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Immunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer.

Metzger P, Kirchleitner SV, Kluge M, Koenig LM, Hörth C, Rambuscheck CA, Böhmer D, Ahlfeld J, Kobold S, Friedel CC, Endres S, Schnurr M, Duewell P.

J Immunother Cancer. 2019 Nov 6;7(1):288. doi: 10.1186/s40425-019-0778-7.


IFN Regulatory Factor 4 Controls Post-ischemic Inflammation and Prevents Chronic Kidney Disease.

Lorenz G, Moschovaki-Filippidou F, Würf V, Metzger P, Steiger S, Batz F, Carbajo-Lozoya J, Koziel J, Schnurr M, Cohen CD, Schmaderer C, Anders HJ, Lindenmeyer M, Lech M.

Front Immunol. 2019 Oct 1;10:2162. doi: 10.3389/fimmu.2019.02162. eCollection 2019.


Utility of the RIG-I agonist triphosphate RNA for melanoma therapy.

Helms MW, Jahn-Hofmann K, Gnerlich F, Metz-Weidmann C, Braun M, Dietert G, Scherer P, Grandien K, Theilhaber J, Cao H, Wagenaar TR, Schnurr MM, Endres S, Wiederschain D, Scheidler S, Rothenfußer S, Brunner B, König LM.

Mol Cancer Ther. 2019 Sep 12. pii: molcanther.1262.2018. doi: 10.1158/1535-7163.MCT-18-1262. [Epub ahead of print]


Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches.

Orth M, Metzger P, Gerum S, Mayerle J, Schneider G, Belka C, Schnurr M, Lauber K.

Radiat Oncol. 2019 Aug 8;14(1):141. doi: 10.1186/s13014-019-1345-6. Review.


Ischemic Postconditioning (IPostC) Protects Fibrotic and Cirrhotic Rat Livers after Warm Ischemia.

Schewe J, Makeschin MC, Liss I, Mayr D, Zhang J, Khandoga A, Rothenfußer S, Schnurr M, Gerbes AL, Steib CJ.

Can J Gastroenterol Hepatol. 2019 Jun 9;2019:5683479. doi: 10.1155/2019/5683479. eCollection 2019.


Engineered Polymer Nanoparticles with Unprecedented Antimicrobial Efficacy and Therapeutic Indices against Multidrug-Resistant Bacteria and Biofilms.

Gupta A, Landis RF, Li CH, Schnurr M, Das R, Lee YW, Yazdani M, Liu Y, Kozlova A, Rotello VM.

J Am Chem Soc. 2018 Sep 26;140(38):12137-12143. doi: 10.1021/jacs.8b06961. Epub 2018 Sep 13.


High Exchange Rate Complexes of 129 Xe with Water-Soluble Pillar[5]arenes for Adjustable Magnetization Transfer MRI.

Schnurr M, Joseph R, Naugolny-Keisar A, Kaizerman-Kane D, Bogdanoff N, Schuenke P, Cohen Y, Schröder L.

Chemphyschem. 2019 Jan 21;20(2):246-251. doi: 10.1002/cphc.201800618. Epub 2018 Aug 21.


Dying cells expose a nuclear antigen cross-reacting with anti-PD-1 monoclonal antibodies.

Metzger P, Kirchleitner SV, Koenig LM, Hörth C, Kobold S, Endres S, Schnurr M, Duewell P.

Sci Rep. 2018 Jun 11;8(1):8810. doi: 10.1038/s41598-018-27125-6.


Nlrp3-dependent IL-1β inhibits CD103+ dendritic cell differentiation in the gut.

Mak'Anyengo R, Duewell P, Reichl C, Hörth C, Lehr HA, Fischer S, Clavel T, Denk G, Hohenester S, Kobold S, Endres S, Schnurr M, Bauer C.

JCI Insight. 2018 Mar 8;3(5). pii: 96322. doi: 10.1172/jci.insight.96322.


Volcanic Ash Activates the NLRP3 Inflammasome in Murine and Human Macrophages.

Damby DE, Horwell CJ, Baxter PJ, Kueppers U, Schnurr M, Dingwell DB, Duewell P.

Front Immunol. 2018 Jan 22;8:2000. doi: 10.3389/fimmu.2017.02000. eCollection 2017.


Time-resolved monitoring of enzyme activity with ultrafast Hyper-CEST spectroscopy.

Döpfert J, Schnurr M, Kunth M, Rose HM, Hennig A, Schröder L.

Magn Reson Chem. 2018 Jul;56(7):679-688. doi: 10.1002/mrc.4702. Epub 2018 Jan 18.


Cancer cells induce interleukin-22 production from memory CD4+ T cells via interleukin-1 to promote tumor growth.

