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Items: 1 to 50 of 504

1.

Mitochondrial 2,4-dienoyl-CoA reductase (Decr) deficiency and impairment of thermogenesis in mouse brown adipose tissue.

Mäkelä AM, Hohtola E, Miinalainen IJ, Autio JA, Schmitz W, Niemi KJ, Hiltunen JK, Autio KJ.

Sci Rep. 2019 Aug 19;9(1):12038. doi: 10.1038/s41598-019-48562-x.

2.

The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling.

Mayer AE, Löffler MC, Loza Valdés AE, Schmitz W, El-Merahbi R, Viera JT, Erk M, Zhang T, Braun U, Heikenwalder M, Leitges M, Schulze A, Sumara G.

Sci Signal. 2019 Aug 6;12(593). pii: eaav9150. doi: 10.1126/scisignal.aav9150.

PMID:
31387939
3.

Complementary substrate specificity and distinct quaternary assembly of the Escherichia coli aerobic and anaerobic β-oxidation trifunctional enzyme complexes.

Sah-Teli SK, Hynönen MJ, Schmitz W, Geraets JA, Seitsonen J, Pedersen JS, Butcher SJ, Wierenga RK, Venkatesan R.

Biochem J. 2019 Jul 15;476(13):1975-1994. doi: 10.1042/BCJ20190314.

PMID:
31235482
4.

The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry.

Kiema TR, Thapa CJ, Laitaoja M, Schmitz W, Maksimainen MM, Fukao T, Rouvinen J, Jänis J, Wierenga RK.

Biochem J. 2019 Jan 25;476(2):307-332. doi: 10.1042/BCJ20180788.

PMID:
30573650
5.

Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity.

Löffler MC, Mayer AE, Trujillo Viera J, Loza Valdes A, El-Merahbi R, Ade CP, Karwen T, Schmitz W, Slotta A, Erk M, Janaki-Raman S, Matesanz N, Torres JL, Marcos M, Sabio G, Eilers M, Schulze A, Sumara G.

EMBO J. 2018 Nov 15;37(22). pii: e99182. doi: 10.15252/embj.201899182. Epub 2018 Nov 2.

PMID:
30389661
6.

Guazuma ulmifolia Lam. Decreases Oxidative Stress in Blood Cells and Prevents Doxorubicin-Induced Cardiotoxicity.

Dos Santos JM, Alfredo TM, Antunes KÁ, da Cunha JDSM, Costa EMA, Lima ES, Silva DB, Carollo CA, Schmitz WO, Boleti APA, Dos Santos EL, de Picoli Souza K.

Oxid Med Cell Longev. 2018 Jun 28;2018:2935051. doi: 10.1155/2018/2935051. eCollection 2018.

7.

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma.

Miess H, Dankworth B, Gouw AM, Rosenfeldt M, Schmitz W, Jiang M, Saunders B, Howell M, Downward J, Felsher DW, Peck B, Schulze A.

Oncogene. 2018 Oct;37(40):5435-5450. doi: 10.1038/s41388-018-0315-z. Epub 2018 Jun 5.

8.

Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation.

Yao C, Veleva T, Scott L Jr, Cao S, Li L, Chen G, Jeyabal P, Pan X, Alsina KM, Abu-Taha I Dr, Ghezelbash S, Reynolds CL, Shen YH, LeMaire SA, Schmitz W, Müller FU, El-Armouche A, Tony Eissa N, Beeton C, Nattel S, Wehrens XHT, Dobrev D, Li N.

Circulation. 2018 Nov 13;138(20):2227-2242. doi: 10.1161/CIRCULATIONAHA.118.035202. Erratum in: Circulation. 2019 Apr 23;139(17):e889.

PMID:
29802206
9.

Successful overexpression of wild-type inhibitor-2 of PP1 in cardiovascular cells.

Krause T, Grote-Wessels S, Balzer F, Boknik P, Gergs U, Kirchhefer U, Buchwalow IB, Müller FU, Schmitz W, Neumann J.

Naunyn Schmiedebergs Arch Pharmacol. 2018 Aug;391(8):859-873. doi: 10.1007/s00210-018-1515-3. Epub 2018 May 24.

PMID:
29797049
10.

Phenotyping of Mice with Heart Specific Overexpression of A2A-Adenosine Receptors: Evidence for Cardioprotective Effects of A2A-Adenosine Receptors.

Boknik P, Drzewiecki K, Eskandar J, Gergs U, Grote-Wessels S, Fabritz L, Kirchhof P, Müller FU, Stümpel F, Schmitz W, Zimmermann N, Kirchhefer U, Neumann J.

