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Items: 1 to 50 of 536

1.

A Noninvasive Comparison Study between Human Gliomas with IDH1 and IDH2 Mutations by MR Spectroscopy.

Shen X, Voets NL, Larkin SJ, de Pennington N, Plaha P, Stacey R, McCullagh JSO, Schofield CJ, Clare S, Jezzard P, Cadoux-Hudson T, Ansorge O, Emir UE.

Metabolites. 2019 Feb 20;9(2). pii: E35. doi: 10.3390/metabo9020035.

2.

Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library.

Shaikh F, Zhao Y, Alvarez L, Iliopoulou M, Lohans C, Schofield CJ, Padilla-Parra S, Siu SWI, Fry EE, Ren J, Stuart DI.

J Med Chem. 2019 Mar 6. doi: 10.1021/acs.jmedchem.8b01328. [Epub ahead of print]

PMID:
30785281
3.

Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates.

Cahill ST, Tyrrell JM, Navratilova IH, Calvopiña K, Robinson SW, Lohans CT, McDonough MA, Cain R, Fishwick CWG, Avison MB, Walsh TR, Schofield CJ, Brem J.

Biochim Biophys Acta Gen Subj. 2019 Apr;1863(4):742-748. doi: 10.1016/j.bbagen.2019.02.004. Epub 2019 Feb 7.

4.

Inhibition of a viral prolyl hydroxylase.

Langley GW, Abboud MI, Lohans CT, Schofield CJ.

Bioorg Med Chem. 2019 Jan 23. pii: S0968-0896(18)31936-9. doi: 10.1016/j.bmc.2019.01.018. [Epub ahead of print]

PMID:
30737136
5.

Conformational flexibility influences structure-function relationships in nucleic acid N-methyl demethylases.

Waheed SO, Ramanan R, Chaturvedi SS, Ainsley J, Evison M, Ames JM, Schofield CJ, Christov CZ, Karabencheva-Christova TG.

Org Biomol Chem. 2019 Feb 20;17(8):2223-2231. doi: 10.1039/c9ob00162j.

PMID:
30720838
6.

An essential role for dNTP homeostasis following CDK-induced replication stress.

Pai CC, Hsu KF, Durley SC, Keszthelyi A, Kearsey SE, Rallis C, Folkes LK, Deegan R, Wilkins SE, Pfister SX, De Leόn N, Schofield CJ, Bähler J, Carr AM, Humphrey TC.

J Cell Sci. 2019 Feb 15. pii: jcs.226969. doi: 10.1242/jcs.226969. [Epub ahead of print]

7.

New developments for prevention of type 1 diabetes: a paradigm shift?

Schofield CJ, Sutherland C.

Br J Hosp Med (Lond). 2019 Jan 2;80(1):4-5. doi: 10.12968/hmed.2019.80.1.4. No abstract available.

PMID:
30592679
8.

Non-Hydrolytic β-Lactam Antibiotic Fragmentation by l,d-Transpeptidases and Serine β-Lactamase Cysteine Variants.

Lohans CT, Chan HTH, Malla TR, Kumar K, Kamps JJAG, McArdle DJB, van Groesen E, de Munnik M, Tooke CL, Spencer J, Paton RS, Brem J, Schofield CJ.

Angew Chem Int Ed Engl. 2019 Feb 11;58(7):1990-1994. doi: 10.1002/anie.201809424. Epub 2019 Jan 21.

9.

Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens.

Lippl K, Boleininger A, McDonough MA, Abboud MI, Tarhonskaya H, Chowdhury R, Loenarz C, Schofield CJ.

Hypoxia (Auckl). 2018 Nov 9;6:57-71. doi: 10.2147/HP.S174655. eCollection 2018.

10.

Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease.

Pettinati I, Grzechnik P, Ribeiro de Almeida C, Brem J, McDonough MA, Dhir S, Proudfoot NJ, Schofield CJ.

Elife. 2018 Dec 3;7. pii: e39865. doi: 10.7554/eLife.39865.

