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Time-resolved protein activation.

Schnell C.

Nat Methods. 2019 Jul;16(7):579. doi: 10.1038/s41592-019-0482-z. No abstract available.


Spatially resolved isotope labeling.

Schnell C.

Nat Methods. 2019 Apr;16(4):287. doi: 10.1038/s41592-019-0379-x. No abstract available.


Quantum imaging in biological samples.

Schnell C.

Nat Methods. 2019 Mar;16(3):214. doi: 10.1038/s41592-019-0346-6. No abstract available.


Characterization and phase I study of CLR457, an orally bioavailable pan-class I PI3-kinase inhibitor.

Harding JJ, Bauer TM, Tan DSW, Bedard PL, Rodon J, Doi T, Schnell C, Iyer V, Baffert F, Radhakrishnan R, Fabre C, Juric D.

Invest New Drugs. 2019 Apr;37(2):271-281. doi: 10.1007/s10637-018-0627-4. Epub 2018 Aug 3.


Antibiotic treatment in childhood community-acquired pneumonia - clinical practice versus guidelines: results from two university hospitals.

Man SC, Sas V, Schnell C, Florea C, Ţuţu A, Szilágyi A, Belenes S, Hebriştean A, Bonaţ A, Cladovan C, Aldea C.

Clujul Med. 2018;91(1):53-57. doi: 10.15386/cjmed-808. Epub 2018 Jan 15.


Performance of lung ultrasonography for the diagnosis of communityacquired pneumonia in hospitalized children.

Man SC, Fufezan O, Sas V, Schnell C.

Med Ultrason. 2017 May 10;19(3):276-281. doi: 10.11152/mu-1027.


A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response.

Haenseler W, Sansom SN, Buchrieser J, Newey SE, Moore CS, Nicholls FJ, Chintawar S, Schnell C, Antel JP, Allen ND, Cader MZ, Wade-Martins R, James WS, Cowley SA.

Stem Cell Reports. 2017 Jun 6;8(6):1727-1742. doi: 10.1016/j.stemcr.2017.05.017.


Autoimmune hepatitis with sclerosing cholangitis in a patient with thiopurine methyltransferase deficiency: case presentation.

Man SC, Schnell CN, Sas V, Buzoianu AD, Gheban D.

Rom J Morphol Embryol. 2017;58(1):211-217.


Limitations of Sulforhodamine 101 for Brain Imaging.

Hülsmann S, Hagos L, Heuer H, Schnell C.

Front Cell Neurosci. 2017 Feb 28;11:44. doi: 10.3389/fncel.2017.00044. eCollection 2017.


Quantitative computed tomography measurements to evaluate airway disease in chronic obstructive pulmonary disease: Relationship to physiological measurements, clinical index and visual assessment of airway disease.

Nambu A, Zach J, Schroeder J, Jin G, Kim SS, Kim YI, Schnell C, Bowler R, Lynch DA.

Eur J Radiol. 2016 Nov;85(11):2144-2151. doi: 10.1016/j.ejrad.2016.09.010. Epub 2016 Sep 13. Review.


Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA.

Kemp PJ, Rushton DJ, Yarova PL, Schnell C, Geater C, Hancock JM, Wieland A, Hughes A, Badder L, Cope E, Riccardi D, Randall AD, Brown JT, Allen ND, Telezhkin V.

J Physiol. 2016 Nov 15;594(22):6583-6594. doi: 10.1113/JP270655. Review.


Increasing metabolic stability via the deuterium kinetic isotope effect: An example from a proline-amide-urea aminothiazole series of phosphatidylinositol-3 kinase alpha inhibitors.

Fairhurst RA, Caravatti G, Guagnano V, Aichholz R, Blanz J, Blasco F, Wipfli P, Fritsch C, Maira SM, Schnell C, Seiler FH.

Bioorg Med Chem Lett. 2016 Oct 1;26(19):4729-4734. doi: 10.1016/j.bmcl.2016.08.041. Epub 2016 Aug 17.