Front Pharmacol. 2018 Jan 22;9:13. doi: 10.3389/fphar.2018.00013. eCollection 2018.

11.

Structural enzymology comparisons of multifunctional enzyme, type-1 (MFE1): the flexibility of its dehydrogenase part.

Kasaragod P, Midekessa GB, Sridhar S, Schmitz W, Kiema TR, Hiltunen JK, Wierenga RK.

FEBS Open Bio. 2017 Nov 6;7(12):1830-1842. doi: 10.1002/2211-5463.12337. eCollection 2017 Dec.

12.

Site-Directed Immobilization of BMP-2: Two Approaches for the Production of Innovative Osteoinductive Scaffolds.

Tabisz B, Schmitz W, Schmitz M, Luehmann T, Heusler E, Rybak JC, Meinel L, Fiebig JE, Mueller TD, Nickel J.

Biomacromolecules. 2017 Mar 13;18(3):695-708. doi: 10.1021/acs.biomac.6b01407. Epub 2017 Feb 17.

PMID:
28211679
13.

Antioxidant and Antihyperlipidemic Effects of Campomanesia adamantium O. Berg Root.

Espindola PP, da Rocha Pdos S, Carollo CA, Schmitz WO, Pereira ZV, Vieira Mdo C, Dos Santos EL, de Picoli Souza K.

Oxid Med Cell Longev. 2016;2016:7910340. doi: 10.1155/2016/7910340. Epub 2016 Jul 14.

14.

Evidence for a functional role of calsequestrin 2 in mouse atrium.

Gergs U, Fahrion CM, Bock P, Fischer M, Wache H, Hauptmann S, Schmitz W, Neumann J.

Acta Physiol (Oxf). 2017 Mar;219(3):669-682. doi: 10.1111/apha.12766. Epub 2016 Aug 31.

PMID:
27484853
15.

Sphingosine-1-Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca2+ Sensitivity and Na+/H+ Exchange and Mediates Protection by Ischemic Preconditioning.

Keul P, van Borren MM, Ghanem A, Müller FU, Baartscheer A, Verkerk AO, Stümpel F, Schulte JS, Hamdani N, Linke WA, van Loenen P, Matus M, Schmitz W, Stypmann J, Tiemann K, Ravesloot JH, Alewijnse AE, Hermann S, Spijkers LJ, Hiller KH, Herr D, Heusch G, Schäfers M, Peters SL, Chun J, Levkau B.

J Am Heart Assoc. 2016 May 20;5(5). pii: e003393. doi: 10.1161/JAHA.116.003393.

16.

Cardiac expression of the CREM repressor isoform CREM-IbΔC-X in mice leads to arrhythmogenic alterations in ventricular cardiomyocytes.

Schulte JS, Fehrmann E, Tekook MA, Kranick D, Fels B, Li N, Wehrens XH, Heinick A, Seidl MD, Schmitz W, Müller FU.

Basic Res Cardiol. 2016 Mar;111(2):15. doi: 10.1007/s00395-016-0532-y. Epub 2016 Jan 27.

17.

Structures of yeast peroxisomal Δ(3),Δ(2)-enoyl-CoA isomerase complexed with acyl-CoA substrate analogues: the importance of hydrogen-bond networks for the reactivity of the catalytic base and the oxyanion hole.

Onwukwe GU, Koski MK, Pihko P, Schmitz W, Wierenga RK.

Acta Crystallogr D Biol Crystallogr. 2015 Nov;71(Pt 11):2178-91. doi: 10.1107/S139900471501559X. Epub 2015 Oct 27.

PMID:
26527136
18.

GDF-5 can act as a context-dependent BMP-2 antagonist.

Klammert U, Mueller TD, Hellmann TV, Wuerzler KK, Kotzsch A, Schliermann A, Schmitz W, Kuebler AC, Sebald W, Nickel J.

BMC Biol. 2015 Sep 18;13:77. doi: 10.1186/s12915-015-0183-8.

19.

Risk factors for cardiovascular disease in rheumatoid arthritis patients from Mato Grosso do Sul.

de Deus Junior RS, Ferraz AL, Oesterreich SA, Schmitz WO, Shinzato MM.

Rev Bras Reumatol. 2015 Nov-Dec;55(6):493-500. doi: 10.1016/j.rbr.2015.02.001. Epub 2015 Jul 16. English, Portuguese.

20.

α-Methyl Acyl CoA Racemase Provides Mycobacterium tuberculosis Catabolic Access to Cholesterol Esters.

Lu R, Schmitz W, Sampson NS.

