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Iron deficiency-induced loss of skeletal muscle mitochondrial proteins and respiratory capacity; the role of mitophagy and secretion of mitochondria-containing vesicles.

Leermakers PA, Remels AHV, Zonneveld MI, Rouschop KMA, Schols AMWJ, Gosker HR.

FASEB J. 2020 Mar 23. doi: 10.1096/fj.201901815R. [Epub ahead of print]


Recovery of muscle mass and muscle oxidative phenotype following disuse does not require GSK-3 inactivation.

Theeuwes WF, Pansters NAM, Gosker HR, Schols AMWJ, Verhees KJP, de Theije CC, van Gorp RHP, Kelders MCJM, Ronda O, Haegens A, Remels AHV, Langen RCJ.

Biochim Biophys Acta Mol Basis Dis. 2020 Feb 19;1866(6):165740. doi: 10.1016/j.bbadis.2020.165740. [Epub ahead of print]


Handgrip weakness, low fat-free mass, and overall survival in non-small cell lung cancer treated with curative-intent radiotherapy.

Burtin C, Bezuidenhout J, Sanders KJC, Dingemans AC, Schols AMWJ, Peeters STH, Spruit MA, De Ruysscher DKM.

J Cachexia Sarcopenia Muscle. 2020 Apr;11(2):424-431. doi: 10.1002/jcsm.12526. Epub 2020 Feb 11.


Resveratrol and metabolic health in COPD: A proof-of-concept randomized controlled trial.

Beijers RJ, Gosker HR, Sanders KJ, de Theije C, Kelders M, Clarke G, Cryan JF, van den Borst B, Schols AM.

Clin Nutr. 2020 Jan 13. pii: S0261-5614(20)30007-8. doi: 10.1016/j.clnu.2020.01.002. [Epub ahead of print]


Pulmonary inflammation-induced alterations in key regulators of mitophagy and mitochondrial biogenesis in murine skeletal muscle.

Leermakers PA, Remels AHV, Langen RCJ, Schols AMWJ, Gosker HR.

BMC Pulm Med. 2020 Jan 21;20(1):20. doi: 10.1186/s12890-020-1047-8.


Prediction model for tube feeding dependency during chemoradiotherapy for at least four weeks in head and neck cancer patients: A tool for prophylactic gastrostomy decision making.

Willemsen ACH, Kok A, van Kuijk SMJ, Baijens LWJ, de Bree R, Devriese LA, Hoebers FJP, Lalisang RI, Schols AMWJ, Terhaard CHJ, Hoeben A.

Clin Nutr. 2019 Dec 3. pii: S0261-5614(19)33160-7. doi: 10.1016/j.clnu.2019.11.033. [Epub ahead of print]


Identification of microRNAs in skeletal muscle associated with lung cancer cachexia.

van de Worp WRPH, Schols AMWJ, Dingemans AC, Op den Kamp CMH, Degens JHRJ, Kelders MCJM, Coort S, Woodruff HC, Kratassiouk G, Harel-Bellan A, Theys J, van Helvoort A, Langen RCJ.

J Cachexia Sarcopenia Muscle. 2020 Apr;11(2):452-463. doi: 10.1002/jcsm.12512. Epub 2019 Dec 11.


Regulation of PGC-1α expression by a GSK-3β-TFEB signaling axis in skeletal muscle.

Theeuwes WF, Gosker HR, Schols AMWJ, Langen RCJ, Remels AHV.

Biochim Biophys Acta Mol Cell Res. 2020 Feb;1867(2):118610. doi: 10.1016/j.bbamcr.2019.118610. Epub 2019 Nov 16.


Automated CT-derived skeletal muscle mass determination in lower hind limbs of mice using a 3D U-Net deep learning network.

van der Heyden B, van de Worp WRPH, van Helvoort A, Theys J, Schols AMWJ, Langen RCJ, Verhaegen F.

J Appl Physiol (1985). 2020 Jan 1;128(1):42-49. doi: 10.1152/japplphysiol.00465.2019. Epub 2019 Nov 7.


Disease-induced and treatment-induced alterations in body composition in locally advanced head and neck squamous cell carcinoma.