Effects of prophylactic ibuprofen and paracetamol administration on the immunogenicity and reactogenicity of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugated vaccine (PHiD-CV) co-administered with DTPa-combined vaccines in children: An open-label, randomized, controlled, non-inferiority trial.

Falup-Pecurariu O, Man SC, Neamtu ML, Chicin G, Baciu G, Pitic C, Cara AC, Neculau AE, Burlea M, Brinza IL, Schnell CN, Sas V, Lupu VV, François N, Swinnen K, Borys D.

Hum Vaccin Immunother. 2017 Mar 4;13(3):649-660. doi: 10.1080/21645515.2016.1223001. Epub 2016 Aug 19.


Cationic and anionic polyelectrolyte complexes of xylan and chitosan. Interaction with lignocellulosic surfaces.

Mocchiutti P, Schnell CN, Rossi GD, Peresin MS, Zanuttini MA, Galván MV.

Carbohydr Polym. 2016 Oct 5;150:89-98. doi: 10.1016/j.carbpol.2016.04.111. Epub 2016 Apr 28.


Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.

Fairhurst RA, Marsilje TH, Stutz S, Boos A, Niklaus M, Chen B, Jiang S, Lu W, Furet P, McCarthy C, Stauffer F, Guagnano V, Vaupel A, Michellys PY, Schnell C, Jeay S.

Bioorg Med Chem Lett. 2016 Apr 15;26(8):2057-64. doi: 10.1016/j.bmcl.2016.02.075. Epub 2016 Feb 26.


Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons.

Telezhkin V, Schnell C, Yarova P, Yung S, Cope E, Hughes A, Thompson BA, Sanders P, Geater C, Hancock JM, Joy S, Badder L, Connor-Robson N, Comella A, Straccia M, Bombau G, Brown JT, Canals JM, Randall AD, Allen ND, Kemp PJ.

Am J Physiol Cell Physiol. 2016 Apr 1;310(7):C520-41. doi: 10.1152/ajpcell.00166.2015. Epub 2015 Dec 30.


A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis.

Bold G, Schnell C, Furet P, McSheehy P, Brüggen J, Mestan J, Manley PW, Drückes P, Burglin M, Dürler U, Loretan J, Reuter R, Wartmann M, Theuer A, Bauer-Probst B, Martiny-Baron G, Allegrini P, Goepfert A, Wood J, Littlewood-Evans A.

J Med Chem. 2016 Jan 14;59(1):132-46. doi: 10.1021/acs.jmedchem.5b01582. Epub 2015 Dec 21.


Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition.

Herkert B, Kauffmann A, Mollé S, Schnell C, Ferrat T, Voshol H, Juengert J, Erasimus H, Marszalek G, Kazic-Legueux M, Billy E, Ruddy D, Stump M, Guthy D, Ristov M, Calkins K, Maira SM, Sellers WR, Hofmann F, Hall MN, Brachmann SM.

Cancer Res. 2016 Jan 15;76(2):390-402. doi: 10.1158/0008-5472.CAN-14-3358. Epub 2015 Nov 17.


Norepinephrine-induced calcium signaling in astrocytes in the respiratory network of the ventrolateral medulla.

Schnell C, Negm M, Driehaus J, Scheller A, Hülsmann S.

Respir Physiol Neurobiol. 2016 Jun;226:18-23. doi: 10.1016/j.resp.2015.10.008. Epub 2015 Nov 2.


High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response.

