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The expression of TAP1 candidate gene, but not its polymorphism and methylation, is associated with colonic polyp formation in a porcine model of human familial adenomatous polyposis.

Perkowska A, Flisikowska T, Perleberg C, Flisikowski K, Stachowiak M, Nowacka-Woszuk J, Saur D, Kind A, Schnieke A, Switonski M.

Anim Biotechnol. 2019 Apr 5:1-8. doi: 10.1080/10495398.2019.1590377. [Epub ahead of print]


Porcine endogenous retroviruses: Quantification of the copy number in cell lines, pig breeds, and organs.

Fiebig U, Fischer K, Bähr A, Runge C, Schnieke A, Wolf E, Denner J.

Xenotransplantation. 2018 Jul;25(4):e12445. doi: 10.1111/xen.12445.


Elevated expression of p53 in early colon polyps in a pig model of human familial adenomatous polyposis.

Sikorska A, Flisikowska T, Stachowiak M, Kind A, Schnieke A, Flisikowski K, Switonski M.

J Appl Genet. 2018 Nov;59(4):485-491. doi: 10.1007/s13353-018-0461-6. Epub 2018 Aug 25.


Assembling multiple xenoprotective transgenes in pigs.

Fischer K, Kind A, Schnieke A.

Xenotransplantation. 2018 Nov;25(6):e12431. doi: 10.1111/xen.12431. Epub 2018 Jul 28. Review.


Generation of functional cardiomyocytes from rat embryonic and induced pluripotent stem cells using feeder-free expansion and differentiation in suspension culture.

Dahlmann J, Awad G, Dolny C, Weinert S, Richter K, Fischer KD, Munsch T, Leßmann V, Volleth M, Zenker M, Chen Y, Merkl C, Schnieke A, Baraki H, Kutschka I, Kensah G.

PLoS One. 2018 Mar 7;13(3):e0192652. doi: 10.1371/journal.pone.0192652. eCollection 2018.


Genetically engineered pigs as models for human disease.

Perleberg C, Kind A, Schnieke A.

Dis Model Mech. 2018 Jan 22;11(1). pii: dmm030783. doi: 10.1242/dmm.030783. Review.


Strong xenoprotective function by single-copy transgenes placed sequentially at a permissive locus.

Rieblinger B, Fischer K, Kind A, Saller BS, Baars W, Schuster M, Wolf-van Buerck L, Schäffler A, Flisikowska T, Kurome M, Zakhartchenko V, Kessler B, Flisikowski K, Wolf E, Seissler J, Schwinzer R, Schnieke A.

Xenotransplantation. 2018 Mar;25(2):e12382. doi: 10.1111/xen.12382. Epub 2018 Jan 23.


Altered microRNA profiles during early colon adenoma progression in a porcine model of familial adenomatous polyposis.

Stachowiak M, Flisikowska T, Bauersachs S, Perleberg C, Pausch H, Switonski M, Kind A, Saur D, Schnieke A, Flisikowski K.

Oncotarget. 2017 Oct 10;8(56):96154-96160. doi: 10.18632/oncotarget.21774. eCollection 2017 Nov 10.


Porcine familial adenomatous polyposis model enables systematic analysis of early events in adenoma progression.

Flisikowska T, Stachowiak M, Xu H, Wagner A, Hernandez-Caceres A, Wurmser C, Perleberg C, Pausch H, Perkowska A, Fischer K, Frishman D, Fries R, Switonski M, Kind A, Saur D, Schnieke A, Flisikowski K.

Sci Rep. 2017 Jul 26;7(1):6613. doi: 10.1038/s41598-017-06741-8.


Maternal placenta modulates a deleterious fetal mutation.

Xu H, Pausch H, Venhoranta H, Rutkowska K, Wurmser C, Rieblinger B, Flisikowska T, Frishman D, Zwierzchowski L, Fries R, Andersson M, Kind A, Schnieke A, Flisikowski K.

Biol Reprod. 2017 Aug 1;97(2):249-257. doi: 10.1093/biolre/iox064.


