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Items: 1 to 50 of 171


Enhancing clinical trial development for pediatric kidney diseases.

Schnaper HW, Flynn JT, Gross C, Cropp AB, Dehmel B, Patel LB, Greenbaum LA, Houtsmuller E, Kaskel F, Moxey-Mims M, Nowak K, Silverstein D, Thompson A, Yao L, Darsey E, Smoyer WE.

Pediatr Res. 2017 Nov;82(5):727-732. doi: 10.1038/pr.2017.180. Epub 2017 Aug 30. Review.


Keeping the customers stratified: moving toward genetics-based treatment options in childhood NS.

Puckelwartz M, Schnaper HW.

Kidney Int. 2017 Apr;91(4):781-783. doi: 10.1016/j.kint.2016.12.032.


The Tubulointerstitial Pathophysiology of Progressive Kidney Disease.

Schnaper HW.

Adv Chronic Kidney Dis. 2017 Mar;24(2):107-116. doi: 10.1053/j.ackd.2016.11.011. Review.


Hypoxia-inducible factor-1α promotes glomerulosclerosis and regulates COL1A2 expression through interactions with Smad3.

Baumann B, Hayashida T, Liang X, Schnaper HW.

Kidney Int. 2016 Oct;90(4):797-808. doi: 10.1016/j.kint.2016.05.026. Epub 2016 Aug 5.


Anti-TGF-β Antibody, 1D11, Ameliorates Glomerular Fibrosis in Mouse Models after the Onset of Proteinuria.

Liang X, Schnaper HW, Matsusaka T, Pastan I, Ledbetter S, Hayashida T.

PLoS One. 2016 May 17;11(5):e0155534. doi: 10.1371/journal.pone.0155534. eCollection 2016.


Training the next generation of pediatric nephrology advocates: the John E. Lewy Foundation Advocacy Scholars Program.

Schnaper HW, Schubert K, Perlman SA, Clark SL, Hains DS, Roach JL, Skversky AL, Spencer JD, Springel T, Swartz SJ, Norwood VF, Satlin LM.

J Pediatr. 2015 Feb;166(2):218-9.e1. doi: 10.1016/j.jpeds.2014.10.032. No abstract available.


Defining new surrogate markers for CKD progression.

Schnaper HW, Furth SL, Yao LP.

Pediatr Nephrol. 2015 Feb;30(2):193-8. doi: 10.1007/s00467-014-2995-0. Epub 2014 Nov 5.


Epidermal growth factor inhibits transforming growth factor-β-induced fibrogenic differentiation marker expression through ERK activation.

Liu X, Hubchak SC, Browne JA, Schnaper HW.

Cell Signal. 2014 Oct;26(10):2276-83. doi: 10.1016/j.cellsig.2014.05.018. Epub 2014 Jun 3.


Serine-204 in the linker region of Smad3 mediates the collagen-I response to TGF-β in a cell phenotype-specific manner.

Browne JA, Liu X, Schnaper HW, Hayashida T.

Exp Cell Res. 2013 Nov 15;319(19):2928-37. doi: 10.1016/j.yexcr.2013.07.013. Epub 2013 Sep 27.


Hypoxia-inducible factor-2α and TGF-β signaling interact to promote normoxic glomerular fibrogenesis.

Hanna C, Hubchak SC, Liang X, Rozen-Zvi B, Schumacker PT, Hayashida T, Schnaper HW.

Am J Physiol Renal Physiol. 2013 Nov 1;305(9):F1323-31. doi: 10.1152/ajprenal.00155.2013. Epub 2013 Aug 14.


TGFβ receptor I transactivation mediates stretch-induced Pak1 activation and CTGF upregulation in mesangial cells.

Chen G, Chen X, Sukumar A, Gao B, Curley J, Schnaper HW, Ingram AJ, Krepinsky JC.

J Cell Sci. 2013 Aug 15;126(Pt 16):3697-712. doi: 10.1242/jcs.126714. Epub 2013 Jun 18.


TGF-β/Smad3 activates mammalian target of rapamycin complex-1 to promote collagen production by increasing HIF-1α expression.

Rozen-Zvi B, Hayashida T, Hubchak SC, Hanna C, Platanias LC, Schnaper HW.

Am J Physiol Renal Physiol. 2013 Aug 15;305(4):F485-94. doi: 10.1152/ajprenal.00215.2013. Epub 2013 Jun 12.


Remnant nephron physiology and the progression of chronic kidney disease.

Schnaper HW.