Gao H, Korn JM, Ferretti S, Monahan JE, Wang Y, Singh M, Zhang C, Schnell C, Yang G, Zhang Y, Balbin OA, Barbe S, Cai H, Casey F, Chatterjee S, Chiang DY, Chuai S, Cogan SM, Collins SD, Dammassa E, Ebel N, Embry M, Green J, Kauffmann A, Kowal C, Leary RJ, Lehar J, Liang Y, Loo A, Lorenzana E, Robert McDonald E 3rd, McLaughlin ME, Merkin J, Meyer R, Naylor TL, Patawaran M, Reddy A, Röelli C, Ruddy DA, Salangsang F, Santacroce F, Singh AP, Tang Y, Tinetto W, Tobler S, Velazquez R, Venkatesan K, Von Arx F, Wang HQ, Wang Z, Wiesmann M, Wyss D, Xu F, Bitter H, Atadja P, Lees E, Hofmann F, Li E, Keen N, Cozens R, Jensen MR, Pryer NK, Williams JA, Sellers WR.

Nat Med. 2015 Nov;21(11):1318-25. doi: 10.1038/nm.3954. Epub 2015 Oct 19.


Identification and optimisation of 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole and 4,5-dihydrothiazolo[4,5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors.

Fairhurst RA, Gerspacher M, Imbach-Weese P, Mah R, Caravatti G, Furet P, Fritsch C, Schnell C, Blanz J, Blasco F, Desrayaud S, Guthy DA, Knapp M, Arz D, Wirth J, Roehn-Carnemolla E, Luu VH.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3575-81. doi: 10.1016/j.bmcl.2015.06.067. Epub 2015 Jun 26.


Relationships between diffusing capacity for carbon monoxide (DLCO), and quantitative computed tomography measurements and visual assessment for chronic obstructive pulmonary disease.

Nambu A, Zach J, Schroeder J, Jin GY, Kim SS, Kim YI, Schnell C, Bowler R, Lynch DA.

Eur J Radiol. 2015 May;84(5):980-5. doi: 10.1016/j.ejrad.2015.01.010. Epub 2015 Jan 22.


Complexes of xylan and synthetic polyelectrolytes. Characterization and adsorption onto high quality unbleached fibres.

Mocchiutti P, Galván MV, Peresin MS, Schnell CN, Zanuttini MA.

Carbohydr Polym. 2015 Feb 13;116:131-9. doi: 10.1016/j.carbpol.2014.04.081. Epub 2014 Apr 28.


Genetic ablation of VIAAT in glycinergic neurons causes a severe respiratory phenotype and perinatal death.

Rahman J, Besser S, Schnell C, Eulenburg V, Hirrlinger J, Wojcik SM, Hülsmann S.

Brain Struct Funct. 2015 Sep;220(5):2835-49. doi: 10.1007/s00429-014-0829-2. Epub 2014 Jul 16.


Targeting PI3K/mTOR overcomes resistance to HER2-targeted therapy independent of feedback activation of AKT.

O'Brien NA, McDonald K, Tong L, von Euw E, Kalous O, Conklin D, Hurvitz SA, di Tomaso E, Schnell C, Linnartz R, Finn RS, Hirawat S, Slamon DJ.

Clin Cancer Res. 2014 Jul 1;20(13):3507-20. doi: 10.1158/1078-0432.CCR-13-2769. Epub 2014 May 30.


Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials.

Fritsch C, Huang A, Chatenay-Rivauday C, Schnell C, Reddy A, Liu M, Kauffmann A, Guthy D, Erdmann D, De Pover A, Furet P, Gao H, Ferretti S, Wang Y, Trappe J, Brachmann SM, Maira SM, Wilson C, Boehm M, Garcia-Echeverria C, Chene P, Wiesmann M, Cozens R, Lehar J, Schlegel R, Caravatti G, Hofmann F, Sellers WR.

Mol Cancer Ther. 2014 May;13(5):1117-29. doi: 10.1158/1535-7163.MCT-13-0865. Epub 2014 Mar 7.


The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes.

Schnell C, Shahmoradi A, Wichert SP, Mayerl S, Hagos Y, Heuer H, Rossner MJ, Hülsmann S.

Brain Struct Funct. 2015 Jan;220(1):193-203. doi: 10.1007/s00429-013-0645-0. Epub 2013 Oct 16.