Willemsen ACH, Hoeben A, Lalisang RI, Van Helvoort A, Wesseling FWR, Hoebers F, Baijens LWJ, Schols AMWJ.

J Cachexia Sarcopenia Muscle. 2020 Feb;11(1):145-159. doi: 10.1002/jcsm.12487. Epub 2019 Sep 19.


Sarcopenia: A Time for Action. An SCWD Position Paper.

Bauer J, Morley JE, Schols AMWJ, Ferrucci L, Cruz-Jentoft AJ, Dent E, Baracos VE, Crawford JA, Doehner W, Heymsfield SB, Jatoi A, Kalantar-Zadeh K, Lainscak M, Landi F, Laviano A, Mancuso M, Muscaritoli M, Prado CM, Strasser F, von Haehling S, Coats AJS, Anker SD.

J Cachexia Sarcopenia Muscle. 2019 Oct;10(5):956-961. doi: 10.1002/jcsm.12483. Epub 2019 Sep 15.


Can radiomics help to predict skeletal muscle response to chemotherapy in stage IV non-small cell lung cancer?

de Jong EEC, Sanders KJC, Deist TM, van Elmpt W, Jochems A, van Timmeren JE, Leijenaar RTH, Degens JHRJ, Schols AMWJ, Dingemans AC, Lambin P.

Eur J Cancer. 2019 Oct;120:107-113. doi: 10.1016/j.ejca.2019.07.023. Epub 2019 Sep 9.


Skeletal muscle unloading results in increased mitophagy and decreased mitochondrial biogenesis regulation.

Leermakers PA, Kneppers AEM, Schols AMWJ, Kelders MCJM, de Theije CC, Verdijk LB, van Loon LJC, Langen RCJ, Gosker HR.

Muscle Nerve. 2019 Dec;60(6):769-778. doi: 10.1002/mus.26702. Epub 2019 Oct 23.


Network Analysis of Genome-Wide Association Studies for Chronic Obstructive Pulmonary Disease in the Context of Biological Pathways.

Mount S, Cirillo E, Stewart K, Coort S, Evelo CT, Wesselius A, Zeegers MP, Schols AMWJ.

Am J Respir Crit Care Med. 2019 Dec 1;200(11):1439-1441. doi: 10.1164/rccm.201904-0902LE. No abstract available.


Safety and Tolerability of Targeted Medical Nutrition for Cachexia in Non-Small-Cell Lung Cancer: A Randomized, Double-Blind, Controlled Pilot Trial.

Laviano A, Calder PC, Schols AMWJ, Lonnqvist F, Bech M, Muscaritoli M.

Nutr Cancer. 2020;72(3):439-450. doi: 10.1080/01635581.2019.1634746. Epub 2019 Jul 10.


A Nationwide Flash-Mob Study for Suspected Acute Coronary Syndrome.

Schols AMR, Willemsen RTA, Bonten TN, Rutten MH, Stassen PM, Kietselaer BLJH, Dinant GJ, Cals JWL.

Ann Fam Med. 2019 Jul;17(4):296-303. doi: 10.1370/afm.2401.


Impaired Skeletal Muscle Kynurenine Metabolism in Patients with Chronic Obstructive Pulmonary Disease.

Gosker HR, Clarke G, de Theije CC, Cryan JF, Schols AMWJ.

J Clin Med. 2019 Jun 26;8(7). pii: E915. doi: 10.3390/jcm8070915.


The prognostic value of early onset, CT derived loss of muscle and adipose tissue during chemotherapy in metastatic non-small cell lung cancer.

Degens JHRJ, Sanders KJC, de Jong EEC, Groen HJM, Smit EF, Aerts JG, Schols AMWJ, Dingemans AC.

Lung Cancer. 2019 Jul;133:130-135. doi: 10.1016/j.lungcan.2019.05.021. Epub 2019 May 20.


General practitioner use of D-dimer in suspected venous thromboembolism: historical cohort study in one geographical region in the Netherlands.

Schols AMR, Meijs E, Dinant GJ, Stoffers HEJH, Krekels MME, Cals JWL.