11.

Small-molecules that covalently react with a human prolyl hydroxylase - towards activity modulation and substrate capture.

Bush JT, Leśniak RK, Yeh TL, Belle R, Kramer H, Tumber A, Chowdhury R, Flashman E, Mecinović J, Schofield CJ.

Chem Commun (Camb). 2019 Jan 22;55(8):1020-1023. doi: 10.1039/c8cc07706a.

12.

Crystal structures of VIM-1 complexes explain active site heterogeneity in VIM-class metallo-β-lactamases.

Salimraj R, Hinchliffe P, Kosmopoulou M, Tyrrell JM, Brem J, van Berkel SS, Verma A, Owens RJ, McDonough MA, Walsh TR, Schofield CJ, Spencer J.

FEBS J. 2019 Jan;286(1):169-183. doi: 10.1111/febs.14695. Epub 2018 Nov 23.

13.

Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding.

Thinnes CC, Lohans CT, Abboud MI, Yeh TL, Tumber A, Nowak RP, Attwood M, Cockman ME, Oppermann U, Loenarz C, Schofield CJ.

Chemistry. 2019 Feb 6;25(8):2019-2024. doi: 10.1002/chem.201804790. Epub 2019 Jan 8.

PMID:
30427558
14.

A Fluorescent Benzo[g]isoquinoline-Based HIF Prolyl Hydroxylase Inhibitor for Cellular Imaging.

Mayer M, Fey K, Heinze E, Wick CR, Abboud MI, Yeh TL, Tumber A, Orth N, Schley G, Buchholz B, Clark T, Schofield CJ, Willam C, Burzlaff N.

ChemMedChem. 2019 Jan 8;14(1):94-99. doi: 10.1002/cmdc.201800483. Epub 2018 Dec 21.

PMID:
30380199
15.

Histone H2A monoubiquitylation and p38-MAPKs regulate immediate-early gene-like reactivation of latent retrovirus HTLV-1.

Kulkarni A, Taylor GP, Klose RJ, Schofield CJ, Bangham CR.

JCI Insight. 2018 Oct 18;3(20). pii: 123196. doi: 10.1172/jci.insight.123196.

16.

Nuclear entry and export of FIH are mediated by HIF1α and exportin1, respectively.

Wang Y, Zhong S, Schofield CJ, Ratcliffe PJ, Lu X.

J Cell Sci. 2018 Nov 19;131(22). pii: jcs219782. doi: 10.1242/jcs.219782.

17.

Mechanistic and structural studies of KDM-catalysed demethylation of histone 1 isotype 4 at lysine 26.

Walport LJ, Hopkinson RJ, Chowdhury R, Zhang Y, Bonnici J, Schiller R, Kawamura A, Schofield CJ.

FEBS Lett. 2018 Oct;592(19):3264-3273. doi: 10.1002/1873-3468.13231. Epub 2018 Sep 14.

18.

Adventures in Defining Roles of Oxygenases in the Regulation of Protein Biosynthesis.

Walport LJ, Schofield CJ.

Chem Rec. 2018 Dec;18(12):1760-1781. doi: 10.1002/tcr.201800056. Epub 2018 Aug 27. Review.

PMID:
30151867
19.

Studies on the Substrate Selectivity of the Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain.

Abboud MI, Chowdhury R, Leung IKH, Lippl K, Loenarz C, Claridge TDW, Schofield CJ.

Chembiochem. 2018 Nov 2;19(21):2262-2267. doi: 10.1002/cbic.201800246. Epub 2018 Sep 26.

PMID:
30144273
20.

Synthesis and Biological Evaluation of Tripartin, a Putative KDM4 Natural Product Inhibitor, and 1-Dichloromethylinden-1-ol Analogues.

Guillade L, Sarno F, Tarhonskaya H, Nebbioso A, Alvarez S, Kawamura A, Schofield CJ, Altucci L, de Lera ÁR.

