Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 214

1.

Targeting repulsive guidance molecule A to promote regeneration and neuroprotection in multiple sclerosis.

Demicheva E, Cui YF, Bardwell P, Barghorn S, Kron M, Meyer AH, Schmidt M, Gerlach B, Leddy M, Barlow E, O'Connor E, Choi CH, Huang L, Veldman GM, Rus H, Shabanzadeh AP, Tassew NG, Monnier PP, Müller T, Calabresi PA, Schoemaker H, Mueller BK.

Cell Rep. 2015 Mar 24;10(11):1887-98.

2.

Establishment of a secondary screening assay for P/Q-type calcium channel blockers.

Hermann D, Mezler M, Swensen AM, Bruehl C, Obergrußerger A, Wicke K, Schoemaker H, Gross G, Draguhn A, Nimmrich V.

Comb Chem High Throughput Screen. 2013 Mar;16(3):233-43.

PMID:
23228050
3.

Development of disease-modifying treatment of schizophrenia.

Bespalov A, Klein C, Behl B, Gross G, Schoemaker H.

Handb Exp Pharmacol. 2012;(213):419-42. doi: 10.1007/978-3-642-25758-2_14. Review.

PMID:
23027423
4.

Development and validation of a fluorescence-based HTS assay for the identification of P/Q-type calcium channel blockers.

Mezler M, Hermann D, Swensen AM, Draguhn A, Terstappen GC, Gross G, Schoemaker H, Freiberg G, Pratt S, Gopalakrishnan SM, Nimmrich V.

Comb Chem High Throughput Screen. 2012 Jun 1;15(5):372-85.

PMID:
22272661
5.

A β-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes.

Mezler M, Barghorn S, Schoemaker H, Gross G, Nimmrich V.

Br J Pharmacol. 2012 Mar;165(5):1572-83. doi: 10.1111/j.1476-5381.2011.01646.x.

6.

Effects of a positive allosteric modulator of group II metabotropic glutamate receptors, LY487379, on cognitive flexibility and impulsive-like responding in rats.

Nikiforuk A, Popik P, Drescher KU, van Gaalen M, Relo AL, Mezler M, Marek G, Schoemaker H, Gross G, Bespalov A.

J Pharmacol Exp Ther. 2010 Dec;335(3):665-73. doi: 10.1124/jpet.110.170506. Epub 2010 Aug 25.

PMID:
20739457
7.

Double dissociation of the effects of haloperidol and the dopamine D3 receptor antagonist ABT-127 on acquisition vs. expression of cocaine-conditioned activity in rats.

Banasikowski TJ, Bespalov A, Drescher K, Behl B, Unger L, Haupt A, Schoemaker H, Sullivan JP, Gross G, Beninger RJ.

J Pharmacol Exp Ther. 2010 Nov;335(2):506-15. doi: 10.1124/jpet.110.171348. Epub 2010 Aug 19.

PMID:
20724485
8.

Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies.

Hillen H, Barghorn S, Striebinger A, Labkovsky B, Müller R, Nimmrich V, Nolte MW, Perez-Cruz C, van der Auwera I, van Leuven F, van Gaalen M, Bespalov AY, Schoemaker H, Sullivan JP, Ebert U.

J Neurosci. 2010 Aug 4;30(31):10369-79. doi: 10.1523/JNEUROSCI.5721-09.2010.

9.

Calpain inhibition prevents amyloid-beta-induced neurodegeneration and associated behavioral dysfunction in rats.

Granic I, Nyakas C, Luiten PG, Eisel UL, Halmy LG, Gross G, Schoemaker H, Möller A, Nimmrich V.

Neuropharmacology. 2010 Sep-Oct;59(4-5):334-42. doi: 10.1016/j.neuropharm.2010.07.013. Epub 2010 Jul 23.

PMID:
20650285
10.

Inhibition of calpain prevents NMDA-induced cell death and beta-amyloid-induced synaptic dysfunction in hippocampal slice cultures.

Nimmrich V, Reymann KG, Strassburger M, Schöder UH, Gross G, Hahn A, Schoemaker H, Wicke K, Möller A.

Br J Pharmacol. 2010 Apr;159(7):1523-31. doi: 10.1111/j.1476-5381.2010.00652.x. Epub 2010 Mar 3.

11.

Glutamatergic (N-methyl-D-aspartate receptor) hypofrontality in schizophrenia: too little juice or a miswired brain?

Marek GJ, Behl B, Bespalov AY, Gross G, Lee Y, Schoemaker H.

Mol Pharmacol. 2010 Mar;77(3):317-26. doi: 10.1124/mol.109.059865. Epub 2009 Nov 23. Review. Erratum in: Mol Pharmacol. 2010 May;77(5):884.

