Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 74

1.

5-Amino-1-β-D-Ribofuranosyl-Imidazole-4-Carboxamide (AICAR) Reduces Peripheral Inflammation by Macrophage Phenotype Shift.

Martin LM, Möller M, Weiss U, Russe OQ, Scholich K, Pierre S, Geisslinger G, Niederberger E.

Int J Mol Sci. 2019 Jul 2;20(13). pii: E3255. doi: 10.3390/ijms20133255.

2.

Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase.

Schwiebs A, Herrero San Juan M, Schmidt KG, Wiercinska E, Anlauf M, Ottenlinger F, Thomas D, Elwakeel E, Weigert A, Farin HF, Bonig H, Scholich K, Geisslinger G, Pfeilschifter JM, Radeke HH.

Oncogene. 2019 Jun;38(24):4788-4803. doi: 10.1038/s41388-019-0758-x. Epub 2019 Feb 28.

PMID:
30816345
3.

Thromboxane-Induced α-CGRP Release from Peripheral Neurons Is an Essential Positive Feedback Loop in Capsaicin-Induced Neurogenic Inflammation.

Tarighi N, Menger D, Pierre S, Kornstädt L, Thomas D, Ferreirós N, Nüsing RM, Geisslinger G, Scholich K.

J Invest Dermatol. 2019 Mar;139(3):656-664. doi: 10.1016/j.jid.2018.10.011. Epub 2018 Oct 26.

PMID:
30612974
4.

The G2A Receptor Controls Polarization of Macrophage by Determining Their Localization Within the Inflamed Tissue.

Kern K, Schäfer SMG, Cohnen J, Pierre S, Osthues T, Tarighi N, Hohmann S, Ferreiros N, Brüne B, Weigert A, Geisslinger G, Sisignano M, Scholich K.

Front Immunol. 2018 Oct 1;9:2261. doi: 10.3389/fimmu.2018.02261. eCollection 2018.

5.

The prostaglandin E2 receptor EP3 controls CC-chemokine ligand 2-mediated neuropathic pain induced by mechanical nerve damage.

Treutlein EM, Kern K, Weigert A, Tarighi N, Schuh CD, Nüsing RM, Schreiber Y, Ferreirós N, Brüne B, Geisslinger G, Pierre S, Scholich K.

J Biol Chem. 2018 Jun 22;293(25):9685-9695. doi: 10.1074/jbc.RA118.002492. Epub 2018 May 11.

6.

The oxidized linoleic acid metabolite 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain.

Zimmer B, Angioni C, Osthues T, Toewe A, Thomas D, Pierre SC, Geisslinger G, Scholich K, Sisignano M.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Jul;1863(7):669-678. doi: 10.1016/j.bbalip.2018.03.012. Epub 2018 Apr 4.

PMID:
29625231
7.

Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment.

Mertens C, Mora J, Ören B, Grein S, Winslow S, Scholich K, Weigert A, Malmström P, Forsare C, Fernö M, Schmid T, Brüne B, Jung M.

Oncoimmunology. 2017 Dec 22;7(3):e1408751. doi: 10.1080/2162402X.2017.1408751. eCollection 2018.

8.

20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1.

Tunaru S, Bonnavion R, Brandenburger I, Preussner J, Thomas D, Scholich K, Offermanns S.

Nat Commun. 2018 Jan 12;9(1):177. doi: 10.1038/s41467-017-02539-4.

9.

Myc binding protein 2 suppresses M2-like phenotypes in macrophages during zymosan-induced inflammation in mice.

Pierre S, Zhang DD, Suo J, Kern K, Tarighi N, Scholich K.

Eur J Immunol. 2018 Feb;48(2):239-249. doi: 10.1002/eji.201747129. Epub 2017 Nov 10.

10.

S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β.

Weichand B, Popp R, Dziumbla S, Mora J, Strack E, Elwakeel E, Frank AC, Scholich K, Pierre S, Syed SN, Olesch C, Ringleb J, Ören B, Döring C, Savai R, Jung M, von Knethen A, Levkau B, Fleming I, Weigert A, Brüne B.

