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Items: 1 to 50 of 52

1.

SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M4 PAMs.

Chopko TC, Han C, Gregro AR, Engers DW, Felts AS, Poslusney MS, Bollinger KA, Morrison RD, Bubser M, Lamsal A, Luscombe VB, Cho HP, Schnetz-Boutaud NC, Rodriguez AL, Chang S, Daniels JS, Stec DF, Niswender CM, Jones CK, Wood MR, Wood MW, Duggan ME, Brandon NJ, Conn PJ, Bridges TM, Lindsley CW, Melancon BJ.

Bioorg Med Chem Lett. 2019 Aug 15;29(16):2224-2228. doi: 10.1016/j.bmcl.2019.06.032. Epub 2019 Jun 20.

PMID:
31248774
2.

Replication of SCN5A Associations with Electrocardio-graphic Traits in African Americans from Clinical and Epidemiologic Studies.

Jeff JM, Brown-Gentry K, Goodloe R, Ritchie MD, Denny JC, Kho AN, Armstrong LL, McClellan B Jr, Mayo P, Allen M, Jin H, Gillani NB, Schnetz-Boutaud N, Dilks HH, Basford MA, Pacheco JA, Jarvik GP, Chisholm RL, Roden DM, Hayes MG, Crawford DC.

Evol Comput Mach Learn Data Min Bioinform. 2014;2014:939-951.

3.

Detection of pleiotropy through a Phenome-wide association study (PheWAS) of epidemiologic data as part of the Environmental Architecture for Genes Linked to Environment (EAGLE) study.

Hall MA, Verma A, Brown-Gentry KD, Goodloe R, Boston J, Wilson S, McClellan B, Sutcliffe C, Dilks HH, Gillani NB, Jin H, Mayo P, Allen M, Schnetz-Boutaud N, Crawford DC, Ritchie MD, Pendergrass SA.

PLoS Genet. 2014 Dec 4;10(12):e1004678. doi: 10.1371/journal.pgen.1004678. eCollection 2014 Dec.

4.

Rare variant APOC3 R19X is associated with cardio-protective profiles in a diverse population-based survey as part of the Epidemiologic Architecture for Genes Linked to Environment Study.

Crawford DC, Dumitrescu L, Goodloe R, Brown-Gentry K, Boston J, McClellan B Jr, Sutcliffe C, Wiseman R, Baker P, Pericak-Vance MA, Scott WK, Allen M, Mayo P, Schnetz-Boutaud N, Dilks HH, Haines JL, Pollin TI.

Circ Cardiovasc Genet. 2014 Dec;7(6):848-53. doi: 10.1161/CIRCGENETICS.113.000369. Epub 2014 Nov 1.

5.

Detection of copy number variation by SNP-allelotyping.

Parker B, Alexander R, Wu X, Feely S, Shy M, Schnetz-Boutaud N, Li J.

J Neurogenet. 2015 Mar;29(1):4-7. doi: 10.3109/01677063.2014.923884. Epub 2014 Jun 2.

6.

KIAA1462, a coronary artery disease associated gene, is a candidate gene for late onset Alzheimer disease in APOE carriers.

Murdock DG, Bradford Y, Schnetz-Boutaud N, Mayo P, Allen MJ, D'Aoust LN, Liang X, Mitchell SL, Zuchner S, Small GW, Gilbert JR, Pericak-Vance MA, Haines JL.

PLoS One. 2013 Dec 12;8(12):e82194. doi: 10.1371/journal.pone.0082194. eCollection 2013.

7.

Lipid trait-associated genetic variation is associated with gallstone disease in the diverse Third National Health and Nutrition Examination Survey (NHANES III).

Goodloe R, Brown-Gentry K, Gillani NB, Jin H, Mayo P, Allen M, McClellan B Jr, Boston J, Sutcliffe C, Schnetz-Boutaud N, Dilks HH, Crawford DC.

BMC Med Genet. 2013 Nov 21;14:120. doi: 10.1186/1471-2350-14-120.

8.