PMID:
19933774
12.

Amphetamine decreases behavioral inhibition by stimulation of dopamine D2, but not D3, receptors.

van Gaalen MM, Unger L, Jongen-Rêlo AL, Schoemaker H, Gross G.

Behav Pharmacol. 2009 Sep;20(5-6):484-91. doi: 10.1097/FBP.0b013e3283305e3b.

PMID:
19696659
13.

Improvement of an acid phosphatase/DHAP-dependent aldolase cascade reaction by using directed evolution.

van Herk T, Hartog AF, Babich L, Schoemaker HE, Wever R.

Chembiochem. 2009 Sep 4;10(13):2230-5. doi: 10.1002/cbic.200900102.

PMID:
19623595
14.

Complementary chemoenzymatic routes to both enantiomers of febrifugine.

Wijdeven MA, van den Berg RJ, Wijtmans R, Botman PN, Blaauw RH, Schoemaker HE, van Delft FL, Rutjes FP.

Org Biomol Chem. 2009 Jul 21;7(14):2976-80. doi: 10.1039/b901670h. Epub 2009 Jun 4.

PMID:
19582308
15.

Synaptic transmission is impaired prior to plaque formation in amyloid precursor protein-overexpressing mice without altering behaviorally-correlated sharp wave-ripple complexes.

Hermann D, Both M, Ebert U, Gross G, Schoemaker H, Draguhn A, Wicke K, Nimmrich V.

Neuroscience. 2009 Sep 15;162(4):1081-90. doi: 10.1016/j.neuroscience.2009.05.044. Epub 2009 May 27.

PMID:
19477243
16.

Stimulating neuroregeneration as a therapeutic drug approach for traumatic brain injury.

Mueller BK, Mueller R, Schoemaker H.

Br J Pharmacol. 2009 Jul;157(5):675-85. doi: 10.1111/j.1476-5381.2009.00220.x. Epub 2009 May 5. Review.

17.

Running wheel activity is sensitive to acute treatment with selective inhibitors for either serotonin or norepinephrine reuptake.

Weber M, Talmon S, Schulze I, Boeddinghaus C, Gross G, Schoemaker H, Wicke KM.

Psychopharmacology (Berl). 2009 May;203(4):753-62. doi: 10.1007/s00213-008-1420-4. Epub 2008 Dec 23.

PMID:
19104776
18.

Inhibitors of GlyT1 affect glycine transport via discrete binding sites.

Mezler M, Hornberger W, Mueller R, Schmidt M, Amberg W, Braje W, Ochse M, Schoemaker H, Behl B.

Mol Pharmacol. 2008 Dec;74(6):1705-15. doi: 10.1124/mol.108.049312. Epub 2008 Sep 24. Erratum in: Mol Pharmacol. 2009 Jan;75(1):258.. Amberg, Martin Schmidt Willi [corrected to Schmidt, Martin]; Amberg, Martin Schmidt Willi [corrected to Amberg, Willi].

PMID:
18815213
19.

N,N-acetals as N-acyliminium ion precursors: synthesis and absolute stereochemistry of epiquinamide.

Wijdeven MA, Wijtmans R, van den Berg RJ, Noorduin W, Schoemaker HE, Sonke T, van Delft FL, Blaauw RH, Fitch RW, Spande TF, Daly JW, Rutjes FP.

Org Lett. 2008 Sep 18;10(18):4001-3. doi: 10.1021/ol801490m. Epub 2008 Aug 15.

PMID:
18702495
20.

Inhibition of Calpain Prevents N-Methyl-D-aspartate-Induced Degeneration of the Nucleus Basalis and Associated Behavioral Dysfunction.

Nimmrich V, Szabo R, Nyakas C, Granic I, Reymann KG, Schröder UH, Gross G, Schoemaker H, Wicke K, Möller A, Luiten P.

J Pharmacol Exp Ther. 2008 Nov;327(2):343-52. doi: 10.1124/jpet.108.142679. Epub 2008 Aug 13.

PMID:
18701765
21.

SSR149415, a non-peptide vasopressin V1b receptor antagonist, has long-lasting antidepressant effects in the olfactory bulbectomy-induced hyperactivity depression model.

Breuer ME, van Gaalen MM, Wernet W, Claessens SE, Oosting RS, Behl B, Korte SM, Schoemaker H, Gross G, Olivier B, Groenink L.

Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):101-6. doi: 10.1007/s00210-008-0336-1. Epub 2008 Jul 31.

PMID:
18668225
22.

Behavioral characterization of the mGlu group II/III receptor antagonist, LY-341495, in animal models of anxiety and depression.

Bespalov AY, van Gaalen MM, Sukhotina IA, Wicke K, Mezler M, Schoemaker H, Gross G.