J Exp Med. 2017 Sep 4;214(9):2695-2713. doi: 10.1084/jem.20160392. Epub 2017 Jul 24.

11.

CXCL16/CXCR6-mediated adhesion of human peripheral blood mononuclear cells to inflamed endothelium.

Linke B, Meyer Dos Santos S, Picard-Willems B, Keese M, Harder S, Geisslinger G, Scholich K.

Cytokine. 2019 Oct;122:154081. doi: 10.1016/j.cyto.2017.06.008. Epub 2017 Jun 21.

PMID:
28647282
12.

Activated Platelets Induce an Anti-Inflammatory Response of Monocytes/Macrophages through Cross-Regulation of PGE2 and Cytokines.

Linke B, Schreiber Y, Picard-Willems B, Slattery P, Nüsing RM, Harder S, Geisslinger G, Scholich K.

Mediators Inflamm. 2017;2017:1463216. doi: 10.1155/2017/1463216. Epub 2017 May 16.

13.

CD200 selectively upregulates prostaglandin E2 and D2 synthesis in LPS-treated bone marrow-derived macrophages.

Kern K, Pierre S, Schreiber Y, Angioni C, Thomas D, Ferreirós N, Geisslinger G, Scholich K.

Prostaglandins Other Lipid Mediat. 2017 Nov;133:53-59. doi: 10.1016/j.prostaglandins.2017.06.002. Epub 2017 Jun 3.

PMID:
28583890
14.

Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis.

Schmitz K, Brunkhorst R, de Bruin N, Mayer CA, Häussler A, Ferreiros N, Schiffmann S, Parnham MJ, Tunaru S, Chun J, Offermanns S, Foerch C, Scholich K, Vogt J, Wicker S, Lötsch J, Geisslinger G, Tegeder I.

Acta Neuropathol Commun. 2017 Jun 2;5(1):42. doi: 10.1186/s40478-017-0446-4.

15.

Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity.

Oertel S, Scholich K, Weigert A, Thomas D, Schmetzer J, Trautmann S, Wegner MS, Radeke HH, Filmann N, Brüne B, Geisslinger G, Tegeder I, Grösch S.

Cell Mol Life Sci. 2017 Aug;74(16):3039-3055. doi: 10.1007/s00018-017-2518-9. Epub 2017 Apr 12.

PMID:
28405720
16.

The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity.

Hohmann SW, Angioni C, Tunaru S, Lee S, Woolf CJ, Offermanns S, Geisslinger G, Scholich K, Sisignano M.

Sci Rep. 2017 Mar 27;7(1):446. doi: 10.1038/s41598-017-00591-0.

17.

The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons.

Zinn S, Sisignano M, Kern K, Pierre S, Tunaru S, Jordan H, Suo J, Treutlein EM, Angioni C, Ferreiros N, Leffler A, DeBruin N, Offermanns S, Geisslinger G, Scholich K.

J Biol Chem. 2017 Apr 14;292(15):6123-6134. doi: 10.1074/jbc.M116.769125. Epub 2017 Feb 27.

18.

GPVI and Thromboxane Receptor on Platelets Promote Proinflammatory Macrophage Phenotypes during Cutaneous Inflammation.

Pierre S, Linke B, Suo J, Tarighi N, Del Turco D, Thomas D, Ferreiros N, Stegner D, Frölich S, Sisignano M, Meyer Dos Santos S, deBruin N, Nüsing RM, Deller T, Nieswandt B, Geisslinger G, Scholich K.

J Invest Dermatol. 2017 Mar;137(3):686-695. doi: 10.1016/j.jid.2016.09.036. Epub 2016 Nov 3.

19.

Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain.

Sisignano M, Angioni C, Park CK, Meyer Dos Santos S, Jordan H, Kuzikov M, Liu D, Zinn S, Hohman SW, Schreiber Y, Zimmer B, Schmidt M, Lu R, Suo J, Zhang DD, Schäfer SM, Hofmann M, Yekkirala AS, de Bruin N, Parnham MJ, Woolf CJ, Ji RR, Scholich K, Geisslinger G.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12544-12549. Epub 2016 Oct 17.