Voigt C, May P, Gottschlich A, Markota A, Wenk D, Gerlach I, Voigt S, Stathopoulos GT, Arendt KAM, Heise C, Rataj F, Janssen KP, Königshoff M, Winter H, Himsl I, Thasler WE, Schnurr M, Rothenfußer S, Endres S, Kobold S.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12994-12999. doi: 10.1073/pnas.1705165114. Epub 2017 Nov 17.


Data on chow, liver tissue and mitochondrial fatty acid compositions as well as mitochondrial proteome changes after feeding mice a western diet for 6-24 weeks.

Einer C, Hohenester S, Wimmer R, Wottke L, Artmann R, Schulz S, Gosmann C, Simmons A, Leitzinger C, Eberhagen C, Borchard S, Schmitt S, Hauck SM, von Toerne C, Jastroch M, Walheim E, Rust C, Gerbes AL, Popper B, Mayr D, Schnurr M, Vollmar AM, Denk G, Zischka H.

Data Brief. 2017 Sep 18;15:163-169. doi: 10.1016/j.dib.2017.09.019. eCollection 2017 Dec.


Mitochondrial adaptation in steatotic mice.

Einer C, Hohenester S, Wimmer R, Wottke L, Artmann R, Schulz S, Gosmann C, Simmons A, Leitzinger C, Eberhagen C, Borchard S, Schmitt S, Hauck SM, von Toerne C, Jastroch M, Walheim E, Rust C, Gerbes AL, Popper B, Mayr D, Schnurr M, Vollmar AM, Denk G, Zischka H.

Mitochondrion. 2018 May;40:1-12. doi: 10.1016/j.mito.2017.08.015. Epub 2017 Sep 19.


Inter- and Intramolecular Electron Transfer in Copper Complexes: Electronic Entatic State with Redox-Active Guanidine Ligands.

Schrempp DF, Leingang S, Schnurr M, Kaifer E, Wadepohl H, Himmel HJ.

Chemistry. 2017 Oct 4;23(55):13607-13611. doi: 10.1002/chem.201703611. Epub 2017 Sep 6.


Prevailing over T cell exhaustion: New developments in the immunotherapy of pancreatic cancer.

Bauer C, Kühnemuth B, Duewell P, Ormanns S, Gress T, Schnurr M.

Cancer Lett. 2016 Oct 10;381(1):259-68. doi: 10.1016/j.canlet.2016.02.057. Epub 2016 Mar 8. Review.


Immunotherapy in Tumors.

Kobold S, Duewell P, Schnurr M, Subklewe M, Rothenfusser S, Endres S.

Dtsch Arztebl Int. 2015 Nov 27;112(48):809-15. doi: 10.3238/arztebl.2015.0809. Review.


Targeted activation of melanoma differentiation-associated protein 5 (MDA5) for immunotherapy of pancreatic carcinoma.

Duewell P, Beller E, Kirchleitner SV, Adunka T, Bourhis H, Siveke J, Mayr D, Kobold S, Endres S, Schnurr M.

Oncoimmunology. 2015 Apr 14;4(10):e1029698. eCollection 2015 Oct.


Supramolecular Assays for Mapping Enzyme Activity by Displacement-Triggered Change in Hyperpolarized (129)Xe Magnetization Transfer NMR Spectroscopy.

Schnurr M, Sloniec-Myszk J, Döpfert J, Schröder L, Hennig A.

Angew Chem Int Ed Engl. 2015 Nov 2;54(45):13444-7. doi: 10.1002/anie.201507002. Epub 2015 Oct 1.


Impact of a New Fusion Receptor on PD-1-Mediated Immunosuppression in Adoptive T Cell Therapy.

Kobold S, Grassmann S, Chaloupka M, Lampert C, Wenk S, Kraus F, Rapp M, Düwell P, Zeng Y, Schmollinger JC, Schnurr M, Endres S, Rothenfußer S.

J Natl Cancer Inst. 2015 Jun 23;107(8). pii: djv146. doi: 10.1093/jnci/djv146. Print 2015 Aug.


Induction of immunogenic cell death by targeting RIG-I-like helicases in pancreatic cancer.

Schnurr M, Duewell P.

Oncoimmunology. 2014 Dec 13;3(9):e955687. eCollection 2014 Oct.


Strategies to relieve immunosuppression in pancreatic cancer.

Schnurr M, Duewell P, Bauer C, Rothenfusser S, Lauber K, Endres S, Kobold S.

Immunotherapy. 2015;7(4):363-76. doi: 10.2217/imt.15.9. Review.


Proapoptotic and antiapoptotic proteins of the Bcl-2 family regulate sensitivity of pancreatic cancer cells toward gemcitabine and T-cell-mediated cytotoxicity.

Bauer C, Hees C, Sterzik A, Bauernfeind F, Mak'Anyengo R, Duewell P, Lehr HA, Noessner E, Wank R, Trauzold A, Endres S, Dauer M, Schnurr M.