Human neutrophil elastase degrades SPLUNC1 and impairs airway epithelial defense against bacteria.

Jiang D, Wenzel SE, Wu Q, Bowler RP, Schnell C, Chu HW.

PLoS One. 2013 May 31;8(5):e64689. doi: 10.1371/journal.pone.0064689. Print 2013.


Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease.

Bahr TM, Hughes GJ, Armstrong M, Reisdorph R, Coldren CD, Edwards MG, Schnell C, Kedl R, LaFlamme DJ, Reisdorph N, Kechris KJ, Bowler RP.

Am J Respir Cell Mol Biol. 2013 Aug;49(2):316-23. doi: 10.1165/rcmb.2012-0230OC.


Active sulforhodamine 101 uptake into hippocampal astrocytes.

Schnell C, Hagos Y, Hülsmann S.

PLoS One. 2012;7(11):e49398. doi: 10.1371/journal.pone.0049398. Epub 2012 Nov 26.


Restraint Stress Intensifies Interstitial K(+) Accumulation during Severe Hypoxia.

Schnell C, Janc OA, Kempkes B, Callis CA, Flügge G, Hülsmann S, Müller M.

Front Pharmacol. 2012 Mar 28;3:53. doi: 10.3389/fphar.2012.00053. eCollection 2012.


Myositis ossificans traumatica of the neck - a pediatric case.

Man SC, Schnell CN, Fufezan O, Mihut G.

Maedica (Buchar). 2011 Apr;6(2):128-31.


Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor.

Maira SM, Pecchi S, Huang A, Burger M, Knapp M, Sterker D, Schnell C, Guthy D, Nagel T, Wiesmann M, Brachmann S, Fritsch C, Dorsch M, Chène P, Shoemaker K, De Pover A, Menezes D, Martiny-Baron G, Fabbro D, Wilson CJ, Schlegel R, Hofmann F, García-Echeverría C, Sellers WR, Voliva CF.

Mol Cancer Ther. 2012 Feb;11(2):317-28. doi: 10.1158/1535-7163.MCT-11-0474. Epub 2011 Dec 21.


Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor.

Wyder L, Suply T, Ricoux B, Billy E, Schnell C, Baumgarten BU, Maira SM, Koelbing C, Ferretti M, Kinzel B, Müller M, Seuwen K, Ludwig MG.

Angiogenesis. 2011 Dec;14(4):533-44. doi: 10.1007/s10456-011-9238-9. Epub 2011 Nov 2.


Determinants of functional coupling between astrocytes and respiratory neurons in the pre-Bötzinger complex.

Schnell C, Fresemann J, Hülsmann S.

PLoS One. 2011;6(10):e26309. doi: 10.1371/journal.pone.0026309. Epub 2011 Oct 19.


Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.

Guagnano V, Furet P, Spanka C, Bordas V, Le Douget M, Stamm C, Brueggen J, Jensen MR, Schnell C, Schmid H, Wartmann M, Berghausen J, Drueckes P, Zimmerlin A, Bussiere D, Murray J, Graus Porta D.

J Med Chem. 2011 Oct 27;54(20):7066-83. doi: 10.1021/jm2006222. Epub 2011 Sep 21.


LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice.

Herzig MC, Kolly C, Persohn E, Theil D, Schweizer T, Hafner T, Stemmelen C, Troxler TJ, Schmid P, Danner S, Schnell CR, Mueller M, Kinzel B, Grevot A, Bolognani F, Stirn M, Kuhn RR, Kaupmann K, van der Putten PH, Rovelli G, Shimshek DR.

Hum Mol Genet. 2011 Nov 1;20(21):4209-23. doi: 10.1093/hmg/ddr348. Epub 2011 Aug 9.


Angiogenesis is present in experimental autoimmune encephalomyelitis and pro-angiogenic factors are increased in multiple sclerosis lesions.

