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Items: 45

1.

Metabolomics Test Materials for Quality Control: A Study of a Urine Materials Suite.

Bearden DW, Sheen DA, Simón-Manso Y, Benner BA Jr, Rocha WFC, Blonder N, Lippa KA, Beger RD, Schnackenberg LK, Sun J, Mehta KY, Cheema AK, Gu H, Marupaka R, Nagana Gowda GA, Raftery D.

Metabolites. 2019 Nov 7;9(11). pii: E270. doi: 10.3390/metabo9110270.

2.

Stability of the Human Plasma Proteome to Pre-analytical Variability as Assessed by an Aptamer-Based Approach.

Daniels JR, Cao Z, Maisha M, Schnackenberg LK, Sun J, Pence L, Schmitt TC, Kamlage B, Rogstad S, Beger RD, Yu LR.

J Proteome Res. 2019 Oct 4;18(10):3661-3670. doi: 10.1021/acs.jproteome.9b00320. Epub 2019 Sep 12.

PMID:
31442052
3.

An Integrated Analysis of Metabolites, Peptides, and Inflammation Biomarkers for Assessment of Preanalytical Variability of Human Plasma.

Cao Z, Kamlage B, Wagner-Golbs A, Maisha M, Sun J, Schnackenberg LK, Pence L, Schmitt TC, Daniels JR, Rogstad S, Beger RD, Yu LR.

J Proteome Res. 2019 Jun 7;18(6):2411-2421. doi: 10.1021/acs.jproteome.8b00903. Epub 2019 May 22.

PMID:
31074987
4.

Metabolomics Analysis of Urine Samples from Children after Acetaminophen Overdose.

Schnackenberg LK, Sun J, Bhattacharyya S, Gill P, James LP, Beger RD.

Metabolites. 2017 Sep 6;7(3). pii: E46. doi: 10.3390/metabo7030046.

5.

Dose-response analysis of epigenetic, metabolic, and apical endpoints after short-term exposure to experimental hepatotoxicants.

Miousse IR, Murphy LA, Lin H, Schisler MR, Sun J, Chalbot MG, Sura R, Johnson K, LeBaron MJ, Kavouras IG, Schnackenberg LK, Beger RD, Rasoulpour RJ, Koturbash I.

Food Chem Toxicol. 2017 Nov;109(Pt 1):690-702. doi: 10.1016/j.fct.2017.05.013. Epub 2017 May 8.

6.

Early metabolomics changes in heart and plasma during chronic doxorubicin treatment in B6C3F1 mice.

Schnackenberg LK, Pence L, Vijay V, Moland CL, George N, Cao Z, Yu LR, Fuscoe JC, Beger RD, Desai VG.

J Appl Toxicol. 2016 Nov;36(11):1486-95. doi: 10.1002/jat.3307. Epub 2016 Mar 2.

PMID:
26934058
7.

Translational biomarkers of acetaminophen-induced acute liver injury.

Beger RD, Bhattacharyya S, Yang X, Gill PS, Schnackenberg LK, Sun J, James LP.

Arch Toxicol. 2015 Sep;89(9):1497-522. doi: 10.1007/s00204-015-1519-4. Epub 2015 May 17. Review.

8.

Identification of a metabolic biomarker panel in rats for prediction of acute and idiosyncratic hepatotoxicity.

Sun J, Slavov S, Schnackenberg LK, Ando Y, Greenhaw J, Yang X, Salminen W, Mendrick DL, Beger R.

Comput Struct Biotechnol J. 2014 Aug 9;10(17):78-89. doi: 10.1016/j.csbj.2014.08.001. eCollection 2014 Jul.

9.

Metabolomics evaluation of the effects of green tea extract on acetaminophen-induced hepatotoxicity in mice.

Lu Y, Sun J, Petrova K, Yang X, Greenhaw J, Salminen WF, Beger RD, Schnackenberg LK.

Food Chem Toxicol. 2013 Dec;62:707-21. doi: 10.1016/j.fct.2013.09.025. Epub 2013 Sep 27.

PMID:
24080264
10.

Evaluating effects of penicillin treatment on the metabolome of rats.