Biochemistry. 2015 Sep 22;54(37):5669-72. doi: 10.1021/acs.biochem.5b00911. Epub 2015 Sep 11.

21.

Peroxiredoxin 6 triggers melanoma cell growth by increasing arachidonic acid-dependent lipid signalling.

Schmitt A, Schmitz W, Hufnagel A, Schartl M, Meierjohann S.

Biochem J. 2015 Oct 15;471(2):267-79. doi: 10.1042/BJ20141204. Epub 2015 Aug 18.

PMID:
26285655
22.

Phytol is lethal for Amacr-deficient mice.

Selkälä EM, Nair RR, Schmitz W, Kvist AP, Baes M, Hiltunen JK, Autio KJ.

Biochim Biophys Acta. 2015 Oct;1851(10):1394-405. doi: 10.1016/j.bbalip.2015.07.008. Epub 2015 Aug 4.

PMID:
26248199
23.

Annexin A4 is a novel direct regulator of adenylyl cyclase type 5.

Heinick A, Husser X, Himmler K, Kirchhefer U, Nunes F, Schulte JS, Seidl MD, Rolfes C, Dedman JR, Kaetzel MA, Gerke V, Schmitz W, Müller FU.

FASEB J. 2015 Sep;29(9):3773-87. doi: 10.1096/fj.14-269837. Epub 2015 May 28.

PMID:
26023182
24.

Human Δ³,Δ²-enoyl-CoA isomerase, type 2: a structural enzymology study on the catalytic role of its ACBP domain and helix-10.

Onwukwe GU, Kursula P, Koski MK, Schmitz W, Wierenga RK.

FEBS J. 2015 Feb;282(4):746-68. doi: 10.1111/febs.13179. Epub 2015 Jan 14.

25.

Acute and subacute (28 days) oral toxicity assessment of the oil extracted from Acrocomia aculeata pulp in rats.

Traesel GK, de Souza JC, de Barros AL, Souza MA, Schmitz WO, Muzzi RM, Oesterreich SA, Arena AC.

Food Chem Toxicol. 2014 Dec;74:320-25.

26.

Transcription factor cAMP response element modulator (Crem) restrains Pdgf-dependent proliferation of vascular smooth muscle cells in mice.

Seidl MD, Steingräber AK, Wolf CT, Sur TM, Hildebrandt I, Witten A, Stoll M, Fischer JW, Schmitz W, Müller FU.

Pflugers Arch. 2015 Oct;467(10):2165-77. doi: 10.1007/s00424-014-1652-6. Epub 2014 Nov 27.

27.

First report on an inotropic peptide activating tetrodotoxin-sensitive, "neuronal" sodium currents in the heart.

Kirchhof P, Tal T, Fabritz L, Klimas J, Nesher N, Schulte JS, Ehling P, Kanyshkova T, Budde T, Nikol S, Fortmueller L, Stallmeyer B, Müller FU, Schulze-Bahr E, Schmitz W, Zlotkin E, Kirchhefer U.

Circ Heart Fail. 2015 Jan;8(1):79-88. doi: 10.1161/CIRCHEARTFAILURE.113.001066. Epub 2014 Nov 25.

PMID:
25424392
28.

Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase.

Peter S, Bultinck J, Myant K, Jaenicke LA, Walz S, Müller J, Gmachl M, Treu M, Boehmelt G, Ade CP, Schmitz W, Wiegering A, Otto C, Popov N, Sansom O, Kraut N, Eilers M.

EMBO Mol Med. 2014 Dec;6(12):1525-41. doi: 10.15252/emmm.201403927.

29.

Toxicological analysis and antihyperalgesic, antidepressant, and anti-inflammatory effects of Campomanesia adamantium fruit barks.

de Souza JC, Piccinelli AC, Aquino DF, de Souza VV, Schmitz WO, Traesel GK, Cardoso CA, Kassuya CA, Arena AC.

Nutr Neurosci. 2017 Jan;20(1):23-31. doi: 10.1179/1476830514Y.0000000145. Epub 2016 Mar 10.

PMID:
25116451
30.

Role of AMACR (α-methylacyl-CoA racemase) and MFE-1 (peroxisomal multifunctional enzyme-1) in bile acid synthesis in mice.

Autio KJ, Schmitz W, Nair RR, Selkälä EM, Sormunen RT, Miinalainen IJ, Crick PJ, Wang Y, Griffiths WJ, Reddy JK, Baes M, Hiltunen JK.

Biochem J. 2014 Jul 1;461(1):125-35. doi: 10.1042/BJ20130915.

PMID:
24735479
31.