J Immunother. 2015 Apr;38(3):116-26. doi: 10.1097/CJI.0000000000000073.


Selective bispecific T cell recruiting antibody and antitumor activity of adoptive T cell transfer.

Kobold S, Steffen J, Chaloupka M, Grassmann S, Henkel J, Castoldi R, Zeng Y, Chmielewski M, Schmollinger JC, Schnurr M, Rothenfußer S, Schendel DJ, Abken H, Sustmann C, Niederfellner G, Klein C, Bourquin C, Endres S.

J Natl Cancer Inst. 2014 Nov 24;107(1):364. doi: 10.1093/jnci/dju364. Print 2015 Jan.


RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8(+) T cells.

Duewell P, Steger A, Lohr H, Bourhis H, Hoelz H, Kirchleitner SV, Stieg MR, Grassmann S, Kobold S, Siveke JT, Endres S, Schnurr M.

Cell Death Differ. 2014 Dec;21(12):1825-37. doi: 10.1038/cdd.2014.96. Epub 2014 Jul 11. Erratum in: Cell Death Differ. 2014 Dec;21(12):161.


Brain endothelial cell targeting via a peptide-functionalized liposomal carrier for xenon hyper-CEST MRI.

Schnurr M, Sydow K, Rose HM, Dathe M, Schröder L.

Adv Healthc Mater. 2015 Jan 7;4(1):40-5. doi: 10.1002/adhm.201400224. Epub 2014 Jul 1.


Isolation of intratumoral leukocytes of TLR-stimulated tumor-bearing mice.

Rapp M, Anz D, Schnurr M.

Methods Mol Biol. 2014;1169:175-9. doi: 10.1007/978-1-4939-0882-0_16.


Inflammasome-dependent and -independent IL-18 production mediates immunity to the ISCOMATRIX adjuvant.

Wilson NS, Duewell P, Yang B, Li Y, Marsters S, Koernig S, Latz E, Maraskovsky E, Morelli AB, Schnurr M, Ashkenazi A.

J Immunol. 2014 Apr 1;192(7):3259-68. doi: 10.4049/jimmunol.1302011. Epub 2014 Mar 7.


Concomitant gemcitabine therapy negatively affects DC vaccine-induced CD8(+) T-cell and B-cell responses but improves clinical efficacy in a murine pancreatic carcinoma model.

Bauer C, Sterzik A, Bauernfeind F, Duewell P, Conrad C, Kiefl R, Endres S, Eigler A, Schnurr M, Dauer M.

Cancer Immunol Immunother. 2014 Apr;63(4):321-33. doi: 10.1007/s00262-013-1510-y. Epub 2014 Jan 3.


Temperature during embryonic development has persistent effects on metabolic enzymes in the muscle of zebrafish.

Schnurr ME, Yin Y, Scott GR.

J Exp Biol. 2014 Apr 15;217(Pt 8):1370-80. doi: 10.1242/jeb.094037. Epub 2013 Dec 20.


Cell tracking with caged xenon: using cryptophanes as MRI reporters upon cellular internalization.

Klippel S, Döpfert J, Jayapaul J, Kunth M, Rossella F, Schnurr M, Witte C, Freund C, Schröder L.

Angew Chem Int Ed Engl. 2014 Jan 7;53(2):493-6. doi: 10.1002/anie.201307290. Epub 2013 Dec 4.


Multifunctional antitumor molecule 5'-triphosphate siRNA combining glutaminase silencing and RIG-I activation.

Meng G, Xia M, Xu C, Yuan D, Schnurr M, Wei J.

Int J Cancer. 2014 Apr 15;134(8):1958-71. doi: 10.1002/ijc.28416. Epub 2013 Dec 2.


Functionalized 129Xe as a potential biosensor for membrane fluidity.

Schnurr M, Witte C, Schröder L.

Phys Chem Chem Phys. 2013 Sep 14;15(34):14178-81. doi: 10.1039/c3cp51227d. Epub 2013 Jun 24.


Interleukin-22 is frequently expressed in small- and large-cell lung cancer and promotes growth in chemotherapy-resistant cancer cells.

Kobold S, Völk S, Clauditz T, Küpper NJ, Minner S, Tufman A, Düwell P, Lindner M, Koch I, Heidegger S, Rothenfuer S, Schnurr M, Huber RM, Wilczak W, Endres S.

J Thorac Oncol. 2013 Aug;8(8):1032-42. doi: 10.1097/JTO.0b013e31829923c8.


The impact of collective efficacy on risks for adolescents' perpetration of dating violence.

Schnurr MP, Lohman BJ.

J Youth Adolesc. 2013 Apr;42(4):518-35. doi: 10.1007/s10964-013-9909-5. Epub 2013 Jan 30.


Therapeutic efficacy of bifunctional siRNA combining TGF-β1 silencing with RIG-I activation in pancreatic cancer.

