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Known Knowns, Known Unknowns, and Unknown Unknowns: Coverage in MS Experiments.

Koziol JA, Li Y, Schnitzer JE.

Proteomics. 2018 Aug;18(16):e1800124. doi: 10.1002/pmic.201800124. Epub 2018 Aug 6.


Overcoming key biological barriers to cancer drug delivery and efficacy.

Kim SM, Faix PH, Schnitzer JE.

J Control Release. 2017 Dec 10;267:15-30. doi: 10.1016/j.jconrel.2017.09.016. Epub 2017 Sep 14. Review.


Tumor targeting, trifunctional dendritic wedge.

Dubey R, Kushal S, Mollard A, Vojtovich L, Oh P, Levin MD, Schnitzer JE, Zharov I, Olenyuk BZ.

Bioconjug Chem. 2015 Jan 21;26(1):78-89. doi: 10.1021/bc500436b. Epub 2014 Nov 12.


In vivo proteomic imaging analysis of caveolae reveals pumping system to penetrate solid tumors.

Oh P, Testa JE, Borgstrom P, Witkiewicz H, Li Y, Schnitzer JE.

Nat Med. 2014 Sep;20(9):1062-8. doi: 10.1038/nm.3623. Epub 2014 Aug 17.


II. Capsular vaso-mimicry formed by transgenic mammary tumor spheroids implanted ectopically into mouse dorsal skin fold: implications for cellular mechanisms of metastasis.

Witkiewicz H, Oh P, Schnitzer JE.

Version 2. F1000Res. 2013 Jan 10 [revised 2013 Jan 1];2:9. doi: 10.12688/f1000research.2-9.v2. eCollection 2013.


III. Cellular ultrastructures in situ as key to understanding tumor energy metabolism: biological significance of the Warburg effect.

Witkiewicz H, Oh P, Schnitzer JE.

F1000Res. 2013 Jan 10;2:10. doi: 10.12688/f1000research.2-10.v1. eCollection 2013.


Assessing the barriers to image-guided drug delivery.

Lanza GM, Moonen C, Baker JR Jr, Chang E, Cheng Z, Grodzinski P, Ferrara K, Hynynen K, Kelloff G, Lee YE, Patri AK, Sept D, Schnitzer JE, Wood BJ, Zhang M, Zheng G, Farahani K.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2014 Jan-Feb;6(1):1-14. doi: 10.1002/wnan.1247. Epub 2013 Oct 31. Review.


Experimental model of transthoracic, vascular-targeted, photodynamically induced myocardial infarction.

Chrastina A, Pokreisz P, Schnitzer JE.

Am J Physiol Heart Circ Physiol. 2014 Jan 15;306(2):H270-8. doi: 10.1152/ajpheart.00818.2012. Epub 2013 Nov 8.


Suppression of tumor growth by designed dimeric epidithiodiketopiperazine targeting hypoxia-inducible transcription factor complex.

Dubey R, Levin MD, Szabo LZ, Laszlo CF, Kushal S, Singh JB, Oh P, Schnitzer JE, Olenyuk BZ.

J Am Chem Soc. 2013 Mar 20;135(11):4537-49. doi: 10.1021/ja400805b. Epub 2013 Mar 11.


On protein abundance distributions in complex mixtures.

Koziol J, Griffin N, Long F, Li Y, Latterich M, Schnitzer J.

Proteome Sci. 2013 Jan 29;11(1):5. doi: 10.1186/1477-5956-11-5.


Co-implanting orthotopic tissue creates stroma microenvironment enhancing growth and angiogenesis of multiple tumors.

Borgstrom P, Oh P, Czarny M, Racine B, Schnitzer JE.

Version 2. F1000Res. 2013 May 21 [revised 2013 Jan 1];2:129. doi: 10.12688/f1000research.2-129.v2. eCollection 2013.


I. Embryonal vasculature formation recapitulated in transgenic mammary tumor spheroids implanted pseudo-orthotopicly into mouse dorsal skin fold: the organoblasts concept.

Witkiewicz H, Oh P, Schnitzer JE.

Version 2. F1000Res. 2013 Jan 10 [revised 2013 Jan 1];2:8. doi: 10.12688/f1000research.2-8.v2. eCollection 2013.


Endothelin induces rapid, dynamin-mediated budding of endothelial caveolae rich in ET-B.

Oh P, Horner T, Witkiewicz H, Schnitzer JE.

J Biol Chem. 2012 May 18;287(21):17353-62. doi: 10.1074/jbc.M111.338897. Epub 2012 Mar 28.


Laser-targeted photosensitizer-induced lung injury: noninvasive rat model of pulmonary infarction.