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

International Multiple Sclerosis Genetics Consortium (IMSGC), Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, Shah TS, Spencer C, Booth D, Goris A, Oturai A, Saarela J, Fontaine B, Hemmer B, Martin C, Zipp F, D'Alfonso S, Martinelli-Boneschi F, Taylor B, Harbo HF, Kockum I, Hillert J, Olsson T, Ban M, Oksenberg JR, Hintzen R, Barcellos LF; Wellcome Trust Case Control Consortium 2 (WTCCC2); International IBD Genetics Consortium (IIBDGC), Agliardi C, Alfredsson L, Alizadeh M, Anderson C, Andrews R, Søndergaard HB, Baker A, Band G, Baranzini SE, Barizzone N, Barrett J, Bellenguez C, Bergamaschi L, Bernardinelli L, Berthele A, Biberacher V, Binder TM, Blackburn H, Bomfim IL, Brambilla P, Broadley S, Brochet B, Brundin L, Buck D, Butzkueven H, Caillier SJ, Camu W, Carpentier W, Cavalla P, Celius EG, Coman I, Comi G, Corrado L, Cosemans L, Cournu-Rebeix I, Cree BA, Cusi D, Damotte V, Defer G, Delgado SR, Deloukas P, di Sapio A, Dilthey AT, Donnelly P, Dubois B, Duddy M, Edkins S, Elovaara I, Esposito F, Evangelou N, Fiddes B, Field J, Franke A, Freeman C, Frohlich IY, Galimberti D, Gieger C, Gourraud PA, Graetz C, Graham A, Grummel V, Guaschino C, Hadjixenofontos A, Hakonarson H, Halfpenny C, Hall G, Hall P, Hamsten A, Harley J, Harrower T, Hawkins C, Hellenthal G, Hillier C, Hobart J, Hoshi M, Hunt SE, Jagodic M, Jelčić I, Jochim A, Kendall B, Kermode A, Kilpatrick T, Koivisto K, Konidari I, Korn T, Kronsbein H, Langford C, Larsson M, Lathrop M, Lebrun-Frenay C, Lechner-Scott J, Lee MH, Leone MA, Leppä V, Liberatore G, Lie BA, Lill CM, Lindén M, Link J, Luessi F, Lycke J, Macciardi F, Männistö S, Manrique CP, Martin R, Martinelli V, Mason D, Mazibrada G, McCabe C, Mero IL, Mescheriakova J, Moutsianas L, Myhr KM, Nagels G, Nicholas R, Nilsson P, Piehl F, Pirinen M, Price SE, Quach H, Reunanen M, Robberecht W, Robertson NP, Rodegher M, Rog D, Salvetti M, Schnetz-Boutaud NC, Sellebjerg F, Selter RC, Schaefer C, Shaunak S, Shen L, Shields S, Siffrin V, Slee M, Sorensen PS, Sorosina M, Sospedra M, Spurkland A, Strange A, Sundqvist E, Thijs V, Thorpe J, Ticca A, Tienari P, van Duijn C, Visser EM, Vucic S, Westerlind H, Wiley JS, Wilkins A, Wilson JF, Winkelmann J, Zajicek J, Zindler E, Haines JL, Pericak-Vance MA, Ivinson AJ, Stewart G, Hafler D, Hauser SL, Compston A, McVean G, De Jager P, Sawcer SJ, McCauley JL.

Nat Genet. 2013 Nov;45(11):1353-60. doi: 10.1038/ng.2770. Epub 2013 Sep 29.

9.

Putting pleiotropy and selection into context defines a new paradigm for interpreting genetic data.

Predazzi IM, Rokas A, Deinard A, Schnetz-Boutaud N, Williams ND, Bush WS, Tacconelli A, Friedrich K, Fazio S, Novelli G, Haines JL, Sirugo G, Williams SM.

Circ Cardiovasc Genet. 2013 Jun;6(3):299-307. doi: 10.1161/CIRCGENETICS.113.000126. Epub 2013 Apr 24.

10.

Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study.

Fesinmeyer MD, North KE, Lim U, Bůžková P, Crawford DC, Haessler J, Gross MD, Fowke JH, Goodloe R, Love SA, Graff M, Carlson CS, Kuller LH, Matise TC, Hong CP, Henderson BE, Allen M, Rohde RR, Mayo P, Schnetz-Boutaud N, Monroe KR, Ritchie MD, Prentice RL, Kolonel LN, Manson JE, Pankow J, Hindorff LA, Franceschini N, Wilkens LR, Haiman CA, Le Marchand L, Peters U.

BMC Med Genet. 2013 Jan 11;14:6. doi: 10.1186/1471-2350-14-6.

11.

Identification and confirmation of an exonic splicing enhancer variation in exon 5 of the Alzheimer disease associated PICALM gene.

Schnetz-Boutaud NC, Hoffman J, Coe JE, Murdock DG, Pericak-Vance MA, Haines JL.

Ann Hum Genet. 2012 Nov;76(6):448-53. doi: 10.1111/j.1469-1809.2012.00727.x. Epub 2012 Sep 4.

