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Items: 39


A Biliary Tract-Specific Near-Infrared Fluorescent Dye for Image-Guided Hepatobiliary Surgery.

Luciano MP, Namgoong JM, Nani RR, Nam SH, Lee C, Shin IH, Schnermann MJ, Cha J.

Mol Pharm. 2019 Jul 1;16(7):3253-3260. doi: 10.1021/acs.molpharmaceut.9b00453. Epub 2019 Jun 21.


Elucidation of Spirodactylone, a Polycyclic Alkaloid from the Sponge Dactylia sp., and Nonenzymatic Generation from the Co-metabolite Denigrin B.

Kang U, Caldwell DR, Cartner LK, Wang D, Kim CK, Tian X, Bokesch HR, Henrich CJ, Woldemichael GM, Schnermann MJ, Gustafson KR.

Org Lett. 2019 Jun 21;21(12):4750-4753. doi: 10.1021/acs.orglett.9b01636. Epub 2019 May 31.


A Nonaggregating Heptamethine Cyanine for Building Brighter Labeled Biomolecules.

Luciano MP, Crooke SN, Nourian S, Dingle I, Nani RR, Kline G, Patel NL, Robinson CM, Difilippantonio S, Kalen JD, Finn MG, Schnermann MJ.

ACS Chem Biol. 2019 May 17;14(5):934-940. doi: 10.1021/acschembio.9b00122. Epub 2019 Apr 27.


A Cyanine Photooxidation/β-Elimination Sequence Enables Near-infrared Uncaging of Aryl Amine Payloads.

Yamamoto T, Caldwell DR, Gandioso A, Schnermann MJ.

Photochem Photobiol. 2019 Jul;95(4):951-958. doi: 10.1111/php.13090. Epub 2019 Mar 19.


Harnessing Natural Product Diversity for Fluorophore Discovery: Naturally Occurring Fluorescent Hydroxyanthraquinones from the Marine Crinoid Pterometra venusta.

Singh AJ, Gorka AP, Bokesch HR, Wamiru A, O'Keefe BR, Schnermann MJ, Gustafson KR.

J Nat Prod. 2018 Dec 28;81(12):2750-2755. doi: 10.1021/acs.jnatprod.8b00761. Epub 2018 Nov 29.


Harnessing Cyanine Reactivity for Optical Imaging and Drug Delivery.

Gorka AP, Nani RR, Schnermann MJ.

Acc Chem Res. 2018 Dec 18;51(12):3226-3235. doi: 10.1021/acs.accounts.8b00384. Epub 2018 Nov 12.


Glypican-3-Specific Antibody Drug Conjugates Targeting Hepatocellular Carcinoma.

Fu Y, Urban DJ, Nani RR, Zhang YF, Li N, Fu H, Shah H, Gorka AP, Guha R, Chen L, Hall MD, Schnermann MJ, Ho M.

Hepatology. 2019 Aug;70(2):563-576. doi: 10.1002/hep.30326. Epub 2019 Feb 19.


Defining the conditional basis of silicon phthalocyanine near-IR ligand exchange.

Anderson ED, Sova S, Ivanic J, Kelly L, Schnermann MJ.

Phys Chem Chem Phys. 2018 Jul 18;20(28):19030-19036. doi: 10.1039/c8cp03842b.


A chemically stable fluorescent marker of the ureter.

Cha J, Nani RR, Luciano MP, Kline G, Broch A, Kim K, Namgoong JM, Kulkarni RA, Meier JL, Kim P, Schnermann MJ.

Bioorg Med Chem Lett. 2018 Sep 1;28(16):2741-2745. doi: 10.1016/j.bmcl.2018.02.040. Epub 2018 Feb 24.


Pharmacology by Chemical Biology.

Meier JL, Schnermann MJ.

Mol Pharm. 2018 Mar 5;15(3):703-704. doi: 10.1021/acs.molpharmaceut.8b00067. No abstract available.


Cyanine Photocages Enable Spatial Control of Inducible Cre-Mediated Recombination.

Gorka AP, Yamamoto T, Zhu J, Schnermann MJ.

Chembiochem. 2018 Jun 18;19(12):1239-1243. doi: 10.1002/cbic.201800061. Epub 2018 Apr 16.


Molecularly Targeted Cancer Combination Therapy with Near-Infrared Photoimmunotherapy and Near-Infrared Photorelease with Duocarmycin-Antibody Conjugate.

Nagaya T, Gorka AP, Nani RR, Okuyama S, Ogata F, Maruoka Y, Choyke PL, Schnermann MJ, Kobayashi H.

Mol Cancer Ther. 2018 Mar;17(3):661-670. doi: 10.1158/1535-7163.MCT-17-0851. Epub 2017 Dec 13.


Chemical biology: Organic dyes for deep bioimaging.

Schnermann MJ.