Sun J, Schnackenberg LK, Khare S, Yang X, Greenhaw J, Salminen W, Mendrick DL, Beger RD.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Aug 1;932:134-43. doi: 10.1016/j.jchromb.2013.05.030. Epub 2013 Jun 7.

PMID:
23831706
11.

Metabolomics as a tool for personalizing medicine: 2012 update.

Sun J, Beger RD, Schnackenberg LK.

Per Med. 2013 Mar;10(2):149-161. doi: 10.2217/pme.13.8.

PMID:
29758850
12.

Metabolomics techniques in nanotoxicology studies.

Schnackenberg LK, Sun J, Beger RD.

Methods Mol Biol. 2012;926:141-56. doi: 10.1007/978-1-62703-002-1_10. Review.

PMID:
22975962
13.

Erratum: (13)C NMR-Distance Matrix Descriptors: Optimal Abstract 3D Space Granularity for Predicting Estrogen Binding.

Slavov SH, Geesaman EL, Pearce BA, Schnackenberg LK, Buzatu DA, Wilkes JG, Beger RD.

J Chem Inf Model. 2012 Sep 24;52(9):2484. Epub 2012 Aug 24. No abstract available.

PMID:
22920720
14.

Metabolomics evaluation of hydroxyproline as a potential marker of melamine and cyanuric acid nephrotoxicity in male and female Fischer F344 rats.

Schnackenberg LK, Sun J, Pence LM, Bhattacharyya S, Gamboa da Costa G, Beger RD.

Food Chem Toxicol. 2012 Nov;50(11):3978-83. doi: 10.1016/j.fct.2012.08.010. Epub 2012 Aug 10.

PMID:
22902825
15.

¹³C NMR-distance matrix descriptors: optimal abstract 3D space granularity for predicting estrogen binding.

Slavov SH, Geesaman EL, Pearce BA, Schnackenberg LK, Buzatu DA, Wilkes JG, Beger RD.

J Chem Inf Model. 2012 Jul 23;52(7):1854-64. doi: 10.1021/ci3001698. Epub 2012 Jun 22.

PMID:
22681591
16.

The liver toxicity biomarker study phase I: markers for the effects of tolcapone or entacapone.

McBurney RN, Hines WM, VonTungeln LS, Schnackenberg LK, Beger RD, Moland CL, Han T, Fuscoe JC, Chang CW, Chen JJ, Su Z, Fan XH, Tong W, Booth SA, Balasubramanian R, Courchesne PL, Campbell JM, Graber A, Guo Y, Juhasz P, Li TY, Lynch MD, Morel NM, Plasterer TN, Takach EJ, Zeng C, Beland FA.

Toxicol Pathol. 2012 Aug;40(6):951-64. doi: 10.1177/0192623312444026. Epub 2012 May 9.

PMID:
22573522
17.

Serum metabolomic profiles from patients with acute kidney injury: a pilot study.

Sun J, Shannon M, Ando Y, Schnackenberg LK, Khan NA, Portilla D, Beger RD.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Apr 15;893-894:107-13. doi: 10.1016/j.jchromb.2012.02.042. Epub 2012 Mar 6.

18.

Modeling chemical interaction profiles: II. Molecular docking, spectral data-activity relationship, and structure-activity relationship models for potent and weak inhibitors of cytochrome P450 CYP3A4 isozyme.

Tie Y, McPhail B, Hong H, Pearce BA, Schnackenberg LK, Ge W, Buzatu DA, Wilkes JG, Fuscoe JC, Tong W, Fowler BA, Beger RD, Demchuk E.

Molecules. 2012 Mar 15;17(3):3407-60. doi: 10.3390/molecules17033407.

19.

Modeling chemical interaction profiles: I. Spectral data-activity relationship and structure-activity relationship models for inhibitors and non-inhibitors of cytochrome P450 CYP3A4 and CYP2D6 isozymes.

McPhail B, Tie Y, Hong H, Pearce BA, Schnackenberg LK, Ge W, Valerio LG, Fuscoe JC, Tong W, Buzatu DA, Wilkes JG, Fowler BA, Demchuk E, Beger RD.