BMJ Open. 2019 May 28;9(5):e026846. doi: 10.1136/bmjopen-2018-026846.


Measuring successful aging: an exploratory factor analysis of the InCHIANTI Study into different health domains.

Mount S, Ferrucci L, Wesselius A, Zeegers MP, Schols AM.

Aging (Albany NY). 2019 May 24;11(10):3023-3040. doi: 10.18632/aging.101957.


Cross-sectional and longitudinal assessment of muscle from regular chest computed tomography scans: L1 and pectoralis muscle compared to L3 as reference in non-small cell lung cancer.

Sanders KJC, Degens JHRJ, Dingemans AC, Schols AMWJ.

Int J Chron Obstruct Pulmon Dis. 2019 Apr 3;14:781-789. doi: 10.2147/COPD.S194003. eCollection 2019.


Clinical outcome and cost-effectiveness of a 1-year nutritional intervention programme in COPD patients with low muscle mass: The randomized controlled NUTRAIN trial.

van Beers M, Rutten-van Mölken MPMH, van de Bool C, Boland M, Kremers SPJ, Franssen FME, van Helvoort A, Gosker HR, Wouters EF, Schols AMWJ.

Clin Nutr. 2020 Feb;39(2):405-413. doi: 10.1016/j.clnu.2019.03.001. Epub 2019 Mar 18.


Pulmonary rehabilitation, physical activity, respiratory failure and palliative respiratory care.

Spruit MA, Rochester CL, Pitta F, Kenn K, Schols AMWJ, Hart N, Wouters EFM, Nava S, Dreher M, Janssen DJA, Johnson MJ, Curtis RJ, Sastry M, Franssen FME.

Thorax. 2019 Jul;74(7):693-699. doi: 10.1136/thoraxjnl-2018-212044. Epub 2019 Mar 14.


Distinct skeletal muscle molecular responses to pulmonary rehabilitation in chronic obstructive pulmonary disease: a cluster analysis.

Kneppers AEM, Haast RAM, Langen RCJ, Verdijk LB, Leermakers PA, Gosker HR, van Loon LJC, Lainscak M, Schols AMWJ.

J Cachexia Sarcopenia Muscle. 2019 Apr;10(2):311-322. doi: 10.1002/jcsm.12370. Epub 2019 Jan 18.


[Carpal tunnel syndrome: a clinical diagnosis].

Schols AMR, Beekman R, Cals JWL, van Alfen N, Ottenheijm RPG.

Ned Tijdschr Geneeskd. 2018 Oct 12;162. pii: D2862. Dutch.


Factors Associated with Acceptability, Consideration and Intention of Uptake of Direct-To-Consumer Genetic Testing: A Survey Study.

Stewart KFJ, Kokole D, Wesselius A, Schols AMWJ, Zeegers MP, de Vries H, van Osch LADM.

Public Health Genomics. 2018;21(1-2):45-52. doi: 10.1159/000492960. Epub 2018 Oct 25.


Psychological co-morbidities in COPD: Targeting systemic inflammation, a benefit for both?

Pelgrim CE, Peterson JD, Gosker HR, Schols AMWJ, van Helvoort A, Garssen J, Folkerts G, Kraneveld AD.

Eur J Pharmacol. 2019 Jan 5;842:99-110. doi: 10.1016/j.ejphar.2018.10.001. Epub 2018 Oct 15. Review.


Molecular signalling towards mitochondrial breakdown is enhanced in skeletal muscle of patients with chronic obstructive pulmonary disease (COPD).

Leermakers PA, Schols AMWJ, Kneppers AEM, Kelders MCJM, de Theije CC, Lainscak M, Gosker HR.

Sci Rep. 2018 Oct 9;8(1):15007. doi: 10.1038/s41598-018-33471-2.


Cognitive impairment in chronic obstructive pulmonary disease: disease burden, determinants and possible future interventions.

van Beers M, Janssen DJA, Gosker HR, Schols AMWJ.

Expert Rev Respir Med. 2018 Dec;12(12):1061-1074. doi: 10.1080/17476348.2018.1533405. Epub 2018 Oct 14. Review.


The "Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies" (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants.

