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Items: 23


In situ crystallography as an emerging method for structure solution of membrane proteins: the case of CCR2A.

Cheng R, Huang CY, Hennig M, Nar H, Schnapp G.

FEBS J. 2019 Oct 17. doi: 10.1111/febs.15098. [Epub ahead of print]


MALDI-TOF Mass Spectrometry-Based High-Throughput Screening for Inhibitors of the Cytosolic DNA Sensor cGAS.

Simon RP, Winter M, Kleiner C, Ries R, Schnapp G, Heimann A, Li J, Zuvela-Jelaska L, Bretschneider T, Luippold AH, Reindl W, Bischoff D, Büttner FH.

SLAS Discov. 2019 Oct 4:2472555219880185. doi: 10.1177/2472555219880185. [Epub ahead of print]


Enhancing Drug Residence Time by Shielding of Intra-Protein Hydrogen Bonds: A Case Study on CCR2 Antagonists.

Magarkar A, Schnapp G, Apel AK, Seeliger D, Tautermann CS.

ACS Med Chem Lett. 2019 Feb 7;10(3):324-328. doi: 10.1021/acsmedchemlett.8b00590. eCollection 2019 Mar 14.


Crystal Structure of CC Chemokine Receptor 2A in Complex with an Orthosteric Antagonist Provides Insights for the Design of Selective Antagonists.

Apel AK, Cheng RKY, Tautermann CS, Brauchle M, Huang CY, Pautsch A, Hennig M, Nar H, Schnapp G.

Structure. 2019 Mar 5;27(3):427-438.e5. doi: 10.1016/j.str.2018.10.027. Epub 2018 Dec 20.


Engineering Salt Bridge Networks between Transmembrane Helices Confers Thermostability in G-Protein-Coupled Receptors.

Ghosh S, Bierig T, Lee S, Jana S, Löhle A, Schnapp G, Tautermann CS, Vaidehi N.

J Chem Theory Comput. 2018 Dec 11;14(12):6574-6585. doi: 10.1021/acs.jctc.8b00602. Epub 2018 Nov 6.


Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule.

Tautermann CS, Binder F, Büttner FH, Eickmeier C, Fiegen D, Gross U, Grundl MA, Heilker R, Hobson S, Hoerer S, Luippold A, Mack V, Montel F, Peters S, Bhattacharya S, Vaidehi N, Schnapp G, Thamm S, Zeeb M.

J Med Chem. 2019 Jan 10;62(1):306-316. doi: 10.1021/acs.jmedchem.8b00857. Epub 2018 Sep 12.


Comparative Analysis of Binding Kinetics and Thermodynamics of Dipeptidyl Peptidase-4 Inhibitors and Their Relationship to Structure.

Schnapp G, Klein T, Hoevels Y, Bakker RA, Nar H.

J Med Chem. 2016 Aug 25;59(16):7466-77. doi: 10.1021/acs.jmedchem.6b00475. Epub 2016 Aug 4.


Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib.

Mathea S, Abdul Azeez KR, Salah E, Tallant C, Wolfreys F, Konietzny R, Fischer R, Lou HJ, Brennan PE, Schnapp G, Pautsch A, Kessler BM, Turk BE, Knapp S.

ACS Chem Biol. 2016 Jun 17;11(6):1595-602. doi: 10.1021/acschembio.6b00043. Epub 2016 Mar 31.


Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis.

Wollin L, Wex E, Pautsch A, Schnapp G, Hostettler KE, Stowasser S, Kolb M.

Eur Respir J. 2015 May;45(5):1434-45. doi: 10.1183/09031936.00174914. Epub 2015 Mar 5. Review.


Fast native-SAD phasing for routine macromolecular structure determination.

Weinert T, Olieric V, Waltersperger S, Panepucci E, Chen L, Zhang H, Zhou D, Rose J, Ebihara A, Kuramitsu S, Li D, Howe N, Schnapp G, Pautsch A, Bargsten K, Prota AE, Surana P, Kottur J, Nair DT, Basilico F, Cecatiello V, Pasqualato S, Boland A, Weichenrieder O, Wang BC, Steinmetz MO, Caffrey M, Wang M.

Nat Methods. 2015 Feb;12(2):131-3. doi: 10.1038/nmeth.3211. Epub 2014 Dec 15. Erratum in: Nat Methods. 2015 Jul;12(7):692.


Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy.

Li D, Howe N, Dukkipati A, Shah ST, Bax BD, Edge C, Bridges A, Hardwicke P, Singh OM, Giblin G, Pautsch A, Pfau R, Schnapp G, Wang M, Olieric V, Caffrey M.

Cryst Growth Des. 2014 Apr 2;14(4):2034-2047. Epub 2014 Mar 7.


Crystal structure of glucokinase regulatory protein.

Pautsch A, Stadler N, Löhle A, Rist W, Berg A, Glocker L, Nar H, Reinert D, Lenter M, Heckel A, Schnapp G, Kauschke SG.

Biochemistry. 2013 May 21;52(20):3523-31. doi: 10.1021/bi4000782. Epub 2013 May 9.


A systematic approach to increase the efficiency of membrane protein production in cell-free expression systems.

Haberstock S, Roos C, Hoevels Y, Dötsch V, Schnapp G, Pautsch A, Bernhard F.

Protein Expr Purif. 2012 Apr;82(2):308-16. doi: 10.1016/j.pep.2012.01.018. Epub 2012 Feb 8.


Design, synthesis, and evaluation of indolinones as inhibitors of the transforming growth factor β receptor I (TGFβRI).

Roth GJ, Heckel A, Brandl T, Grauert M, Hoerer S, Kley JT, Schnapp G, Baum P, Mennerich D, Schnapp A, Park JE.

J Med Chem. 2010 Oct 28;53(20):7287-95. doi: 10.1021/jm100812a.


BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo.

Sapkota GP, Cummings L, Newell FS, Armstrong C, Bain J, Frodin M, Grauert M, Hoffmann M, Schnapp G, Steegmaier M, Cohen P, Alessi DR.

Biochem J. 2007 Jan 1;401(1):29-38.


The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint.

Hauf S, Cole RW, LaTerra S, Zimmer C, Schnapp G, Walter R, Heckel A, van Meel J, Rieder CL, Peters JM.

J Cell Biol. 2003 Apr 28;161(2):281-94. Epub 2003 Apr 21.


Control of human telomere length by TRF1 and TRF2.

Smogorzewska A, van Steensel B, Bianchi A, Oelmann S, Schaefer MR, Schnapp G, de Lange T.

Mol Cell Biol. 2000 Mar;20(5):1659-68.


Telomerase is not an epidermal stem cell marker and is downregulated by calcium.

Bickenbach JR, Vormwald-Dogan V, Bachor C, Bleuel K, Schnapp G, Boukamp P.

J Invest Dermatol. 1998 Dec;111(6):1045-52.


One-step affinity purification protocol for human telomerase.

Schnapp G, Rodi HP, Rettig WJ, Schnapp A, Damm K.

Nucleic Acids Res. 1998 Jul 1;26(13):3311-3.


TFIIS binds to mouse RNA polymerase I and stimulates transcript elongation and hydrolytic cleavage of nascent rRNA.

Schnapp G, Graveley BR, Grummt I.

Mol Gen Genet. 1996 Sep 25;252(4):412-9.


TIF-IC, a factor involved in both transcription initiation and elongation of RNA polymerase I.

Schnapp G, Schnapp A, Rosenbauer H, Grummt I.

EMBO J. 1994 Sep 1;13(17):4028-35.


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