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Rethinking Lupus Nephritis Classification on a Molecular Level.

Almaani S, Prokopec SD, Zhang J, Yu L, Avila-Casado C, Wither J, Scholey JW, Alberton V, Malvar A, Parikh SV, Boutros PC, Rovin BH, Reich HN.

J Clin Med. 2019 Sep 23;8(10). pii: E1524. doi: 10.3390/jcm8101524.


Olmesartan Attenuates Kidney Fibrosis in a Murine Model of Alport Syndrome by Suppressing Tubular Expression of TGFβ.

Suh SH, Choi HS, Kim CS, Kim IJ, Ma SK, Scholey JW, Kim SW, Bae EH.

Int J Mol Sci. 2019 Aug 6;20(15). pii: E3843. doi: 10.3390/ijms20153843.


B-Cell Deficiency Lowers Blood Pressure in Mice.

Dingwell LS, Shikatani EA, Besla R, Levy AS, Dinh DD, Momen A, Zhang H, Afroze T, Chen MB, Chiu F, Simmons CA, Billia F, Gommerman JL, John R, Heximer S, Scholey JW, Bolz SS, Robbins CS, Husain M.

Hypertension. 2019 Mar;73(3):561-570. doi: 10.1161/HYPERTENSIONAHA.118.11828.


Social Determinants of Health Are Associated with Markers of Renal Injury in Adolescents with Type 1 Diabetes.

Cummings LAM, Clarke A, Sochett E, Daneman D, Cherney DZ, Reich HN, Scholey JW, Dunger DB, Mahmud FH.

J Pediatr. 2018 Jul;198:247-253.e1. doi: 10.1016/j.jpeds.2018.03.030. Epub 2018 May 8.


Nrf2 Deficiency Upregulates Intrarenal Angiotensin-Converting Enzyme-2 and Angiotensin 1-7 Receptor Expression and Attenuates Hypertension and Nephropathy in Diabetic Mice.

Zhao S, Ghosh A, Lo CS, Chenier I, Scholey JW, Filep JG, Ingelfinger JR, Zhang SL, Chan JSD.

Endocrinology. 2018 Feb 1;159(2):836-852. doi: 10.1210/en.2017-00752.


Angiotensin-converting enzyme 2 and renal disease.

Williams VR, Scholey JW.

Curr Opin Nephrol Hypertens. 2018 Jan;27(1):35-41. doi: 10.1097/MNH.0000000000000378. Review.


Murine recombinant angiotensin-converting enzyme 2 attenuates kidney injury in experimental Alport syndrome.

Bae EH, Fang F, Williams VR, Konvalinka A, Zhou X, Patel VB, Song X, John R, Oudit GY, Pei Y, Scholey JW.

Kidney Int. 2017 Jun;91(6):1347-1361. doi: 10.1016/j.kint.2016.12.022. Epub 2017 Feb 27.


Cloudy urine in the postpartum period.

Ward FL, Scholey JW.

Kidney Int. 2017 Mar;91(3):760. doi: 10.1016/j.kint.2016.09.034. No abstract available.


Insights into Diabetic Kidney Disease Using Urinary Proteomics and Bioinformatics.

Van JA, Scholey JW, Konvalinka A.

J Am Soc Nephrol. 2017 Apr;28(4):1050-1061. doi: 10.1681/ASN.2016091018. Epub 2017 Feb 3. Review.


Stable Isotope Labeling with Amino Acids (SILAC)-Based Proteomics of Primary Human Kidney Cells Reveals a Novel Link between Male Sex Hormones and Impaired Energy Metabolism in Diabetic Kidney Disease.

Clotet S, Soler MJ, Riera M, Pascual J, Fang F, Zhou J, Batruch I, Vasiliou SK, Dimitromanolakis A, Barrios C, Diamandis EP, Scholey JW, Konvalinka A.

Mol Cell Proteomics. 2017 Mar;16(3):368-385. doi: 10.1074/mcp.M116.061903. Epub 2017 Jan 4.


Influence of sex on hyperfiltration in patients with uncomplicated type 1 diabetes.

