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Items: 1 to 50 of 129

1.

Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.

Schneider RK, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, Van Strien PMH, Bindels EM, Heckl D, Büsche G, Fleck D, Müller-Newen G, Wongboonsin J, Ventura Ferreira M, Puelles VG, Saez-Rodriguez J, Ebert BL, Humphreys BD, Kramann R.

Cell Stem Cell. 2018 Aug 2;23(2):308-309. doi: 10.1016/j.stem.2018.07.006. No abstract available.

PMID:
30075132
2.

Puzzling pieces of chromosome 7 loss or deletion.

Schneider RK, Delwel R.

Blood. 2018 Jun 28;131(26):2871-2872. doi: 10.1182/blood-2018-04-844746. No abstract available.

PMID:
29954818
3.

Parabiosis and single-cell RNA sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis.

Kramann R, Machado F, Wu H, Kusaba T, Hoeft K, Schneider RK, Humphreys BD.

JCI Insight. 2018 May 3;3(9). pii: 99561. doi: 10.1172/jci.insight.99561. [Epub ahead of print]

4.

Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms.

Wolach O, Sellar RS, Martinod K, Cherpokova D, McConkey M, Chappell RJ, Silver AJ, Adams D, Castellano CA, Schneider RK, Padera RF, DeAngelo DJ, Wadleigh M, Steensma DP, Galinsky I, Stone RM, Genovese G, McCarroll SA, Iliadou B, Hultman C, Neuberg D, Mullally A, Wagner DD, Ebert BL.

Sci Transl Med. 2018 Apr 11;10(436). pii: eaan8292. doi: 10.1126/scitranslmed.aan8292.

PMID:
29643232
5.

The identification of fibrosis-driving myofibroblast precursors reveals new therapeutic avenues in myelofibrosis.

Kramann R, Schneider RK.

Blood. 2018 May 10;131(19):2111-2119. doi: 10.1182/blood-2018-02-834820. Epub 2018 Mar 23. Review.

PMID:
29572380
6.

Understanding deregulated cellular and molecular dynamics in the haematopoietic stem cell niche to develop novel therapeutics for bone marrow fibrosis.

Gleitz HF, Kramann R, Schneider RK.

J Pathol. 2018 Jun;245(2):138-146. doi: 10.1002/path.5078. Epub 2018 Apr 19. Review.

7.

Mesenchymal Stem Cells in Fibrotic Disease.

El Agha E, Kramann R, Schneider RK, Li X, Seeger W, Humphreys BD, Bellusci S.

Cell Stem Cell. 2017 Aug 3;21(2):166-177. doi: 10.1016/j.stem.2017.07.011. Review.

8.

Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.

Schneider RK, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, Van Strien PMH, Bindels EM, Heckl D, Büsche G, Fleck D, Müller-Newen G, Wongboonsin J, Ventura Ferreira M, Puelles VG, Saez-Rodriguez J, Ebert BL, Humphreys BD, Kramann R.

Cell Stem Cell. 2017 Jun 1;20(6):785-800.e8. doi: 10.1016/j.stem.2017.03.008. Epub 2017 Apr 27. Erratum in: Cell Stem Cell. 2018 Aug 2;23(2):308-309.

9.

Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation.

Obeng EA, Chappell RJ, Seiler M, Chen MC, Campagna DR, Schmidt PJ, Schneider RK, Lord AM, Wang L, Gambe RG, McConkey ME, Ali AM, Raza A, Yu L, Buonamici S, Smith PG, Mullally A, Wu CJ, Fleming MD, Ebert BL.

Cancer Cell. 2016 Sep 12;30(3):404-417. doi: 10.1016/j.ccell.2016.08.006.

10.

Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease.

Kramann R, Goettsch C, Wongboonsin J, Iwata H, Schneider RK, Kuppe C, Kaesler N, Chang-Panesso M, Machado FG, Gratwohl S, Madhurima K, Hutcheson JD, Jain S, Aikawa E, Humphreys BD.

Cell Stem Cell. 2016 Nov 3;19(5):628-642. doi: 10.1016/j.stem.2016.08.001. Epub 2016 Sep 8.

11.