Chrastina A, Schnitzer JE.

Exp Lung Res. 2012 Feb;38(1):1-8. doi: 10.3109/01902148.2011.627085. Epub 2011 Nov 28.


Streamlining biomarker discovery.

Latterich M, Schnitzer JE.

Nat Biotechnol. 2011 Jul 11;29(7):600-2. doi: 10.1038/nbt.1917. No abstract available.


Overcoming in vivo barriers to targeted nanodelivery.

Chrastina A, Massey KA, Schnitzer JE.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011 Jul-Aug;3(4):421-37. doi: 10.1002/wnan.143. Epub 2011 Apr 27. Review.


Systems analysis of endothelial cell plasma membrane proteome of rat lung microvasculature.

Li Y, Massey K, Witkiewicz H, Schnitzer JE.

Proteome Sci. 2011 Mar 29;9(1):15. doi: 10.1186/1477-5956-9-15.


Construction of metabolically biotinylated adenovirus with deleted fiber knob as targeting vector.

Liu Y, Valadon P, Schnitzer JE.

Virol J. 2010 Nov 12;7:316. doi: 10.1186/1743-422X-7-316.


Iodine-125 radiolabeling of silver nanoparticles for in vivo SPECT imaging.

Chrastina A, Schnitzer JE.

Int J Nanomedicine. 2010 Sep 7;5:653-9. doi: 10.2147/IJN.S11677.


Overcoming key technological challenges in using mass spectrometry for mapping cell surfaces in tissues.

Griffin NM, Schnitzer JE.

Mol Cell Proteomics. 2011 Feb;10(2):R110.000935. doi: 10.1074/mcp.R110.000935. Epub 2010 Jun 14. Review.


Lung vascular targeting using antibody to aminopeptidase P: CT-SPECT imaging, biodistribution and pharmacokinetic analysis.

Chrastina A, Valadon P, Massey KA, Schnitzer JE.

J Vasc Res. 2010;47(6):531-43. doi: 10.1159/000313880. Epub 2010 Apr 30.


T cell pathways involving CTLA4 contribute to a model of acute lung injury.

Nakajima T, Suarez CJ, Lin KW, Jen KY, Schnitzer JE, Makani SS, Parker N, Perkins DL, Finn PW.

J Immunol. 2010 May 15;184(10):5835-41. doi: 10.4049/jimmunol.0903238. Epub 2010 Apr 12.


Caveolae and cancer.

Massey KA, Schnitzer JE.

Recent Results Cancer Res. 2010;180:217-31. doi: 10.1007/978-3-540-78281-0_13. Review.


Label-free, normalized quantification of complex mass spectrometry data for proteomic analysis.

Griffin NM, Yu J, Long F, Oh P, Shore S, Li Y, Koziol JA, Schnitzer JE.

Nat Biotechnol. 2010 Jan;28(1):83-9. doi: 10.1038/nbt.1592. Epub 2009 Dec 13.


Designed auto-assembly of nanostreptabodies for rapid tissue-specific targeting in vivo.

Valadon P, Darsow B, Buss TN, Czarny M, Griffin NM, Nguyen HN, Oh P, Borgstrom P, Chrastina A, Schnitzer JE.

J Biol Chem. 2010 Jan 1;285(1):713-22. doi: 10.1074/jbc.M109.061838. Epub 2009 Oct 22.


Impaired tumor growth, metastasis, angiogenesis and wound healing in annexin A1-null mice.

Yi M, Schnitzer JE.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17886-91. doi: 10.1073/pnas.0901324106. Epub 2009 Oct 1.


Targeting and imaging signature caveolar molecules in lungs.

Massey KA, Schnitzer JE.

Proc Am Thorac Soc. 2009 Aug 15;6(5):419-30. doi: 10.1513/pats.200903-011AW.


Immunotargeting and cloning of two CD34 variants exhibiting restricted expression in adult rat endothelia in vivo.

Testa JE, Chrastina A, Oh P, Li Y, Witkiewicz H, Czarny M, Buss T, Schnitzer JE.

Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L251-62. doi: 10.1152/ajplung.90565.2008. Epub 2009 May 22.


Enhancing identifications of lipid-embedded proteins by mass spectrometry for improved mapping of endothelial plasma membranes in vivo.

Li Y, Yu J, Wang Y, Griffin NM, Long F, Shore S, Oh P, Schnitzer JE.

Mol Cell Proteomics. 2009 Jun;8(6):1219-35. doi: 10.1074/mcp.M800215-MCP200. Epub 2009 Jan 19.


Ubiquitous yet distinct expression of podocalyxin on vascular surfaces in normal and tumor tissues in the rat.

