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Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene Expression.

Riedlinger T, Bartkuhn M, Zimmermann T, Hake SB, Nist A, Stiewe T, Kracht M, Schmitz ML.

Cancers (Basel). 2019 Jun 25;11(6). pii: E883. doi: 10.3390/cancers11060883.


Differential intracellular localization and dynamic nucleocytoplasmic shuttling of homeodomain-interacting protein kinase family members.

Ritter O, Schmitz ML.

Biochim Biophys Acta Mol Cell Res. 2019 Oct;1866(10):1676-1686. doi: 10.1016/j.bbamcr.2019.04.009. Epub 2019 Apr 25.


Phosphoproteome Analysis of Cells Infected with Adapted and Nonadapted Influenza A Virus Reveals Novel Pro- and Antiviral Signaling Networks.

Weber A, Dam S, Saul VV, Kuznetsova I, Müller C, Fritz-Wolf K, Becker K, Linne U, Gu H, Stokes MP, Pleschka S, Kracht M, Schmitz ML.

J Virol. 2019 Jun 14;93(13). pii: e00528-19. doi: 10.1128/JVI.00528-19. Print 2019 Jul 1.


CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation.

Seibert M, Krüger M, Watson NA, Sen O, Daum JR, Slotman JA, Braun T, Houtsmuller AB, Gorbsky GJ, Jacob R, Kracht M, Higgins JMG, Schmitz ML.

J Cell Biol. 2019 Apr 1;218(4):1164-1181. doi: 10.1083/jcb.201806057. Epub 2019 Feb 14.


NF-κB p65 dimerization and DNA-binding is important for inflammatory gene expression.

Riedlinger T, Liefke R, Meier-Soelch J, Jurida L, Nist A, Stiewe T, Kracht M, Schmitz ML.

FASEB J. 2019 Mar;33(3):4188-4202. doi: 10.1096/fj.201801638R. Epub 2018 Dec 7.


Olecranon fractures in children and adolescents: outcomes based on fracture fixation.

Perkins CA, Busch MT, Christino MA, Axelrod J, Devito DP, Fabregas JA, Flanagan JC, Murphy J, Olszewski D, Schmitz ML, Schrader T, Willimon SC.

J Child Orthop. 2018 Oct 1;12(5):497-501. doi: 10.1302/1863-2548.12.180029.


Incidence of Immediate Extubation After Pediatric Cardiac Surgery and Predictors for Reintubation.

Shinkawa T, Tang X, Gossett JM, Dasgupta R, Schmitz ML, Gupta P, Imamura M.

World J Pediatr Congenit Heart Surg. 2018 Sep;9(5):529-536. doi: 10.1177/2150135118779010.


Nighttime bracing with the Providence thoracolumbosacral orthosis for treatment of adolescent idiopathic scoliosis: A retrospective consecutive clinical series.

Davis L, Murphy JS, Shaw KA, Cash K, Devito DP, Schmitz ML.

Prosthet Orthot Int. 2019 Apr;43(2):158-162. doi: 10.1177/0309364618792727. Epub 2018 Aug 13.


The Crosstalk of Endoplasmic Reticulum (ER) Stress Pathways with NF-κB: Complex Mechanisms Relevant for Cancer, Inflammation and Infection.

Schmitz ML, Shaban MS, Albert BV, Gökçen A, Kracht M.

Biomedicines. 2018 May 16;6(2). pii: E58. doi: 10.3390/biomedicines6020058. Review.


Correction: Riedlinger, T. et al. The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-In Mice. Biomedicines, 2018, 6, 36.

Riedlinger T, Haas J, Busch J, van de Sluis B, Kracht M, Schmitz ML.

Biomedicines. 2018 May 16;6(2). pii: E57. doi: 10.3390/biomedicines6020057. No abstract available.


RNAi-Based Identification of Gene-Specific Nuclear Cofactor Networks Regulating Interleukin-1 Target Genes.