Evaluation of a New Surgical Treatment for Equine Hind Limb Proximal Suspensory Desmitis.

Brokken MT, Schneider RK, Roberts GD, Holmes SP, Gavin PR, Sampson SN, Farnsworth KD, Dahlgren LA.

Vet Surg. 2016 Oct;45(7):868-878. doi: 10.1111/vsu.12527. Epub 2016 Aug 22.

PMID:
27545972
12.

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.

Puram RV, Kowalczyk MS, de Boer CG, Schneider RK, Miller PG, McConkey M, Tothova Z, Tejero H, Heckl D, Järås M, Chen MC, Li H, Tamayo A, Cowley GS, Rozenblatt-Rosen O, Al-Shahrour F, Regev A, Ebert BL.

Cell. 2016 Apr 7;165(2):303-16. doi: 10.1016/j.cell.2016.03.015.

13.

Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation.

Elf S, Abdelfattah NS, Chen E, Perales-Patón J, Rosen EA, Ko A, Peisker F, Florescu N, Giannini S, Wolach O, Morgan EA, Tothova Z, Losman JA, Schneider RK, Al-Shahrour F, Mullally A.

Cancer Discov. 2016 Apr;6(4):368-81. doi: 10.1158/2159-8290.CD-15-1434. Epub 2016 Mar 7.

14.

Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9.

Schneider RK, Schenone M, Ferreira MV, Kramann R, Joyce CE, Hartigan C, Beier F, Brümmendorf TH, Germing U, Platzbecker U, Büsche G, Knüchel R, Chen MC, Waters CS, Chen E, Chu LP, Novina CD, Lindsley RC, Carr SA, Ebert BL.

Nat Med. 2016 Mar;22(3):288-97. doi: 10.1038/nm.4047. Epub 2016 Feb 15.

15.

An engineered multicomponent bone marrow niche for the recapitulation of hematopoiesis at ectopic transplantation sites.

Ventura Ferreira MS, Bergmann C, Bodensiek I, Peukert K, Abert J, Kramann R, Kachel P, Rath B, Rütten S, Knuchel R, Ebert BL, Fischer H, Brümmendorf TH, Schneider RK.

J Hematol Oncol. 2016 Jan 25;9:4. doi: 10.1186/s13045-016-0234-9.

16.

Medical treatment of horses with deep digital flexor tendon injuries diagnosed with high-field-strength magnetic resonance imaging: 118 cases (2000-2010).

Lutter JD, Schneider RK, Sampson SN, Cary JA, Roberts GD, Vahl CI.

J Am Vet Med Assoc. 2015 Dec 1;247(11):1309-18. doi: 10.2460/javma.247.11.1309.

PMID:
26594815
17.

Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition.

Wen QJ, Yang Q, Goldenson B, Malinge S, Lasho T, Schneider RK, Breyfogle LJ, Schultz R, Gilles L, Koppikar P, Abdel-Wahab O, Pardanani A, Stein B, Gurbuxani S, Mullally A, Levine RL, Tefferi A, Crispino JD.

Nat Med. 2015 Dec;21(12):1473-80. doi: 10.1038/nm.3995. Epub 2015 Nov 16.

18.

Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells.

Kowalczyk MS, Tirosh I, Heckl D, Rao TN, Dixit A, Haas BJ, Schneider RK, Wagers AJ, Ebert BL, Regev A.

Genome Res. 2015 Dec;25(12):1860-72. doi: 10.1101/gr.192237.115. Epub 2015 Oct 1.

19.

Telomere dynamics in patients with del (5q) MDS before and under treatment with lenalidomide.

Beier F, Masouleh BK, Buesche G, Ventura Ferreira MS, Schneider RK, Ziegler P, Wilop S, Vankann L, Gattermann N, Platzbecker U, Giagounidis A, Götze KS, Nolte F, Hofmann WK, Haase D, Kreipe H, Panse J, Blasco MA, Germing U, Brümmendorf TH.

Leuk Res. 2015 Sep 21. pii: S0145-2126(15)30380-5. doi: 10.1016/j.leukres.2015.09.003. [Epub ahead of print]

PMID:
26427727
20.

Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis.