Annotation of the Domestic Pig Genome by Quantitative Proteogenomics.

Marx H, Hahne H, Ulbrich SE, Schnieke A, Rottmann O, Frishman D, Kuster B.

J Proteome Res. 2017 Aug 4;16(8):2887-2898. doi: 10.1021/acs.jproteome.7b00184. Epub 2017 Jun 29.


Advancing ovarian folliculometry with selective plane illumination microscopy.

Lin HA, Dutta R, Mandal S, Kind A, Schnieke A, Razansky D.

Sci Rep. 2016 Dec 1;6:38057. doi: 10.1038/srep38057.


Efficient production of multi-modified pigs for xenotransplantation by 'combineering', gene stacking and gene editing.

Fischer K, Kraner-Scheiber S, Petersen B, Rieblinger B, Buermann A, Flisikowska T, Flisikowski K, Christan S, Edlinger M, Baars W, Kurome M, Zakhartchenko V, Kessler B, Plotzki E, Szczerbal I, Switonski M, Denner J, Wolf E, Schwinzer R, Niemann H, Kind A, Schnieke A.

Sci Rep. 2016 Jun 29;6:29081. doi: 10.1038/srep29081.


Non-invasive assessment of porcine oocyte quality by supravital staining of cumulus-oocyte complexes with lissamine green B.

Dutta R, Li S, Fischer K, Kind A, Flisikowska T, Flisikowski K, Rottmann O, Schnieke A.

Zygote. 2016 Jun;24(3):418-27. doi: 10.1017/S0967199415000349.


Pigs as models of human cancers.

Flisikowska T, Kind A, Schnieke A.

Theriogenology. 2016 Jul 1;86(1):433-7. doi: 10.1016/j.theriogenology.2016.04.058. Epub 2016 Apr 21. Review.


A frameshift mutation in GON4L is associated with proportionate dwarfism in Fleckvieh cattle.

Schwarzenbacher H, Wurmser C, Flisikowski K, Misurova L, Jung S, Langenmayer MC, Schnieke A, Knubben-Schweizer G, Fries R, Pausch H.

Genet Sel Evol. 2016 Mar 31;48:25. doi: 10.1186/s12711-016-0207-z.


A porcine model of osteosarcoma.

Saalfrank A, Janssen KP, Ravon M, Flisikowski K, Eser S, Steiger K, Flisikowska T, Müller-Fliedner P, Schulze É, Brönner C, Gnann A, Kappe E, Böhm B, Schade B, Certa U, Saur D, Esposito I, Kind A, Schnieke A.

Oncogenesis. 2016 Mar 14;5:e210. doi: 10.1038/oncsis.2016.19.


Germline gene polymorphisms predisposing domestic mammals to carcinogenesis.

Flisikowski K, Flisikowska T, Sikorska A, Perkowska A, Kind A, Schnieke A, Switonski M.

Vet Comp Oncol. 2017 Jun;15(2):289-298. doi: 10.1111/vco.12186. Epub 2015 Nov 17. Review.


PEG3 domain gene expression in maternal and foetal placenta in intrauterine growth restricted bovine foetuses.

Li S, Pausch H, Venhoranta H, Adamowicz K, Andersson M, Zwierzchowski L, Kind A, Schnieke A, Flisikowski K.

Anim Genet. 2016 Feb;47(1):106-9. doi: 10.1111/age.12373. Epub 2015 Nov 5.


Homozygous haplotype deficiency reveals deleterious mutations compromising reproductive and rearing success in cattle.

Pausch H, Schwarzenbacher H, Burgstaller J, Flisikowski K, Wurmser C, Jansen S, Jung S, Schnieke A, Wittek T, Fries R.

BMC Genomics. 2015 Apr 18;16:312. doi: 10.1186/s12864-015-1483-7.


Viable pigs with a conditionally-activated oncogenic KRAS mutation.

