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Extracellular signal-regulated kinase 1/2 regulates NAD metabolism during acute kidney injury through microRNA-34a-mediated NAMPT expression.

Collier JB, Schnellmann RG.

Cell Mol Life Sci. 2019 Dec 23. doi: 10.1007/s00018-019-03391-z. [Epub ahead of print]


Elucidation of cGMP-dependent induction of mitochondrial biogenesis through PKG and p38 MAPK in the kidney.

Bhargava P, Janda J, Schnellmann RG.

Am J Physiol Renal Physiol. 2020 Feb 1;318(2):F322-F328. doi: 10.1152/ajprenal.00533.2019. Epub 2019 Dec 16.


5-hydroxytryptamine 1F Receptor Agonist Induces Mitochondrial Biogenesis and Promotes Recovery from Spinal Cord Injury.

Simmons EC, Scholpa NE, Cleveland KH, Schnellmann RG.

J Pharmacol Exp Ther. 2020 Feb;372(2):216-223. doi: 10.1124/jpet.119.262410. Epub 2019 Nov 27.


The 5-hydroxytryptamine receptor 1F stimulates mitochondrial biogenesis and angiogenesis in endothelial cells.

Dupre TV, Jenkins DP, Muise-Helmericks RC, Schnellmann RG.

Biochem Pharmacol. 2019 Nov;169:113644. doi: 10.1016/j.bcp.2019.113644. Epub 2019 Sep 19.


β2-adrenergic receptor-mediated mitochondrial biogenesis improves skeletal muscle recovery following spinal cord injury.

Scholpa NE, Simmons EC, Tilley DG, Schnellmann RG.

Exp Neurol. 2019 Dec;322:113064. doi: 10.1016/j.expneurol.2019.113064. Epub 2019 Sep 13.


Mitochondrial biogenesis induced by the β2-adrenergic receptor agonist formoterol accelerates podocyte recovery from glomerular injury.

Arif E, Solanki AK, Srivastava P, Rahman B, Fitzgibbon WR, Deng P, Budisavljevic MN, Baicu CF, Zile MR, Megyesi J, Janech MG, Kwon SH, Collier J, Schnellmann RG, Nihalani D.

Kidney Int. 2019 Sep;96(3):656-673. doi: 10.1016/j.kint.2019.03.023. Epub 2019 May 6.


Author Correction: Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol.

Cameron RB, Peterson YK, Beeson CC, Schnellmann RG.

Sci Rep. 2019 May 1;9(1):6790. doi: 10.1038/s41598-019-42463-9.


Proximal Tubule β 2-Adrenergic Receptor Mediates Formoterol-Induced Recovery of Mitochondrial and Renal Function after Ischemia-Reperfusion Injury.

Cameron RB, Gibbs WS, Miller SR, Dupre TV, Megyesi J, Beeson CC, Schnellmann RG.

J Pharmacol Exp Ther. 2019 Apr;369(1):173-180. doi: 10.1124/jpet.118.252833. Epub 2019 Feb 1.


Pharmacological Stimulation of Mitochondrial Biogenesis Using the Food and Drug Administration-Approved β2-Adrenoreceptor Agonist Formoterol for the Treatment of Spinal Cord Injury.

Scholpa NE, Williams H, Wang W, Corum D, Narang A, Tomlinson S, Sullivan PG, Rabchevsky AG, Schnellmann RG.

J Neurotrauma. 2019 Mar 19;36(6):962-972. doi: 10.1089/neu.2018.5669. Epub 2018 Nov 16.


5-HT1F receptor regulates mitochondrial homeostasis and its loss potentiates acute kidney injury and impairs renal recovery.

Gibbs WS, Collier JB, Morris M, Beeson CC, Megyesi J, Schnellmann RG.

Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F1119-F1128. doi: 10.1152/ajprenal.00077.2018. Epub 2018 May 30.


Extracellular Signal-Regulated Kinase 1/2 Regulates Mouse Kidney Injury Molecule-1 Expression Physiologically and Following Ischemic and Septic Renal Injury.

Collier JB, Schnellmann RG.

J Pharmacol Exp Ther. 2017 Dec;363(3):419-427. doi: 10.1124/jpet.117.244152. Epub 2017 Oct 26.


5-HT1F receptor-mediated mitochondrial biogenesis for the treatment of Parkinson's disease.

Scholpa NE, Lynn MK, Corum D, Boger HA, Schnellmann RG.

Br J Pharmacol. 2018 Jan;175(2):348-358. doi: 10.1111/bph.14076. Epub 2017 Dec 22.