Škrtić M, Lytvyn Y, Bjornstad P, Reich HN, Scholey JW, Yip P, Sochett EB, Perkins B, Cherney DZ.

Am J Physiol Renal Physiol. 2017 Apr 1;312(4):F599-F606. doi: 10.1152/ajprenal.00357.2016. Epub 2016 Dec 28.


Assessment of urinary microparticles in normotensive patients with type 1 diabetes.

Lytvyn Y, Xiao F, Kennedy CR, Perkins BA, Reich HN, Scholey JW, Cherney DZ, Burger D.

Diabetologia. 2017 Mar;60(3):581-584. doi: 10.1007/s00125-016-4190-2. Epub 2016 Dec 21.


The relationship between urinary renin-angiotensin system markers, renal function, and blood pressure in adolescents with type 1 diabetes.

Burns KD, Lytvyn Y, Mahmud FH, Daneman D, Deda L, Dunger DB, Deanfield J, Dalton RN, Elia Y, Har R, Van JA, Bradley TJ, Slorach C, Hui W, Xiao F, Zimpelmann J, Mertens L, Moineddin R, Reich HN, Sochett E, Scholey JW, Cherney DZ.

Am J Physiol Renal Physiol. 2017 Feb 1;312(2):F335-F342. doi: 10.1152/ajprenal.00438.2016. Epub 2016 Oct 12.


Quantification of angiotensin II-regulated proteins in urine of patients with polycystic and other chronic kidney diseases by selected reaction monitoring.

Konvalinka A, Batruch I, Tokar T, Dimitromanolakis A, Reid S, Song X, Pei Y, Drabovich AP, Diamandis EP, Jurisica I, Scholey JW.

Clin Proteomics. 2016 Aug 5;13:16. doi: 10.1186/s12014-016-9117-x. eCollection 2016.


Chronology of mitochondrial and cellular events during skeletal muscle ischemia-reperfusion.

Paradis S, Charles AL, Meyer A, Lejay A, Scholey JW, Chakfé N, Zoll J, Geny B.

Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C968-82. doi: 10.1152/ajpcell.00356.2015. Epub 2016 Apr 13. Review.


Association Between Plasma Uric Acid Levels and Cardiorenal Function in Adolescents With Type 1 Diabetes.

Lytvyn Y, Mahmud FH, Daneman D, Deda L, Dunger DB, Deanfield J, Dalton RN, Elia Y, Har R, Bradley TJ, Slorach C, Hui W, Moineddin R, Reich HN, Scholey JW, Mertens L, Sochett E, Cherney DZ.

Diabetes Care. 2016 Apr;39(4):611-6. doi: 10.2337/dc15-2345. Epub 2016 Feb 19.


Early changes in cardiovascular structure and function in adolescents with type 1 diabetes.

Bradley TJ, Slorach C, Mahmud FH, Dunger DB, Deanfield J, Deda L, Elia Y, Har RL, Hui W, Moineddin R, Reich HN, Scholey JW, Mertens L, Sochett E, Cherney DZ.

Cardiovasc Diabetol. 2016 Feb 16;15:31. doi: 10.1186/s12933-016-0351-3.


Recombinant N-Terminal Slit2 Inhibits TGF-β-Induced Fibroblast Activation and Renal Fibrosis.

Yuen DA, Huang YW, Liu GY, Patel S, Fang F, Zhou J, Thai K, Sidiqi A, Szeto SG, Chan L, Lu M, He X, John R, Gilbert RE, Scholey JW, Robinson LA.

J Am Soc Nephrol. 2016 Sep;27(9):2609-15. doi: 10.1681/ASN.2015040356. Epub 2016 Feb 11.


The urinary inflammatory profile in gluten free diet-adherent adolescents with type 1 diabetes and celiac disease.

De Melo EN, Deda L, Har R, Reich HN, Scholey JW, Daneman D, Moineddin R, Motran L, Elia Y, Cherney DZ, Sochett EB, Mahmud FH.

J Diabetes Complications. 2016 Mar;30(2):295-9. doi: 10.1016/j.jdiacomp.2015.11.020. Epub 2015 Nov 25.


Ischemia reperfusion injury, ischemic conditioning and diabetes mellitus.