Nature. 2017 Nov 9;551(7679):176-177. doi: 10.1038/nature24755. Epub 2017 Nov 1. No abstract available.


Cyanine Conformational Restraint in the Far-Red Range.

Michie MS, Götz R, Franke C, Bowler M, Kumari N, Magidson V, Levitus M, Loncarek J, Sauer M, Schnermann MJ.

J Am Chem Soc. 2017 Sep 13;139(36):12406-12409. doi: 10.1021/jacs.7b07272. Epub 2017 Sep 1.


Fluorous Phase-Directed Peptide Assembly Affords Nano-Peptisomes Capable of Ultrasound-Triggered Cellular Delivery.

Medina SH, Michie MS, Miller SE, Schnermann MJ, Schneider JP.

Angew Chem Int Ed Engl. 2017 Sep 11;56(38):11404-11408. doi: 10.1002/anie.201704649. Epub 2017 Aug 16.


In Vivo Activation of Duocarmycin-Antibody Conjugates by Near-Infrared Light.

Nani RR, Gorka AP, Nagaya T, Yamamoto T, Ivanic J, Kobayashi H, Schnermann MJ.

ACS Cent Sci. 2017 Apr 26;3(4):329-337. doi: 10.1021/acscentsci.7b00026. Epub 2017 Feb 24.


Characterization and Synthesis of Eudistidine C, a Bioactive Marine Alkaloid with an Intriguing Molecular Scaffold.

Chan ST, Nani RR, Schauer EA, Martin GE, Williamson RT, Saurí J, Buevich AV, Schafer WA, Joyce LA, Goey AK, Figg WD, Ransom TT, Henrich CJ, McKee TC, Moser A, MacDonald SA, Khan S, McMahon JB, Schnermann MJ, Gustafson KR.

J Org Chem. 2016 Nov 18;81(22):10631-10640. Epub 2016 Nov 10.


Near-infrared uncaging or photosensitizing dictated by oxygen tension.

Anderson ED, Gorka AP, Schnermann MJ.

Nat Commun. 2016 Nov 17;7:13378. doi: 10.1038/ncomms13378.


Effect of charge localization on the in vivo optical imaging properties of near-infrared cyanine dye/monoclonal antibody conjugates.

Sato K, Gorka AP, Nagaya T, Michie MS, Nakamura Y, Nani RR, Coble VL, Vasalatiy OV, Swenson RE, Choyke PL, Schnermann MJ, Kobayashi H.

Mol Biosyst. 2016 Oct 20;12(10):3046-56. doi: 10.1039/c6mb00371k. Epub 2016 Jul 25.


Harnessing cyanine photooxidation: from slowing photobleaching to near-IR uncaging.

Gorka AP, Schnermann MJ.

Curr Opin Chem Biol. 2016 Aug;33:117-25. doi: 10.1016/j.cbpa.2016.05.022. Epub 2016 Jun 24. Review.


An Intrinsically Disordered Peptide Facilitates Non-Endosomal Cell Entry.

Medina SH, Miller SE, Keim AI, Gorka AP, Schnermann MJ, Schneider JP.

Angew Chem Int Ed Engl. 2016 Mar 1;55(10):3369-72. doi: 10.1002/anie.201510518. Epub 2016 Feb 2.


Effect of Metalation on Porphyrin-Based Bifunctional Agents in Tumor Imaging and Photodynamic Therapy.

Patel NJ, Chen Y, Joshi P, Pera P, Baumann H, Missert JR, Ohkubo K, Fukuzumi S, Nani RR, Schnermann MJ, Chen P, Zhu J, Kadish KM, Pandey RK.

Bioconjug Chem. 2016 Mar 16;27(3):667-80. doi: 10.1021/acs.bioconjchem.5b00656. Epub 2016 Jan 21.


Reactive Species Involved in the Regioselective Photooxidation of Heptamethine Cyanines.

Nani RR, Kelley JA, Ivanic J, Schnermann MJ.

Chem Sci. 2015 Nov 1;6(11):6556-6563. Epub 2015 Aug 18.


Role of Fluorophore Charge on the In Vivo Optical Imaging Properties of Near-Infrared Cyanine Dye/Monoclonal Antibody Conjugates.

Sato K, Gorka AP, Nagaya T, Michie MS, Nani RR, Nakamura Y, Coble VL, Vasalatiy OV, Swenson RE, Choyke PL, Schnermann MJ, Kobayashi H.

Bioconjug Chem. 2016 Feb 17;27(2):404-13. doi: 10.1021/acs.bioconjchem.5b00492. Epub 2015 Oct 23.


Near-IR Light-Mediated Cleavage of Antibody-Drug Conjugates Using Cyanine Photocages.

Nani RR, Gorka AP, Nagaya T, Kobayashi H, Schnermann MJ.

Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13635-8. doi: 10.1002/anie.201507391. Epub 2015 Sep 25.