Pediatr Nephrol. 2014 Feb;29(2):193-202. doi: 10.1007/s00467-013-2494-8. Epub 2013 May 29. Review.


Phosphatidylinositol 3-kinase and Rab5 GTPase inversely regulate the Smad anchor for receptor activation (SARA) protein independently of transforming growth factor-β1.

Runyan CE, Liu Z, Schnaper HW.

J Biol Chem. 2012 Oct 19;287(43):35815-24. doi: 10.1074/jbc.M112.380493. Epub 2012 Aug 31.


Divergent roles of Smad3 and PI3-kinase in murine adriamycin nephropathy indicate distinct mechanisms of proteinuria and fibrogenesis.

Finer G, Schnaper HW, Kanwar YS, Liang X, Lin HY, Hayashida T.

Kidney Int. 2012 Sep;82(5):525-36. doi: 10.1038/ki.2012.139. Epub 2012 Apr 25.


Tubulointerstitial injury and the progression of chronic kidney disease.

Hodgkins KS, Schnaper HW.

Pediatr Nephrol. 2012 Jun;27(6):901-9. doi: 10.1007/s00467-011-1992-9. Epub 2011 Sep 27. Review.


Interdependence of HIF-1α and TGF-β/Smad3 signaling in normoxic and hypoxic renal epithelial cell collagen expression.

Basu RK, Hubchak S, Hayashida T, Runyan CE, Schumacker PT, Schnaper HW.

Am J Physiol Renal Physiol. 2011 Apr;300(4):F898-905. doi: 10.1152/ajprenal.00335.2010. Epub 2011 Jan 5.


Loss of beta1-integrin enhances TGF-beta1-induced collagen expression in epithelial cells via increased alphavbeta3-integrin and Rac1 activity.

Hayashida T, Jones JC, Lee CK, Schnaper HW.

J Biol Chem. 2010 Oct 1;285(40):30741-51. doi: 10.1074/jbc.M110.105700. Epub 2010 Jul 22.


A conceptual framework for the molecular pathogenesis of progressive kidney disease.

Schnaper HW, Hubchak SC, Runyan CE, Browne JA, Finer G, Liu X, Hayashida T.

Pediatr Nephrol. 2010 Nov;25(11):2223-30. doi: 10.1007/s00467-010-1503-4. Epub 2010 Mar 30. Review.


Rac1 promotes TGF-beta-stimulated mesangial cell type I collagen expression through a PI3K/Akt-dependent mechanism.

Hubchak SC, Sparks EE, Hayashida T, Schnaper HW.

Am J Physiol Renal Physiol. 2009 Nov;297(5):F1316-23. doi: 10.1152/ajprenal.00345.2009. Epub 2009 Sep 2.


Role of SARA (SMAD anchor for receptor activation) in maintenance of epithelial cell phenotype.

Runyan CE, Hayashida T, Hubchak S, Curley JF, Schnaper HW.

J Biol Chem. 2009 Sep 11;284(37):25181-9. doi: 10.1074/jbc.M109.032847. Epub 2009 Jul 20.


Progression of glomerular and tubular disease in pediatrics.

Woroniecki RP, Schnaper HW.

Semin Nephrol. 2009 Jul;29(4):412-24. doi: 10.1016/j.semnephrol.2009.03.016. Review.


TGF-beta signal transduction in chronic kidney disease.

Schnaper HW, Jandeska S, Runyan CE, Hubchak SC, Basu RK, Curley JF, Smith RD, Hayashida T.

Front Biosci (Landmark Ed). 2009 Jan 1;14:2448-65. Review.


High ambient glucose augments angiotensin II-induced proinflammatory gene mRNA expression in human mesangial cells: effects of valsartan and simvastatin.

Naito M, Shenoy A, Aoyama I, Koopmeiners JS, Komers R, Schnaper HW, Bomsztyk K.

Am J Nephrol. 2009;30(2):99-111. doi: 10.1159/000203619. Epub 2009 Feb 19.


Advances in the biology and genetics of the podocytopathies: implications for diagnosis and therapy.

Barisoni L, Schnaper HW, Kopp JB.

Arch Pathol Lab Med. 2009 Feb;133(2):201-16. doi: 10.1043/1543-2165-133.2.201.


A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseases.

Barisoni L, Schnaper HW, Kopp JB.

Clin J Am Soc Nephrol. 2007 May;2(3):529-42. Epub 2007 Apr 11. Review.


The creation of the Council of Pediatric Subspecialties: addressing the needs of the subspecialties and subspecialists.