12.

Serum vitamins A and E as modifiers of lipid trait genetics in the National Health and Nutrition Examination Surveys as part of the Population Architecture using Genomics and Epidemiology (PAGE) study.

Dumitrescu L, Goodloe R, Brown-Gentry K, Mayo P, Allen M, Jin H, Gillani NB, Schnetz-Boutaud N, Dilks HH, Crawford DC.

Hum Genet. 2012 Nov;131(11):1699-708. doi: 10.1007/s00439-012-1186-y. Epub 2012 Jun 12.

13.

Using genetic variation and environmental risk factor data to identify individuals at high risk for age-related macular degeneration.

Spencer KL, Olson LM, Schnetz-Boutaud N, Gallins P, Agarwal A, Iannaccone A, Kritchevsky SB, Garcia M, Nalls MA, Newman AB, Scott WK, Pericak-Vance MA, Haines JL.

PLoS One. 2011 Mar 24;6(3):e17784. doi: 10.1371/journal.pone.0017784.

14.

Dissection of chromosome 16p12 linkage peak suggests a possible role for CACNG3 variants in age-related macular degeneration susceptibility.

Spencer KL, Olson LM, Schnetz-Boutaud N, Gallins P, Wang G, Scott WK, Agarwal A, Jakobsdottir J, Conley Y, Weeks DE, Gorin MB, Pericak-Vance MA, Haines JL.

Invest Ophthalmol Vis Sci. 2011 Mar 28;52(3):1748-54. doi: 10.1167/iovs.09-5112. Print 2011 Mar.

15.

CNV analysis using TaqMan copy number assays.

Mayo P, Hartshorne T, Li K, McMunn-Gibson C, Spencer K, Schnetz-Boutaud N.

Curr Protoc Hum Genet. 2010 Oct;Chapter 2:Unit2.13. doi: 10.1002/0471142905.hg0213s67.

PMID:
20891030
16.

Examination of tetrahydrobiopterin pathway genes in autism.

Schnetz-Boutaud NC, Anderson BM, Brown KD, Wright HH, Abramson RK, Cuccaro ML, Gilbert JR, Pericak-Vance MA, Haines JL.

Genes Brain Behav. 2009 Nov;8(8):753-7. doi: 10.1111/j.1601-183X.2009.00521.x. Epub 2009 Jul 14.

17.

Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.

McCauley JL, Zuvich RL, Bradford Y, Kenealy SJ, Schnetz-Boutaud N, Gregory SG, Hauser SL, Oksenberg JR, Mortlock DP, Pericak-Vance MA, Haines JL.

Genes Immun. 2009 Oct;10(7):624-30. doi: 10.1038/gene.2009.53. Epub 2009 Jul 23.

18.

CALHM1 polymorphism is not associated with late-onset Alzheimer disease.

Beecham GW, Schnetz-Boutaud N, Haines JL, Pericak-Vance MA.

Ann Hum Genet. 2009 May;73(Pt 3):379-81.

19.

Examination of association to autism of common genetic variationin genes related to dopamine.

Anderson BM, Schnetz-Boutaud N, Bartlett J, Wright HH, Abramson RK, Cuccaro ML, Gilbert JR, Pericak-Vance MA, Haines JL.

Autism Res. 2008 Dec;1(6):364-9. doi: 10.1002/aur.55.

20.

Genomic convergence to identify candidate genes for Alzheimer disease on chromosome 10.

Liang X, Slifer M, Martin ER, Schnetz-Boutaud N, Bartlett J, Anderson B, Züchner S, Gwirtsman H, Gilbert JR, Pericak-Vance MA, Haines JL.

Hum Mutat. 2009 Mar;30(3):463-71. doi: 10.1002/humu.20953.

21.

The enteropathy of prostaglandin deficiency.

Adler DH, Phillips JA 3rd, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA, Brenner DA, Milne GL, Morrow JD, Boutaud O, Oates JA.

J Gastroenterol. 2009;44 Suppl 19:1-7. doi: 10.1007/s00535-008-2253-y. Epub 2009 Jan 16.

22.

Examination of association of genes in the serotonin system to autism.

Anderson BM, Schnetz-Boutaud NC, Bartlett J, Wotawa AM, Wright HH, Abramson RK, Cuccaro ML, Gilbert JR, Pericak-Vance MA, Haines JL.

Neurogenetics. 2009 Jul;10(3):209-16. doi: 10.1007/s10048-009-0171-7. Epub 2009 Jan 28.

23.

