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Items: 46

1.

Retinal Organ Cultures as Alternative Research Models.

Schnichels S, Kiebler T, Hurst J, Maliha AM, Löscher M, Dick HB, Bartz-Schmidt KU, Joachim SC.

Altern Lab Anim. 2019 Mar;47(1):19-29. doi: 10.1177/0261192919840092.

PMID:
31237165
2.

Hypothermia protects retinal ganglion cells against hypoxia-induced cell death in a retina organ culture model.

Klemm P, Hurst J, Dias Blak M, Herrmann T, Melchinger M, Bartz-Schmidt KU, Zeck G, Schultheiss M, Spitzer MS, Schnichels S.

Clin Exp Ophthalmol. 2019 Jun 1. doi: 10.1111/ceo.13565. [Epub ahead of print]

PMID:
31152487
3.

Diminished apoptosis in hypoxic porcine retina explant cultures through hypothermia.

Maliha AM, Kuehn S, Hurst J, Herms F, Fehr M, Bartz-Schmidt KU, Dick HB, Joachim SC, Schnichels S.

Sci Rep. 2019 Mar 20;9(1):4898. doi: 10.1038/s41598-019-41113-4.

4.

Investigating retinal toxicity of a lutein-based dye in a model of isolated and perfused bovine retina.

Mueller S, Krupp C, Schnichels S, Hofmann J, Spitzer M, Bartz-Schmidt KU, Szurman P, Januschowski K.

Graefes Arch Clin Exp Ophthalmol. 2019 May;257(5):961-966. doi: 10.1007/s00417-019-04260-y. Epub 2019 Feb 20.

PMID:
30788607
5.

Ex vivo biophysical characterization of a hydrogel-based artificial vitreous substitute.

Januschowski K, Schnichels S, Hurst J, Hohenadl C, Reither C, Rickmann A, Pohl L, Bartz-Schmidt KU, Spitzer MS.

PLoS One. 2019 Jan 7;14(1):e0209217. doi: 10.1371/journal.pone.0209217. eCollection 2019.

6.

A swarm of slippery micropropellers penetrates the vitreous body of the eye.

Wu Z, Troll J, Jeong HH, Wei Q, Stang M, Ziemssen F, Wang Z, Dong M, Schnichels S, Qiu T, Fischer P.

Sci Adv. 2018 Nov 2;4(11):eaat4388. doi: 10.1126/sciadv.aat4388. eCollection 2018 Nov.

7.

[Wie schreibe ich ein Paper].

Schnichels S.

Ophthalmologe. 2018 Sep;115(9):797-798. doi: 10.1007/s00347-018-0766-1. German. No abstract available.

PMID:
30105565
8.

[Dwarf with gigantic future potential].

Spitzer MS, Schnichels S.

Ophthalmologe. 2018 Mar;115(3):182-183. doi: 10.1007/s00347-017-0634-4. German. No abstract available.

PMID:
29260312
9.

DNA nanoparticles for ophthalmic drug delivery.

Willem de Vries J, Schnichels S, Hurst J, Strudel L, Gruszka A, Kwak M, Bartz-Schmidt KU, Spitzer MS, Herrmann A.

Biomaterials. 2018 Mar;157:98-106. doi: 10.1016/j.biomaterials.2017.11.046. Epub 2017 Nov 29.

PMID:
29258013
10.

Comparison of Different Cell Culture Media in the Model of the Isolated and Superfused Bovine Retina: Investigating the Limits of More Physiological Perfusion Solutions.

Hurst J, Vitkute M, Hofmann K, Müller S, Löscher M, Bartz-Schmidt KU, Spitzer MS, Schnichels S, Januschowski K.

Curr Eye Res. 2018 Feb;43(2):232-243. doi: 10.1080/02713683.2017.1387668. Epub 2017 Nov 7.

PMID:
29111831
11.

[Nanoparticles as drug delivery systems in ophthalmology].

Löscher M, Hurst J, Strudel L, Spitzer MS, Schnichels S.

Ophthalmologe. 2018 Mar;115(3):184-189. doi: 10.1007/s00347-017-0596-6. Review. German.

PMID:
29110121
12.

Establishment of a retinal hypoxia organ culture model.

Schnichels S, Blak M, Hurst J, Dorfi T, Bartz-Schmidt KU, Ziemssen F, Spitzer MS, Schultheiss M.

Biol Open. 2017 Jul 15;6(7):1056-1064. doi: 10.1242/bio.025429.

13.

Characterization of a Standardized Ex-vivo Porcine Model to Assess Short Term Intraocular Pressure Changes and Trabecular Meshwork Vitality After Pars Plana Vitrectomy with Different Silicone Oil and BSS Tamponades.