Meier-Soelch J, Jurida L, Weber A, Newel D, Kim J, Braun T, Schmitz ML, Kracht M.

Front Immunol. 2018 Apr 27;9:775. doi: 10.3389/fimmu.2018.00775. eCollection 2018.


Formaldehyde-assisted Isolation of Regulatory Elements to Measure Chromatin Accessibility in Mammalian Cells.

Rodríguez-Gil A, Riedlinger T, Ritter O, Saul VV, Schmitz ML.

J Vis Exp. 2018 Apr 2;(134). doi: 10.3791/57272.


The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-in Mice.

Riedlinger T, Haas J, Busch J, van de Sluis B, Kracht M, Schmitz ML.

Biomedicines. 2018 Mar 19;6(1). pii: E36. doi: 10.3390/biomedicines6010036. Review. Erratum in: Biomedicines. 2018 May 16;6(2):.


Intraocular pressure in children after congenital heart surgery: A single-center study.

Goyal S, Phillips PH, Corder LA, Robertson MJ, Garcia X, Schmitz ML, Gupta P.

Ann Pediatr Cardiol. 2017 Sep-Dec;10(3):234-239. doi: 10.4103/apc.APC_41_17.


Spectrum of Off-Label Nitric Oxide Utilization After Pediatric Cardiac Surgery Among Centers of Varying Surgical Volume.

Gupta P, Rettiganti M, Wilcox A, Eble BK, Schmitz ML, Zakaria D.

J Intensive Care Med. 2017 Jan 1:885066617728494. doi: 10.1177/0885066617728494. [Epub ahead of print]


NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation.

Riedlinger T, Dommerholt MB, Wijshake T, Kruit JK, Huijkman N, Dekker D, Koster M, Kloosterhuis N, Koonen DPY, de Bruin A, Baker D, Hofker MH, van Deursen J, Jonker JW, Schmitz ML, van de Sluis B.

Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1785-1798. doi: 10.1016/j.bbamcr.2017.07.005. Epub 2017 Jul 16.


The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription.

Rodríguez-Gil A, Ritter O, Saul VV, Wilhelm J, Yang CY, Grosschedl R, Imai Y, Kuba K, Kracht M, Schmitz ML.

Sci Rep. 2017 Jun 14;7(1):3547. doi: 10.1038/s41598-017-03708-7.


Peri-procedural risk stratification and management of patients with Williams syndrome.

Collins Ii RT, Collins MG, Schmitz ML, Hamrick JT.

Congenit Heart Dis. 2017 Mar;12(2):133-142. doi: 10.1111/chd.12447. Review.


The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells.

Poppe M, Wittig S, Jurida L, Bartkuhn M, Wilhelm J, Müller H, Beuerlein K, Karl N, Bhuju S, Ziebuhr J, Schmitz ML, Kracht M.

PLoS Pathog. 2017 Mar 29;13(3):e1006286. doi: 10.1371/journal.ppat.1006286. eCollection 2017 Mar.


K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping.

Tenekeci U, Poppe M, Beuerlein K, Buro C, Müller H, Weiser H, Kettner-Buhrow D, Porada K, Newel D, Xu M, Chen ZJ, Busch J, Schmitz ML, Kracht M.

Mol Cell. 2016 Aug 4;63(3):540. doi: 10.1016/j.molcel.2016.07.009. Epub 2016 Aug 4. No abstract available.


Recanalization and Angiographic Reperfusion Are Both Associated with a Favorable Clinical Outcome in the IMS III Trial.

Schmitz ML, Yeatts SD, Tomsick TA, Liebeskind DS, Vagal A, Broderick JP, Khatri P.

Interv Neurol. 2016 Sep;5(3-4):118-122. Epub 2016 Jun 16.


Testing the Effects of SIAH Ubiquitin E3 Ligases on Lysine Acetyl Transferases.

Hagenbucher J, Stekman H, Rodriguez-Gil A, Kracht M, Schmitz ML.