Testa JE, Chrastina A, Li Y, Oh P, Schnitzer JE.

J Vasc Res. 2009;46(4):311-24. doi: 10.1159/000189792. Epub 2009 Jan 10.


Chapter 8. Proteomic mapping of the vascular endothelium in vivo for vascular targeting.

Griffin NM, Schnitzer JE.

Methods Enzymol. 2008;445:177-208. doi: 10.1016/S0076-6879(08)03008-5.


Range Charts for Agreement in Measurement Comparison Studies, With Application to Replicate Mass Spectrometry Experiments.

Koziol JA, Feng AC, Yu J, Griffin NM, Schnitzer JE.

J Proteomics Bioinform. 2008 Sep 1;1(6):287-292.


Vascular proteomic mapping in vivo.

Simonson AB, Schnitzer JE.

J Thromb Haemost. 2007 Jul;5 Suppl 1:183-7. Review.


Genomics and proteomics of lung disease: conference summary.

Raj JU, Aliferis C, Caprioli RM, Cowley AW Jr, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA.

Am J Physiol Lung Cell Mol Physiol. 2007 Jul;293(1):L45-51. Epub 2007 Apr 27. No abstract available.


Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung.

Oh P, Borgström P, Witkiewicz H, Li Y, Borgström BJ, Chrastina A, Iwata K, Zinn KR, Baldwin R, Testa JE, Schnitzer JE.

Nat Biotechnol. 2007 Mar;25(3):327-37. Epub 2007 Mar 4. Erratum in: Nat Biotechnol. 2007 Apr;25(4):478.


Application of capture-recapture models to estimation of protein count in MudPIT experiments.

Koziol JA, Feng AC, Schnitzer JE.

Anal Chem. 2006 May 1;78(9):3203-7.


Screening phage display libraries for organ-specific vascular immunotargeting in vivo.

Valadon P, Garnett JD, Testa JE, Bauerle M, Oh P, Schnitzer JE.

Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):407-12. Epub 2005 Dec 29.


Direct proteomic mapping of the lung microvascular endothelial cell surface in vivo and in cell culture.

Durr E, Yu J, Krasinska KM, Carver LA, Yates JR, Testa JE, Oh P, Schnitzer JE.

Nat Biotechnol. 2004 Aug;22(8):985-92. Epub 2004 Jul 18.


Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy.

Oh P, Li Y, Yu J, Durr E, Krasinska KM, Carver LA, Testa JE, Schnitzer JE.

Nature. 2004 Jun 10;429(6992):629-35.


Neutral sphingomyelinase inhibitor scyphostatin prevents and ceramide mimics mechanotransduction in vascular endothelium.

Czarny M, Schnitzer JE.

Am J Physiol Heart Circ Physiol. 2004 Sep;287(3):H1344-52. Epub 2004 May 13.


Role of caveolae and lipid rafts in cancer: workshop summary and future needs.

Carver LA, Schnitzer JE, Anderson RG, Mohla S.

Cancer Res. 2003 Oct 15;63(20):6571-4. No abstract available.


Caveolae: mining little caves for new cancer targets.

Carver LA, Schnitzer JE.

Nat Rev Cancer. 2003 Aug;3(8):571-81. Review.


Recruitment of endothelial caveolae into mechanotransduction pathways by flow conditioning in vitro.

Rizzo V, Morton C, DePaola N, Schnitzer JE, Davies PF.

Am J Physiol Heart Circ Physiol. 2003 Oct;285(4):H1720-9. Epub 2003 Jun 19.


Transient mechanoactivation of neutral sphingomyelinase in caveolae to generate ceramide.

Czarny M, Liu J, Oh P, Schnitzer JE.

J Biol Chem. 2003 Feb 14;278(7):4424-30. Epub 2002 Dec 6.


Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide.

Zabel U, Kleinschnitz C, Oh P, Nedvetsky P, Smolenski A, Müller H, Kronich P, Kugler P, Walter U, Schnitzer JE, Schmidt HH.

Nat Cell Biol. 2002 Apr;4(4):307-11.


Caveolae require intact VAMP for targeted transport in vascular endothelium.

McIntosh DP, Schnitzer JE.

Am J Physiol. 1999 Dec;277(6):H2222-32. doi: 10.1152/ajpheart.1999.277.6.H2222.


Immunoisolation of caveolae with high affinity antibody binding to the oligomeric caveolin cage. Toward understanding the basis of purification.

Oh P, Schnitzer JE.

J Biol Chem. 1999 Aug 13;274(33):23144-54. Erratum in: J Biol Chem 1999 Oct 8;274(41):29582.

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