Lejay A, Fang F, John R, Van JA, Barr M, Thaveau F, Chakfe N, Geny B, Scholey JW.

J Mol Cell Cardiol. 2016 Feb;91:11-22. doi: 10.1016/j.yjmcc.2015.12.020. Epub 2015 Dec 21. Review.


Plasma uric acid effects on glomerular haemodynamic profile of patients with uncomplicated Type 1 diabetes mellitus.

Lytvyn Y, Škrtić M, Yang GK, Lai V, Scholey JW, Yip PM, Perkins BA, Cherney DZ.

Diabet Med. 2016 Aug;33(8):1102-11. doi: 10.1111/dme.13051. Epub 2016 Jan 20.


Cystic adventitial pathology as an entity in peripheral arterial disease.

Lejay A, Ohana M, Delay C, Georg Y, Girsowicz E, Thaveau F, Scholey JW, Geny B, Chakfe N.

J Cardiovasc Surg (Torino). 2016 Apr;57(2):282-91. Epub 2015 Oct 16. Review.


Deletion of the gene for adiponectin accelerates diabetic nephropathy in the Ins2 (+/C96Y) mouse.

Fang F, Bae EH, Hu A, Liu GC, Zhou X, Williams V, Maksimowski N, Lu C, Konvalinka A, John R, Scholey JW.

Diabetologia. 2015 Jul;58(7):1668-78. doi: 10.1007/s00125-015-3605-9. Epub 2015 May 10.


Characterization of the intrarenal renin-angiotensin system in experimental alport syndrome.

Bae EH, Konvalinka A, Fang F, Zhou X, Williams V, Maksimowski N, Song X, Zhang SL, John R, Oudit GY, Pei Y, Scholey JW.

Am J Pathol. 2015 May;185(5):1423-35. doi: 10.1016/j.ajpath.2015.01.021. Epub 2015 Mar 14.


The urinary cytokine/chemokine signature of renal hyperfiltration in adolescents with type 1 diabetes.

Har RL, Reich HN, Scholey JW, Daneman D, Dunger DB, Moineddin R, Dalton RN, Motran L, Elia Y, Deda L, Ostrovsky M, Sochett EB, Mahmud FH, Cherney DZ.

PLoS One. 2014 Nov 13;9(11):e111131. doi: 10.1371/journal.pone.0111131. eCollection 2014.


The molecular phenotype of endocapillary proliferation: novel therapeutic targets for IgA nephropathy.

Hodgin JB, Berthier CC, John R, Grone E, Porubsky S, Gröne HJ, Herzenberg AM, Scholey JW, Hladunewich M, Cattran DC, Kretzler M, Reich HN.

PLoS One. 2014 Aug 18;9(8):e103413. doi: 10.1371/journal.pone.0103413. eCollection 2014.


Urinary ACE2 in healthy adults and patients with uncomplicated type 1 diabetes.

Cherney DZ, Xiao F, Zimpelmann J, Har RL, Lai V, Scholey JW, Reich HN, Burns KD.

Can J Physiol Pharmacol. 2014 Aug;92(8):703-6. doi: 10.1139/cjpp-2014-0065. Epub 2014 May 15.


Angiotensin 1-7 mediates renoprotection against diabetic nephropathy by reducing oxidative stress, inflammation, and lipotoxicity.

Mori J, Patel VB, Ramprasath T, Alrob OA, DesAulniers J, Scholey JW, Lopaschuk GD, Oudit GY.

Am J Physiol Renal Physiol. 2014 Apr 15;306(8):F812-21. doi: 10.1152/ajprenal.00655.2013. Epub 2014 Feb 19.


Loss of ACE2 exacerbates murine renal ischemia-reperfusion injury.

Fang F, Liu GC, Zhou X, Yang S, Reich HN, Williams V, Hu A, Pan J, Konvalinka A, Oudit GY, Scholey JW, John R.

PLoS One. 2013 Aug 9;8(8):e71433. doi: 10.1371/journal.pone.0071433. eCollection 2013.


The effect of aliskiren on urinary cytokine/chemokine responses to clamped hyperglycaemia in type 1 diabetes.