Ellermeier J, Wei J, Duewell P, Hoves S, Stieg MR, Adunka T, Noerenberg D, Anders HJ, Mayr D, Poeck H, Hartmann G, Endres S, Schnurr M.

Cancer Res. 2013 Mar 15;73(6):1709-20. doi: 10.1158/0008-5472.CAN-11-3850. Epub 2013 Jan 21.


Biomembrane interactions of functionalized cryptophane-A: combined fluorescence and 129Xe NMR studies of a bimodal contrast agent.

Sloniec J, Schnurr M, Witte C, Resch-Genger U, Schröder L, Hennig A.

Chemistry. 2013 Feb 25;19(9):3110-8. doi: 10.1002/chem.201203773. Epub 2013 Jan 14.


Protective and aggravating effects of Nlrp3 inflammasome activation in IBD models: influence of genetic and environmental factors.

Bauer C, Duewell P, Lehr HA, Endres S, Schnurr M.

Dig Dis. 2012;30 Suppl 1:82-90. doi: 10.1159/000341681. Epub 2012 Oct 11.


Isolation, bulk cultivation, and characterization of coronary microvascular pericytes: the second most frequent myocardial cell type in vitro.

Nees S, Weiss DR, Senftl A, Knott M, Förch S, Schnurr M, Weyrich P, Juchem G.

Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H69-84. doi: 10.1152/ajpheart.00359.2011. Epub 2011 Oct 28.


A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells.

Hoves S, Sutton VR, Haynes NM, Hawkins ED, Fernández Ruiz D, Baschuk N, Sedelies KA, Schnurr M, Stagg J, Andrews DM, Villadangos JA, Trapani JA.

J Immunol. 2011 Aug 1;187(3):1166-75. doi: 10.4049/jimmunol.1001670. Epub 2011 Jun 27.


ISCOMATRIX adjuvant combines immune activation with antigen delivery to dendritic cells in vivo leading to effective cross-priming of CD8+ T cells.

Duewell P, Kisser U, Heckelsmiller K, Hoves S, Stoitzner P, Koernig S, Morelli AB, Clausen BE, Dauer M, Eigler A, Anz D, Bourquin C, Maraskovsky E, Endres S, Schnurr M.

J Immunol. 2011 Jul 1;187(1):55-63. doi: 10.4049/jimmunol.1004114. Epub 2011 May 25.


Dendritic cell-based vaccination of patients with advanced pancreatic carcinoma: results of a pilot study.

Bauer C, Dauer M, Saraj S, Schnurr M, Bauernfeind F, Sterzik A, Junkmann J, Jakl V, Kiefl R, Oduncu F, Emmerich B, Mayr D, Mussack T, Bruns C, Rüttinger D, Conrad C, Jauch KW, Endres S, Eigler A.

Cancer Immunol Immunother. 2011 Aug;60(8):1097-107. doi: 10.1007/s00262-011-1023-5. Epub 2011 May 6.


CD103 is a hallmark of tumor-infiltrating regulatory T cells.

Anz D, Mueller W, Golic M, Kunz WG, Rapp M, Koelzer VH, Ellermeier J, Ellwart JW, Schnurr M, Bourquin C, Endres S.

Int J Cancer. 2011 Nov 15;129(10):2417-26. doi: 10.1002/ijc.25902. Epub 2011 Apr 1.


An ISCOM vaccine combined with a TLR9 agonist breaks immune evasion mediated by regulatory T cells in an orthotopic model of pancreatic carcinoma.

Jacobs C, Duewell P, Heckelsmiller K, Wei J, Bauernfeind F, Ellermeier J, Kisser U, Bauer CA, Dauer M, Eigler A, Maraskovsky E, Endres S, Schnurr M.

Int J Cancer. 2011 Feb 15;128(4):897-907. doi: 10.1002/ijc.25399.


Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome.

Bauer C, Duewell P, Mayer C, Lehr HA, Fitzgerald KA, Dauer M, Tschopp J, Endres S, Latz E, Schnurr M.

Gut. 2010 Sep;59(9):1192-9. doi: 10.1136/gut.2009.197822. Epub 2010 May 4.


Processing and cross-presentation of individual HLA-A, -B, or -C epitopes from NY-ESO-1 or an HLA-A epitope for Melan-A differ according to the mode of antigen delivery.

Robson NC, McAlpine T, Knights AJ, Schnurr M, Shin A, Chen W, Maraskovsky E, Cebon J.

Blood. 2010 Jul 15;116(2):218-25. doi: 10.1182/blood-2009-10-249458. Epub 2010 Apr 29.


NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.

Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nuñez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E.

Nature. 2010 Apr 29;464(7293):1357-61. doi: 10.1038/nature08938. Erratum in: Nature. 2010 Jul 29;466(7306):652.

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