Yanes O, Menche J, Murray PJ, Sharif O, Blüml S, Schabbauer G.

Nat Commun. 2020 Jan 22;11(1):431. doi: 10.1038/s41467-020-14285-1.

3.

Modular Lattice Constructs for Biological Joint Resurfacing.

Gelse K, Biggemann J, Stumpf M, Halmheu M, Grüneboom A, Kleyer A, Scholtysek C, Pachowsky ML, Hueber A, Krönke G, Fey T.

Tissue Eng Part A. 2019 Jul;25(13-14):1053-1062. doi: 10.1089/ten.TEA.2018.0231. Epub 2019 Mar 18.

PMID:
30638150
4.

Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice.

Omata Y, Frech M, Primbs T, Lucas S, Andreev D, Scholtysek C, Sarter K, Kindermann M, Yeremenko N, Baeten DL, Andreas N, Kamradt T, Bozec A, Ramming A, Krönke G, Wirtz S, Schett G, Zaiss MM.

Cell Rep. 2018 Jul 3;24(1):169-180. doi: 10.1016/j.celrep.2018.06.005.

5.

NR4A1 Regulates Motility of Osteoclast Precursors and Serves as Target for the Modulation of Systemic Bone Turnover.

Scholtysek C, Ipseiz N, Böhm C, Krishnacoumar B, Stenzel M, Czerwinski T, Palumbo-Zerr K, Rothe T, Weidner D, Klej A, Stoll C, Distler J, Tuckermann J, Herrmann M, Fabry B, Goldmann WH, Schett G, Krönke G.

J Bone Miner Res. 2018 Nov;33(11):2035-2047. doi: 10.1002/jbmr.3533. Epub 2018 Jul 24.

6.

PPARβ/δ: A master regulator of mesenchymal stem cell functions.

Djouad F, Ipseiz N, Luz-Crawford P, Scholtysek C, Krönke G, Jorgensen C.

Biochimie. 2017 May;136:55-58. doi: 10.1016/j.biochi.2016.11.011. Epub 2016 Nov 30. Review.

PMID:
27914902
7.

PPARβ/δ directs the therapeutic potential of mesenchymal stem cells in arthritis.

Luz-Crawford P, Ipseiz N, Espinosa-Carrasco G, Caicedo A, Tejedor G, Toupet K, Loriau J, Scholtysek C, Stoll C, Khoury M, Noël D, Jorgensen C, Krönke G, Djouad F.

Ann Rheum Dis. 2016 Dec;75(12):2166-2174. doi: 10.1136/annrheumdis-2015-208696. Epub 2016 Mar 8.

PMID:
26964143
8.

Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis.

Palumbo-Zerr K, Zerr P, Distler A, Fliehr J, Mancuso R, Huang J, Mielenz D, Tomcik M, Fürnrohr BG, Scholtysek C, Dees C, Beyer C, Krönke G, Metzger D, Distler O, Schett G, Distler JH.

Nat Med. 2015 Feb;21(2):150-8. doi: 10.1038/nm.3777. Epub 2015 Jan 12.

PMID:
25581517
9.

Adopted orphans as regulators of inflammation, immunity and skeletal homeostasis.

Ipseiz N, Scholtysek C, Culemann S, Krönke G.

Swiss Med Wkly. 2014 Dec 4;144:w14055. doi: 10.4414/smw.2014.14055. eCollection 2014. Review.

10.

The nuclear receptor Nr4a1 mediates anti-inflammatory effects of apoptotic cells.

Ipseiz N, Uderhardt S, Scholtysek C, Steffen M, Schabbauer G, Bozec A, Schett G, Krönke G.

J Immunol. 2014 May 15;192(10):4852-8. doi: 10.4049/jimmunol.1303377. Epub 2014 Apr 16.

11.

Wnt inhibitory factor 1 deficiency uncouples cartilage and bone destruction in tumor necrosis factor α-mediated experimental arthritis.

Stock M, Böhm C, Scholtysek C, Englbrecht M, Fürnrohr BG, Klinger P, Gelse K, Gayetskyy S, Engelke K, Billmeier U, Wirtz S, van den Berg W, Schett G.

Arthritis Rheum. 2013 Sep;65(9):2310-22. doi: 10.1002/art.38054.

12.

PPARβ/δ governs Wnt signaling and bone turnover.