Kramann R, Fleig SV, Schneider RK, Fabian SL, DiRocco DP, Maarouf O, Wongboonsin J, Ikeda Y, Heckl D, Chang SL, Rennke HG, Waikar SS, Humphreys BD.

J Clin Invest. 2015 Aug 3;125(8):2935-51. doi: 10.1172/JCI74929. Epub 2015 Jul 20.

21.

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.

Krönke J, Fink EC, Hollenbach PW, MacBeth KJ, Hurst SN, Udeshi ND, Chamberlain PP, Mani DR, Man HW, Gandhi AK, Svinkina T, Schneider RK, McConkey M, Järås M, Griffiths E, Wetzler M, Bullinger L, Cathers BE, Carr SA, Chopra R, Ebert BL.

Nature. 2015 Jul 9;523(7559):183-188. doi: 10.1038/nature14610. Epub 2015 Jul 1.

22.

Activated fibronectin-secretory phenotype of mesenchymal stromal cells in pre-fibrotic myeloproliferative neoplasms.

Schneider RK, Ziegler S, Leisten I, Ferreira MS, Schumacher A, Rath B, Fahrenkamp D, Müller-Newen G, Crysandt M, Wilop S, Jost E, Koschmieder S, Knüchel R, Brümmendorf TH, Ziegler P.

J Hematol Oncol. 2014 Dec 14;7:92. doi: 10.1186/s13045-014-0092-2.

23.

Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis.

Kramann R, Schneider RK, DiRocco DP, Machado F, Fleig S, Bondzie PA, Henderson JM, Ebert BL, Humphreys BD.

Cell Stem Cell. 2015 Jan 8;16(1):51-66. doi: 10.1016/j.stem.2014.11.004. Epub 2014 Nov 20.

24.

Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms.

Chen E, Schneider RK, Breyfogle LJ, Rosen EA, Poveromo L, Elf S, Ko A, Brumme K, Levine R, Ebert BL, Mullally A.

Blood. 2015 Jan 8;125(2):327-35. doi: 10.1182/blood-2014-04-567024. Epub 2014 Oct 3.

25.

Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.

Schneider RK, Ademà V, Heckl D, Järås M, Mallo M, Lord AM, Chu LP, McConkey ME, Kramann R, Mullally A, Bejar R, Solé F, Ebert BL.

Cancer Cell. 2014 Oct 13;26(4):509-20. doi: 10.1016/j.ccr.2014.08.001. Epub 2014 Sep 18.

26.

Cell fusion enhances mesendodermal differentiation of human induced pluripotent stem cells.

Qin J, Sontag S, Lin Q, Mitzka S, Leisten I, Schneider RK, Wang X, Jauch A, Peitz M, Brüstle O, Wagner W, Zhao RC, Zenke M.

Stem Cells Dev. 2014 Dec 1;23(23):2875-82. doi: 10.1089/scd.2014.0120. Epub 2014 Aug 11.

27.

Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis.

De Vita S, Schneider RK, Garcia M, Wood J, Gavillet M, Ebert BL, Gerbaulet A, Roers A, Levine RL, Mullally A, Williams DA.

PLoS One. 2014 May 2;9(5):e96209. doi: 10.1371/journal.pone.0096209. eCollection 2014.

28.

Speckle tracking echocardiography detects uremic cardiomyopathy early and predicts cardiovascular mortality in ESRD.

Kramann R, Erpenbeck J, Schneider RK, Röhl AB, Hein M, Brandenburg VM, van Diepen M, Dekker F, Marx N, Floege J, Becker M, Schlieper G.

J Am Soc Nephrol. 2014 Oct;25(10):2351-65. doi: 10.1681/ASN.2013070734. Epub 2014 Apr 3.

29.

Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.

Järås M, Miller PG, Chu LP, Puram RV, Fink EC, Schneider RK, Al-Shahrour F, Peña P, Breyfogle LJ, Hartwell KA, McConkey ME, Cowley GS, Root DE, Kharas MG, Mullally A, Ebert BL.

J Exp Med. 2014 Apr 7;211(4):605-12. doi: 10.1084/jem.20131033. Epub 2014 Mar 10.

30.