Methods Mol Biol. 2017;1510:297-312.


Is Administration of Nitric Oxide During Extracorporeal Membrane Oxygenation Associated With Improved Patient Survival?

Tadphale SD, Rettiganti M, Gossett JM, Beam BW, Padiyath A, Schmitz ML, Gupta P.

Pediatr Crit Care Med. 2016 Nov;17(11):1080-1087.


The Influenza A Virus Genotype Determines the Antiviral Function of NF-κB.

Dam S, Kracht M, Pleschka S, Schmitz ML.

J Virol. 2016 Aug 12;90(17):7980-90. doi: 10.1128/JVI.00946-16. Print 2016 Sep 1.


K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping.

Tenekeci U, Poppe M, Beuerlein K, Buro C, Müller H, Weiser H, Kettner-Buhrow D, Porada K, Newel D, Xu M, Chen ZJ, Busch J, Schmitz ML, Kracht M.

Mol Cell. 2016 Jun 16;62(6):943-957. doi: 10.1016/j.molcel.2016.05.017. Erratum in: Mol Cell. 2016 Aug 4;63(3):540.


Thrombolysis in acute ischemic stroke is associated with lower long-term hospital bed day use: A nationwide propensity score-matched follow-up study.

Terkelsen T, Schmitz ML, Simonsen CZ, Hundborg HH, Christensen HK, Gyllenborg J, Sandal BF, Iversen HK, Madsen C, Rasmussen MJ, Vestergaard K, Andersen G, Johnsen SP.

Int J Stroke. 2016 Oct;11(8):910-916. doi: 10.1177/1747493016654491. Epub 2016 Jul 9.


SUMO5, a Novel Poly-SUMO Isoform, Regulates PML Nuclear Bodies.

Liang YC, Lee CC, Yao YL, Lai CC, Schmitz ML, Yang WM.

Sci Rep. 2016 May 23;6:26509. doi: 10.1038/srep26509.


Early neurological deterioration after thrombolysis: Clinical and imaging predictors.

Simonsen CZ, Schmitz ML, Madsen MH, Mikkelsen IK, Chandra RV, Leslie-Mazwi T, Andersen G.

Int J Stroke. 2016 Oct;11(7):776-82. doi: 10.1177/1747493016650454. Epub 2016 May 17.


Chronic Foot Pain due to Pachyonychia Congenita in a Pediatric Patient: A Successful Management Strategy.

Tariq S, Schmitz ML, Kanjia MK.

A A Case Rep. 2016 May 15;6(10):305-7. doi: 10.1213/XAA.0000000000000301.


HIPK family kinases bind and regulate the function of the CCR4-NOT complex.

Rodriguez-Gil A, Ritter O, Hornung J, Stekman H, Krüger M, Braun T, Kremmer E, Kracht M, Schmitz ML.

Mol Biol Cell. 2016 Jun 15;27(12):1969-80. doi: 10.1091/mbc.E15-09-0629. Epub 2016 Apr 27.


Ischemic stroke subtype is associated with outcome in thrombolyzed patients.

Schmitz ML, Simonsen CZ, Svendsen ML, Larsson H, Madsen MH, Mikkelsen IK, Fisher M, Johnsen SP, Andersen G.

Acta Neurol Scand. 2017 Feb;135(2):176-182. doi: 10.1111/ane.12589. Epub 2016 Mar 15.


Cyclin-Dependent Kinases as Coregulators of Inflammatory Gene Expression.

Schmitz ML, Kracht M.

Trends Pharmacol Sci. 2016 Feb;37(2):101-113. doi: 10.1016/ Epub 2015 Dec 22. Review.


Congenital limb deficiency disorders.

Wilcox WR, Coulter CP, Schmitz ML.

Clin Perinatol. 2015 Jun;42(2):281-300, viii. doi: 10.1016/j.clp.2015.02.004. Review.