Ebner M, Mariacher S, Hurst J, Szurman P, Schnichels S, Spitzer MS, Januschowski K.

Curr Eye Res. 2017 Aug;42(8):1130-1135. doi: 10.1080/02713683.2017.1297461. Epub 2017 Apr 25.

PMID:
28441060
14.

A novel porcine ex vivo retina culture model for oxidative stress induced by H₂O₂.

Hurst J, Kuehn S, Jashari A, Tsai T, Bartz-Schmidt KU, Schnichels S, Joachim SC.

Altern Lab Anim. 2017 Mar;45(1):11-25.

PMID:
28409994
15.

Negative Effects of Acid Violet-17 and MBB Dual In Vitro on Different Ocular Cell Lines.

Hurst J, Schnichels S, Spitzer MS, Bartz-Schmidt KU, Farecki ML, Szurman P, Januschowski K.

Curr Eye Res. 2017 Aug;42(8):1209-1214. doi: 10.1080/02713683.2017.1285942. Epub 2017 Mar 30.

PMID:
28358247
16.

Efficacy of two different thiol-modified crosslinked hyaluronate formulations as vitreous replacement compared to silicone oil in a model of retinal detachment.

Schnichels S, Schneider N, Hohenadl C, Hurst J, Schatz A, Januschowski K, Spitzer MS.

PLoS One. 2017 Mar 1;12(3):e0172895. doi: 10.1371/journal.pone.0172895. eCollection 2017.

17.

The novel induction of retinal ganglion cell apoptosis in porcine organ culture by NMDA - an opportunity for the replacement of animals in experiments.

Kuehn S, Hurst J, Jashari A, Ahrens K, Tsai T, Wunderlich IM, Dick HB, Joachim SC, Schnichels S.

Altern Lab Anim. 2016 Dec;44(6):557-568.

PMID:
28094536
18.

Degenerative effects of cobalt-chloride treatment on neurons and microglia in a porcine retina organ culture model.

Kuehn S, Hurst J, Rensinghoff F, Tsai T, Grauthoff S, Satgunarajah Y, Dick HB, Schnichels S, Joachim SC.

Exp Eye Res. 2017 Feb;155:107-120. doi: 10.1016/j.exer.2017.01.003. Epub 2017 Jan 12.

PMID:
28089775
19.

α5β1-Integrin inhibitor (CLT-28643) effective in rabbit trabeculectomy model.

Schultheiss M, Schnichels S, Konrad EM, Bartz-Schmidt KU, Zahn G, Caldirola P, Fsadni MG, Caram-Lelham N, Spitzer MS.

Acta Ophthalmol. 2017 Feb;95(1):e1-e9. doi: 10.1111/aos.13215. Epub 2016 Aug 31.

20.

Novel mouse model for primary uveal melanoma: a pilot study.

Süsskind D, Hurst J, Rohrbach JM, Schnichels S.

Clin Exp Ophthalmol. 2017 Mar;45(2):192-200. doi: 10.1111/ceo.12814. Epub 2016 Sep 7.

PMID:
27505446
21.

Investigation of a novel implantable suprachoroidal pressure transducer for telemetric intraocular pressure monitoring.

Mariacher S, Ebner M, Januschowski K, Hurst J, Schnichels S, Szurman P.

Exp Eye Res. 2016 Oct;151:54-60. doi: 10.1016/j.exer.2016.07.016. Epub 2016 Jul 25.

PMID:
27456134
22.

Ex-vivo-examination of ultrastructural changes in organotypic retina culture using near-infrared imaging and optical coherence tomography.

Schnichels S, Dorfi T, Schultheiss M, Arango-Gonzalez B, Bartz-Schmidt KU, Januschowski K, Spitzer MS, Ziemssen F.

Exp Eye Res. 2016 Jun;147:31-36. doi: 10.1016/j.exer.2016.04.011. Epub 2016 Apr 21.

PMID:
27109031
23.

Toxic effects of melphalan, topotecan and carboplatin on retinal pigment epithelial cells.

Süsskind D, Hagemann U, Schrader M, Januschowski K, Schnichels S, Aisenbrey S.

Acta Ophthalmol. 2016 Aug;94(5):471-8. doi: 10.1111/aos.12990. Epub 2016 Feb 19.

24.

Hypothermia Protects and Prolongs the Tolerance Time of Retinal Ganglion Cells against Ischemia.

Schultheiss M, Schnichels S, Hermann T, Hurst J, Feldkaemper M, Arango-Gonzalez B, Ueffing M, Bartz-Schmidt KU, Zeck G, Spitzer MS.