Cherney DZ, Reich HN, Scholey JW, Daneman D, Mahmud FH, Har RL, Sochett EB.

Diabetologia. 2013 Oct;56(10):2308-17. doi: 10.1007/s00125-013-3000-3. Epub 2013 Jul 28.


Determination of an angiotensin II-regulated proteome in primary human kidney cells by stable isotope labeling of amino acids in cell culture (SILAC).

Konvalinka A, Zhou J, Dimitromanolakis A, Drabovich AP, Fang F, Gurley S, Coffman T, John R, Zhang SL, Diamandis EP, Scholey JW.

J Biol Chem. 2013 Aug 23;288(34):24834-47. doi: 10.1074/jbc.M113.485326. Epub 2013 Jul 11.


Long-term hemodynamic and molecular effects persist after discontinued renin-angiotensin system blockade in patients with type 1 diabetes mellitus.

Cherney DZ, Zinman B, Kennedy CR, Moineddin R, Lai V, Yang S, Miller JA, Prokopec SD, Boutros PC, Scholey JW, Reich HN.

Kidney Int. 2013 Dec;84(6):1246-53. doi: 10.1038/ki.2013.221. Epub 2013 Jun 12.


Adiponectin attenuates angiotensin II-induced oxidative stress in renal tubular cells through AMPK and cAMP-Epac signal transduction pathways.

Fang F, Liu GC, Kim C, Yassa R, Zhou J, Scholey JW.

Am J Physiol Renal Physiol. 2013 Jun 1;304(11):F1366-74. doi: 10.1152/ajprenal.00137.2012. Epub 2013 Mar 27.


NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents.

Koulajian K, Desai T, Liu GC, Ivovic A, Patterson JN, Tang C, El-Benna J, Joseph JW, Scholey JW, Giacca A.

Diabetologia. 2013 May;56(5):1078-87. doi: 10.1007/s00125-013-2858-4. Epub 2013 Feb 21.


The effect of renal hyperfiltration on urinary inflammatory cytokines/chemokines in patients with uncomplicated type 1 diabetes mellitus.

Har R, Scholey JW, Daneman D, Mahmud FH, Dekker R, Lai V, Elia Y, Fritzler ML, Sochett EB, Reich HN, Cherney DZ.

Diabetologia. 2013 May;56(5):1166-73. doi: 10.1007/s00125-013-2857-5. Epub 2013 Feb 15.


Sex differences in renal responses to hyperglycemia, L-arginine, and L-NMMA in humans with uncomplicated type 1 diabetes.

Cherney DZ, Scholey JW, Sochett EB.

Diabetes Care. 2013 May;36(5):1290-6. doi: 10.2337/dc12-1305. Epub 2012 Dec 18.


Loss of TIMP3 selectively exacerbates diabetic nephropathy.

Basu R, Lee J, Wang Z, Patel VB, Fan D, Das SK, Liu GC, John R, Scholey JW, Oudit GY, Kassiri Z.

Am J Physiol Renal Physiol. 2012 Nov 1;303(9):F1341-52. doi: 10.1152/ajprenal.00349.2012. Epub 2012 Aug 15.


Hyperfiltration and effect of nitric oxide inhibition on renal and endothelial function in humans with uncomplicated type 1 diabetes mellitus.

Cherney DZ, Reich HN, Jiang S, Har R, Nasrallah R, Hébert RL, Lai V, Scholey JW, Sochett EB.

Am J Physiol Regul Integr Comp Physiol. 2012 Oct 1;303(7):R710-8. doi: 10.1152/ajpregu.00286.2012. Epub 2012 Aug 1.


The effect of direct renin inhibition alone and in combination with ACE inhibition on endothelial function, arterial stiffness, and renal function in type 1 diabetes.

Cherney DZ, Scholey JW, Jiang S, Har R, Lai V, Sochett EB, Reich HN.

Diabetes Care. 2012 Nov;35(11):2324-30. doi: 10.2337/dc12-0773. Epub 2012 Jul 26.


Deletion of p47phox attenuates the progression of diabetic nephropathy and reduces the severity of diabetes in the Akita mouse.