Peroxisomal membrane channel Pxmp2 in the mammary fat pad is essential for stromal lipid homeostasis and for development of mammary gland epithelium in mice.

Vapola MH, Rokka A, Sormunen RT, Alhonen L, Schmitz W, Conzelmann E, Wärri A, Grunau S, Antonenkov VD, Hiltunen JK.

Dev Biol. 2014 Jul 1;391(1):66-80. doi: 10.1016/j.ydbio.2014.03.022. Epub 2014 Apr 12.

32.

Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model.

Li N, Chiang DY, Wang S, Wang Q, Sun L, Voigt N, Respress JL, Ather S, Skapura DG, Jordan VK, Horrigan FT, Schmitz W, Müller FU, Valderrabano M, Nattel S, Dobrev D, Wehrens XHT.

Circulation. 2014 Mar 25;129(12):1276-1285. doi: 10.1161/CIRCULATIONAHA.113.006611. Epub 2014 Jan 7.

33.

IL-4 analogues with site-specific chemical modification at position 121 inhibit IL-4 and IL-13 biological activities.

Duppatla V, Gjorgjevikj M, Schmitz W, Hermanns HM, Schäfer CM, Kottmair M, Müller T, Sebald W.

Bioconjug Chem. 2014 Jan 15;25(1):52-62. doi: 10.1021/bc400307k. Epub 2013 Dec 31.

PMID:
24341642
34.

Autonomic dysfunction in patients with arrhythmogenic right ventricular cardiomyopathy: biochemical evidence of altered signaling pathways.

Paul M, Meyborg M, Boknik P, Gergs U, Gerss J, Schmitz W, Breithardt G, Wichter T, Neumann J.

Pacing Clin Electrophysiol. 2014 Feb;37(2):173-8. doi: 10.1111/pace.12237. Epub 2013 Sep 11.

PMID:
24025189
35.

A novel intronic promoter of the Crem gene induces small ICER (smICER) isoforms.

Seidl MD, Nunes F, Fels B, Hildebrandt I, Schmitz W, Schulze-Osthoff K, Müller FU.

FASEB J. 2014 Jan;28(1):143-52. doi: 10.1096/fj.13-231977. Epub 2013 Sep 10.

PMID:
24022402
36.

Metabolic adaptation allows Amacr-deficient mice to remain symptom-free despite low levels of mature bile acids.

Selkälä EM, Kuusisto SM, Salonurmi T, Savolainen MJ, Jauhiainen M, Pirilä PL, Kvist AP, Conzelmann E, Schmitz W, Alexson SE, Kotti TJ, Hiltunen JK, Autio KJ.

Biochim Biophys Acta. 2013 Aug;1831(8):1335-43. doi: 10.1016/j.bbalip.2013.05.002. Epub 2013 May 13.

PMID:
23680781
37.

The isomerase and hydratase reaction mechanism of the crotonase active site of the multifunctional enzyme (type-1), as deduced from structures of complexes with 3S-hydroxy-acyl-CoA.

Kasaragod P, Schmitz W, Hiltunen JK, Wierenga RK.

FEBS J. 2013 Jul;280(13):3160-75. doi: 10.1111/febs.12150. Epub 2013 Feb 15.

38.

Human 5-HT₄receptor stimulation in atria of transgenic mice.

Gergs U, Böckler A, Ebelt H, Hauptmann S, Keller N, Otto V, Pönicke K, Schmitz W, Neumann J.

Naunyn Schmiedebergs Arch Pharmacol. 2013 May;386(5):357-67. doi: 10.1007/s00210-013-0831-x. Epub 2013 Jan 11.

PMID:
23307014
39.

Minimally invasive closed-chest ultrasound-guided substance delivery into the pericardial space in mice.

Laakmann S, Fortmüller L, Piccini I, Grote-Wessels S, Schmitz W, Breves G, Kirchhof P, Fabritz L.

Naunyn Schmiedebergs Arch Pharmacol. 2013 Mar;386(3):227-38. doi: 10.1007/s00210-012-0815-2. Epub 2012 Dec 19.

40.

Gene construction, expression and functional testing of an inotropic peptide from the venom of the black scorpion Hottentotta judaicus.

Tekook MA, Fabritz L, Kirchhof P, König S, Müller FU, Schmitz W, Tal T, Zlotkin E, Kirchhefer U.

Toxicon. 2012 Dec 15;60(8):1415-27. doi: 10.1016/j.toxicon.2012.10.008. Epub 2012 Oct 22.

PMID:
23085191
41.

Enzymatic deglutathionylation to generate interleukin-4 cysteine muteins with free thiol.

