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Items: 1 to 50 of 61

1.

Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms.

Jackson SP, Darbousset R, Schoenwaelder SM.

Blood. 2019 Feb 28;133(9):906-918. doi: 10.1182/blood-2018-11-882993. Epub 2019 Jan 14. Review.

PMID:
30642917
2.

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion.

Pleines I, Lebois M, Gangatirkar P, Au AE, Lane RM, Henley KJ, Kauppi M, Corbin J, Cannon P, Bernardini J, Alwis I, Jarman KE, Ellis S, Metcalf D, Jackson SP, Schoenwaelder SM, Kile BT, Josefsson EC.

Blood. 2018 Jul 12;132(2):197-209. doi: 10.1182/blood-2017-11-816355. Epub 2018 May 21.

PMID:
29784641
3.

Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets.

Ju L, McFadyen JD, Al-Daher S, Alwis I, Chen Y, Tønnesen LL, Maiocchi S, Coulter B, Calkin AC, Felner EI, Cohen N, Yuan Y, Schoenwaelder SM, Cooper ME, Zhu C, Jackson SP.

Nat Commun. 2018 Mar 14;9(1):1087. doi: 10.1038/s41467-018-03430-6.

4.

Endogenous fibrinolysis facilitates clot retraction in vivo.

Samson AL, Alwis I, Maclean JAA, Priyananda P, Hawkett B, Schoenwaelder SM, Jackson SP.

Blood. 2017 Dec 7;130(23):2453-2462. doi: 10.1182/blood-2017-06-789032. Epub 2017 Oct 26.

PMID:
29074499
5.

Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia.

Yuan Y, Alwis I, Wu MCL, Kaplan Z, Ashworth K, Bark D Jr, Pham A, Mcfadyen J, Schoenwaelder SM, Josefsson EC, Kile BT, Jackson SP.

Sci Transl Med. 2017 Sep 27;9(409). pii: eaam5861. doi: 10.1126/scitranslmed.aam5861.

PMID:
28954929
6.

Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.

Schoenwaelder SM, Darbousset R, Cranmer SL, Ramshaw HS, Orive SL, Sturgeon S, Yuan Y, Yao Y, Krycer JR, Woodcock J, Maclean J, Pitson S, Zheng Z, Henstridge DC, van der Wal D, Gardiner EE, Berndt MC, Andrews RK, James DE, Lopez AF, Jackson SP.

Nat Commun. 2017 Aug 30;8:16125. doi: 10.1038/ncomms16125.

7.

Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells.

Samson AL, Ho B, Au AE, Schoenwaelder SM, Smyth MJ, Bottomley SP, Kleifeld O, Medcalf RL.

Open Biol. 2016 Nov;6(11). pii: 160098.

8.

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.

Schoenwaelder SM, Darbousset R, Cranmer SL, Ramshaw HS, Orive SL, Sturgeon S, Yuan Y, Yao Y, Krycer JR, Woodcock J, Maclean J, Pitson S, Zheng Z, Henstridge DC, van der Wal D, Gardiner EE, Berndt MC, Andrews RK, James DE, Lopez AF, Jackson SP.

Nat Commun. 2016 Sep 27;7:12862. doi: 10.1038/ncomms12862. Erratum in: Nat Commun. 2017 Aug 30;8:16125.

9.

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922).

Zheng Z, Pinson JA, Mountford SJ, Orive S, Schoenwaelder SM, Shackleford D, Powell A, Nelson EM, Hamilton JR, Jackson SP, Jennings IG, Thompson PE.

Eur J Med Chem. 2016 Oct 21;122:339-351. doi: 10.1016/j.ejmech.2016.06.010. Epub 2016 Jun 10.

PMID:
27387421
10.

MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents.

Samson AL, Ju L, Ah Kim H, Zhang SR, Lee JA, Sturgeon SA, Sobey CG, Jackson SP, Schoenwaelder SM.

Sci Rep. 2015 Nov 4;5:16171. doi: 10.1038/srep16171.

11.

Ferric chloride thrombosis model: unraveling the vascular effects of a highly corrosive oxidant.

Schoenwaelder SM, Jackson SP.

Blood. 2015 Dec 10;126(24):2652-3. doi: 10.1182/blood-2015-09-668384. Epub 2015 Oct 26. No abstract available.

PMID:
26504184
12.

Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4.

Kaplan ZS, Zarpellon A, Alwis I, Yuan Y, McFadyen J, Ghasemzadeh M, Schoenwaelder SM, Ruggeri ZM, Jackson SP.