Clinical outcome after intra-articular administration of bone marrow derived mesenchymal stem cells in 33 horses with stifle injury.

Ferris DJ, Frisbie DD, Kisiday JD, McIlwraith CW, Hague BA, Major MD, Schneider RK, Zubrod CJ, Kawcak CE, Goodrich LR.

Vet Surg. 2014 Mar;43(3):255-65. doi: 10.1111/j.1532-950X.2014.12100.x. Epub 2014 Jan 16.

PMID:
24433318
31.

[Mesenchymal stroma cells and their niche].

Schneider RK.

Pathologe. 2013 Nov;34 Suppl 2:264-8. doi: 10.1007/s00292-013-1818-6. German.

PMID:
24196626
32.

Osteogenesis of heterotopically transplanted mesenchymal stromal cells in rat models of chronic kidney disease.

Kramann R, Kunter U, Brandenburg VM, Leisten I, Ehling J, Klinkhammer BM, Knüchel R, Floege J, Schneider RK.

J Bone Miner Res. 2013 Dec;28(12):2523-34. doi: 10.1002/jbmr.1994.

33.

Parathyroid hormone-related protein and regulation of cell survival in the kidney.

Kramann R, Schneider RK.

Kidney Int. 2013 May;83(5):777-9. doi: 10.1038/ki.2012.469.

34.

Reconsidering pluripotency tests: do we still need teratoma assays?

Buta C, David R, Dressel R, Emgård M, Fuchs C, Gross U, Healy L, Hescheler J, Kolar R, Martin U, Mikkers H, Müller FJ, Schneider RK, Seiler AE, Spielmann H, Weitzer G.

Stem Cell Res. 2013 Jul;11(1):552-62. doi: 10.1016/j.scr.2013.03.001. Epub 2013 Mar 26. Review.

35.

(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible.

Losman JA, Looper RE, Koivunen P, Lee S, Schneider RK, McMahon C, Cowley GS, Root DE, Ebert BL, Kaelin WG Jr.

Science. 2013 Mar 29;339(6127):1621-5. doi: 10.1126/science.1231677. Epub 2013 Feb 7.

36.

Novel insights into osteogenesis and matrix remodelling associated with calcific uraemic arteriolopathy.

Kramann R, Brandenburg VM, Schurgers LJ, Ketteler M, Westphal S, Leisten I, Bovi M, Jahnen-Dechent W, Knüchel R, Floege J, Schneider RK.

Nephrol Dial Transplant. 2013 Apr;28(4):856-68. doi: 10.1093/ndt/gfs466. Epub 2012 Dec 6.

PMID:
23223222
37.

Response to injection of the navicular bursa with corticosteroid and hyaluronan following high-field magnetic resonance imaging in horses with signs of navicular syndrome: 101 cases (2000-2008).

Marsh CA, Schneider RK, Sampson SN, Roberts GD.

J Am Vet Med Assoc. 2012 Nov 15;241(10):1353-64. doi: 10.2460/javma.241.10.1353.

PMID:
23113529
38.

MRI findings in 232 horses with lameness localized to the metacarpo(tarso)phalangeal region and without a radiographic diagnosis.

King JN, Zubrod CJ, Schneider RK, Sampson SN, Roberts G.

Vet Radiol Ultrasound. 2013 Jan-Feb;54(1):36-47. doi: 10.1111/j.1740-8261.2012.01983.x. Epub 2012 Oct 1.

PMID:
23020207
39.

Cord blood-hematopoietic stem cell expansion in 3D fibrin scaffolds with stromal support.

Ferreira MS, Jahnen-Dechent W, Labude N, Bovi M, Hieronymus T, Zenke M, Schneider RK, Neuss S.

Biomaterials. 2012 Oct;33(29):6987-97. doi: 10.1016/j.biomaterials.2012.06.029. Epub 2012 Jul 15. Erratum in: Biomaterials. 2012 Dec;33(35):9165. Neurs, Sabine [corrected to Neuss, Sabine].

PMID:
22800538
40.

[The 'red puffy ear sign'--a clinical sign to diagnose a rare cause of meningoencephalitis].

Prinz S, Dafotakis M, Schneider RK, Mühlenbruch G, Stopschinski BE.