Molecules. 2012 Mar 15;17(3):3383-406. doi: 10.3390/molecules17033383.

20.

Modification of norfloxacin by a Microbacterium sp. strain isolated from a wastewater treatment plant.

Kim DW, Heinze TM, Kim BS, Schnackenberg LK, Woodling KA, Sutherland JB.

Appl Environ Microbiol. 2011 Sep;77(17):6100-8. doi: 10.1128/AEM.00545-11. Epub 2011 Jul 1.

21.

Biotransformation of quinazoline and phthalazine by Aspergillus niger.

Sutherland JB, Heinze TM, Schnackenberg LK, Freeman JP, Williams AJ.

J Biosci Bioeng. 2011 Mar;111(3):333-5. doi: 10.1016/j.jbiosc.2010.11.017. Epub 2010 Dec 18.

PMID:
21169055
22.

Study of valproic acid-induced endogenous and exogenous metabolite alterations using LC-MS-based metabolomics.

Sun J, Schnackenberg LK, Hansen DK, Beger RD.

Bioanalysis. 2010 Feb;2(2):207-16. doi: 10.4155/bio.09.173.

PMID:
21083304
23.

Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity.

Beger RD, Sun J, Schnackenberg LK.

Toxicol Appl Pharmacol. 2010 Mar 1;243(2):154-66. doi: 10.1016/j.taap.2009.11.019. Epub 2009 Nov 22. Review.

PMID:
19932708
24.

Single valproic acid treatment inhibits glycogen and RNA ribose turnover while disrupting glucose-derived cholesterol synthesis in liver as revealed by the [U-C(6)]-d-glucose tracer in mice.

Beger RD, Hansen DK, Schnackenberg LK, Cross BM, Fatollahi JJ, Lagunero FT, Sarnyai Z, Boros LG.

Metabolomics. 2009 Sep;5(3):336-345. Epub 2009 Mar 31.

25.

Studies of acetaminophen and metabolites in urine and their correlations with toxicity using metabolomics.

Sun J, Schnackenberg LK, Beger RD.

Drug Metab Lett. 2009 Aug;3(3):130-6. Epub 2009 Aug 1.

PMID:
19702550
26.

Interaction of dietary resveratrol with animal-associated bacteria.

Jung CM, Heinze TM, Schnackenberg LK, Mullis LB, Elkins SA, Elkins CA, Steele RS, Sutherland JB.

FEMS Microbiol Lett. 2009 Aug;297(2):266-73. doi: 10.1111/j.1574-6968.2009.01691.x. Epub 2009 Jun 22.

27.

Delineating liver events in trichloroethylene-induced autoimmune hepatitis.

Gilbert KM, Przybyla B, Pumford NR, Han T, Fuscoe J, Schnackenberg LK, Holland RD, Doss JC, Macmillan-Crow LA, Blossom SJ.

Chem Res Toxicol. 2009 Apr;22(4):626-32. doi: 10.1021/tx800409r.

PMID:
19254012
28.

The liver toxicity biomarker study: phase I design and preliminary results.

McBurney RN, Hines WM, Von Tungeln LS, Schnackenberg LK, Beger RD, Moland CL, Han T, Fuscoe JC, Chang CW, Chen JJ, Su Z, Fan XH, Tong W, Booth SA, Balasubramanian R, Courchesne PL, Campbell JM, Graber A, Guo Y, Juhasz PJ, Li TY, Lynch MD, Morel NM, Plasterer TN, Takach EJ, Zeng C, Beland FA.

Toxicol Pathol. 2009 Jan;37(1):52-64. doi: 10.1177/0192623308329287. Epub 2009 Jan 26.

PMID:
19171931
29.

Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies.

Schnackenberg LK, Chen M, Sun J, Holland RD, Dragan Y, Tong W, Welsh W, Beger RD.

Toxicol Appl Pharmacol. 2009 Feb 15;235(1):25-32. doi: 10.1016/j.taap.2008.11.015. Epub 2008 Dec 6.

PMID:
19103213
30.

Metabolomics: a tool for personalizing medicine?