Identification of dual mechanisms mediating 5-hydroxytryptamine receptor 1F-induced mitochondrial biogenesis.

Gibbs WS, Garrett SM, Beeson CC, Schnellmann RG.

Am J Physiol Renal Physiol. 2018 Feb 1;314(2):F260-F268. doi: 10.1152/ajprenal.00324.2017. Epub 2017 Oct 18.


Mitochondrial-Based Therapeutics for the Treatment of Spinal Cord Injury: Mitochondrial Biogenesis as a Potential Pharmacological Target.

Scholpa NE, Schnellmann RG.

J Pharmacol Exp Ther. 2017 Dec;363(3):303-313. doi: 10.1124/jpet.117.244806. Epub 2017 Sep 21. Review.


Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol.

Cameron RB, Peterson YK, Beeson CC, Schnellmann RG.

Sci Rep. 2017 Sep 5;7(1):10578. doi: 10.1038/s41598-017-11030-5. Erratum in: Sci Rep. 2019 May 1;9(1):6790.


Mitochondrial energetics in the kidney.

Bhargava P, Schnellmann RG.

Nat Rev Nephrol. 2017 Oct;13(10):629-646. doi: 10.1038/nrneph.2017.107. Epub 2017 Aug 14. Review.


Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury.

Dupre TV, Doll MA, Shah PP, Sharp CN, Siow D, Megyesi J, Shayman J, Bielawska A, Bielawski J, Beverly LJ, Hernandez-Corbacho M, Clarke CJ, Snider AJ, Schnellmann RG, Obeid LM, Hannun YA, Siskind LJ.

J Lipid Res. 2017 Jul;58(7):1439-1452. doi: 10.1194/jlr.M076745. Epub 2017 May 10.


Rapid Renal Regulation of Peroxisome Proliferator-activated Receptor γ Coactivator-1α by Extracellular Signal-Regulated Kinase 1/2 in Physiological and Pathological Conditions.

Collier JB, Whitaker RM, Eblen ST, Schnellmann RG.

J Biol Chem. 2016 Dec 23;291(52):26850-26859. doi: 10.1074/jbc.M116.754762. Epub 2016 Nov 14.


Disrupted mitochondrial genes and inflammation following stroke.

Gibbs WS, Weber RA, Schnellmann RG, Adkins DL.

Life Sci. 2016 Dec 1;166:139-148. doi: 10.1016/j.lfs.2016.09.021. Epub 2016 Sep 28.


Ethanol and High Cholesterol Diet Causes Severe Steatohepatitis and Early Liver Fibrosis in Mice.

Krishnasamy Y, Ramshesh VK, Gooz M, Schnellmann RG, Lemasters JJ, Zhong Z.

PLoS One. 2016 Sep 27;11(9):e0163342. doi: 10.1371/journal.pone.0163342. eCollection 2016.


Development of Therapeutics That Induce Mitochondrial Biogenesis for the Treatment of Acute and Chronic Degenerative Diseases.

Cameron RB, Beeson CC, Schnellmann RG.

J Med Chem. 2016 Dec 8;59(23):10411-10434. Epub 2016 Sep 27. Review.


Striatal Mitochondrial Disruption following Severe Traumatic Brain Injury.

Harmon JL, Gibbs WS, Whitaker RM, Schnellmann RG, Adkins DL.

J Neurotrauma. 2017 Jan 15;34(2):487-494. doi: 10.1089/neu.2015.4395. Epub 2016 Aug 1.


The mitochondria-targeted antioxidant MitoQ attenuates liver fibrosis in mice.

Rehman H, Liu Q, Krishnasamy Y, Shi Z, Ramshesh VK, Haque K, Schnellmann RG, Murphy MP, Lemasters JJ, Rockey DC, Zhong Z.

Int J Physiol Pathophysiol Pharmacol. 2016 Apr 25;8(1):14-27. eCollection 2016.


5-HT2 Receptor Regulation of Mitochondrial Genes: Unexpected Pharmacological Effects of Agonists and Antagonists.

Harmon JL, Wills LP, McOmish CE, Demireva EY, Gingrich JA, Beeson CC, Schnellmann RG.

J Pharmacol Exp Ther. 2016 Apr;357(1):1-9. doi: 10.1124/jpet.115.228395. Epub 2016 Jan 19.


Suramin protects from cisplatin-induced acute kidney injury.