3'-Intercalation of a N2-dG 1R-trans-anti-benzo[c]phenanthrene DNA adduct in an iterated (CG)3 repeat.

Wang Y, Schnetz-Boutaud NC, Kroth H, Yagi H, Sayer JM, Kumar S, Jerina DM, Stone MP.

Chem Res Toxicol. 2008 Jul;21(7):1348-58. doi: 10.1021/tx7004103. Epub 2008 Jun 13.

24.

A genome-wide scan in an Amish pedigree with parkinsonism.

Lee SL, Murdock DG, McCauley JL, Bradford Y, Crunk A, McFarland L, Jiang L, Wang T, Schnetz-Boutaud N, Haines JL.

Ann Hum Genet. 2008 Sep;72(Pt 5):621-9. doi: 10.1111/j.1469-1809.2008.00452.x. Epub 2008 May 21.

25.

Mitochondrial DNA polymorphism A4917G is independently associated with age-related macular degeneration.

Canter JA, Olson LM, Spencer K, Schnetz-Boutaud N, Anderson B, Hauser MA, Schmidt S, Postel EA, Agarwal A, Pericak-Vance MA, Sternberg P Jr, Haines JL.

PLoS One. 2008 May 7;3(5):e2091. doi: 10.1371/journal.pone.0002091.

26.

Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction.

Adler DH, Cogan JD, Phillips JA 3rd, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA, Brenner DA, Morrow JD, Boutaud O, Oates JA.

J Clin Invest. 2008 Jun;118(6):2121-31. doi: 10.1172/JCI30473. Erratum in: J Clin Invest. 2009 Sep;119(9):2844.

27.

Enzymatic synthesis of M(1)G-deoxyribose.

Schnetz-Boutaud NC, Chapeau MC, Marnett LJ.

Curr Protoc Nucleic Acid Chem. 2001 May;Chapter 1:Unit1.2. doi: 10.1002/0471142700.nc0102s00.

PMID:
18428817
28.

C3 R102G polymorphism increases risk of age-related macular degeneration.

Spencer KL, Olson LM, Anderson BM, Schnetz-Boutaud N, Scott WK, Gallins P, Agarwal A, Postel EA, Pericak-Vance MA, Haines JL.

Hum Mol Genet. 2008 Jun 15;17(12):1821-4. doi: 10.1093/hmg/ddn075. Epub 2008 Mar 6.

29.

No association between SNP rs498055 on chromosome 10 and late-onset Alzheimer disease in multiple datasets.

Liang X, Schnetz-Boutaud N, Bartlett J, Allen MJ, Gwirtsman H, Schmechel DE, Carney RM, Gilbert JR, Pericak-Vance MA, Haines JL.

Ann Hum Genet. 2008 Jan;72(Pt 1):141-4. Epub 2007 Aug 24.

30.

Haplotypes spanning the complement factor H gene are protective against age-related macular degeneration.

Spencer KL, Hauser MA, Olson LM, Schnetz-Boutaud N, Scott WK, Schmidt S, Gallins P, Agarwal A, Postel EA, Pericak-Vance MA, Haines JL.

Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4277-83.

PMID:
17724217
31.

SNPs in Multi-species Conserved Sequences (MCS) as useful markers in association studies: a practical approach.

McCauley JL, Kenealy SJ, Margulies EH, Schnetz-Boutaud N, Gregory SG, Hauser SL, Oksenberg JR, Pericak-Vance MA, Haines JL, Mortlock DP.

BMC Genomics. 2007 Aug 6;8:266.

32.
33.

Effect of heterogeneity on the chromosome 10 risk in late-onset Alzheimer disease.

Liang X, Martin ER, Schnetz-Boutaud N, Bartlett J, Anderson B, Züchner S, Gwirtsman H, Schmechel D, Carney R, Gilbert JR, Pericak-Vance MA, Haines JL.

Hum Mutat. 2007 Nov;28(11):1065-73.

PMID:
17573676
34.

Independent effects of complement factor H Y402H polymorphism and cigarette smoking on risk of age-related macular degeneration.

Scott WK, Schmidt S, Hauser MA, Gallins P, Schnetz-Boutaud N, Spencer KL, Gilbert JR, Agarwal A, Postel EA, Haines JL, Pericak-Vance MA.

Ophthalmology. 2007 Jun;114(6):1151-6. Epub 2007 Jan 22.

PMID:
17241667
35.

Association analysis of genetic polymorphisms in the CDC2 gene with late-onset Alzheimer disease.