Liu GC, Fang F, Zhou J, Koulajian K, Yang S, Lam L, Reich HN, John R, Herzenberg AM, Giacca A, Oudit GY, Scholey JW.

Diabetologia. 2012 Sep;55(9):2522-32. doi: 10.1007/s00125-012-2586-1. Epub 2012 Jun 1.


Evaluation of clinical outcomes and renal vascular pathology among patients with lupus.

Barber C, Herzenberg A, Aghdassi E, Su J, Lou W, Qian G, Yip J, Nasr SH, Thomas D, Scholey JW, Wither J, Urowitz M, Gladman D, Reich H, Fortin PR.

Clin J Am Soc Nephrol. 2012 May;7(5):757-64. doi: 10.2215/CJN.02870311. Epub 2012 Mar 22.


Urinary markers of renal inflammation in adolescents with Type 1 diabetes mellitus and normoalbuminuria.

Cherney DZ, Scholey JW, Daneman D, Dunger DB, Dalton RN, Moineddin R, Mahmud FH, Dekker R, Elia Y, Sochett E, Reich HN.

Diabet Med. 2012 Oct;29(10):1297-302. doi: 10.1111/j.1464-5491.2012.03651.x.


Angiotensin-(1-7)-induced activation of ERK1/2 is cAMP/protein kinase A-dependent in glomerular mesangial cells.

Liu GC, Oudit GY, Fang F, Zhou J, Scholey JW.

Am J Physiol Renal Physiol. 2012 Mar 15;302(6):F784-90. doi: 10.1152/ajprenal.00455.2011. Epub 2011 Dec 21.


Systemic hemodynamic function in humans with type 1 diabetes treated with protein kinase Cβ inhibition and renin-angiotensin system blockade: a pilot study.

Cherney DZ, Reich HN, Scholey JW, Lai V, Slorach C, Zinman B, Bradley TJ.

Can J Physiol Pharmacol. 2012 Jan;90(1):113-21. doi: 10.1139/y11-106. Epub 2011 Dec 21.


Searching for new biomarkers of renal diseases through proteomics.

Konvalinka A, Scholey JW, Diamandis EP.

Clin Chem. 2012 Feb;58(2):353-65. doi: 10.1373/clinchem.2011.165969. Epub 2011 Oct 6. Review.


Molecular markers of injury in kidney biopsy specimens of patients with lupus nephritis.

Reich HN, Landolt-Marticorena C, Boutros PC, John R, Wither J, Fortin PR, Yang S, Scholey JW, Herzenberg AM.

J Mol Diagn. 2011 Mar;13(2):143-51. doi: 10.1016/j.jmoldx.2010.10.005.


Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit.

Bodiga S, Zhong JC, Wang W, Basu R, Lo J, Liu GC, Guo D, Holland SM, Scholey JW, Penninger JM, Kassiri Z, Oudit GY.

Cardiovasc Res. 2011 Jul 1;91(1):151-61. doi: 10.1093/cvr/cvr036. Epub 2011 Feb 1.


Persistent proteinuria and dyslipidemia increase the risk of progressive chronic kidney disease in lupus erythematosus.

Reich HN, Gladman DD, Urowitz MB, Bargman JM, Hladunewich MA, Lou W, Fan SC, Su J, Herzenberg AM, Cattran DC, Wither J, Landolt-Marticorena C, Scholey JW, Fortin PR.

Kidney Int. 2011 Apr;79(8):914-20. doi: 10.1038/ki.2010.525. Epub 2011 Jan 19.


Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2.

Zhong J, Guo D, Chen CB, Wang W, Schuster M, Loibner H, Penninger JM, Scholey JW, Kassiri Z, Oudit GY.

Hypertension. 2011 Feb;57(2):314-22. doi: 10.1161/HYPERTENSIONAHA.110.164244. Epub 2010 Dec 28.


A molecular signature of proteinuria in glomerulonephritis.

Reich HN, Tritchler D, Cattran DC, Herzenberg AM, Eichinger F, Boucherot A, Henger A, Berthier CC, Nair V, Cohen CD, Scholey JW, Kretzler M.

PLoS One. 2010 Oct 18;5(10):e13451. doi: 10.1371/journal.pone.0013451.

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