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Items: 1 to 50 of 357

1.

Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.

Macan AM, Harej A, Cazin I, Klobučar M, Stepanić V, Pavelić K, Pavelić SK, Schols D, Snoeck R, Andrei G, Raić-Malić S.

Eur J Med Chem. 2019 Sep 28;184:111739. doi: 10.1016/j.ejmech.2019.111739. [Epub ahead of print]

PMID:
31586832
2.

Synthesis and Evaluations of "1,4-Triazolyl Combretacoumarins" and Desmethoxy Analogues.

Khandaker TA, Hess JD, Aguilera R, Andrei G, Snoeck R, Schols D, Pradhan P, Lakshman MK.

European J Org Chem. 2019 Sep 8;2019(33):5610-5623. doi: 10.1002/ejoc.201900569. Epub 2019 Aug 7.

PMID:
31579393
3.

Design, synthesis and antiviral evaluation of novel acyclic phosphonate nucleotide analogs with triazolo[4,5-b]pyridine, imidazo[4,5-b]pyridine and imidazo[4,5-b]pyridin-2(3H)-one systems.

Hartwich A, Zdzienicka N, Schols D, Andrei G, Snoeck R, Głowacka IE.

Nucleosides Nucleotides Nucleic Acids. 2019 Sep 25:1-50. doi: 10.1080/15257770.2019.1669046. [Epub ahead of print]

PMID:
31550993
4.

Modifications in the branched arms of a class of dual inhibitors of HIV and EV71 replication expand their antiviral spectrum.

Martínez-Gualda B, Sun L, Martí-Marí O, Mirabelli C, Delang L, Neyts J, Schols D, Camarasa MJ, San-Félix A.

Antiviral Res. 2019 Aug;168:210-214. doi: 10.1016/j.antiviral.2019.06.006. Epub 2019 Jun 20.

PMID:
31228490
5.

Copper-64 PET imaging of the CXCR4 chemokine receptor using a cross-bridged cyclam bis-tetraazamacrocyclic antagonist.

Burke B, Miranda C, Lee R, Renard I, Nigam S, Clemente G, D'huys T, Ruest T, Domarkas J, Thompson J, Schols D, Hubin T, Cawthorne C, Archibald S.

J Nucl Med. 2019 Jun 14. pii: jnumed.118.218008. doi: 10.2967/jnumed.118.218008. [Epub ahead of print]

PMID:
31201250
6.

Diversion of the Arbuzov reaction: alkylation of C-Cl instead of phosphonic ester formation on the fullerene cage.

Kraevaya OA, Peregudov AS, Troyanov SI, Godovikov I, Fedorova NE, Klimova RR, Sergeeva VA, Kameneva LV, Ershova ES, Martynenko VM, Claes S, Kushch AA, Kostyuk SV, Schols D, Shestakov AF, Troshin PA.

Org Biomol Chem. 2019 Aug 14;17(30):7155-7160. doi: 10.1039/c9ob00593e. Epub 2019 Jun 6.

PMID:
31169856
7.

Advantages and shortcomings of cell-based electrical impedance measurements as a GPCR drug discovery tool.

Doijen J, Van Loy T, Landuyt B, Luyten W, Schols D, Schoofs L.

Biosens Bioelectron. 2019 Jul 15;137:33-44. doi: 10.1016/j.bios.2019.04.041. Epub 2019 Apr 28. Review.

PMID:
31077988
8.

Highly stable hexitol based XNA aptamers targeting the vascular endothelial growth factor.

Eremeeva E, Fikatas A, Margamuljana L, Abramov M, Schols D, Groaz E, Herdewijn P.

Nucleic Acids Res. 2019 Jun 4;47(10):4927-4939. doi: 10.1093/nar/gkz252.

9.

Prone Positioning During Ex Vivo Lung Perfusion Influences Regional Edema Accumulation.

Ordies S, Frick AE, Claes S, Schols D, Verleden SE, Van Raemdonck DE, Neyrinck AP; Leuven Lung Transplant Group.

J Surg Res. 2019 Jul;239:300-308. doi: 10.1016/j.jss.2019.02.003. Epub 2019 Mar 19.