Dupre TV, Doll MA, Shah PP, Sharp CN, Kiefer A, Scherzer MT, Saurabh K, Saforo D, Siow D, Casson L, Arteel GE, Jenson AB, Megyesi J, Schnellmann RG, Beverly LJ, Siskind LJ.

Am J Physiol Renal Physiol. 2016 Feb 1;310(3):F248-58. doi: 10.1152/ajprenal.00433.2015. Epub 2015 Dec 9.


Mitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases.

Whitaker RM, Corum D, Beeson CC, Schnellmann RG.

Annu Rev Pharmacol Toxicol. 2016;56:229-49. doi: 10.1146/annurev-pharmtox-010715-103155. Epub 2015 Nov 4. Review.


Disrupted Renal Mitochondrial Homeostasis after Liver Transplantation in Rats.

Liu Q, Krishnasamy Y, Rehman H, Lemasters JJ, Schnellmann RG, Zhong Z.

PLoS One. 2015 Oct 19;10(10):e0140906. doi: 10.1371/journal.pone.0140906. eCollection 2015.


NKT cell modulates NAFLD potentiation of metabolic oxidative stress-induced mesangial cell activation and proximal tubular toxicity.

Alhasson F, Dattaroy D, Das S, Chandrashekaran V, Seth RK, Schnellmann RG, Chatterjee S.

Am J Physiol Renal Physiol. 2016 Jan 1;310(1):F85-F101. doi: 10.1152/ajprenal.00243.2015. Epub 2015 Oct 7.


Urinary mitochondrial DNA is a biomarker of mitochondrial disruption and renal dysfunction in acute kidney injury.

Whitaker RM, Stallons LJ, Kneff JE, Alge JL, Harmon JL, Rahn JJ, Arthur JM, Beeson CC, Chan SL, Schnellmann RG.

Kidney Int. 2015 Dec;88(6):1336-1344. doi: 10.1038/ki.2015.240. Epub 2015 Aug 19.


Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells.

Subathra M, Korrapati M, Howell LA, Arthur JM, Shayman JA, Schnellmann RG, Siskind LJ.

Am J Physiol Renal Physiol. 2015 Aug 1;309(3):F204-15. doi: 10.1152/ajprenal.00150.2015. Epub 2015 Jun 3.


Assessment of ToxCast Phase II for Mitochondrial Liabilities Using a High-Throughput Respirometric Assay.

Wills LP, Beeson GC, Hoover DB, Schnellmann RG, Beeson CC.

Toxicol Sci. 2015 Aug;146(2):226-34. doi: 10.1093/toxsci/kfv085. Epub 2015 Apr 28.


Calpain-10 Activity Underlies Angiotensin II-Induced Aldosterone Production in an Adrenal Glomerulosa Cell Model.

Seremwe M, Schnellmann RG, Bollag WB.

Endocrinology. 2015 Jun;156(6):2138-49. doi: 10.1210/en.2014-1866. Epub 2015 Apr 2.


Improvement of liver injury and survival by JNK2 and iNOS deficiency in liver transplants from cardiac death mice.

Liu Q, Rehman H, Krishnasamy Y, Schnellmann RG, Lemasters JJ, Zhong Z.

J Hepatol. 2015 Jul;63(1):68-74. doi: 10.1016/j.jhep.2015.02.017. Epub 2015 Feb 19.


Intereukin-10 and Kupffer cells protect steatotic mice livers from ischemia-reperfusion injury.

Sutter AG, Palanisamy AP, Ellet JD, Schmidt MG, Schnellmann RG, Chavin KD.

Eur Cytokine Netw. 2014 Oct-Dec;25(4):69-76. doi: 10.1684/ecn.2015.0359.


Urinary ATP Synthase Subunit β Is a Novel Biomarker of Renal Mitochondrial Dysfunction in Acute Kidney Injury.

Whitaker RM, Korrapati MC, Stallons LJ, Jesinkey SR, Arthur JM, Beeson CC, Zhong Z, Schnellmann RG.

Toxicol Sci. 2015 May;145(1):108-17. doi: 10.1093/toxsci/kfv038. Epub 2015 Feb 9.


Suppression of mitochondrial biogenesis through toll-like receptor 4-dependent mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling in endotoxin-induced acute kidney injury.

Smith JA, Stallons LJ, Collier JB, Chavin KD, Schnellmann RG.

J Pharmacol Exp Ther. 2015 Feb;352(2):346-57. doi: 10.1124/jpet.114.221085. Epub 2014 Dec 12.


Quantitative analysis of mitochondrial morphology and membrane potential in living cells using high-content imaging, machine learning, and morphological binning.

