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Comparative transcriptome and metabolome analysis suggests bottlenecks that limit seed and oil yields in transgenic Camelina sativa expressing diacylglycerol acyltransferase 1 and glycerol-3-phosphate dehydrogenase.

Abdullah HM, Chhikara S, Akbari P, Schnell DJ, Pareek A, Dhankher OP.

Biotechnol Biofuels. 2018 Dec 19;11:335. doi: 10.1186/s13068-018-1326-2. eCollection 2018.


Exit route evolved into entry path in plants.

Schnell DJ.

Nature. 2018 Dec;564(7734):45-46. doi: 10.1038/d41586-018-07426-6. No abstract available.


Understanding the microbial basis of body odor in pre-pubescent children and teenagers.

Lam TH, Verzotto D, Brahma P, Ng AHQ, Hu P, Schnell D, Tiesman J, Kong R, Ton TMU, Li J, Ong M, Lu Y, Swaile D, Liu P, Liu J, Nagarajan N.

Microbiome. 2018 Nov 29;6(1):213. doi: 10.1186/s40168-018-0588-z.


Performance of Doppler-based resistive index and semi-quantitative renal perfusion in predicting persistent AKI: results of a prospective multicenter study.

Darmon M, Bourmaud A, Reynaud M, Rouleau S, Meziani F, Boivin A, Benyamina M, Vincent F, Lautrette A, Leroy C, Cohen Y, Legrand M, Morel J, Terreaux J, Schnell D.

Intensive Care Med. 2018 Nov;44(11):1904-1913. doi: 10.1007/s00134-018-5386-3. Epub 2018 Oct 5.


Spike-in genomic DNA for validating performance of metagenomics workflows.

Venkataraman A, Parlov M, Hu P, Schnell D, Wei X, Tiesman JP.

Biotechniques. 2018 Dec;65(6):315-321. doi: 10.2144/btn-2018-0089. Epub 2018 Sep 17.


Comparison of etomidate and sodium thiopental for induction during rapid sequence intubation in convulsive status epilepticus: A retrospective single-center study.

Perier F, Chateauneuf AL, Jacq G, Holleville M, Schnell D, Merceron S, Cavelot S, Richard O, Legriel S; ICTAL Study Group.

Seizure. 2018 Oct;61:170-176. doi: 10.1016/j.seizure.2018.08.022. Epub 2018 Aug 28.


Molecular Topology of the Transit Peptide during Chloroplast Protein Import.

Richardson LGL, Small EL, Inoue H, Schnell DJ.

Plant Cell. 2018 Aug;30(8):1789-1806. doi: 10.1105/tpc.18.00172. Epub 2018 Jul 10.


A Phase I/Randomized Phase II Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of Nintedanib versus Sorafenib in Asian Patients with Advanced Hepatocellular Carcinoma.

Yen CJ, Kim TY, Feng YH, Chao Y, Lin DY, Ryoo BY, Huang DC, Schnell D, Hocke J, Loembé AB, Cheng AL.

Liver Cancer. 2018 May;7(2):165-178. doi: 10.1159/000486460. Epub 2018 Mar 15.


Phase I dose-escalation trial of afatinib, an irreversible ErbB family blocker, in combination with gemcitabine or docetaxel in patients with relapsed or refractory solid tumors.

Hiret S, Isambert N, Gomez-Roca C, Bennouna J, Sassi M, de Mont-Serrat H, Fan J, Schnell D, Delord JP.

Invest New Drugs. 2018 Dec;36(6):1044-1059. doi: 10.1007/s10637-018-0601-1. Epub 2018 May 29.


Analysis of gene expression profiles of multiple skin diseases identifies a conserved signature of disrupted homeostasis.

Mills KJ, Robinson MK, Sherrill JD, Schnell DJ, Xu J.

Exp Dermatol. 2018 Sep;27(9):1000-1008. doi: 10.1111/exd.13694. Epub 2018 Jul 30.


A phase I study of nintedanib combined with cisplatin/gemcitabine as first-line therapy for advanced squamous non-small cell lung cancer (LUME-Lung 3).