Marzetti E, Cesari M, Calvani R, Msihid J, Tosato M, Rodriguez-Mañas L, Lattanzio F, Cherubini A, Bejuit R, Di Bari M, Maggio M, Vellas B, Dantoine T, Cruz-Jentoft AJ, Sieber CC, Freiberger E, Skalska A, Grodzicki T, Sinclair AJ, Topinkova E, Rýznarová I, Strandberg T, Schols AMWJ, Schols JMGA, Roller-Wirnsberger R, Jónsson PV, Ramel A, Del Signore S, Pahor M, Roubenoff R, Bernabei R, Landi F; SPRINTT Consortium.

Exp Gerontol. 2018 Nov;113:48-57. doi: 10.1016/j.exger.2018.09.017. Epub 2018 Sep 24.


Strength exercises during physical education classes in secondary schools improve body composition: a cluster randomized controlled trial.

Ten Hoor GA, Rutten GM, Van Breukelen GJP, Kok G, Ruiter RAC, Meijer K, Kremers SPJ, Feron FJM, Crutzen R, Schols AMJW, Plasqui G.

Int J Behav Nutr Phys Act. 2018 Sep 25;15(1):92. doi: 10.1186/s12966-018-0727-8.


Hypoxia impairs adaptation of skeletal muscle protein turnover- and AMPK signaling during fasting-induced muscle atrophy.

de Theije CC, Schols AMWJ, Lamers WH, Neumann D, Köhler SE, Langen RCJ.

PLoS One. 2018 Sep 13;13(9):e0203630. doi: 10.1371/journal.pone.0203630. eCollection 2018.


Whole body protein anabolism in COPD patients and healthy older adults is not enhanced by adding either carbohydrates or leucine to a serving of protein.

Jonker R, Deutz NEP, Schols AMWJ, Veley EA, Harrykissoon R, Zachria AJ, Engelen MPKJ.

Clin Nutr. 2019 Aug;38(4):1684-1691. doi: 10.1016/j.clnu.2018.08.006. Epub 2018 Aug 16.


Coordinated regulation of skeletal muscle mass and metabolic plasticity during recovery from disuse.

Kneppers A, Leermakers P, Pansters N, Backx E, Gosker H, van Loon L, Schols A, Langen R, Verdijk L.

FASEB J. 2019 Jan;33(1):1288-1298. doi: 10.1096/fj.201701403RRR. Epub 2018 Aug 22.


CT-derived muscle remodelling after bronchoscopic lung volume reduction in advanced emphysema.

Sanders KJC, Klooster K, Vanfleteren LEGW, Slebos DJ, Schols AMWJ.

Thorax. 2019 Feb;74(2):206-207. doi: 10.1136/thoraxjnl-2018-211931. Epub 2018 Aug 12.


Point-of-care testing in general practice: just what the doctor ordered?

Schols AM, Dinant GJ, Cals JW.

Br J Gen Pract. 2018 Aug;68(673):362-363. doi: 10.3399/bjgp18X698033. No abstract available.


Altered protein turnover signaling and myogenesis during impaired recovery of inflammation-induced muscle atrophy in emphysematous mice.

Ceelen JJM, Schols AMWJ, Kneppers AEM, Rosenbrand RPHA, Drożdż MM, van Hoof SJ, de Theije CC, Kelders MCJM, Verhaegen F, Langen RCJ.

Sci Rep. 2018 Jul 17;8(1):10761. doi: 10.1038/s41598-018-28579-4.


Inactivation of glycogen synthase kinase 3β (GSK-3β) enhances mitochondrial biogenesis during myogenesis.

Theeuwes WF, Gosker HR, Langen RCJ, Pansters NAM, Schols AMWJ, Remels AHV.

Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2913-2926. doi: 10.1016/j.bbadis.2018.06.002. Epub 2018 Jun 6.


Pulmonary inflammation-induced loss and subsequent recovery of skeletal muscle mass require functional poly-ubiquitin conjugation.

Ceelen JJM, Schols AMWJ, Thielen NGM, Haegens A, Gray DA, Kelders MCJM, de Theije CC, Langen RCJ.