Eur J Pharmacol. 2008 Sep 11;592(1-3):96-102. doi: 10.1016/j.ejphar.2008.06.089. Epub 2008 Jul 2.

PMID:
18634781
23.

Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents.

Nimmrich V, Grimm C, Draguhn A, Barghorn S, Lehmann A, Schoemaker H, Hillen H, Gross G, Ebert U, Bruehl C.

J Neurosci. 2008 Jan 23;28(4):788-97. doi: 10.1523/JNEUROSCI.4771-07.2008.

24.

Biocatalytic reductions: from lab curiosity to "first choice".

De Wildeman SM, Sonke T, Schoemaker HE, May O.

Acc Chem Res. 2007 Dec;40(12):1260-6. Epub 2007 Oct 18. Review.

PMID:
17941701
25.

Enzymatic enantioselective C-C-bond formation in microreactors.

Koch K, van den Berg RJ, Nieuwland PJ, Wijtmans R, Schoemaker HE, van Hest JC, Rutjes FP.

Biotechnol Bioeng. 2008 Mar 1;99(4):1028-33.

PMID:
17879309
26.

Laser capture microdissection and microarray analysis of dividing neural progenitor cells from the adult rat hippocampus.

Gurok U, Loebbert RW, Meyer AH, Mueller R, Schoemaker H, Gross G, Behl B.

Eur J Neurosci. 2007 Sep;26(5):1079-90.

PMID:
17767487
27.

The pharmacokinetics and effects of a long-acting preparation of superoxide dismutase (PC-SOD) in man.

Broeyer FJ, van Aken BE, Suzuki J, Kemme MJ, Schoemaker HC, Cohen AF, Mizushima Y, Burggraaf J.

Br J Clin Pharmacol. 2008 Jan;65(1):22-9. Epub 2007 Jul 4.

28.

Habituation deficits induced by metabotropic glutamate receptors 2/3 receptor blockade in mice: reversal by antipsychotic drugs.

Bespalov A, Jongen-Rêlo AL, van Gaalen M, Harich S, Schoemaker H, Gross G.

J Pharmacol Exp Ther. 2007 Feb;320(2):944-50. Epub 2006 Nov 29.

PMID:
17135347
29.

Nitrile hydrolysis activity of Rhodococcus erythropolis NCIMB 11540 whole cells.

Vink MK, Wijtmans R, Reisinger C, van den Berg RJ, Schortinghuis CA, Schwab H, Schoemaker HE, Rutjes FP.

Biotechnol J. 2006 May;1(5):569-73.

PMID:
16892293
31.

Biocatalytic single-step alkene cleavage from aryl alkenes: an enzymatic equivalent to reductive ozonization.

Mang H, Gross J, Lara M, Goessler C, Schoemaker HE, Guebitz GM, Kroutil W.

Angew Chem Int Ed Engl. 2006 Aug 4;45(31):5201-3. No abstract available.

PMID:
16856194
32.

An ELISA-based method for the quantification of incorporated BrdU as a measure of cell proliferation in vivo.

Behl B, Klos M, Serr M, Ebert U, Janson B, Drescher K, Gross G, Schoemaker H.

J Neurosci Methods. 2006 Nov 15;158(1):37-49. Epub 2006 Jun 15.

PMID:
16780957
33.

Enantioselective high-performance liquid chromatographic separation of N-methyloxycarbonyl unsaturated amino acids on macrocyclic glycopeptide stationary phases.

Boesten JM, Berkheij M, Schoemaker HE, Hiemstra H, Duchateau AL.

J Chromatogr A. 2006 Mar 3;1108(1):26-30. Epub 2006 Jan 26.

PMID:
16443231
34.

L-selective amidase with extremely broad substrate specificity from Ochrobactrum anthropi NCIMB 40321.

Sonke T, Ernste S, Tandler RF, Kaptein B, Peeters WP, van Assema FB, Wubbolts MG, Schoemaker HE.

Appl Environ Microbiol. 2005 Dec;71(12):7961-73.

35.

Synthetic applications of aliphatic unsaturated alpha-H-alpha-amino acids.

Kaiser J, Kinderman SS, van Esseveldt BC, van Delft FL, Schoemaker HE, Blaauw RH, Rutjes FP.

Org Biomol Chem. 2005 Oct 7;3(19):3435-67. Epub 2005 Sep 5. Review.

PMID:
16172678
36.

Total synthesis of (+)-epiquinamide.

Wijdeven MA, Botman PN, Wijtmans R, Schoemaker HE, Rutjes FP, Blaauw RH.

Org Lett. 2005 Sep 1;7(18):4005-7.

PMID:
16119953
37.