PMID:
30901722
10.

Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Ribofuranonucleosides as Potential Antitumor or/and Antiviral Agents.

Kollatos N, Mitsos C, Manta S, Tzioumaki N, Giannakas C, Alexouli T, Panagiotopoulou A, Schols D, Andrei G, Komioti D.

Med Chem. 2019 Feb 24. doi: 10.2174/1573406415666190225112950. [Epub ahead of print]

PMID:
30799795
11.

Acetate as a model for aspartate-based CXCR4 chemokine receptor binding of cobalt and nickel complexes of cross-bridged tetraazamacrocycles.

Cain AN, Carder Freeman TN, Roewe KD, Cockriel DL, Hasley TR, Maples RD, Allbritton EMA, D'Huys T, van Loy T, Burke BP, Prior TJ, Schols D, Archibald SJ, Hubin TJ.

Dalton Trans. 2019 Feb 19;48(8):2785-2801. doi: 10.1039/c8dt04728f.

PMID:
30729243
12.

A yellow fever-Zika chimeric virus vaccine candidate protects against Zika infection and congenital malformations in mice.

Kum DB, Mishra N, Boudewijns R, Gladwyn-Ng I, Alfano C, Ma J, Schmid MA, Marques RE, Schols D, Kaptein S, Nguyen L, Neyts J, Dallmeier K.

NPJ Vaccines. 2018 Dec 13;3:56. doi: 10.1038/s41541-018-0092-2. eCollection 2018.

13.

Synthesis and Anti-HIV Activity of Guanine Modified Fluorinated Acyclic Nucleoside Phosphonate Derivatives.

Luo M, Groaz E, De Jonghe S, Schols D, Herdewijn P.

Chem Biodivers. 2019 Feb;16(2):e1800532. doi: 10.1002/cbdv.201800532. Epub 2019 Jan 23.

PMID:
30431702
14.

Synthesis, Anti-varicella-zoster virus and Anti-cytomegalovirus Activity of 4,5-Disubstituted 1,2,3-(1H)-Triazoles.

Yuan WY, Chen X, Liu NN, Wen YN, Yang B, Andrei G, Snoeck R, Xiang YH, Wu YW, Jiang Z, Schols D, Zhang ZY, Wu QP.

Med Chem. 2018 Nov 8. doi: 10.2174/1573406414666181109095239. [Epub ahead of print]

PMID:
30411688
15.

CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry.

Van Hout A, Klarenbeek A, Bobkov V, Doijen J, Arimont M, Zhao C, Heukers R, Rimkunas R, de Graaf C, Verrips T, van der Woning B, de Haard H, Rucker JB, Vermeire K, Handel T, Van Loy T, Smit MJ, Schols D.

Biochem Pharmacol. 2018 Dec;158:402-412. doi: 10.1016/j.bcp.2018.10.015. Epub 2018 Oct 17.

PMID:
30342024
16.

Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions.

Bobkov V, Zarca AM, Van Hout A, Arimont M, Doijen J, Bialkowska M, Toffoli E, Klarenbeek A, van der Woning B, van der Vliet HJ, Van Loy T, de Haard H, Schols D, Heukers R, Smit MJ.

Biochem Pharmacol. 2018 Dec;158:413-424. doi: 10.1016/j.bcp.2018.10.014. Epub 2018 Oct 17.

17.

Tri-armed ligands of G-quadruplex on heteroarene-fused anthraquinone scaffolds: Design, synthesis and pre-screening of biological properties.

Tikhomirov AS, Tsvetkov VB, Kaluzhny DN, Volodina YL, Zatonsky GV, Schols D, Shchekotikhin AE.

Eur J Med Chem. 2018 Nov 5;159:59-73. doi: 10.1016/j.ejmech.2018.09.054. Epub 2018 Sep 22.

PMID:
30268824
18.

Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation in vivo and Anti-HIV-1 Activity.

Janssens R, Boff D, Ruytinx P, Mortier A, Vanheule V, Larsen O, Daugvilaite V, Rosenkilde MM, Noppen S, Liekens S, Schols D, De Meester I, Opdenakker G, Struyf S, Teixeira MM, Amaral FA, Proost P.