Duppatla V, Gjorgjevikj M, Schmitz W, Kottmair M, Mueller TD, Sebald W.

Bioconjug Chem. 2012 Jul 18;23(7):1396-405. doi: 10.1021/bc2004389. Epub 2012 Jun 20.

PMID:
22681442
42.

Preventing suicide through improved training in suicide risk assessment and care: an American Association of Suicidology Task Force report addressing serious gaps in U.S. mental health training.

Schmitz WM Jr, Allen MH, Feldman BN, Gutin NJ, Jahn DR, Kleespies PM, Quinnett P, Simpson S.

Suicide Life Threat Behav. 2012 Jun;42(3):292-304. doi: 10.1111/j.1943-278X.2012.00090.x. Epub 2012 Apr 11.

PMID:
22494118
43.

Modulation of SR Ca2+ release by the triadin-to-calsequestrin ratio in ventricular myocytes.

Kučerová D, Baba HA, Bokník P, Fabritz L, Heinick A, Mát'uš M, Müller FU, Neumann J, Schmitz W, Kirchhefer U.

Am J Physiol Heart Circ Physiol. 2012 May 15;302(10):H2008-17. doi: 10.1152/ajpheart.00457.2011. Epub 2012 Mar 16.

44.

CREB critically regulates action potential shape and duration in the adult mouse ventricle.

Schulte JS, Seidl MD, Nunes F, Freese C, Schneider M, Schmitz W, Müller FU.

Am J Physiol Heart Circ Physiol. 2012 May 15;302(10):H1998-2007. doi: 10.1152/ajpheart.00057.2011. Epub 2012 Mar 16.

45.

The enolization chemistry of a thioester-dependent racemase: the 1.4 Å crystal structure of a reaction intermediate complex characterized by detailed QM/MM calculations.

Sharma S, Bhaumik P, Schmitz W, Venkatesan R, Hiltunen JK, Conzelmann E, Juffer AH, Wierenga RK.

J Phys Chem B. 2012 Mar 22;116(11):3619-29. doi: 10.1021/jp210185m. Epub 2012 Mar 7.

PMID:
22360758
46.

Proarrhythmia in a non-failing murine model of cardiac-specific Na+/Ca 2+ exchanger overexpression: whole heart and cellular mechanisms.

Pott C, Muszynski A, Ruhe M, Bögeholz N, Schulte JS, Milberg P, Mönnig G, Fabritz L, Goldhaber JI, Breithardt G, Schmitz W, Philipson KD, Eckardt L, Kirchhof P, Müller FU.

Basic Res Cardiol. 2012 Mar;107(2):247. doi: 10.1007/s00395-012-0247-7. Epub 2012 Feb 11.

47.

Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5Rα.

Patino E, Kotzsch A, Saremba S, Nickel J, Schmitz W, Sebald W, Mueller TD.

Structure. 2011 Dec 7;19(12):1864-75. doi: 10.1016/j.str.2011.08.015.

48.

Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice.

Kirchhof P, Marijon E, Fabritz L, Li N, Wang W, Wang T, Schulte K, Hanstein J, Schulte JS, Vogel M, Mougenot N, Laakmann S, Fortmueller L, Eckstein J, Verheule S, Kaese S, Staab A, Grote-Wessels S, Schotten U, Moubarak G, Wehrens XH, Schmitz W, Hatem S, Müller FU.

Int J Cardiol. 2013 Jun 20;166(2):366-74. doi: 10.1016/j.ijcard.2011.10.057. Epub 2011 Nov 16. Erratum in: Int J Cardiol. 2014 Apr 1;172(3):631.

PMID:
22093963
49.

Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium.

Wijnker PJ, Boknik P, Gergs U, Müller FU, Neumann J, dos Remedios C, Schmitz W, Sindermann JR, Stienen GJ, van der Velden J, Kirchhefer U.

J Muscle Res Cell Motil. 2011 Nov;32(3):221-33. doi: 10.1007/s10974-011-9261-x. Epub 2011 Sep 30.

50.

Mutational spectrum in the Ca(2+)--activated cation channel gene TRPM4 in patients with cardiac conductance disturbances.

Stallmeyer B, Zumhagen S, Denjoy I, Duthoit G, Hébert JL, Ferrer X, Maugenre S, Schmitz W, Kirchhefer U, Schulze-Bahr E, Guicheney P, Schulze-Bahr E.

Hum Mutat. 2012 Jan;33(1):109-17. doi: 10.1002/humu.21599. Epub 2011 Oct 20.

PMID:
21887725

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