ChemMedChem. 2018 Sep 19;13(18):1949-1956. doi: 10.1002/cmdc.201800377. Epub 2018 Aug 21.

PMID:
30047603
21.

In Vitro Enzyme Assays for JmjC-Domain-Containing Lysine Histone Demethylases (JmjC-KDMs).

Tarhonskaya H, Tumber A, Kawamura A, Schofield CJ.

Curr Protoc Pharmacol. 2018 Mar;80(1):3.15.1-3.15.12. doi: 10.1002/cpph.34.

PMID:
30040204
22.

Preclinical Evaluation of Discorhabdins in Antiangiogenic and Antitumor Models.

Harris EM, Strope JD, Beedie SL, Huang PA, Goey AKL, Cook KM, Schofield CJ, Chau CH, Cadelis MM, Copp BR, Gustafson KR, Figg WD.

Mar Drugs. 2018 Jul 19;16(7). pii: E241. doi: 10.3390/md16070241.

23.

Symmetry breaking by enzyme-catalyzed epoxide hydrolysis.

Schofield CJ.

IUCrJ. 2018 May 18;5(Pt 4):373-374. doi: 10.1107/S2052252518007005. eCollection 2018 Jul 1.

24.

Human histone demethylase KDM6B can catalyse sequential oxidations.

Hopkinson RJ, Langley GW, Belle R, Walport LJ, Dunne K, Münzel M, Salah E, Kawamura A, Claridge TDW, Schofield CJ.

Chem Commun (Camb). 2018 Jul 12;54(57):7975-7978. doi: 10.1039/c8cc04057e.

25.

Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.

Markolovic S, Zhuang Q, Wilkins SE, Eaton CD, Abboud MI, Katz MJ, McNeil HE, Leśniak RK, Hall C, Struwe WB, Konietzny R, Davis S, Yang M, Ge W, Benesch JLP, Kessler BM, Ratcliffe PJ, Cockman ME, Fischer R, Wappner P, Chowdhury R, Coleman ML, Schofield CJ.

Nat Chem Biol. 2018 Oct;14(10):988. doi: 10.1038/s41589-018-0104-6.

PMID:
29950663
26.

The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.

Markolovic S, Zhuang Q, Wilkins SE, Eaton CD, Abboud MI, Katz MJ, McNeil HE, Leśniak RK, Hall C, Struwe WB, Konietzny R, Davis S, Yang M, Ge W, Benesch JLP, Kessler BM, Ratcliffe PJ, Cockman ME, Fischer R, Wappner P, Chowdhury R, Coleman ML, Schofield CJ.

Nat Chem Biol. 2018 Jul;14(7):688-695. doi: 10.1038/s41589-018-0071-y. Epub 2018 Jun 18. Erratum in: Nat Chem Biol. 2018 Jun 27;:.

27.

Non-competitive cyclic peptides for targeting enzyme-substrate complexes.

McAllister TE, Yeh TL, Abboud MI, Leung IKH, Hookway ES, King ONF, Bhushan B, Williams ST, Hopkinson RJ, Münzel M, Loik ND, Chowdhury R, Oppermann U, Claridge TDW, Goto Y, Suga H, Schofield CJ, Kawamura A.

Chem Sci. 2018 Apr 23;9(20):4569-4578. doi: 10.1039/c8sc00286j. eCollection 2018 May 28.

28.

Antibiotics as food for bacteria.

Schofield CJ.

Nat Microbiol. 2018 Jul;3(7):752-753. doi: 10.1038/s41564-018-0181-z. No abstract available.

PMID:
29891863
29.

Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis.

Rabe P, Kamps JJAG, Schofield CJ, Lohans CT.

Nat Prod Rep. 2018 Aug 15;35(8):735-756. doi: 10.1039/c8np00002f. Review.

30.

NMR analyses on N-hydroxymethylated nucleobases - implications for formaldehyde toxicity and nucleic acid demethylases.

Shishodia S, Zhang D, El-Sagheer AH, Brown T, Claridge TDW, Schofield CJ, Hopkinson RJ.