20.

Islet-Expressed CXCL10 Promotes Autoimmune Destruction of Islet Isografts in Mice With Type 1 Diabetes.

Bender C, Christen S, Scholich K, Bayer M, Pfeilschifter JM, Hintermann E, Christen U.

Diabetes. 2017 Jan;66(1):113-126. doi: 10.2337/db16-0547. Epub 2016 Oct 26.

21.

Sphingosine-1-phosphate receptor inhibition prevents denervation-induced dendritic atrophy.

Willems LM, Zahn N, Ferreirós N, Scholich K, Maggio N, Deller T, Vlachos A.

Acta Neuropathol Commun. 2016 Mar 31;4:28. doi: 10.1186/s40478-016-0303-x.

22.

In Vivo Availability of Pro-Resolving Lipid Mediators in Oxazolone Induced Dermal Inflammation in the Mouse.

Homann J, Suo J, Schmidt M, de Bruin N, Scholich K, Geisslinger G, Ferreirós N.

PLoS One. 2015 Nov 23;10(11):e0143141. doi: 10.1371/journal.pone.0143141. eCollection 2015.

23.

MYCBP2 Is a Guanosine Exchange Factor for Ran Protein and Determines Its Localization in Neurons of Dorsal Root Ganglia.

Dörr A, Pierre S, Zhang DD, Henke M, Holland S, Scholich K.

J Biol Chem. 2015 Oct 16;290(42):25620-35. doi: 10.1074/jbc.M115.646901. Epub 2015 Aug 24.

24.

Platelets from flowing blood attach to the inflammatory chemokine CXCL16 expressed in the endothelium of the human vessel wall.

Meyer Dos Santos S, Blankenbach K, Scholich K, Dörr A, Monsefi N, Keese M, Linke B, Deckmyn H, Nelson K, Harder S.

Thromb Haemost. 2015 Aug;114(2):297-312. doi: 10.1160/TH14-11-0911. Epub 2015 Apr 23.

PMID:
25904061
25.

Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors.

Zhang DD, Linke B, Suo J, Zivkovic A, Schreiber Y, Ferreirós N, Henke M, Geisslinger G, Stark H, Scholich K.

Biol Chem. 2015 Jun;396(6-7):783-94. doi: 10.1515/hsz-2014-0276.

PMID:
25720064
26.

Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain.

Sisignano M, Baron R, Scholich K, Geisslinger G.

Nat Rev Neurol. 2014 Dec;10(12):694-707. doi: 10.1038/nrneurol.2014.211. Epub 2014 Nov 4. Review.

PMID:
25366108
27.

Nano-LC-MS/MS for the quantitation of prostanoids in immune cells.

Thomas D, Suo J, Ulshöfer T, Jordan H, de Bruin N, Scholich K, Geisslinger G, Ferreirós N.

Anal Bioanal Chem. 2014 Nov;406(28):7103-16. doi: 10.1007/s00216-014-8134-8. Epub 2014 Sep 6.

PMID:
25192790
28.

Neutrophils mediate edema formation but not mechanical allodynia during zymosan-induced inflammation.

Suo J, Linke B, Meyer dos Santos S, Pierre S, Stegner D, Zhang DD, Denis CV, Geisslinger G, Nieswandt B, Scholich K.

J Leukoc Biol. 2014 Jul;96(1):133-42. doi: 10.1189/jlb.3A1213-628R. Epub 2014 Feb 20.

PMID:
24555986
29.

The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.

30.

PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis.

Schiffmann S, Weigert A, Männich J, Eberle M, Birod K, Häussler A, Ferreiros N, Schreiber Y, Kunkel H, Grez M, Weichand B, Brüne B, Pfeilschifter W, Nüsing R, Niederberger E, Grösch S, Scholich K, Geisslinger G.

Biochem Pharmacol. 2014 Feb 15;87(4):625-35. doi: 10.1016/j.bcp.2013.12.006. Epub 2013 Dec 16.

PMID:
24355567
31.

Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice.