Impact of C4'-O-Alkyl Linker on in Vivo Pharmacokinetics of Near-Infrared Cyanine/Monoclonal Antibody Conjugates.

Sato K, Nagaya T, Nakamura Y, Harada T, Nani RR, Shaum JB, Gorka AP, Kim I, Paik CH, Choyke PL, Schnermann MJ, Kobayashi H.

Mol Pharm. 2015 Sep 8;12(9):3303-11. doi: 10.1021/acs.molpharmaceut.5b00472. Epub 2015 Aug 18.


Impact of Substituents in Tumor Uptake and Fluorescence Imaging Ability of Near-Infrared Cyanine-like Dyes.

Patel NJ, Manivannan E, Joshi P, Ohulchanskyy TJ, Nani RR, Schnermann MJ, Pandey RK.

Photochem Photobiol. 2015 Sep-Oct;91(5):1219-30. doi: 10.1111/php.12482. Epub 2015 Jul 30.


Cyanine polyene reactivity: scope and biomedical applications.

Gorka AP, Nani RR, Schnermann MJ.

Org Biomol Chem. 2015 Jul 28;13(28):7584-98. doi: 10.1039/c5ob00788g. Review.


Structural Elucidation and Synthesis of Eudistidine A: An Unusual Polycyclic Marine Alkaloid that Blocks Interaction of the Protein Binding Domains of p300 and HIF-1α.

Chan ST, Patel PR, Ransom TR, Henrich CJ, McKee TC, Goey AK, Cook KM, Figg WD, McMahon JB, Schnermann MJ, Gustafson KR.

J Am Chem Soc. 2015 Apr 29;137(16):5569-75. doi: 10.1021/jacs.5b02156. Epub 2015 Apr 20.


Electrophile-integrating Smiles rearrangement provides previously inaccessible C4'-O-alkyl heptamethine cyanine fluorophores.

Nani RR, Shaum JB, Gorka AP, Schnermann MJ.

Org Lett. 2015 Jan 16;17(2):302-5. doi: 10.1021/ol503398f. Epub 2015 Jan 6.


Syntheses and biological studies of marine terpenoids derived from inorganic cyanide.

Schnermann MJ, Shenvi RA.

Nat Prod Rep. 2015 Apr;32(4):543-77. doi: 10.1039/c4np00109e. Review.


A near-IR uncaging strategy based on cyanine photochemistry.

Gorka AP, Nani RR, Zhu J, Mackem S, Schnermann MJ.

J Am Chem Soc. 2014 Oct 8;136(40):14153-9. doi: 10.1021/ja5065203. Epub 2014 Sep 24.


Forming tertiary organolithiums and organocuprates from nitrile precursors and their bimolecular reactions with carbon electrophiles to form quaternary carbon stereocenters.

Schnermann MJ, Untiedt NL, Jiménez-Osés G, Houk KN, Overman LE.

Angew Chem Int Ed Engl. 2012 Sep 17;51(38):9581-6. doi: 10.1002/anie.201205001. Epub 2012 Aug 24. No abstract available.


A concise synthesis of (-)-aplyviolene facilitated by a strategic tertiary radical conjugate addition.

Schnermann MJ, Overman LE.

Angew Chem Int Ed Engl. 2012 Sep 17;51(38):9576-80. doi: 10.1002/anie.201204977. Epub 2012 Aug 24. No abstract available. Erratum in: Angew Chem Int Ed Engl. 2014 Mar 3;53(10):2527.


Divergent synthesis and chemical reactivity of bicyclic lactone fragments of complex rearranged spongian diterpenes.

Schnermann MJ, Beaudry CM, Genung NE, Canham SM, Untiedt NL, Karanikolas BD, Sütterlin C, Overman LE.

J Am Chem Soc. 2011 Nov 2;133(43):17494-503. doi: 10.1021/ja207727h. Epub 2011 Oct 11.


Enantioselective total synthesis of aplyviolene.

Schnermann MJ, Overman LE.

J Am Chem Soc. 2011 Oct 19;133(41):16425-7. doi: 10.1021/ja208018s. Epub 2011 Sep 23.


Golgi-modifying properties of macfarlandin E and the synthesis and evaluation of its 2,7-dioxabicyclo[3.2.1]octan-3-one core.

Schnermann MJ, Beaudry CM, Egorova AV, Polishchuk RS, Sütterlin C, Overman LE.

Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6158-63. doi: 10.1073/pnas.1001421107. Epub 2010 Mar 23.


Total synthesis of piericidin A1 and B1 and key analogues.

Schnermann MJ, Romero FA, Hwang I, Nakamaru-Ogiso E, Yagi T, Boger DL.

J Am Chem Soc. 2006 Sep 13;128(36):11799-807.


Total synthesis of piericidin A1 and B1.

Schnermann MJ, Boger DL.

J Am Chem Soc. 2005 Nov 16;127(45):15704-5.

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