Fortschr Neurol Psychiatr. 2012 Aug;80(8):463-7. doi: 10.1055/s-0031-1299439. Epub 2012 Jul 9. German.

PMID:
22777885
41.

Two-dimensional polymer-based cultures expand cord blood-derived hematopoietic stem cells and support engraftment of NSG mice.

Ferreira MS, Schneider RK, Wagner W, Jahnen-Dechent W, Labude N, Bovi M, Piroth D, Knüchel R, Hieronymus T, Müller AM, Zenke M, Neuss S.

Tissue Eng Part C Methods. 2013 Jan;19(1):25-38. doi: 10.1089/ten.TEC.2011.0706. Epub 2012 Aug 23.

42.

Human platelet lysate gel provides a novel three dimensional-matrix for enhanced culture expansion of mesenchymal stromal cells.

Walenda G, Hemeda H, Schneider RK, Merkel R, Hoffmann B, Wagner W.

Tissue Eng Part C Methods. 2012 Dec;18(12):924-34. doi: 10.1089/ten.TEC.2011.0541. Epub 2012 Jul 16.

PMID:
22670863
43.

Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera.

Mullally A, Poveromo L, Schneider RK, Al-Shahrour F, Lane SW, Ebert BL.

Blood. 2012 Jul 5;120(1):166-72. doi: 10.1182/blood-2012-01-402396. Epub 2012 May 24.

44.

Epithelial morphogenesis of germline-derived pluripotent stem cells on organotypic skin equivalents in vitro.

van de Kamp J, Kramann R, Anraths J, Schöler HR, Ko K, Knüchel R, Zenke M, Neuss S, Schneider RK.

Differentiation. 2012 Mar;83(3):138-47. doi: 10.1016/j.diff.2011.11.014. Epub 2011 Dec 21.

PMID:
22364881
45.

Uraemia disrupts the vascular niche in a 3D co-culture system of human mesenchymal stem cells and endothelial cells.

Kramann R, Couson SK, Neuss S, Floege J, Knüchel R, Schneider RK.

Nephrol Dial Transplant. 2012 Jul;27(7):2693-702. doi: 10.1093/ndt/gfr656. Epub 2011 Dec 29.

PMID:
22207324
46.

3D co-culture of hematopoietic stem and progenitor cells and mesenchymal stem cells in collagen scaffolds as a model of the hematopoietic niche.

Leisten I, Kramann R, Ventura Ferreira MS, Bovi M, Neuss S, Ziegler P, Wagner W, Knüchel R, Schneider RK.

Biomaterials. 2012 Feb;33(6):1736-47. doi: 10.1016/j.biomaterials.2011.11.034. Epub 2011 Dec 1.

PMID:
22136713
47.

[Mesenchymal stem cells and their interaction with biomaterials: potential applications in tissue engineering].

Schneider RK, Knüchel R, Neuss S.

Pathologe. 2011 Nov;32 Suppl 2:296-303. doi: 10.1007/s00292-011-1485-4. German.

PMID:
21826499
48.

Exposure to uremic serum induces a procalcific phenotype in human mesenchymal stem cells.

Kramann R, Couson SK, Neuss S, Kunter U, Bovi M, Bornemann J, Knüchel R, Jahnen-Dechent W, Floege J, Schneider RK.

Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):e45-54. doi: 10.1161/ATVBAHA.111.228601. Epub 2011 Jun 16.

PMID:
21680902
49.

Brief report: evaluating the potential of putative pluripotent cells derived from human testis.

Ko K, Reinhardt P, Tapia N, Schneider RK, Araúzo-Bravo MJ, Han DW, Greber B, Kim J, Kliesch S, Zenke M, Schöler HR.

Stem Cells. 2011 Aug;29(8):1304-9. doi: 10.1002/stem.671.

50.

Desmotomy of the accessory ligament of the deep digital flexor tendon in the forelimb of 24 horses 2 years and older.

Yiannikouris S, Schneider RK, Sampson SN, Roberts G.

Vet Surg. 2011 Apr;40(3):272-6. doi: 10.1111/j.1532-950X.2011.00815.x. Epub 2011 Mar 1.

PMID:
21361994

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