Sisignano M, Angioni C, Ferreiros N, Schuh CD, Suo J, Schreiber Y, Dawes JM, Antunes-Martins A, Bennett DL, McMahon SB, Geisslinger G, Scholich K.

PLoS One. 2013 Dec 9;8(12):e81228. doi: 10.1371/journal.pone.0081228. eCollection 2013.

32.

Prostacyclin mediates neuropathic pain through interleukin 1β-expressing resident macrophages.

Schuh CD, Pierre S, Weigert A, Weichand B, Altenrath K, Schreiber Y, Ferreiros N, Zhang DD, Suo J, Treutlein EM, Henke M, Kunkel H, Grez M, Nüsing R, Brüne B, Geisslinger G, Scholich K.

Pain. 2014 Mar;155(3):545-55. doi: 10.1016/j.pain.2013.12.006. Epub 2013 Dec 11.

PMID:
24333781
33.

TRP-channels as key integrators of lipid pathways in nociceptive neurons.

Sisignano M, Bennett DL, Geisslinger G, Scholich K.

Prog Lipid Res. 2014 Jan;53:93-107. doi: 10.1016/j.plipres.2013.11.002. Epub 2013 Nov 25. Review.

PMID:
24287369
34.

Prostacyclin regulates spinal nociceptive processing through cyclic adenosine monophosphate-induced translocation of glutamate receptors.

Schuh CD, Brenneis C, Zhang DD, Angioni C, Schreiber Y, Ferreiros-Bouzas N, Pierre S, Henke M, Linke B, Nüsing R, Scholich K, Geisslinger G.

Anesthesiology. 2014 Feb;120(2):447-58. doi: 10.1097/ALN.0b013e3182a76f74.

PMID:
23969560
35.

Overdose of the histamine H₃ inverse agonist pitolisant increases thermal pain thresholds.

Zhang DD, Sisignano M, Schuh CD, Sander K, Stark H, Scholich K.

Inflamm Res. 2012 Nov;61(11):1283-91. doi: 10.1007/s00011-012-0528-5. Epub 2012 Jul 21.

PMID:
22820944
36.

Analysis of sphingolipid and prostaglandin synthesis during zymosan-induced inflammation.

Linke B, Schreiber Y, Zhang DD, Pierre S, Coste O, Henke M, Suo J, Fuchs J, Angioni C, Ferreiros-Bouzas N, Geisslinger G, Scholich K.

Prostaglandins Other Lipid Mediat. 2012 Oct;99(1-2):15-23. doi: 10.1016/j.prostaglandins.2012.06.002. Epub 2012 Jun 23.

PMID:
22732087
37.

Lack of microsomal prostaglandin E(2) synthase-1 in bone marrow-derived myeloid cells impairs left ventricular function and increases mortality after acute myocardial infarction.

Degousee N, Simpson J, Fazel S, Scholich K, Angoulvant D, Angioni C, Schmidt H, Korotkova M, Stefanski E, Wang XH, Lindsay TF, Ofek E, Pierre S, Butany J, Jakobsson PJ, Keating A, Li RK, Nahrendorf M, Geisslinger G, Backx PH, Rubin BB.

Circulation. 2012 Jun 12;125(23):2904-13. doi: 10.1161/CIRCULATIONAHA.112.099754. Epub 2012 May 15.

PMID:
22589381
38.

5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals.

Sisignano M, Park CK, Angioni C, Zhang DD, von Hehn C, Cobos EJ, Ghasemlou N, Xu ZZ, Kumaran V, Lu R, Grant A, Fischer MJ, Schmidtko A, Reeh P, Ji RR, Woolf CJ, Geisslinger G, Scholich K, Brenneis C.

J Neurosci. 2012 May 2;32(18):6364-72. doi: 10.1523/JNEUROSCI.5793-11.2012.

39.

Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis.

Schiffmann S, Ferreiros N, Birod K, Eberle M, Schreiber Y, Pfeilschifter W, Ziemann U, Pierre S, Scholich K, Grösch S, Geisslinger G.