Li S, Edlinger M, Saalfrank A, Flisikowski K, Tschukes A, Kurome M, Zakhartchenko V, Kessler B, Saur D, Kind A, Wolf E, Schnieke A, Flisikowska T.

Transgenic Res. 2015 Jun;24(3):509-17. doi: 10.1007/s11248-015-9866-8. Epub 2015 Feb 26.


Xenotransplantation of porcine islet cells as a potential option for the treatment of type 1 diabetes in the future.

Reichart B, Niemann H, Chavakis T, Denner J, Jaeckel E, Ludwig B, Marckmann G, Schnieke A, Schwinzer R, Seissler J, Tönjes RR, Klymiuk N, Wolf E, Bornstein SR.

Horm Metab Res. 2015 Jan;47(1):31-5. doi: 10.1055/s-0034-1395518. Epub 2014 Dec 15. Review.


A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer.

Schönhuber N, Seidler B, Schuck K, Veltkamp C, Schachtler C, Zukowska M, Eser S, Feyerabend TB, Paul MC, Eser P, Klein S, Lowy AM, Banerjee R, Yang F, Lee CL, Moding EJ, Kirsch DG, Scheideler A, Alessi DR, Varela I, Bradley A, Kind A, Schnieke AE, Rodewald HR, Rad R, Schmid RM, Schneider G, Saur D.

Nat Med. 2014 Nov;20(11):1340-1347. doi: 10.1038/nm.3646. Epub 2014 Oct 19. Erratum in: Nat Med. 2015 Apr;21(4):414.


In frame exon skipping in UBE3B is associated with developmental disorders and increased mortality in cattle.

Venhoranta H, Pausch H, Flisikowski K, Wurmser C, Taponen J, Rautala H, Kind A, Schnieke A, Fries R, Lohi H, Andersson M.

BMC Genomics. 2014 Oct 12;15:890. doi: 10.1186/1471-2164-15-890.


Dual fluorescent reporter pig for Cre recombination: transgene placement at the ROSA26 locus.

Li S, Flisikowska T, Kurome M, Zakhartchenko V, Kessler B, Saur D, Kind A, Wolf E, Flisikowski K, Schnieke A.

PLoS One. 2014 Jul 15;9(7):e102455. doi: 10.1371/journal.pone.0102455. eCollection 2014.


Hybrid voltage sensor imaging of eGFP-F expressing neurons in chicken midbrain slices.

Weigel S, Flisikowska T, Schnieke A, Luksch H.

J Neurosci Methods. 2014 Aug 15;233:28-33. doi: 10.1016/j.jneumeth.2014.05.034. Epub 2014 Jun 4.


Oncogenic KRAS signalling in pancreatic cancer.

Eser S, Schnieke A, Schneider G, Saur D.

Br J Cancer. 2014 Aug 26;111(5):817-22. doi: 10.1038/bjc.2014.215. Epub 2014 Apr 22. Review.


Polymorphism in 3' untranslated region of the pig PPARA gene influences its transcript level and is associated with adipose tissue accumulation.

Stachowiak M, Szydlowski M, Flisikowski K, Flisikowska T, Bartz M, Schnieke A, Switonski M.

J Anim Sci. 2014 Jun;92(6):2363-71. doi: 10.2527/jas.2013-7509. Epub 2014 Mar 26.


Non-CpG hypermethylation in placenta of mutation-induced intrauterine growth restricted bovine foetuses.

Venhoranta H, Li S, Salamon S, Flisikowska T, Andersson M, Switonski M, Kind A, Schnieke A, Flisikowski K.

Biochem Biophys Res Commun. 2014 Feb 14;444(3):391-4. doi: 10.1016/j.bbrc.2014.01.071. Epub 2014 Jan 27.


Genetically modified pigs to model human diseases.

Flisikowska T, Kind A, Schnieke A.

J Appl Genet. 2014 Feb;55(1):53-64. Review.


The new pig on the block: modelling cancer in pigs.

Flisikowska T, Kind A, Schnieke A.

Transgenic Res. 2013 Aug;22(4):673-80. doi: 10.1007/s11248-013-9720-9. Epub 2013 Jun 8. Review.