Forster M, Hackshaw A, De Pas T, Cobo M, Garrido P, Summers Y, Dingemans AC, Flynn M, Schnell D, von Wangenheim U, Loembé AB, Kaiser R, Lee SM.

Lung Cancer. 2018 Jun;120:27-33. doi: 10.1016/j.lungcan.2018.03.007. Epub 2018 Mar 9.


Cardiac Arrest in Patients Managed for Convulsive Status Epilepticus: Characteristics, Predictors, and Outcome.

Legriel S, Bresson E, Deye N, Grimaldi D, Sauneuf B, Lesieur O, Lascarrou JB, Argaud L, Chelly J, Beuret P, Schnell D, Chateauneuf AL, Holleville M, Perier F, Lemiale V, Bruel C, Cronier P, Pichon N, Mongardon N, de-Prost N, Dumas F, Cariou A.

Crit Care Med. 2018 Aug;46(8):e751-e760. doi: 10.1097/CCM.0000000000003196.


A multicentre, open-label, phase-I/randomised phase-II study to evaluate safety, pharmacokinetics, and efficacy of nintedanib vs. sorafenib in European patients with advanced hepatocellular carcinoma.

Palmer DH, Ma YT, Peck-Radosavljevic M, Ross P, Graham J, Fartoux L, Deptala A, Studeny M, Schnell D, Hocke J, Loembé AB, Meyer T.

Br J Cancer. 2018 May;118(9):1162-1168. doi: 10.1038/s41416-018-0051-8. Epub 2018 Mar 22.


Phase I open-label study of afatinib plus vinorelbine in patients with solid tumours overexpressing EGFR and/or HER2.

Bahleda R, Varga A, Bergé Y, Soria JC, Schnell D, Tschoepe I, Uttenreuther-Fischer M, Delord JP.

Br J Cancer. 2018 Feb 6;118(3):344-352. doi: 10.1038/bjc.2017.436. Epub 2018 Jan 16.


The integration of chloroplast protein targeting with plant developmental and stress responses.

Richardson LGL, Singhal R, Schnell DJ.

BMC Biol. 2017 Dec 7;15(1):118. doi: 10.1186/s12915-017-0458-3. Review.


Pharmacokinetics of Nintedanib in Subjects With Hepatic Impairment.

Marzin K, Kretschmar G, Luedtke D, Kraemer S, Kuelzer R, Schlenker-Herceg R, Schmid U, Schnell D, Dallinger C.

J Clin Pharmacol. 2017 Nov 6. doi: 10.1002/jcph.1025. [Epub ahead of print]


Calcitriol concomitantly enhances insulin sensitivity and alters myocellular lipid partitioning in high fat-treated skeletal muscle cells.

Jefferson GE, Schnell DM, Thomas DT, Bollinger LM.

J Physiol Biochem. 2017 Nov;73(4):613-621. doi: 10.1007/s13105-017-0595-8. Epub 2017 Oct 4.


Engineering Camelina sativa (L.) Crantz for enhanced oil and seed yields by combining diacylglycerol acyltransferase1 and glycerol-3-phosphate dehydrogenase expression.

Chhikara S, Abdullah HM, Akbari P, Schnell D, Dhankher OP.

Plant Biotechnol J. 2018 May;16(5):1034-1045. doi: 10.1111/pbi.12847. Epub 2017 Nov 19.


Physiological and self-assessed psychological stress induced by a high fidelity simulation course among third year anesthesia and critical care residents: An observational study.

Geeraerts T, Roulleau P, Cheisson G, Marhar F, Aidan K, Lallali K, Leguen M, Schnell D, Trabold F, Fauquet-Alekhine P, Duranteau J, Benhamou D.

Anaesth Crit Care Pain Med. 2017 Dec;36(6):403-406. doi: 10.1016/j.accpm.2017.06.002. Epub 2017 Jun 23.


A phase Ib trial of continuous once-daily oral afatinib plus sirolimus in patients with epidermal growth factor receptor mutation-positive non-small cell lung cancer and/or disease progression following prior erlotinib or gefitinib.

Moran T, Palmero R, Provencio M, Insa A, Majem M, Reguart N, Bosch-Barrera J, Isla D, Costa EC, Lee C, Puig M, Kraemer S, Schnell D, Rosell R.