Leonard AP, Cameron RB, Speiser JL, Wolf BJ, Peterson YK, Schnellmann RG, Beeson CC, Rohrer B.

Biochim Biophys Acta. 2015 Feb;1853(2):348-60. doi: 10.1016/j.bbamcr.2014.11.002. Epub 2014 Nov 13.


Atomoxetine prevents dexamethasone-induced skeletal muscle atrophy in mice.

Jesinkey SR, Korrapati MC, Rasbach KA, Beeson CC, Schnellmann RG.

J Pharmacol Exp Ther. 2014 Dec;351(3):663-73. doi: 10.1124/jpet.114.217380. Epub 2014 Oct 7.


Renal cortical hexokinase and pentose phosphate pathway activation through the EGFR/Akt signaling pathway in endotoxin-induced acute kidney injury.

Smith JA, Stallons LJ, Schnellmann RG.

Am J Physiol Renal Physiol. 2014 Aug 15;307(4):F435-44. doi: 10.1152/ajprenal.00271.2014. Epub 2014 Jul 2.


Agonism of the 5-hydroxytryptamine 1F receptor promotes mitochondrial biogenesis and recovery from acute kidney injury.

Garrett SM, Whitaker RM, Beeson CC, Schnellmann RG.

J Pharmacol Exp Ther. 2014 Aug;350(2):257-64. doi: 10.1124/jpet.114.214700. Epub 2014 May 21.


Formoterol restores mitochondrial and renal function after ischemia-reperfusion injury.

Jesinkey SR, Funk JA, Stallons LJ, Wills LP, Megyesi JK, Beeson CC, Schnellmann RG.

J Am Soc Nephrol. 2014 Jun;25(6):1157-62. doi: 10.1681/ASN.2013090952. Epub 2014 Feb 7.


Mitochondrial Homeostasis in Acute Organ Failure.

Stallons LJ, Funk JA, Schnellmann RG.

Curr Pathobiol Rep. 2013 Sep;1(3). doi: 10.1007/s40139-013-0023-x.


Suppressed mitochondrial biogenesis in folic acid-induced acute kidney injury and early fibrosis.

Stallons LJ, Whitaker RM, Schnellmann RG.

Toxicol Lett. 2014 Jan 30;224(3):326-32. doi: 10.1016/j.toxlet.2013.11.014. Epub 2013 Nov 22.


Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia-reperfusion injury.

Funk JA, Schnellmann RG.

Toxicol Appl Pharmacol. 2013 Dec 1;273(2):345-54. doi: 10.1016/j.taap.2013.09.026. Epub 2013 Oct 3.


cGMP-selective phosphodiesterase inhibitors stimulate mitochondrial biogenesis and promote recovery from acute kidney injury.

Whitaker RM, Wills LP, Stallons LJ, Schnellmann RG.

J Pharmacol Exp Ther. 2013 Dec;347(3):626-34. doi: 10.1124/jpet.113.208017. Epub 2013 Sep 16.


Suramin: a potential therapy for diabetic nephropathy.

Korrapati MC, Howell LA, Shaner BE, Megyesi JK, Siskind LJ, Schnellmann RG.

PLoS One. 2013 Sep 9;8(9):e73655. doi: 10.1371/journal.pone.0073655. eCollection 2013. Erratum in: PLoS One. 2014;9(1):e114426. Howell, Lauren H [corrected to Howell, Lauren A].


β2-Adrenoceptor agonists in the regulation of mitochondrial biogenesis.

Peterson YK, Cameron RB, Wills LP, Trager RE, Lindsey CC, Beeson CC, Schnellmann RG.

Bioorg Med Chem Lett. 2013 Oct 1;23(19):5376-81. doi: 10.1016/j.bmcl.2013.07.052. Epub 2013 Jul 31.


Systematic study of mitochondrial toxicity of environmental chemicals using quantitative high throughput screening.

Attene-Ramos MS, Huang R, Sakamuru S, Witt KL, Beeson GC, Shou L, Schnellmann RG, Beeson CC, Tice RR, Austin CP, Xia M.

Chem Res Toxicol. 2013 Sep 16;26(9):1323-32. doi: 10.1021/tx4001754. Epub 2013 Aug 15.


High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury.

Wills LP, Beeson GC, Trager RE, Lindsey CC, Beeson CC, Peterson YK, Schnellmann RG.

Toxicol Appl Pharmacol. 2013 Oct 15;272(2):490-502. doi: 10.1016/j.taap.2013.06.014. Epub 2013 Jun 26.

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