Org Biomol Chem. 2018 May 30;16(21):4021-4032. doi: 10.1039/c8ob00734a.

31.

Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases.

Bhushan B, Erdmann A, Zhang Y, Belle R, Johannson C, Oppermann U, Hopkinson RJ, Schofield CJ, Kawamura A.

Bioorg Med Chem. 2018 Jul 15;26(11):2984-2991. doi: 10.1016/j.bmc.2018.03.030. Epub 2018 Mar 19. Review.

32.

Publisher Correction: JMJD5 is a human arginyl C-3 hydroxylase.

Wilkins SE, Islam MS, Gannon JM, Markolovic S, Hopkinson RJ, Ge W, Schofield CJ, Chowdhury R.

Nat Commun. 2018 Apr 23;9(1):1675. doi: 10.1038/s41467-018-04196-7.

33.

Inhibitors of both the N-methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases.

Bonnici J, Tumber A, Kawamura A, Schofield CJ.

Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748). pii: 20170071. doi: 10.1098/rstb.2017.0071.

34.

Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases.

Zhang D, Markoulides MS, Stepanovs D, Rydzik AM, El-Hussein A, Bon C, Kamps JJAG, Umland KD, Collins PM, Cahill ST, Wang DY, von Delft F, Brem J, McDonough MA, Schofield CJ.

Bioorg Med Chem. 2018 Jul 15;26(11):2928-2936. doi: 10.1016/j.bmc.2018.02.043. Epub 2018 Feb 23.

35.

Direct sulfonylation of anilines mediated by visible light.

Johnson TC, Elbert BL, Farley AJM, Gorman TW, Genicot C, Lallemand B, Pasau P, Flasz J, Castro JL, MacCoss M, Dixon DJ, Paton RS, Schofield CJ, Smith MD, Willis MC.

Chem Sci. 2017 Nov 16;9(3):629-633. doi: 10.1039/c7sc03891g. eCollection 2018 Jan 21.

36.

JMJD5 is a human arginyl C-3 hydroxylase.

Wilkins SE, Islam MS, Gannon JM, Markolovic S, Hopkinson RJ, Ge W, Schofield CJ, Chowdhury R.

Nat Commun. 2018 Mar 21;9(1):1180. doi: 10.1038/s41467-018-03410-w. Erratum in: Nat Commun. 2018 Apr 23;9(1):1675.

37.

YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase.

Sekirnik R, Wilkins SE, Bush J, Tarhonskaya H, Münzel M, Hussein A, Flashman E, Mohammed S, McDonough MA, Loenarz C, Schofield CJ.

Extremophiles. 2018 May;22(3):553-562. doi: 10.1007/s00792-018-1016-9. Epub 2018 Mar 9.

38.

2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2.

Abboud MI, McAllister TE, Leung IKH, Chowdhury R, Jorgensen C, Domene C, Mecinović J, Lippl K, Hancock RL, Hopkinson RJ, Kawamura A, Claridge TDW, Schofield CJ.

Chem Commun (Camb). 2018 Mar 28;54(25):3130-3133. doi: 10.1039/c8cc00387d. Epub 2018 Mar 9.

39.

2-Oxoglutarate-Dependent Oxygenases.

Islam MS, Leissing TM, Chowdhury R, Hopkinson RJ, Schofield CJ.

Annu Rev Biochem. 2018 Jun 20;87:585-620. doi: 10.1146/annurev-biochem-061516-044724. Epub 2018 Mar 1.

PMID:
29494239
40.

Lysine-241 Has a Role in Coupling 2OG Turnover with Substrate Oxidation During KDM4-Catalysed Histone Demethylation.

Hancock RL, Abboud MI, Smart TJ, Flashman E, Kawamura A, Schofield CJ, Hopkinson RJ.

Chembiochem. 2018 May 4;19(9):917-921. doi: 10.1002/cbic.201800002. Epub 2018 Apr 6.

41.

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.