Front Immunol. 2018 Aug 28;9:1933. doi: 10.3389/fimmu.2018.01933. eCollection 2018.

19.

Synthesis and Antiviral Activity of Water-Soluble Polycarboxylic Derivatives of [60]Fullerene Loaded with 3,4-Dichlorophenyl Units.

Voronov II, Martynenko VM, Chernyak AV, Balzarini J, Schols D, Troshin PA.

Chem Biodivers. 2018 Nov;15(11):e1800293. doi: 10.1002/cbdv.201800293. Epub 2018 Oct 29.

PMID:
30168652
20.

Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3',4',5'-trimethoxyphenyl)-3-(2'-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach.

Preti D, Romagnoli R, Rondanin R, Cacciari B, Hamel E, Balzarini J, Liekens S, Schols D, Estévez-Sarmiento F, Quintana J, Estévez F.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1225-1238. doi: 10.1080/14756366.2018.1493473.

21.

Synthesis of a 3'-C-ethynyl-β-d-ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides.

Hulpia F, Noppen S, Schols D, Andrei G, Snoeck R, Liekens S, Vervaeke P, Van Calenbergh S.

Eur J Med Chem. 2018 Sep 5;157:248-267. doi: 10.1016/j.ejmech.2018.07.062. Epub 2018 Jul 29.

PMID:
30098481
22.

Isoxazolidine Conjugates of N3-Substituted 6-Bromoquinazolinones-Synthesis, Anti-Varizella-Zoster Virus, and Anti-Cytomegalovirus Activity.

Grabkowska-Drużyc M, Andrei G, Schols D, Snoeck R, Piotrowska DG.

Molecules. 2018 Jul 28;23(8). pii: E1889. doi: 10.3390/molecules23081889.

23.

Engineering Lactobacillus rhamnosus GG and GR-1 to express HIV-inhibiting griffithsin.

Petrova MI, van den Broek MFL, Spacova I, Verhoeven TLA, Balzarini J, Vanderleyden J, Schols D, Lebeer S.

Int J Antimicrob Agents. 2018 Nov;52(5):599-607. doi: 10.1016/j.ijantimicag.2018.07.013. Epub 2018 Jul 21.

PMID:
30040991
24.

Asymmetric Primaquine and Halogenaniline Fumardiamides as Novel Biologically Active Michael Acceptors.

Rajić Z, Beus M, Michnová H, Vlainić J, Persoons L, Kosalec I, Jampílek J, Schols D, Keser T, Zorc B.

Molecules. 2018 Jul 14;23(7). pii: E1724. doi: 10.3390/molecules23071724.

25.

Synthesis and Antiviral Evaluation of TriPPPro-AbacavirTP, TriPPPro-CarbovirTP, and Their 1',2'-cis-Disubstituted Analogues.

Weising S, Sterrenberg V, Schols D, Meier C.

ChemMedChem. 2018 Sep 6;13(17):1771-1778. doi: 10.1002/cmdc.201800361. Epub 2018 Jul 25.

PMID:
29943432
26.

Iterative Chemical Engineering of Vancomycin Leads to Novel Vancomycin Analogs With a High in Vitro Therapeutic Index.

Mishra NM, Stolarzewicz I, Cannaerts D, Schuermans J, Lavigne R, Looz Y, Landuyt B, Schoofs L, Schols D, Paeshuyse J, Hickenbotham P, Clokie M, Luyten W, Van der Eycken EV, Briers Y.

Front Microbiol. 2018 Jun 7;9:1175. doi: 10.3389/fmicb.2018.01175. eCollection 2018.

27.

Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs.

Pileggi E, Serpi M, Andrei G, Schols D, Snoeck R, Pertusati F.

Bioorg Med Chem. 2018 Jul 23;26(12):3596-3609. doi: 10.1016/j.bmc.2018.05.034. Epub 2018 May 23.

PMID:
29880251
28.

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4.

Schoofs G, Van Hout A, D'huys T, Schols D, Van Loy T.