Lung Cancer. 2017 Jun;108:154-160. doi: 10.1016/j.lungcan.2017.03.009. Epub 2017 Mar 22.


The POTRA domains of Toc75 exhibit chaperone-like function to facilitate import into chloroplasts.

O'Neil PK, Richardson LGL, Paila YD, Piszczek G, Chakravarthy S, Noinaj N, Schnell D.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4868-E4876. doi: 10.1073/pnas.1621179114. Epub 2017 May 30.


Gastrointestinal emergencies in critically ill cancer patients.

Lebon D, Biard L, Buyse S, Schnell D, Lengliné E, Roussel C, Gornet JM, Munoz-Bongrand N, Quéro L, Resche-Rigon M, Azoulay E, Canet E.

J Crit Care. 2017 Aug;40:69-75. doi: 10.1016/j.jcrc.2017.03.015. Epub 2017 Mar 24.


Cuff Leak Test for the Diagnosis of Post-Extubation Stridor.

Schnell D, Planquette B, Berger A, Merceron S, Mayaux J, Strasbach L, Legriel S, Valade S, Darmon M, Meziani F.

J Intensive Care Med. 2017 Jan 1:885066617700095. doi: 10.1177/0885066617700095. [Epub ahead of print]


Manganese superoxide dismutase deficiency triggers mitochondrial uncoupling and the Warburg effect.

Xu Y, Miriyala S, Fang F, Bakthavatchalu V, Noel T, Schnell DM, Wang C, St Clair WH, St Clair DK.

Oncogene. 2017 Jul 13;36(28):4087. doi: 10.1038/onc.2016.513. Epub 2017 Mar 13.


Mechanism of Dual Targeting of the Phytochrome Signaling Component HEMERA/pTAC12 to Plastids and the Nucleus.

Nevarez PA, Qiu Y, Inoue H, Yoo CY, Benfey PN, Schnell DJ, Chen M.

Plant Physiol. 2017 Apr;173(4):1953-1966. doi: 10.1104/pp.16.00116. Epub 2017 Feb 23.


Targeted temperature management after intraoperative cardiac arrest: a multicenter retrospective study.

Constant AL, Mongardon N, Morelot Q, Pichon N, Grimaldi D, Bordenave L, Soummer A, Sauneuf B, Merceron S, Ricome S, Misset B, Bruel C, Schnell D, Boisramé-Helms J, Dubuisson E, Brunet J, Lasocki S, Cronier P, Bouhemad B, Carreira S, Begot E, Vandenbunder B, Dhonneur G, Jullien P, Resche-Rigon M, Bedos JP, Montlahuc C, Legriel S.

Intensive Care Med. 2017 Apr;43(4):485-495. doi: 10.1007/s00134-017-4709-0. Epub 2017 Feb 20.


RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells.

Wei X, Xu Y, Xu FF, Chaiswing L, Schnell D, Noel T, Wang C, Chen J, St Clair DK, St Clair WH.

Cancer Res. 2017 Mar 15;77(6):1345-1356. doi: 10.1158/0008-5472.CAN-16-0785. Epub 2017 Jan 20.


A phase I study of afatinib combined with paclitaxel and bevacizumab in patients with advanced solid tumors.

Spicer J, Irshad S, Ang JE, Enting D, Kristeleit R, Uttenreuther-Fischer M, Pemberton K, Pelling K, Schnell D, de Bono J.

Cancer Chemother Pharmacol. 2017 Jan;79(1):17-27. doi: 10.1007/s00280-016-3189-1. Epub 2016 Nov 21.


Management of neutropenic patients in the intensive care unit (NEWBORNS EXCLUDED) recommendations from an expert panel from the French Intensive Care Society (SRLF) with the French Group for Pediatric Intensive Care Emergencies (GFRUP), the French Society of Anesthesia and Intensive Care (SFAR), the French Society of Hematology (SFH), the French Society for Hospital Hygiene (SF2H), and the French Infectious Diseases Society (SPILF).