Nat Commun. 2015 Jul 23;6:7835. doi: 10.1038/ncomms8835.

PMID:
26204458
13.

The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.

Mountford JK, Petitjean C, Putra HW, McCafferty JA, Setiabakti NM, Lee H, Tønnesen LL, McFadyen JD, Schoenwaelder SM, Eckly A, Gachet C, Ellis S, Voss AK, Dickins RA, Hamilton JR, Jackson SP.

Nat Commun. 2015 Mar 17;6:6535. doi: 10.1038/ncomms7535.

14.

Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in mice.

Hughan SC, Spring CM, Schoenwaelder SM, Sturgeon S, Alwis I, Yuan Y, McFadyen JD, Westein E, Goddard D, Ono A, Yamanashi Y, Nesbitt WS, Jackson SP.

J Biol Chem. 2014 Feb 21;289(8):5051-60. doi: 10.1074/jbc.M113.520148. Epub 2014 Jan 2.

15.

The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi.

Ghasemzadeh M, Kaplan ZS, Alwis I, Schoenwaelder SM, Ashworth KJ, Westein E, Hosseini E, Salem HH, Slattery R, McColl SR, Hickey MJ, Ruggeri ZM, Yuan Y, Jackson SP.

Blood. 2013 May 30;121(22):4555-66. doi: 10.1182/blood-2012-09-459636. Epub 2013 Apr 2.

16.

Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263).

Qiao J, Schoenwaelder SM, Mason KD, Tran H, Davis AK, Kaplan ZS, Jackson SP, Kile BT, Andrews RK, Roberts AW, Gardiner EE.

Blood. 2013 Feb 21;121(8):1479-81. doi: 10.1182/blood-2012-12-467415. No abstract available.

PMID:
23429990
17.

Antithrombotic phosphoinositide 3-kinase β inhibitors in humans: a 'shear' delight!

Jackson SP, Schoenwaelder SM.

J Thromb Haemost. 2012 Oct;10(10):2123-6. doi: 10.1111/j.1538-7836.2012.04912.x. No abstract available.

18.

Bcl-xL-inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function.

Schoenwaelder SM, Jackson SP.

Blood. 2012 Feb 2;119(5):1320-1; author reply 1321-2. doi: 10.1182/blood-2011-10-387399. No abstract available.

PMID:
22308285
19.

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function.

White MJ, Schoenwaelder SM, Josefsson EC, Jarman KE, Henley KJ, James C, Debrincat MA, Jackson SP, Huang DC, Kile BT.

Blood. 2012 May 3;119(18):4283-90. doi: 10.1182/blood-2011-11-394858. Epub 2012 Jan 31.

PMID:
22294729
20.

A live cell micro-imaging technique to examine platelet calcium signaling dynamics under blood flow.

Nesbitt WS, Harper IS, Schoenwaelder SM, Yuan Y, Jackson SP.

Methods Mol Biol. 2012;788:73-89. doi: 10.1007/978-1-61779-307-3_6.

PMID:
22130701
21.

Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells.

Wen PJ, Osborne SL, Zanin M, Low PC, Wang HT, Schoenwaelder SM, Jackson SP, Wedlich-Söldner R, Vanhaesebroeck B, Keating DJ, Meunier FA.

Nat Commun. 2011 Oct 4;2:491. doi: 10.1038/ncomms1500.

PMID:
21971506
22.

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets.

Schoenwaelder SM, Jarman KE, Gardiner EE, Hua M, Qiao J, White MJ, Josefsson EC, Alwis I, Ono A, Willcox A, Andrews RK, Mason KD, Salem HH, Huang DC, Kile BT, Roberts AW, Jackson SP.

Blood. 2011 Aug 11;118(6):1663-74. doi: 10.1182/blood-2011-04-347849. Epub 2011 Jun 14.

PMID:
21673344
23.

A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance.

Guerreiro AS, Fattet S, Kulesza DW, Atamer A, Elsing AN, Shalaby T, Jackson SP, Schoenwaelder SM, Grotzer MA, Delattre O, Arcaro A.

Mol Cancer Res. 2011 Jul;9(7):925-35. doi: 10.1158/1541-7786.MCR-10-0200. Epub 2011 Jun 7.

24.

The catalytic class I(A) PI3K isoforms play divergent roles in breast cancer cell migration.

De Laurentiis A, Pardo OE, Palamidessi A, Jackson SP, Schoenwaelder SM, Reichmann E, Scita G, Arcaro A.