J Vis Exp. 2018 Mar 10;(133). doi: 10.3791/57271.

PMID:
29578516
29.

CXCR7/ACKR3-targeting ligands interfere with X7 HIV-1 and HIV-2 entry and replication in human host cells.

D'huys T, Claes S, Van Loy T, Schols D.

Heliyon. 2018 Mar 1;4(3):e00557. doi: 10.1016/j.heliyon.2018.e00557. eCollection 2018 Mar.

30.

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators.

Claes S, D'huys T, Van Hout A, Schols D, Van Loy T.

J Vis Exp. 2018 Feb 20;(132). doi: 10.3791/56780.

PMID:
29553532
31.

SYNTHESIS AND CYTOTOXIC EVALUATION OF SOME 2-{4-[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL] PHENOXY}-N-PHENYLACETAMIDE.

Bhadauria VS, Sravanthi V, Kumar S, DAS D, DE Clercq E, Schols D, Tokuda H, Karki SS.

Acta Pol Pharm. 2017 Jan;74(1):137-145.

32.

New antitumor anthra[2,3-b]furan-3-carboxamides: Synthesis and structure-activity relationship.

Tikhomirov AS, Lin CY, Volodina YL, Dezhenkova LG, Tatarskiy VV, Schols D, Shtil AA, Kaur P, Chueh PJ, Shchekotikhin AE.

Eur J Med Chem. 2018 Mar 25;148:128-139. doi: 10.1016/j.ejmech.2018.02.027. Epub 2018 Feb 10.

PMID:
29459273
33.

Chloro-1,4-dimethyl-9H-carbazole Derivatives Displaying Anti-HIV Activity.

Saturnino C, Grande F, Aquaro S, Caruso A, Iacopetta D, Bonomo MG, Longo P, Schols D, Sinicropi MS.

Molecules. 2018 Jan 30;23(2). pii: E286. doi: 10.3390/molecules23020286.

34.

Different contributions of chemokine N-terminal features attest to a different ligand binding mode and a bias towards activation of ACKR3/CXCR7 compared with CXCR4 and CXCR3.

Szpakowska M, Nevins AM, Meyrath M, Rhainds D, D'huys T, Guité-Vinet F, Dupuis N, Gauthier PA, Counson M, Kleist A, St-Onge G, Hanson J, Schols D, Volkman BF, Heveker N, Chevigné A.

Br J Pharmacol. 2018 May;175(9):1419-1438. doi: 10.1111/bph.14132. Epub 2018 Mar 23.

35.

Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.

Nadysev GY, Tikhomirov AS, Lin MH, Yang YT, Dezhenkova LG, Chen HY, Kaluzhny DN, Schols D, Shtil AA, Shchekotikhin AE, Chueh PJ.

Eur J Med Chem. 2018 Jan 1;143:1553-1562. doi: 10.1016/j.ejmech.2017.10.055. Epub 2017 Oct 19.

PMID:
29137865
36.

Signaling properties of the human chemokine receptors CXCR4 and CXCR7 by cellular electric impedance measurements.

Doijen J, Van Loy T, De Haes W, Landuyt B, Luyten W, Schoofs L, Schols D.

PLoS One. 2017 Sep 25;12(9):e0185354. doi: 10.1371/journal.pone.0185354. eCollection 2017.

37.

Design, Synthesis, and the Biological Evaluation of a New Series of Acyclic 1,2,3-Triazole Nucleosides.

Głowacka IE, Andrei G, Schols D, Snoeck R, Gawron K.

Arch Pharm (Weinheim). 2017 Sep;350(9). doi: 10.1002/ardp.201700166. Epub 2017 Aug 1.

PMID:
28763115
38.

Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.

Luo M, Groaz E, Andrei G, Snoeck R, Kalkeri R, Ptak RG, Hartman T, Buckheit RW Jr, Schols D, De Jonghe S, Herdewijn P.

J Med Chem. 2017 Jul 27;60(14):6220-6238. doi: 10.1021/acs.jmedchem.7b00416. Epub 2017 Jul 6.

PMID:
28682067
39.