Seabrook TJ, Littlewood-Evans A, Brinkmann V, Pöllinger B, Schnell C, Hiestand PC.

J Neuroinflammation. 2010 Dec 22;7:95. doi: 10.1186/1742-2094-7-95.


The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis.

Martiny-Baron G, Holzer P, Billy E, Schnell C, Brueggen J, Ferretti M, Schmiedeberg N, Wood JM, Furet P, Imbach P.

Angiogenesis. 2010 Sep;13(3):259-67. doi: 10.1007/s10456-010-9183-z. Epub 2010 Aug 29.


Everolimus and PTK/ZK show synergistic growth inhibition in the orthotopic BL16/BL6 murine melanoma model.

O'Reilly T, Lane HA, Wood JM, Schnell C, Littlewood-Evans A, Brueggen J, McSheehy PM.

Cancer Chemother Pharmacol. 2011 Jan;67(1):193-200. doi: 10.1007/s00280-010-1307-z. Epub 2010 May 30.


beta2-agonists promote host defense against bacterial infection in primary human bronchial epithelial cells.

Gross CA, Bowler RP, Green RM, Weinberger AR, Schnell C, Chu HW.

BMC Pulm Med. 2010 May 14;10:30. doi: 10.1186/1471-2466-10-30.


Glycinergic interneurons in the respiratory network of the rhythmic slice preparation.

Winter SM, Fresemann J, Schnell C, Oku Y, Hirrlinger J, Hülsmann S.

Adv Exp Med Biol. 2010;669:97-100. doi: 10.1007/978-1-4419-5692-7_20.


Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells.

Brachmann SM, Hofmann I, Schnell C, Fritsch C, Wee S, Lane H, Wang S, Garcia-Echeverria C, Maira SM.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22299-304. doi: 10.1073/pnas.0905152106. Epub 2009 Dec 10.


Prenatal dexamethasone exposure does not alter blood pressure and nephron number in the young adult marmoset monkey.

Bramlage CP, Schlumbohm C, Pryce CR, Mirza S, Schnell C, Amann K, Amstrong VW, Eitner F, Zapf A, Feldon J, Oellerich M, Fuchs E, Müller GA, Strutz F.

Hypertension. 2009 Nov;54(5):1115-22. doi: 10.1161/HYPERTENSIONAHA.109.136580. Epub 2009 Sep 21.


The P1N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin.

Yamaguchi Y, Menear K, Cohen NC, Mah R, Cumin F, Schnell C, Wood JM, Maibaum J.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4863-7. doi: 10.1016/j.bmcl.2009.05.128. Epub 2009 Jun 26.


Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors.

Marone R, Erhart D, Mertz AC, Bohnacker T, Schnell C, Cmiljanovic V, Stauffer F, Garcia-Echeverria C, Giese B, Maira SM, Wymann MP.

Mol Cancer Res. 2009 Apr;7(4):601-13. doi: 10.1158/1541-7786.MCR-08-0366.


Glycinergic interneurons are functionally integrated into the inspiratory network of mouse medullary slices.

Winter SM, Fresemann J, Schnell C, Oku Y, Hirrlinger J, Hülsmann S.

Pflugers Arch. 2009 Jul;458(3):459-69. doi: 10.1007/s00424-009-0647-1. Epub 2009 Feb 24.


mTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor.

Lane HA, Wood JM, McSheehy PM, Allegrini PR, Boulay A, Brueggen J, Littlewood-Evans A, Maira SM, Martiny-Baron G, Schnell CR, Sini P, O'Reilly T.

Clin Cancer Res. 2009 Mar 1;15(5):1612-22. doi: 10.1158/1078-0432.CCR-08-2057. Epub 2009 Feb 17.


PI3K inhibitors for cancer treatment: where do we stand?

Maira SM, Stauffer F, Schnell C, García-Echeverría C.

Biochem Soc Trans. 2009 Feb;37(Pt 1):265-72. doi: 10.1042/BST0370265. Review.


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