Sectish TC, Stapleton FB, Schnaper HW, Degnon LE, Behrman RE.

J Pediatr. 2007 Aug;151(2):105-6, 106.e1-2. No abstract available.


Cell phenotype-specific down-regulation of Smad3 involves decreased gene activation as well as protein degradation.

Poncelet AC, Schnaper HW, Tan R, Liu Y, Runyan CE.

J Biol Chem. 2007 May 25;282(21):15534-40. Epub 2007 Mar 30.


RACK1 binds to Smad3 to modulate transforming growth factor-beta1-stimulated alpha2(I) collagen transcription in renal tubular epithelial cells.

Okano K, Schnaper HW, Bomsztyk K, Hayashida T.

J Biol Chem. 2006 Sep 8;281(36):26196-204. Epub 2006 Jul 18.


TGF-beta receptor-binding proteins: complex interactions.

Runyan CE, Poncelet AC, Schnaper HW.

Cell Signal. 2006 Dec;18(12):2077-88. Epub 2006 May 23.


Why kidneys fail: report from an American Society of Nephrology Advances in Research Conference.

Schnaper HW, Kopp JB.

J Am Soc Nephrol. 2006 Jul;17(7):1777-81. Epub 2006 Jun 14.


Renal fibrosis.

Schnaper HW.

Methods Mol Med. 2005;117:45-68. Review.


Renal endowment: developmental origins of adult disease.

Ingelfinger JR, Schnaper HW.

J Am Soc Nephrol. 2005 Sep;16(9):2533-6. Epub 2005 Jul 27. Review. No abstract available.


Hypoxia regulates PDGF-B interactions between glomerular capillary endothelial and mesangial cells.

Eng E, Holgren C, Hubchak S, Naaz P, Schnaper HW.

Kidney Int. 2005 Aug;68(2):695-703.


17 beta-estradiol transiently disrupts adherens junctions in endothelial cells.

Groten T, Pierce AA, Huen AC, Schnaper HW.

FASEB J. 2005 Aug;19(10):1368-70. Epub 2005 May 31.


Estradiol enhances endothelial cell interactions with extracellular matrix proteins via an increase in integrin expression and function.

Cid MC, Esparza J, Schnaper HW, Juan M, Yague J, Grant DS, Urbano-Márquez A, Hoffman GS, Kleinman HK.

Angiogenesis. 1999;3(3):271-80.


Cytoskeletal rearrangement and signal transduction in TGF-beta1-stimulated mesangial cell collagen accumulation.

Hubchak SC, Runyan CE, Kreisberg JI, Schnaper HW.

J Am Soc Nephrol. 2003 Aug;14(8):1969-80.


Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta-dependent responses in human mesangial cells.

Hayashida T, Decaestecker M, Schnaper HW.

FASEB J. 2003 Aug;17(11):1576-8. Epub 2003 Jun 17.


Smad3 and PKCdelta mediate TGF-beta1-induced collagen I expression in human mesangial cells.

Runyan CE, Schnaper HW, Poncelet AC.

Am J Physiol Renal Physiol. 2003 Sep;285(3):F413-22. Epub 2003 May 20.


Idiopathic focal segmental glomerulosclerosis.

Schnaper HW.

Semin Nephrol. 2003 Mar;23(2):183-93. Review.


TGF-beta signal transduction and mesangial cell fibrogenesis.

Schnaper HW, Hayashida T, Hubchak SC, Poncelet AC.

Am J Physiol Renal Physiol. 2003 Feb;284(2):F243-52. Review.


Renal fibrosis.

Schnaper HW, Kopp JB.

Front Biosci. 2003 Jan 1;8:e68-86. Review.


Estrogens and the vascular endothelium.

Cid MC, Schnaper HW, Kleinman HK.

Ann N Y Acad Sci. 2002 Jun;966:143-57. Review.


It's a Smad world: regulation of TGF-beta signaling in the kidney.

Schnaper HW, Hayashida T, Poncelet AC.

J Am Soc Nephrol. 2002 Apr;13(4):1126-8. Review. No abstract available.


Talking at cross purposes: molecular interactions downstream from TGF-beta.

Schnaper HW, Poncelet AC, Hayashida T.

Kidney Int. 2001 Dec;60(6):2415-6. No abstract available.


Risk factors for cardiovascular disease in children on maintenance dialysis.

Chavers B, Schnaper HW.

Adv Ren Replace Ther. 2001 Jul;8(3):180-90. Review.


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