PLoS One. 2016 Feb 5;11(2):e0148616. doi: 10.1371/journal.pone.0148616. eCollection 2016.

25.

Investigating short-term toxicity of melphalan in a model of an isolated and superfused bovine retina.

Januschowski K, Krupp C, Mueller S, Hofmann K, Schnichels S, Hagemann U, Spitzer MS, Bartz-Schmidt KU, Aisenbrey S.

Graefes Arch Clin Exp Ophthalmol. 2016 Jan;254(1):91-6. doi: 10.1007/s00417-015-3149-1. Epub 2015 Sep 3.

PMID:
26335534
26.

Glutamate and hypoxia as a stress model for the isolated perfused vertebrate retina.

Januschowski K, Müller S, Krupp C, Spitzer MS, Hurst J, Schultheiss M, Bartz-Schmidt KU, Szurman P, Schnichels S.

J Vis Exp. 2015 Mar 22;(97). doi: 10.3791/52270.

27.

Investigating retinal toxicity of tempol in a model of isolated and perfused bovine retina.

Januschowski K, Mueller S, Dollinger R, Schnichels S, Hofmann J, Spitzer MS, Bartz-Schmidt KU, Szurman P, Thaler S.

Graefes Arch Clin Exp Ophthalmol. 2014 Jun;252(6):935-41. doi: 10.1007/s00417-014-2632-4. Epub 2014 May 2.

PMID:
24789463
28.

Cyclosporine a protects RGC-5 cells from excitotoxic cell death.

Schultheiss M, Schnichels S, Mlynczak T, Dipl-Ing JH, Bartz-Schmidt KU, Szurman P, Spitzer MS.

J Glaucoma. 2014 Apr-May;23(4):219-24. doi: 10.1097/IJG.0000000000000040.

PMID:
24633087
29.

Electrophysiological toxicity testing of VEGF Trap-Eye in an isolated perfused vertebrate retina organ culture model.

Januschowski K, Schnichels S, Hagemann U, Koch V, Hofmann J, Spitzer MS, Bartz-Schmidt KU, Szurman P, Lüke M, Aisenbrey S.

Acta Ophthalmol. 2014 Jun;92(4):e305-11. doi: 10.1111/aos.12300. Epub 2013 Nov 8.

30.

Comparative toxicity and proliferation testing of aflibercept, bevacizumab and ranibizumab on different ocular cells.

Schnichels S, Hagemann U, Januschowski K, Hofmann J, Bartz-Schmidt KU, Szurman P, Spitzer MS, Aisenbrey S.

Br J Ophthalmol. 2013 Jul;97(7):917-23. doi: 10.1136/bjophthalmol-2013-303130. Epub 2013 May 17.

PMID:
23686000
31.

Dulbecco's Modified Eagle Medium is neuroprotective when compared to standard vitrectomy irrigation solution.

Schultheiss M, Januschowski K, Ruschenburg H, Schramm C, Schnichels S, Szurman P, Bartz-Schmidt KU, Spitzer MS.

Graefes Arch Clin Exp Ophthalmol. 2013 Jun;251(6):1613-9. doi: 10.1007/s00417-012-2255-6. Epub 2013 Jan 11.

PMID:
23306786
32.

Biocompatibility and antifibrotic effect of UV-cross-linked hyaluronate as a release-system for tranilast after trabeculectomy in a rabbit model--a pilot study.

Spitzer MS, Sat M, Schramm C, Schnichels S, Schultheiss M, Yoeruek E, Dzhelebov D, Szurman P.

Curr Eye Res. 2012 Jun;37(6):463-70. doi: 10.3109/02713683.2012.658593.

PMID:
22577763
33.

Testing the biocompatibility of a glutathione-containing intra-ocular irrigation solution by using an isolated perfused bovine retina organ culture model - an alternative to animal testing.

Januschowski K, Zhour A, Lee A, Maddani R, Mueller S, Spitzer MS, Schnichels S, Schultheiss M, Doycheva D, Bartz-Schmidt KU, Szurman P.

Altern Lab Anim. 2012 Mar;40(1):23-32.

PMID:
22558975
34.

Trichostatin A induces cell death at the concentration recommended to differentiate the RGC-5 cell line.

Schnichels S, Schultheiss M, Hofmann J, Szurman P, Bartz-Schmidt KU, Spitzer MS.

Neurochem Int. 2012 May;60(6):581-91. doi: 10.1016/j.neuint.2012.02.017. Epub 2012 Feb 25.

PMID:
22391323
35.