Respir Res. 2018 May 2;19(1):80. doi: 10.1186/s12931-018-0753-8.


Stages of behavioural change after direct-to-consumer disease risk profiling: study protocol of two integrated controlled pragmatic trials.

Stewart KFJ, Wesselius A, Schols AMWJ, Zeegers MP.

Trials. 2018 Apr 19;19(1):240. doi: 10.1186/s13063-018-2630-7.


A Benefit of Being Heavier Is Being Strong: a Cross-Sectional Study in Young Adults.

Ten Hoor GA, Plasqui G, Schols AMWJ, Kok G.

Sports Med Open. 2018 Mar 1;4(1):12. doi: 10.1186/s40798-018-0125-4.


A novel in vitro model for the assessment of postnatal myonuclear accretion.

Kneppers A, Verdijk L, de Theije C, Corten M, Gielen E, van Loon L, Schols A, Langen R.

Skelet Muscle. 2018 Feb 14;8(1):4. doi: 10.1186/s13395-018-0151-4.


International definition of a point-of-care test in family practice: a modified e-Delphi procedure.

Schols AMR, Dinant GJ, Hopstaken R, Price CP, Kusters R, Cals JWL.

Fam Pract. 2018 Jul 23;35(4):475-480. doi: 10.1093/fampra/cmx134.


Development, Implementation, and Evaluation of an Interdisciplinary Theory- and Evidence-Based Intervention to Prevent Childhood Obesity: Theoretical and Methodological Lessons Learned.

Ten Hoor GA, Plasqui G, Schols AMWJ, Kok G.

Front Public Health. 2017 Dec 22;5:352. doi: 10.3389/fpubh.2017.00352. eCollection 2017. Review.


Correction to: Behavioural changes, sharing behaviour and psychological responses after receiving direct-to-consumer genetic test results:a systematic review and meta-analysis.

Stewart KFJ, Wesselius A, Schreurs MAC, Schols AMWJ, Zeegers MP.

J Community Genet. 2019 Apr;10(2):321. doi: 10.1007/s12687-017-0353-1.


Alterations in the in vitro and in vivo regulation of muscle regeneration in healthy ageing and the influence of sarcopenia.

Brzeszczyńska J, Meyer A, McGregor R, Schilb A, Degen S, Tadini V, Johns N, Langen R, Schols A, Glass DJ, Roubenoff R, Ross JA, Fearon KCH, Greig CA, Jacobi C.

J Cachexia Sarcopenia Muscle. 2018 Feb;9(1):93-105. doi: 10.1002/jcsm.12252. Epub 2017 Dec 6.


Resveratrol for patients with chronic obstructive pulmonary disease: hype or hope?

Beijers RJHCG, Gosker HR, Schols AMWJ.

Curr Opin Clin Nutr Metab Care. 2018 Mar;21(2):138-144. doi: 10.1097/MCO.0000000000000444. Review.


The effect of acute and 7-days dietary nitrate on mechanical efficiency, exercise performance and cardiac biomarkers in patients with chronic obstructive pulmonary disease.

Beijers RJHCG, Huysmans SMD, van de Bool C, Kingma BRM, Verdijk LB, van Loon LJC, Meex SJR, Gosker HR, Schols AMWJ.

Clin Nutr. 2018 Dec;37(6 Pt A):1852-1861. doi: 10.1016/j.clnu.2017.10.011. Epub 2017 Oct 31.


Glucocorticoid Receptor Signaling Impairs Protein Turnover Regulation in Hypoxia-Induced Muscle Atrophy in Male Mice.

de Theije CC, Schols AMWJ, Lamers WH, Ceelen JJM, van Gorp RH, Hermans JJR, Köhler SE, Langen RCJ.

Endocrinology. 2018 Jan 1;159(1):519-534. doi: 10.1210/en.2017-00603.


Imaging in metabolic research: challenges and opportunities.

Schrauwen-Hinderling VB, Schols AMWJ.

J Appl Physiol (1985). 2018 Jan 1;124(1):jap009062017. doi: 10.1152/japplphysiol.00906.2017. Epub 2017 Oct 12. No abstract available.

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