J Immunol. 2012 Jun 1;188(11):5723-33. doi: 10.4049/jimmunol.1103109. Epub 2012 Apr 27.

40.

Regulation of neuronal functions by the E3-ubiquitinligase protein associated with MYC (MYCBP2).

Holland S, Scholich K.

Commun Integr Biol. 2011 Sep;4(5):513-5. doi: 10.4161/cib.4.5.15967. Epub 2011 Sep 1.

41.

Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation.

Brenneis C, Sisignano M, Coste O, Altenrath K, Fischer MJ, Angioni C, Fleming I, Brandes RP, Reeh PW, Woolf CJ, Geisslinger G, Scholich K.

Mol Pain. 2011 Oct 4;7:78. doi: 10.1186/1744-8069-7-78.

42.

The CX3C chemokine fractalkine mediates platelet adhesion via the von Willebrand receptor glycoprotein Ib.

Meyer dos Santos S, Klinkhardt U, Scholich K, Nelson K, Monsefi N, Deckmyn H, Kuczka K, Zorn A, Harder S.

Blood. 2011 May 5;117(18):4999-5008. doi: 10.1182/blood-2011-02-335471. Epub 2011 Mar 11.

PMID:
21398580
43.

The ubiquitin ligase MYCBP2 regulates transient receptor potential vanilloid receptor 1 (TRPV1) internalization through inhibition of p38 MAPK signaling.

Holland S, Coste O, Zhang DD, Pierre SC, Geisslinger G, Scholich K.

J Biol Chem. 2011 Feb 4;286(5):3671-80. doi: 10.1074/jbc.M110.154765. Epub 2010 Nov 23.

44.

Anti-inflammatory role of microsomal prostaglandin E synthase-1 in a model of neuroinflammation.

Brenneis C, Coste O, Altenrath K, Angioni C, Schmidt H, Schuh CD, Zhang DD, Henke M, Weigert A, Brüne B, Rubin B, Nusing R, Scholich K, Geisslinger G.

J Biol Chem. 2011 Jan 21;286(3):2331-42. doi: 10.1074/jbc.M110.157362. Epub 2010 Nov 12.

45.

Toponomics: studying protein-protein interactions and protein networks in intact tissue.

Pierre S, Scholich K.

Mol Biosyst. 2010 Apr;6(4):641-7. doi: 10.1039/b910653g. Epub 2010 Jan 12. Review.

PMID:
20237641
46.

Toponomics analysis of drug-induced changes in arachidonic acid-dependent signaling pathways during spinal nociceptive processing.

Linke B, Pierre S, Coste O, Angioni C, Becker W, Maier TJ, Steinhilber D, Wittpoth C, Geisslinger G, Scholich K.

J Proteome Res. 2009 Oct;8(10):4851-9. doi: 10.1021/pr900106v.

PMID:
19697962
47.

Capturing adenylyl cyclases as potential drug targets.

Pierre S, Eschenhagen T, Geisslinger G, Scholich K.

Nat Rev Drug Discov. 2009 Apr;8(4):321-35. doi: 10.1038/nrd2827. Review.

PMID:
19337273
48.

A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain.

Oertel BG, Kettner M, Scholich K, Renné C, Roskam B, Geisslinger G, Schmidt PH, Lötsch J.

J Biol Chem. 2009 Mar 6;284(10):6530-5. doi: 10.1074/jbc.M807030200. Epub 2008 Dec 30.

49.

Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM.

Maeurer C, Holland S, Pierre S, Potstada W, Scholich K.

Cell Signal. 2009 Feb;21(2):293-300. doi: 10.1016/j.cellsig.2008.10.016. Epub 2008 Oct 30.

PMID:
19000755
50.

Sphingosine 1-phosphate modulates spinal nociceptive processing.

Coste O, Brenneis C, Linke B, Pierre S, Maeurer C, Becker W, Schmidt H, Gao W, Geisslinger G, Scholich K.

J Biol Chem. 2008 Nov 21;283(47):32442-51. doi: 10.1074/jbc.M806410200. Epub 2008 Sep 19.

Supplemental Content

Loading ...
Support Center