Scholtysek C, Katzenbeisser J, Fu H, Uderhardt S, Ipseiz N, Stoll C, Zaiss MM, Stock M, Donhauser L, Böhm C, Kleyer A, Hess A, Engelke K, David JP, Djouad F, Tuckermann JP, Desvergne B, Schett G, Krönke G.

Nat Med. 2013 May;19(5):608-13. doi: 10.1038/nm.3146. Epub 2013 Mar 31.

PMID:
23542786
13.

Autophagy regulates TNFα-mediated joint destruction in experimental arthritis.

Lin NY, Beyer C, Giessl A, Kireva T, Scholtysek C, Uderhardt S, Munoz LE, Dees C, Distler A, Wirtz S, Krönke G, Spencer B, Distler O, Schett G, Distler JH.

Ann Rheum Dis. 2013 May;72(5):761-8. doi: 10.1136/annrheumdis-2012-201671. Epub 2012 Sep 12.

PMID:
22975756
14.

Liver X receptors orchestrate osteoblast/osteoclast crosstalk and counteract pathologic bone loss.

Kleyer A, Scholtysek C, Bottesch E, Hillienhof U, Beyer C, Distler JH, Tuckermann JP, Schett G, Krönke G.

J Bone Miner Res. 2012 Dec;27(12):2442-51. doi: 10.1002/jbmr.1702.

15.

RSK2 protects mice against TNF-induced bone loss.

Böhm C, Derer A, Axmann R, Hillienhoff U, Zaiss MM, Luther J, Zech C, Stock M, Scholtysek C, Engelke K, Hess A, Tuckermann JP, Schett G, David JP.

J Cell Sci. 2012 May 1;125(Pt 9):2160-71. doi: 10.1242/jcs.096008. Epub 2012 Feb 17.

16.

Inflammation-associated changes in bone homeostasis.

Scholtysek C, Krönke G, Schett G.

Inflamm Allergy Drug Targets. 2012 Jun;11(3):188-95. Review.

PMID:
22280240
17.

The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis.

Krönke G, Reich N, Scholtysek C, Akhmetshina A, Uderhardt S, Zerr P, Palumbo K, Lang V, Dees C, Distler O, Schett G, Distler JH.

Ann Rheum Dis. 2012 Jun;71(6):1081-7. doi: 10.1136/annrheumdis-2011-200745. Epub 2012 Jan 20.

PMID:
22267335
18.

IL-33 shifts the balance from osteoclast to alternatively activated macrophage differentiation and protects from TNF-alpha-mediated bone loss.

Zaiss MM, Kurowska-Stolarska M, Böhm C, Gary R, Scholtysek C, Stolarski B, Reilly J, Kerr S, Millar NL, Kamradt T, McInnes IB, Fallon PG, David JP, Liew FY, Schett G.

J Immunol. 2011 Jun 1;186(11):6097-105. doi: 10.4049/jimmunol.1003487. Epub 2011 Apr 22.

19.

R-spondin 1 protects against inflammatory bone damage during murine arthritis by modulating the Wnt pathway.

Krönke G, Uderhardt S, Kim KA, Stock M, Scholtysek C, Zaiss MM, Surmann-Schmitt C, Luther J, Katzenbeisser J, David JP, Abdollahi-Roodsaz S, Tran K, Bright JM, Binnerts ME, Akhmetshina A, Böhm C, Distler JH, Joosten LA, Schett G, Abo A.

Arthritis Rheum. 2010 Aug;62(8):2303-12. doi: 10.1002/art.27496.

20.

12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis.

Krönke G, Katzenbeisser J, Uderhardt S, Zaiss MM, Scholtysek C, Schabbauer G, Zarbock A, Koenders MI, Axmann R, Zwerina J, Baenckler HW, van den Berg W, Voll RE, Kühn H, Joosten LA, Schett G.

J Immunol. 2009 Sep 1;183(5):3383-9. doi: 10.4049/jimmunol.0900327. Epub 2009 Aug 12.

21.

Characterizing components of the Saw Palmetto Berry Extract (SPBE) on prostate cancer cell growth and traction.

Scholtysek C, Krukiewicz AA, Alonso JL, Sharma KP, Sharma PC, Goldmann WH.

Biochem Biophys Res Commun. 2009 Feb 13;379(3):795-8. doi: 10.1016/j.bbrc.2008.11.114. Epub 2008 Dec 6.

PMID:
19059205

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