Neuroprotective effects of a taurine-containing irrigation solution for vitrectomy.

Schultheiss M, Ruschenburg H, Warga M, Schramm C, Januschowski K, Schnichels S, Biedermann T, Szurman P, Spitzer MS.

Retina. 2012 Jul;32(7):1343-9. doi: 10.1097/IAE.0b013e318232c37c.

PMID:
22322280
36.

Staurosporine-induced differentiation of the RGC-5 cell line leads to apoptosis and cell death at the lowest differentiating concentration.

Schultheiss M, Schnichels S, Miteva K, Warstat K, Szurman P, Spitzer MS, Van Linthout S.

Graefes Arch Clin Exp Ophthalmol. 2012 Aug;250(8):1221-9. doi: 10.1007/s00417-011-1906-3. Epub 2012 Jan 6.

PMID:
22222923
37.

RGMA and neogenin protein expression are influenced by lens injury following optic nerve crush in the rat retina.

Schnichels S, Heiduschka P, Julien S.

Graefes Arch Clin Exp Ophthalmol. 2012 Jan;250(1):39-50. doi: 10.1007/s00417-011-1791-9. Epub 2011 Sep 2.

PMID:
21887516
38.

GDF-15: a novel serum marker for metastases in uveal melanoma patients.

Suesskind D, Schatz A, Schnichels S, Coupland SE, Lake SL, Wissinger B, Bartz-Schmidt KU, Henke-Fahle S.

Graefes Arch Clin Exp Ophthalmol. 2012 Jun;250(6):887-95. doi: 10.1007/s00417-011-1786-6. Epub 2011 Sep 1.

PMID:
21881845
39.

The histone acetyltransferase p300 promotes intrinsic axonal regeneration.

Gaub P, Joshi Y, Wuttke A, Naumann U, Schnichels S, Heiduschka P, Di Giovanni S.

Brain. 2011 Jul;134(Pt 7):2134-48. doi: 10.1093/brain/awr142.

PMID:
21705428
40.

Different spatial and temporal protein expressions of repulsive guidance molecule a and neogenin in the rat optic nerve after optic nerve crush with and without lens injury.

Schnichels S, Heiduschka P, Julien S.

J Neurosci Res. 2011 Apr;89(4):490-505. doi: 10.1002/jnr.22584. Epub 2011 Feb 2.

PMID:
21290411
41.

Loss of retinal function in aged DBA/2J mice - New insights into retinal neurodegeneration.

Heiduschka P, Julien S, Schuettauf F, Schnichels S.

Exp Eye Res. 2010 Nov;91(5):779-83. doi: 10.1016/j.exer.2010.09.001. Epub 2010 Sep 9.

PMID:
20832401
42.

Electrophysiological and histologic assessment of retinal ganglion cell fate in a mouse model for OPA1-associated autosomal dominant optic atrophy.

Heiduschka P, Schnichels S, Fuhrmann N, Hofmeister S, Schraermeyer U, Wissinger B, Alavi MV.

Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1424-31. doi: 10.1167/iovs.09-3606. Epub 2009 Oct 15.

PMID:
19834041
43.

Ultrastructural analysis of the pigment dispersion syndrome in DBA/2J mice.

Schraermeyer M, Schnichels S, Julien S, Heiduschka P, Bartz-Schmidt KU, Schraermeyer U.

Graefes Arch Clin Exp Ophthalmol. 2009 Nov;247(11):1493-504. doi: 10.1007/s00417-009-1146-y. Epub 2009 Jul 30.

PMID:
19641932
44.

A reproducible and quantifiable model of choroidal neovascularization induced by VEGF A165 after subretinal adenoviral gene transfer in the rabbit.

Julien S, Kreppel F, Beck S, Heiduschka P, Brito V, Schnichels S, Kochanek S, Schraermeyer U.

Mol Vis. 2008 Jul 30;14:1358-72.

45.

Gene expression of the repulsive guidance molecules/neogenin in the developing and mature mouse visual system: C57BL/6J vs. the glaucoma model DBA/2J.

Schnichels S, Conrad S, Warstat K, Henke-Fahle S, Skutella T, Schraermeyer U, Julien S.

Gene Expr Patterns. 2007 Dec;8(1):1-11. Epub 2007 Sep 18.

PMID:
17942375
46.

Purkinje cell survival in organotypic cultures: implication of Rho and its downstream effector ROCK.

Julien S, Schnichels S, Teng H, Tassew N, Henke-Fahle S, Mueller BK, Monnier PP.

J Neurosci Res. 2008 Feb 15;86(3):531-6.

PMID:
17893923

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