Cell Signal. 2011 Mar;23(3):529-41. doi: 10.1016/j.cellsig.2010.10.021. Epub 2010 Nov 5.

PMID:
21056654
25.

Procoagulant platelets: are they necrotic?

Jackson SP, Schoenwaelder SM.

Blood. 2010 Sep 23;116(12):2011-8. doi: 10.1182/blood-2010-01-261669. Epub 2010 Jun 10. Review.

PMID:
20538794
26.

PI 3-Kinase p110β regulation of platelet integrin α(IIb)β3.

Jackson SP, Schoenwaelder SM.

Curr Top Microbiol Immunol. 2010;346:203-24. doi: 10.1007/82_2010_61. Review.

PMID:
20517720
27.

Role of phosphoinositide 3-kinase beta in platelet aggregation and thromboxane A2 generation mediated by Gi signalling pathways.

Garcia A, Kim S, Bhavaraju K, Schoenwaelder SM, Kunapuli SP.

Biochem J. 2010 Jul 15;429(2):369-77. doi: 10.1042/BJ20100166.

PMID:
20441566
28.

Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene.

Qiu MR, Jiang L, Matthaei KI, Schoenwaelder SM, Kuffner T, Mangin P, Joseph JE, Low J, Connor D, Valenzuela SM, Curmi PM, Brown LJ, Mahaut-Smith M, Jackson SP, Breit SN.

Genesis. 2010 Feb;48(2):127-36. doi: 10.1002/dvg.20590. Erratum in: Genesis. 2010 May;48(5):351.

PMID:
20049953
29.

Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.

Schoenwaelder SM, Ono A, Nesbitt WS, Lim J, Jarman K, Jackson SP.

J Biol Chem. 2010 Jan 22;285(4):2886-96. doi: 10.1074/jbc.M109.029132. Epub 2009 Nov 23.

30.

Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux.

Calkin AC, Drew BG, Ono A, Duffy SJ, Gordon MV, Schoenwaelder SM, Sviridov D, Cooper ME, Kingwell BA, Jackson SP.

Circulation. 2009 Nov 24;120(21):2095-104. doi: 10.1161/CIRCULATIONAHA.109.870709. Epub 2009 Nov 9.

PMID:
19901191
31.

New insights into the haemostatic function of platelets.

Wei AH, Schoenwaelder SM, Andrews RK, Jackson SP.

Br J Haematol. 2009 Nov;147(4):415-30. doi: 10.1111/j.1365-2141.2009.07819.x. Epub 2009 Jul 28. Review.

PMID:
19656155
32.

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function.

Schoenwaelder SM, Yuan Y, Josefsson EC, White MJ, Yao Y, Mason KD, O'Reilly LA, Henley KJ, Ono A, Hsiao S, Willcox A, Roberts AW, Huang DC, Salem HH, Kile BT, Jackson SP.

Blood. 2009 Jul 16;114(3):663-6. doi: 10.1182/blood-2009-01-200345. Epub 2009 Apr 22.

PMID:
19387006
33.

Targeting the PI3K p110alpha isoform inhibits medulloblastoma proliferation, chemoresistance, and migration.

Guerreiro AS, Fattet S, Fischer B, Shalaby T, Jackson SP, Schoenwaelder SM, Grotzer MA, Delattre O, Arcaro A.

Clin Cancer Res. 2008 Nov 1;14(21):6761-9. doi: 10.1158/1078-0432.CCR-08-0385.

34.

Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells.

Heller R, Chang Q, Ehrlich G, Hsieh SN, Schoenwaelder SM, Kuhlencordt PJ, Preissner KT, Hirsch E, Wetzker R.

Cardiovasc Res. 2008 Oct 1;80(1):96-105. doi: 10.1093/cvr/cvn159. Epub 2008 Jun 16.

PMID:
18558630
35.

Selective inhibition of the platelet phosphoinositide 3-kinase p110beta as promising new strategy for platelet protection during extracorporeal circulation.

Straub A, Wendel HP, Dietz K, Schiebold D, Peter K, Schoenwaelder SM, Ziemer G.

Thromb Haemost. 2008 Mar;99(3):609-15. doi: 10.1160/TH07-07-0452.

PMID:
18327411
36.

Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth.

Ono A, Westein E, Hsiao S, Nesbitt WS, Hamilton JR, Schoenwaelder SM, Jackson SP.

Blood. 2008 Jul 1;112(1):90-9. doi: 10.1182/blood-2007-12-127001. Epub 2008 Feb 29.

PMID:
18310501
37.