Schnackenberg LK, Kaput J, Beger RD.

Per Med. 2008 Sep;5(5):495-504. doi: 10.2217/17410541.5.5.495.

PMID:
29783453
31.

Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS.

Sun J, Schnackenberg LK, Holland RD, Schmitt TC, Cantor GH, Dragan YP, Beger RD.

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Aug 15;871(2):328-40. doi: 10.1016/j.jchromb.2008.04.008. Epub 2008 Apr 12. Erratum in: J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 1;877(1-2):105.

PMID:
18472313
32.

Metabonomics of acute kidney injury in children after cardiac surgery.

Beger RD, Holland RD, Sun J, Schnackenberg LK, Moore PC, Dent CL, Devarajan P, Portilla D.

Pediatr Nephrol. 2008 Jun;23(6):977-84. doi: 10.1007/s00467-008-0756-7.

PMID:
18320237
33.

The role of metabolic biomarkers in drug toxicity studies.

Schnackenberg LK, Beger RD.

Toxicol Mech Methods. 2008;18(4):301-11. doi: 10.1080/15376510701623193.

PMID:
20020895
34.

Modeling and assaying dioxin-like biological effects for both dioxin-like and certain non-dioxin-like compounds.

Wilkes JG, Hass BS, Buzatu DA, Pence LM, Archer JC, Beger RD, Schnackenberg LK, Halbert MK, Jennings L, Kodell RL.

Toxicol Sci. 2008 Mar;102(1):187-95. Epub 2007 Dec 7.

PMID:
18065775
35.
36.

Identification of C-glycoside flavonoids as potential mutagenic compounds in kava.

Jhoo JW, Ang CY, Heinze TM, Deck J, Schnackenberg LK, Beger RD, Dragull K, Tang CS.

J Food Sci. 2007 Mar;72(2):C120-5.

PMID:
17995826
37.

Age-related differences in susceptibility to toxic effects of valproic acid in rats.

Espandiari P, Zhang J, Schnackenberg LK, Miller TJ, Knapton A, Herman EH, Beger RD, Hanig JP.

J Appl Toxicol. 2008 Jul;28(5):628-37.

PMID:
17994530
38.

Metabolomic biomarkers: their role in the critical path.

Schnackenberg LK, Beger RD.

Drug Discov Today Technol. 2007 Autumn;4(1):13-6. doi: 10.1016/j.ddtec.2007.10.012.

PMID:
24980715
39.
40.

Monitoring the health to disease continuum with global metabolic profiling and systems biology.

Schnackenberg LK, Beger RD.

Pharmacogenomics. 2006 Oct;7(7):1077-86. Review.

PMID:
17054417
41.

Metabolomics Special Focus: an introduction.

Schnackenberg LK.

Pharmacogenomics. 2006 Oct;7(7):1053-4. No abstract available.

42.

In vitro cytotoxicity of nonpolar constituents from different parts of kava plant (Piper methysticum).

Jhoo JW, Freeman JP, Heinze TM, Moody JD, Schnackenberg LK, Beger RD, Dragull K, Tang CS, Ang CY.

J Agric Food Chem. 2006 Apr 19;54(8):3157-62.

PMID:
16608246
43.

An integrated study of acute effects of valproic acid in the liver using metabonomics, proteomics, and transcriptomics platforms.

Schnackenberg LK, Jones RC, Thyparambil S, Taylor JT, Han T, Tong W, Hansen DK, Fuscoe JC, Edmondson RD, Beger RD, Dragan YP.

OMICS. 2006 Spring;10(1):1-14.

PMID:
16584314
44.

High resolution 1H NMR structural studies of sucrose octaacetate in supercritical carbon dioxide.

Chandrika B, Schnackenberg LK, Raveendran P, Wallen SL.

Chemistry. 2005 Oct 21;11(21):6266-71.

PMID:
16078290
45.

Whole-molecule calculation of log p based on molar volume, hydrogen bonds, and simulated 13C NMR spectra.

Schnackenberg LK, Beger RD.

J Chem Inf Model. 2005 Mar-Apr;45(2):360-5.

PMID:
15807500

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