Selective azetidine and tetrahydropyridine formation via Pd-catalyzed cyclizations of allene-substituted amines and amino acids.

Rutjes FP, Tjen KC, Wolf LB, Karstens WF, Schoemaker HE, Hiemstra H.

Org Lett. 1999 Sep 9;1(5):717-20.

PMID:
16118871
38.

Catalytic N-sulfonyliminium ion-mediated cyclizations to alpha-vinyl-substituted isoquinolines and beta-carbolines and applications in metathesis.

Kinderman SS, Wekking MM, van Maarseveen JH, Schoemaker HE, Hiemstra H, Rutjes FP.

J Org Chem. 2005 Jul 8;70(14):5519-27.

PMID:
15989333
39.

Diastereoselective synthesis of (2S,5R)-5-hydroxypipecolic acid and 6-substituted derivatives.

Botman PN, Dommerholt FJ, de Gelder R, Broxterman QB, Schoemaker HE, Rutjes FP, Blaauw RH.

Org Lett. 2004 Dec 23;6(26):4941-4.

PMID:
15606105
40.

Enzymatic hydrolysis of cyanohydrins with recombinant nitrile hydratase and amidase from Rhodococcus erythropolis.

Reisinger Ch, Osprian I, Glieder A, Schoemaker HE, Griengl H, Schwab H.

Biotechnol Lett. 2004 Nov;26(21):1675-80.

PMID:
15604819
41.

Clinical ototoxicity of teicoplanin.

Bonnet RM, Mattie H, de Laat JA, Schoemaker HC, Frijns JH.

Ann Otol Rhinol Laryngol. 2004 Apr;113(4):310-2.

PMID:
15112975
42.

Amidopalladation of alkoxyallenes applied in the synthesis of an enantiopure 1-ethylquinolizidine frog alkaloid.

Kinderman SS, De Gelder R, Van Maarseveen JH, Schoemaker HE, Hiemstra H, Rutjes FP.

J Am Chem Soc. 2004 Apr 7;126(13):4100-1.

PMID:
15053587
43.

Intramolecular Staudinger ligation: a powerful ring-closure method to form medium-sized lactams.

David O, Meester WJ, Bieräugel H, Schoemaker HE, Hiemstra H, van Maarseveen JH.

Angew Chem Int Ed Engl. 2003 Sep 22;42(36):4373-5. No abstract available.

PMID:
14502715
44.

A pincer auxiliary to force difficult lactamisations.

Bieräugel H, Schoemaker HE, Hiemstra H, van Maarseveen JH.

Org Biomol Chem. 2003 Jun 7;1(11):1830-2.

PMID:
12945758
45.

SSR181507, a dopamine D(2) receptor antagonist and 5-HT(1A) receptor agonist. I: Neurochemical and electrophysiological profile.

Claustre Y, Peretti DD, Brun P, Gueudet C, Allouard N, Alonso R, Lourdelet J, Oblin A, Damoiseau G, Françon D, Suaud-Chagny MF, Steinberg R, Sevrin M, Schoemaker H, George P, Soubrié P, Scatton B.

Neuropsychopharmacology. 2003 Dec;28(12):2064-76.

46.

The effect of motilin on the rectum in healthy volunteers.

Kamerling IM, Burggraaf J, van Haarst AD, Oppenhuizen-Duinker MF, Schoemaker HC, Biemond I, Jones R, Heinzerling H, Cohen AF, Masclee AA.

Br J Clin Pharmacol. 2003 Jun;55(6):538-43.

47.

Synthesis of novel acetylene-containing amino acids.

IJsselstijn M, Kaiser J, van Delft FL, Schoemaker HE, Rutjes FP.

Amino Acids. 2003 Apr;24(3):263-6.

PMID:
12707807
48.

Dispelling the myths--biocatalysis in industrial synthesis.

Schoemaker HE, Mink D, Wubbolts MG.

Science. 2003 Mar 14;299(5613):1694-7.

PMID:
12637735
49.

SL651498, a GABAA receptor agonist with subtype-selective efficacy, as a potential treatment for generalized anxiety disorder and muscle spasms.

Griebel G, Perrault G, Simiand J, Cohen C, Granger P, Depoortere H, Françon D, Avenet P, Schoemaker H, Evanno Y, Sevrin M, George P, Scatton B.

CNS Drug Rev. 2003 Spring;9(1):3-20. Review.

50.

A stereodivergent approach to substituted 4-hydroxypiperidines.

Vink MK, Schortinghuis CA, Luten J, Van Maarseveen JH, Schoemaker HE, Hiemstra H, Rutjes FP.

J Org Chem. 2002 Nov 1;67(22):7869-71.

PMID:
12398517

Supplemental Content

Loading ...
Support Center