Yeh TL, Leissing TM, Abboud MI, Thinnes CC, Atasoylu O, Holt-Martyn JP, Zhang D, Tumber A, Lippl K, Lohans CT, Leung IKH, Morcrette H, Clifton IJ, Claridge TDW, Kawamura A, Flashman E, Lu X, Ratcliffe PJ, Chowdhury R, Pugh CW, Schofield CJ.

Chem Sci. 2017 Nov 1;8(11):7651-7668. doi: 10.1039/c7sc02103h. Epub 2017 Sep 11.

42.

Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses in vitro and in vivo.

Dickinson RS, Murphy F, Doherty C, Williams S, Mirchandani A, Willson J, Scotti JS, Preston G, Schofield CJ, Whyte MKB, Walmsley SR.

Wellcome Open Res. 2017 Oct 26;2:104. doi: 10.12688/wellcomeopenres.12871.1. eCollection 2017.

43.

Deciphering Functions of Intracellular Formaldehyde: Linking Cancer and Aldehyde Metabolism.

Hopkinson RJ, Schofield CJ.

Biochemistry. 2018 Feb 13;57(6):904-906. doi: 10.1021/acs.biochem.7b01304. Epub 2018 Jan 25. No abstract available.

PMID:
29368521
44.

A comparison of 2-hydroxyglutarate detection at 3 and 7 T with long-TE semi-LASER.

Berrington A, Voets NL, Larkin SJ, de Pennington N, Mccullagh J, Stacey R, Schofield CJ, Jezzard P, Clare S, Cadoux-Hudson T, Plaha P, Ansorge O, Emir UE.

NMR Biomed. 2018 Mar;31(3). doi: 10.1002/nbm.3886. Epub 2018 Jan 5.

PMID:
29315915
45.

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.

Cain R, Brem J, Zollman D, McDonough MA, Johnson RM, Spencer J, Makena A, Abboud MI, Cahill S, Lee SY, McHugh PJ, Schofield CJ, Fishwick CWG.

J Med Chem. 2018 Feb 8;61(3):1255-1260. doi: 10.1021/acs.jmedchem.7b01728. Epub 2018 Jan 10.

46.

Cyclobutanone Mimics of Intermediates in Metallo-β-Lactamase Catalysis.

Abboud MI, Kosmopoulou M, Krismanich AP, Johnson JW, Hinchliffe P, Brem J, Claridge TDW, Spencer J, Schofield CJ, Dmitrienko GI.

Chemistry. 2018 Apr 17;24(22):5734-5737. doi: 10.1002/chem.201705886. Epub 2018 Jan 17.

47.

A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation.

Lohans CT, van Groesen E, Kumar K, Tooke CL, Spencer J, Paton RS, Brem J, Schofield CJ.

Angew Chem Int Ed Engl. 2018 Jan 26;57(5):1282-1285. doi: 10.1002/anie.201711308. Epub 2018 Jan 5.

48.

Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition.

Belle R, Al Temimi AHK, Kumar K, Pieters BJGE, Tumber A, Dunford JE, Johansson C, Oppermann U, Brown T, Schofield CJ, Hopkinson RJ, Paton RS, Kawamura A, Mecinović J.

Chem Commun (Camb). 2017 Dec 12;53(99):13264-13267. doi: 10.1039/c7cc08028j.

49.

New Delhi Metallo-β-Lactamase 1 Catalyzes Avibactam and Aztreonam Hydrolysis.

Lohans CT, Brem J, Schofield CJ.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01224-17. doi: 10.1128/AAC.01224-17. Print 2017 Dec. No abstract available.

50.

Glucose Metabolism and Oxygen Availability Govern Reactivation of the Latent Human Retrovirus HTLV-1.

Kulkarni A, Mateus M, Thinnes CC, McCullagh JS, Schofield CJ, Taylor GP, Bangham CRM.

Cell Chem Biol. 2017 Nov 16;24(11):1377-1387.e3. doi: 10.1016/j.chembiol.2017.08.016. Epub 2017 Sep 28.

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