Dual P2Y 12 receptor signaling in thrombin-stimulated platelets--involvement of phosphoinositide 3-kinase beta but not gamma isoform in Ca2+ mobilization and procoagulant activity.

van der Meijden PE, Schoenwaelder SM, Feijge MA, Cosemans JM, Munnix IC, Wetzker R, Heller R, Jackson SP, Heemskerk JW.

FEBS J. 2008 Jan;275(2):371-85. Epub 2007 Dec 13. Erratum in: FEBS J. 2008 Feb;275(4):811.

38.

Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets.

Schoenwaelder SM, Ono A, Sturgeon S, Chan SM, Mangin P, Maxwell MJ, Turnbull S, Mulchandani M, Anderson K, Kauffenstein G, Rewcastle GW, Kendall J, Gachet C, Salem HH, Jackson SP.

J Biol Chem. 2007 Sep 28;282(39):28648-58. Epub 2007 Aug 2.

39.

Novel role for insulin as an autocrine growth factor for malignant brain tumour cells.

Arcaro A, Doepfner KT, Boller D, Guerreiro AS, Shalaby T, Jackson SP, Schoenwaelder SM, Delattre O, Grotzer MA, Fischer B.

Biochem J. 2007 Aug 15;406(1):57-66.

40.

A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis.

McCormack MP, Hall MA, Schoenwaelder SM, Zhao Q, Ellis S, Prentice JA, Clarke AJ, Slater NJ, Salmon JM, Jackson SP, Jane SM, Curtis DJ.

Blood. 2006 Oct 1;108(7):2248-56. Epub 2006 Jun 8.

41.

Type I phosphoinositide 3-kinases: potential antithrombotic targets?

Jackson SF, Schoenwaelder SM.

Cell Mol Life Sci. 2006 May;63(10):1085-90. Review.

PMID:
16649145
42.

Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency.

Mangin P, Yap CL, Nonne C, Sturgeon SA, Goncalves I, Yuan Y, Schoenwaelder SM, Wright CE, Lanza F, Jackson SP.

Blood. 2006 Jun 1;107(11):4346-53. Epub 2006 Jan 3.

PMID:
16391010
43.

PI 3-kinase p110beta: a new target for antithrombotic therapy.

Jackson SP, Schoenwaelder SM, Goncalves I, Nesbitt WS, Yap CL, Wright CE, Kenche V, Anderson KE, Dopheide SM, Yuan Y, Sturgeon SA, Prabaharan H, Thompson PE, Smith GD, Shepherd PR, Daniele N, Kulkarni S, Abbott B, Saylik D, Jones C, Lu L, Giuliano S, Hughan SC, Angus JA, Robertson AD, Salem HH.

Nat Med. 2005 May;11(5):507-14. Epub 2005 Apr 17.

44.

Rap1b is required for normal platelet function and hemostasis in mice.

Chrzanowska-Wodnicka M, Smyth SS, Schoenwaelder SM, Fischer TH, White GC 2nd.

J Clin Invest. 2005 Mar;115(3):680-7. Erratum in: J Clin Invest. 2005 Aug;115(8):2296.

45.

Antiplatelet therapy: in search of the 'magic bullet'.

Jackson SP, Schoenwaelder SM.

Nat Rev Drug Discov. 2003 Oct;2(10):775-89. Review.

PMID:
14526381
46.

Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2.

Goncalves I, Hughan SC, Schoenwaelder SM, Yap CL, Yuan Y, Jackson SP.

J Biol Chem. 2003 Sep 12;278(37):34812-22. Epub 2003 Jun 27.

47.

Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling.

Lawrenson ID, Wimmer-Kleikamp SH, Lock P, Schoenwaelder SM, Down M, Boyd AW, Alewood PF, Lackmann M.

J Cell Sci. 2002 Mar 1;115(Pt 5):1059-72.

48.

RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear.

Schoenwaelder SM, Hughan SC, Boniface K, Fernando S, Holdsworth M, Thompson PE, Salem HH, Jackson SP.

J Biol Chem. 2002 Apr 26;277(17):14738-46. Epub 2002 Feb 5.

49.

The protein tyrosine phosphatase Shp-2 regulates RhoA activity.

Schoenwaelder SM, Petch LA, Williamson D, Shen R, Feng GS, Burridge K.

Curr Biol. 2000 Nov 30;10(23):1523-6.

50.

Calpain regulation of integrin alpha IIb beta 3 signaling in human platelets.

Schoenwaelder SM, Yuan Y, Jackson SP.

Platelets. 2000 Jun;11(4):189-98. Review.

PMID:
10938897

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