Schnell D, Azoulay E, Benoit D, Clouzeau B, Demaret P, Ducassou S, Frange P, Lafaurie M, Legrand M, Meert AP, Mokart D, Naudin J, Pene F, Rabbat A, Raffoux E, Ribaud P, Richard JC, Vincent F, Zahar JR, Darmon M.

Ann Intensive Care. 2016 Dec;6(1):90. doi: 10.1186/s13613-016-0189-6. Epub 2016 Sep 15. Review.


Clinical Pharmacokinetics and Pharmacodynamics of Afatinib.

Wind S, Schnell D, Ebner T, Freiwald M, Stopfer P.

Clin Pharmacokinet. 2017 Mar;56(3):235-250. doi: 10.1007/s40262-016-0440-1. Review.


Influence of Renal Impairment on the Pharmacokinetics of Afatinib: An Open-Label, Single-Dose Study.

Wiebe S, Schnell D, Külzer R, Gansser D, Weber A, Wallenstein G, Halabi A, Conrad A, Wind S.

Eur J Drug Metab Pharmacokinet. 2017 Jun;42(3):461-469. doi: 10.1007/s13318-016-0359-9.


Acetaminophen-Induced Changes in Systemic Blood Pressure in Critically Ill Patients: Results of a Multicenter Cohort Study.

Cantais A, Schnell D, Vincent F, Hammouda Z, Perinel S, Balichard S, Abroug F, Zeni F, Meziani F, Bornstain C, Darmon M.

Crit Care Med. 2016 Dec;44(12):2192-2198.


Transcriptome profiling of Camelina sativa to identify genes involved in triacylglycerol biosynthesis and accumulation in the developing seeds.

Abdullah HM, Akbari P, Paulose B, Schnell D, Qi W, Park Y, Pareek A, Dhankher OP.

Biotechnol Biofuels. 2016 Jul 4;9:136. doi: 10.1186/s13068-016-0555-5. eCollection 2016.


The Treatment of Localized Prostate Cancer in Everyday Practice in Germany.

Herden J, Ansmann L, Ernstmann N, Schnell D, Weißbac L.

Dtsch Arztebl Int. 2016 May 13;113(19):329-36. doi: 10.3238/arztebl.2016.0329.


Multi-functional roles for the polypeptide transport associated domains of Toc75 in chloroplast protein import.

Paila YD, Richardson LG, Inoue H, Parks ES, McMahon J, Inoue K, Schnell DJ.

Elife. 2016 Mar 21;5. pii: e12631. doi: 10.7554/eLife.12631.


A phase I study of two dosing schedules of oral BI 847325 in patients with advanced solid tumors.

Schöffski P, Aftimos P, Dumez H, Deleporte A, De Block K, Costermans J, Billiet M, Meeus MA, Lee C, Schnell D, Goeldner RG, Awada A.

Cancer Chemother Pharmacol. 2016 Jan;77(1):99-108. doi: 10.1007/s00280-015-2914-5. Epub 2015 Dec 9.


Changing use of noninvasive ventilation in critically ill patients: trends over 15 years in francophone countries.

Demoule A, Chevret S, Carlucci A, Kouatchet A, Jaber S, Meziani F, Schmidt M, Schnell D, Clergue C, Aboab J, Rabbat A, Eon B, Guérin C, Georges H, Zuber B, Dellamonica J, Das V, Cousson J, Perez D, Brochard L, Azoulay E; oVNI Study Group; REVA Network (Research Network in Mechanical Ventilation).

Intensive Care Med. 2016 Jan;42(1):82-92. doi: 10.1007/s00134-015-4087-4. Epub 2015 Oct 13.


Implementation of Clinical Ethics Consultation in German Hospitals.

Schochow M, Schnell D, Steger F.

Sci Eng Ethics. 2015 Sep 24. [Epub ahead of print]


HAROW: the first comprehensive prospective observational study comparing treatment options in localized prostate cancer.

Weissbach L, Stuerzebecher S, Mumperow E, Klotz T, Schnell D.

World J Urol. 2016 May;34(5):641-7. doi: 10.1007/s00345-015-1675-4. Epub 2015 Sep 15.


A phase I study of daily afatinib, an irreversible ErbB family blocker, in combination with weekly paclitaxel in patients with advanced solid tumours.