Fetal growth restriction caused by MIMT1 deletion alters brain transcriptome in cattle.

Venhoranta H, Bauersachs S, Taponen J, Lohi H, Taira T, Andersson M, Kind A, Schnieke A, Flisikowski K.

Int J Dev Neurosci. 2013 Nov;31(7):463-7. doi: 10.1016/j.ijdevneu.2013.05.003. Epub 2013 May 29.


Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set.

Kurome M, Geistlinger L, Kessler B, Zakhartchenko V, Klymiuk N, Wuensch A, Richter A, Baehr A, Kraehe K, Burkhardt K, Flisikowski K, Flisikowska T, Merkl C, Landmann M, Durkovic M, Tschukes A, Kraner S, Schindelhauer D, Petri T, Kind A, Nagashima H, Schnieke A, Zimmer R, Wolf E.

BMC Biotechnol. 2013 May 20;13:43. doi: 10.1186/1472-6750-13-43.


Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer.

Eser S, Reiff N, Messer M, Seidler B, Gottschalk K, Dobler M, Hieber M, Arbeiter A, Klein S, Kong B, Michalski CW, Schlitter AM, Esposito I, Kind AJ, Rad L, Schnieke AE, Baccarini M, Alessi DR, Rad R, Schmid RM, Schneider G, Saur D.

Cancer Cell. 2013 Mar 18;23(3):406-20. doi: 10.1016/j.ccr.2013.01.023. Epub 2013 Feb 28.


Efficient generation of rat induced pluripotent stem cells using a non-viral inducible vector.

Merkl C, Saalfrank A, Riesen N, Kühn R, Pertek A, Eser S, Hardt MS, Kind A, Saur D, Wurst W, Iglesias A, Schnieke A.

PLoS One. 2013;8(1):e55170. doi: 10.1371/journal.pone.0055170. Epub 2013 Jan 31.


Truncation of MIMT1 gene in the PEG3 domain leads to major changes in placental gene expression and stillbirth in cattle.

Flisikowski K, Venhoranta H, Bauersachs S, Hänninen R, Fürst RW, Saalfrank A, Ulbrich SE, Taponen J, Lohi H, Wolf E, Kind A, Andersson M, Schnieke A.

Biol Reprod. 2012 Dec 21;87(6):140. doi: 10.1095/biolreprod.112.104240. Print 2012 Jun.


Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs.

Leuchs S, Saalfrank A, Merkl C, Flisikowska T, Edlinger M, Durkovic M, Rezaei N, Kurome M, Zakhartchenko V, Kessler B, Flisikowski K, Kind A, Wolf E, Schnieke A.

PLoS One. 2012;7(10):e43323. doi: 10.1371/journal.pone.0043323. Epub 2012 Oct 5.


A porcine model of familial adenomatous polyposis.

Flisikowska T, Merkl C, Landmann M, Eser S, Rezaei N, Cui X, Kurome M, Zakhartchenko V, Kessler B, Wieland H, Rottmann O, Schmid RM, Schneider G, Kind A, Wolf E, Saur D, Schnieke A.

Gastroenterology. 2012 Nov;143(5):1173-1175.e7. doi: 10.1053/j.gastro.2012.07.110. Epub 2012 Aug 1.


Polymorphisms in the promoter region of the adiponectin (ADIPOQ) gene are presumably associated with transcription level and carcass traits in pigs.

Cieslak J, Flisikowska T, Schnieke A, Kind A, Szydlowski M, Switonski M, Flisikowski K.

Anim Genet. 2013 Jun;44(3):340-3. doi: 10.1111/j.1365-2052.2012.02397.x. Epub 2012 Jul 20.


Cytomegalovirus replicon-based regulation of gene expression in vitro and in vivo.

Mohr H, Mohr CA, Schneider MR, Scrivano L, Adler B, Kraner-Schreiber S, Schnieke A, Dahlhoff M, Wolf E, Koszinowski UH, Ruzsics Z.