Liang X, Schnetz-Boutaud N, Bartlett J, Anderson BM, Gwirtsman H, Schmechel D, Carney R, Gilbert JR, Pericak-Vance MA, Haines JL.

Dement Geriatr Cogn Disord. 2007;23(2):126-32. Epub 2006 Dec 8.

36.

Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration.

Schmidt S, Hauser MA, Scott WK, Postel EA, Agarwal A, Gallins P, Wong F, Chen YS, Spencer K, Schnetz-Boutaud N, Haines JL, Pericak-Vance MA.

Am J Hum Genet. 2006 May;78(5):852-864. doi: 10.1086/503822. Epub 2006 Mar 20.

37.

Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6.

Haines JL, Schnetz-Boutaud N, Schmidt S, Scott WK, Agarwal A, Postel EA, Olson L, Kenealy SJ, Hauser M, Gilbert JR, Pericak-Vance MA.

Invest Ophthalmol Vis Sci. 2006 Jan;47(1):329-35.

PMID:
16384981
38.

Examination of seven candidate regions for multiple sclerosis: strong evidence of linkage to chromosome 1q44.

Kenealy SJ, Herrel LA, Bradford Y, Schnetz-Boutaud N, Oksenberg JR, Hauser SL, Barcellos LF, Schmidt S, Gregory SG, Pericak-Vance MA, Haines JL.

Genes Immun. 2006 Jan;7(1):73-6.

PMID:
16341055
39.

Covariate analysis of late-onset Alzheimer disease refines the chromosome 12 locus.

Liang X, Schnetz-Boutaud N, Kenealy SJ, Jiang L, Bartlett J, Lynch B, Gaskell PC, Gwirtsman H, McFarland L, Bembe ML, Bronson P, Gilbert JR, Martin ER, Pericak-Vance MA, Haines JL.

Mol Psychiatry. 2006 Mar;11(3):280-5.

PMID:
16222332
40.

Interaction between the alpha-T catenin gene (VR22) and APOE in Alzheimer's disease.

Martin ER, Bronson PG, Li YJ, Wall N, Chung RH, Schmechel DE, Small G, Xu PT, Bartlett J, Schnetz-Boutaud N, Haines JL, Gilbert JR, Pericak-Vance MA.

J Med Genet. 2005 Oct;42(10):787-92.

41.

Complement factor H variant increases the risk of age-related macular degeneration.

Haines JL, Hauser MA, Schmidt S, Scott WK, Olson LM, Gallins P, Spencer KL, Kwan SY, Noureddine M, Gilbert JR, Schnetz-Boutaud N, Agarwal A, Postel EA, Pericak-Vance MA.

Science. 2005 Apr 15;308(5720):419-21. Epub 2005 Mar 10.

42.

A second-generation genomic screen for multiple sclerosis.

Kenealy SJ, Babron MC, Bradford Y, Schnetz-Boutaud N, Haines JL, Rimmler JB, Schmidt S, Pericak-Vance MA, Barcellos LF, Lincoln RR, Oksenberg JR, Hauser SL, Clanet M, Brassat D, Edan G, Yaouanq J, Semana G, Cournu-Rebeix I, Lyon-Caen O, Fontaine B; American-French Multiple Sclerosis Genetics Group.

Am J Hum Genet. 2004 Dec;75(6):1070-8. Epub 2004 Oct 19.

43.
44.

Structural refinement of the 8,9-dihydro-8-(N7-guanyl)-9-hydroxy-aflatoxin B(1) adduct in a 5'-Cp(AFB)G-3' sequence.

Giri I, Jenkins MD, Schnetz-Boutaud NC, Stone MP.

Chem Res Toxicol. 2002 May;15(5):638-47.

PMID:
12018984
47.

Pyrimido[1,2-alpha]purin-10(3H)-one: a reactive electrophile in the genome.

Schnetz-Boutaud N, Daniels JS, Hashim MF, Scholl P, Burrus T, Marnett LJ.

Chem Res Toxicol. 2000 Oct;13(10):967-70.

PMID:
11080044
48.

Synthesis of oligonucleotides containing the alkali-labile pyrimidopurinone adduct, M(1)G.

Schnetz-Boutaud NC, Mao H, Stone MP, Marnett LJ.

Chem Res Toxicol. 2000 Feb;13(2):90-5.

PMID:
10688532
49.

Duplex DNA catalyzes the chemical rearrangement of a malondialdehyde deoxyguanosine adduct.

Mao H, Schnetz-Boutaud NC, Weisenseel JP, Marnett LJ, Stone MP.

Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6615-20.

50.

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