Immunoregulatory effects of multipotent adult progenitor cells in a porcine ex vivo lung perfusion model.

Martens A, Ordies S, Vanaudenaerde BM, Verleden SE, Vos R, Van Raemdonck DE, Verleden GM, Roobrouck VD, Claes S, Schols D, Verbeken E, Verfaillie CM, Neyrinck AP.

Stem Cell Res Ther. 2017 Jul 5;8(1):159. doi: 10.1186/s13287-017-0603-5.

40.

A porcine ex vivo lung perfusion model with maximal argon exposure to attenuate ischemia-reperfusion injury.

Martens A, Ordies S, Vanaudenaerde BM, Verleden SE, Vos R, Verleden GM, Verbeken EK, Van Raemdonck DE, Claes S, Schols D, Chalopin M, Katz I, Farjot G, Neyrinck AP.

Med Gas Res. 2017 Mar 30;7(1):28-36. doi: 10.4103/2045-9912.202907. eCollection 2017 Jan-Mar.

41.

Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors.

Van Hout A, D'huys T, Oeyen M, Schols D, Van Loy T.

PLoS One. 2017 Apr 14;12(4):e0176057. doi: 10.1371/journal.pone.0176057. eCollection 2017.

42.

Synthesis and Ativiral Activity of 5-(Benzylthio)-4-carbamyl-1,2,3-triazoles Against Human Cytomegalovirus (CMV) and Varicella-zoster Virus (VZV).

Wen YN, Zhang ZF, Liu NN, Andrei G, Snoeck R, Xiang YH, Schols D, Chen X, Zhang ZY, Zhang QS, Wu QP.

Med Chem. 2017;13(5):453-464. doi: 10.2174/1573406413666170307165236.

PMID:
28290250
43.
44.
45.

Structure-activity relationship studies on a Trp dendrimer with dual activities against HIV and enterovirus A71. Modifications on the amino acid.

Martínez-Gualda B, Sun L, Rivero-Buceta E, Flores A, Quesada E, Balzarini J, Noppen S, Liekens S, Schols D, Neyts J, Leyssen P, Mirabelli C, Camarasa MJ, San-Félix A.

Antiviral Res. 2017 Mar;139:32-40. doi: 10.1016/j.antiviral.2016.12.010. Epub 2016 Dec 23.

46.

A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA).

Van Puyenbroeck V, Claeys E, Schols D, Bell TW, Vermeire K.

Mol Cell Proteomics. 2017 Feb;16(2):157-167. doi: 10.1074/mcp.M116.061051. Epub 2016 Dec 20.

47.

Design, Synthesis and Biological Evaluation of Novel Primaquine-Cinnamic Acid Conjugates of the Amide and Acylsemicarbazide Type.

Pavić K, Perković I, Gilja P, Kozlina F, Ester K, Kralj M, Schols D, Hadjipavlou-Litina D, Pontiki E, Zorc B.

Molecules. 2016 Nov 28;21(12). pii: E1629.

48.

Acyclic nucleoside phosphonates containing the amide bond.

Głowacka IE, Piotrowska DG, Andrei G, Schols D, Snoeck R, Wróblewski AE.

Monatsh Chem. 2016;147(12):2163-2177. Epub 2016 Oct 26.

49.

The lectin-like protein 1 in Lactobacillus rhamnosus GR-1 mediates tissue-specific adherence to vaginal epithelium and inhibits urogenital pathogens.

Petrova MI, Lievens E, Verhoeven TL, Macklaim JM, Gloor G, Schols D, Vanderleyden J, Reid G, Lebeer S.

Sci Rep. 2016 Nov 21;6:37437. doi: 10.1038/srep37437.

50.

High mannose-specific lectin Msl mediates key interactions of the vaginal Lactobacillus plantarum isolate CMPG5300.

Malik S, Petrova MI, Imholz NC, Verhoeven TL, Noppen S, Van Damme EJ, Liekens S, Balzarini J, Schols D, Vanderleyden J, Lebeer S.

Sci Rep. 2016 Nov 17;6:37339. doi: 10.1038/srep37339.

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