PLoS Pathog. 2012;8(6):e1002728. doi: 10.1371/journal.ppat.1002728. Epub 2012 Jun 7.


MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells toward HDAC inhibitors.

Labisso WL, Wirth M, Stojanovic N, Stauber RH, Schnieke A, Schmid RM, Krämer OH, Saur D, Schneider G.

Cell Cycle. 2012 Apr 15;11(8):1593-602. doi: 10.4161/cc.20008. Epub 2012 Apr 15.


Disclosure of erlotinib as a multikinase inhibitor in pancreatic ductal adenocarcinoma.

Conradt L, Godl K, Schaab C, Tebbe A, Eser S, Diersch S, Michalski CW, Kleeff J, Schnieke A, Schmid RM, Saur D, Schneider G.

Neoplasia. 2011 Nov;13(11):1026-34.


Efficient immunoglobulin gene disruption and targeted replacement in rabbit using zinc finger nucleases.

Flisikowska T, Thorey IS, Offner S, Ros F, Lifke V, Zeitler B, Rottmann O, Vincent A, Zhang L, Jenkins S, Niersbach H, Kind AJ, Gregory PD, Schnieke AE, Platzer J.

PLoS One. 2011;6(6):e21045. doi: 10.1371/journal.pone.0021045. Epub 2011 Jun 13.


In vivo diagnosis of murine pancreatic intraepithelial neoplasia and early-stage pancreatic cancer by molecular imaging.

Eser S, Messer M, Eser P, von Werder A, Seidler B, Bajbouj M, Vogelmann R, Meining A, von Burstin J, Algül H, Pagel P, Schnieke AE, Esposito I, Schmid RM, Schneider G, Saur D.

Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9945-50. doi: 10.1073/pnas.1100890108. Epub 2011 May 31.


RNA interference in pigs: comparison of RNAi test systems and expression vectors.

Merkl C, Leuchs S, Saalfrank A, Kind A, Schnieke A.

Mol Biotechnol. 2011 May;48(1):38-48. doi: 10.1007/s12033-010-9346-6.


Cell-mediated transgenesis in rabbits: chimeric and nuclear transfer animals.

Zakhartchenko V, Flisikowska T, Li S, Richter T, Wieland H, Durkovic M, Rottmann O, Kessler B, Gungor T, Brem G, Kind A, Wolf E, Schnieke A.

Biol Reprod. 2011 Feb;84(2):229-37. doi: 10.1095/biolreprod.110.087098. Epub 2010 Oct 13.


The role of means and goals in technology acceptance. A differentiated landscape of public perceptions of pharming.

Pardo R, Engelhard M, Hagen K, Jørgensen RB, Rehbinder E, Schnieke A, Szmulewicz M, Thiele F.

EMBO Rep. 2009 Oct;10(10):1069-75. doi: 10.1038/embor.2009.208. Epub 2009 Sep 18. No abstract available.


HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-only protein NOXA.

Fritsche P, Seidler B, Schüler S, Schnieke A, Göttlicher M, Schmid RM, Saur D, Schneider G.

Gut. 2009 Oct;58(10):1399-409. doi: 10.1136/gut.2009.180711. Epub 2009 Jun 14.


E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex.

von Burstin J, Eser S, Paul MC, Seidler B, Brandl M, Messer M, von Werder A, Schmidt A, Mages J, Pagel P, Schnieke A, Schmid RM, Schneider G, Saur D.

Gastroenterology. 2009 Jul;137(1):361-71, 371.e1-5. doi: 10.1053/j.gastro.2009.04.004. Epub 2009 Apr 9.


Highly sensitive detection of early-stage pancreatic cancer by multimodal near-infrared molecular imaging in living mice.

von Burstin J, Eser S, Seidler B, Meining A, Bajbouj M, Mages J, Lang R, Kind AJ, Schnieke AE, Schmid RM, Schneider G, Saur D.

Int J Cancer. 2008 Nov 1;123(9):2138-47. doi: 10.1002/ijc.23780.

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