Suder A, Ang JE, Kyle F, Harris D, Rudman S, Kristeleit R, Solca F, Uttenreuther-Fischer M, Pemberton K, Pelling K, Schnell D, de Bono J, Spicer J.

Eur J Cancer. 2015 Nov;51(16):2275-84. doi: 10.1016/j.ejca.2015.07.041. Epub 2015 Aug 18.


Stereoscopic (3D) versus monoscopic (2D) laparoscopy: comparative study of performance using advanced HD optical systems in a surgical simulator model.

Schoenthaler M, Schnell D, Wilhelm K, Schlager D, Adams F, Hein S, Wetterauer U, Miernik A.

World J Urol. 2016 Apr;34(4):471-7. doi: 10.1007/s00345-015-1660-y. Epub 2015 Aug 5.


In vitro method for prediction of plaque reduction by dentifrice.

Tepper B, Howard B, Schnell D, Mills L, Xu J.

J Microbiol Methods. 2015 Nov;118:85-92. doi: 10.1016/j.mimet.2015.06.017. Epub 2015 Jul 4.


The authors reply.

Schnell D, Darmon M.

Crit Care Med. 2015 Jul;43(7):e264. doi: 10.1097/CCM.0000000000000988. No abstract available.


Bedside Doppler ultrasound for the assessment of renal perfusion in the ICU: advantages and limitations of the available techniques.

Schnell D, Darmon M.

Crit Ultrasound J. 2015 Dec;7(1):24. doi: 10.1186/s13089-015-0024-6. Epub 2015 May 28.


Genome and Transcriptome of Clostridium phytofermentans, Catalyst for the Direct Conversion of Plant Feedstocks to Fuels.

Petit E, Coppi MV, Hayes JC, Tolonen AC, Warnick T, Latouf WG, Amisano D, Biddle A, Mukherjee S, Ivanova N, Lykidis A, Land M, Hauser L, Kyrpides N, Henrissat B, Lau J, Schnell DJ, Church GM, Leschine SB, Blanchard JL.

PLoS One. 2015 Jun 2;10(6):e0118285. doi: 10.1371/journal.pone.0118285. eCollection 2015.


The Impact of Clinical Information on the Assessment of Endoscopic Activity: Characteristics of the Ulcerative Colitis Endoscopic Index Of Severity [UCEIS].

Travis SP, Schnell D, Feagan BG, Abreu MT, Altman DG, Hanauer SB, Krzeski P, Lichtenstein GR, Marteau PR, Mary JY, Reinisch W, Sands BE, Schnell P, Yacyshyn BR, Colombel JF, Bernhardt CA, Sandborn WJ.

J Crohns Colitis. 2015 Aug;9(8):607-16. doi: 10.1093/ecco-jcc/jjv077. Epub 2015 May 8.


Response to Gao et al: Interobserver reliability of Doppler-based resistive index.

Schnell D, Ninet S, Darmon M.

J Crit Care. 2015 Jun;30(3):651. doi: 10.1016/j.jcrc.2015.03.004. Epub 2015 Mar 7. No abstract available.


Doppler-based renal resistive index for prediction of renal dysfunction reversibility: A systematic review and meta-analysis.

Ninet S, Schnell D, Dewitte A, Zeni F, Meziani F, Darmon M.

J Crit Care. 2015 Jun;30(3):629-35. doi: 10.1016/j.jcrc.2015.02.008. Epub 2015 Feb 24. Review.


Life-threatening complications and outcomes in patients with malignancies and severe pulmonary embolism.

Valade S, Lemiale V, Roux A, Schnell D, Mariotte E, Reuter D, Canet E, Schlemmer B, Azoulay E.

Thromb Res. 2015 Apr;135(4):610-5. doi: 10.1016/j.thromres.2015.01.010. Epub 2015 Jan 13.


[The HAROW study: an example of outcomes research: a prospective, non-interventional study comparing treatment options in localized prostate cancer].

Herden J, Ernstmann N, Schnell D, Weißbach L.

Urologe A. 2014 Dec;53(12):1743-52. doi: 10.1007/s00120-014-3705-z. German.


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