Mutations of c-Cbl in myeloid malignancies.

Katzav S, Schmitz ML.

Oncotarget. 2015 May 10;6(13):10689-96. Review.


Amplitude-integrated EEG in newborns with critical congenital heart disease predicts preoperative brain magnetic resonance imaging findings.

Mulkey SB, Yap VL, Bai S, Ramakrishnaiah RH, Glasier CM, Bornemeier RA, Schmitz ML, Bhutta AT.

Pediatr Neurol. 2015 Jun;52(6):599-605. doi: 10.1016/j.pediatrneurol.2015.02.026. Epub 2015 Mar 5.


The Activation of IL-1-Induced Enhancers Depends on TAK1 Kinase Activity and NF-κB p65.

Jurida L, Soelch J, Bartkuhn M, Handschick K, Müller H, Newel D, Weber A, Dittrich-Breiholz O, Schneider H, Bhuju S, Saul VV, Schmitz ML, Kracht M.

Cell Rep. 2015 Feb 10;10(5):726-739. doi: 10.1016/j.celrep.2015.01.001. Epub 2015 Feb 5.


Association of haematocrit and red blood cell transfusion with outcomes in infants with shunt-dependent pulmonary blood flow and univentricular physiology.

Dasgupta R, Parsons A, Mcclelland S, Morgan E, Robertson MJ, Noel TR, Schmitz ML, Rettiganti M, Gupta P.

Blood Transfus. 2015 Jul;13(3):417-22. doi: 10.2450/2014.0128-14. Epub 2014 Nov 25.


Outcomes associated with the use of renal replacement therapy in children receiving extracorporeal membrane oxygenation after heart surgery: a multi-institutional analysis.

Gupta P, Beam B, Schmitz ML.

Pediatr Nephrol. 2015 Jun;30(6):1019-26. doi: 10.1007/s00467-014-3025-y. Epub 2014 Dec 13.


SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity.

Saul VV, Niedenthal R, Pich A, Weber F, Schmitz ML.

Biochim Biophys Acta. 2015 Jan;1853(1):136-43. doi: 10.1016/j.bbamcr.2014.10.008. Epub 2014 Oct 14.


Sensitivity of diffusion- and perfusion-weighted imaging for diagnosing acute ischemic stroke is 97.5%.

Simonsen CZ, Madsen MH, Schmitz ML, Mikkelsen IK, Fisher M, Andersen G.

Stroke. 2015 Jan;46(1):98-101. doi: 10.1161/STROKEAHA.114.007107. Epub 2014 Nov 11.


Relationship of ECMO duration with outcomes after pediatric cardiac surgery: a multi-institutional analysis.

Gupta P, Robertson MJ, Beam B, Gossett JM, Schmitz ML, Carroll CL, Edwards JD, Fortenberry JD, Butt W.

Minerva Anestesiol. 2015 Jun;81(6):619-27. Epub 2014 Oct 3.


Acute ischemic stroke and long-term outcome after thrombolysis: nationwide propensity score-matched follow-up study.

Schmitz ML, Simonsen CZ, Hundborg H, Christensen H, Ellemann K, Geisler K, Iversen H, Madsen C, Rasmussen MJ, Vestergaard K, Andersen G, Johnsen SP.

Stroke. 2014 Oct;45(10):3070-2. doi: 10.1161/STROKEAHA.114.006570. Epub 2014 Sep 4.


White matter injury in newborns with congenital heart disease: a diffusion tensor imaging study.

Mulkey SB, Ou X, Ramakrishnaiah RH, Glasier CM, Swearingen CJ, Melguizo MS, Yap VL, Schmitz ML, Bhutta AT.

Pediatr Neurol. 2014 Sep;51(3):377-83. doi: 10.1016/j.pediatrneurol.2014.04.008. Epub 2014 Apr 12.


The intricate interplay between RNA viruses and NF-κB.

Schmitz ML, Kracht M, Saul VV.

Biochim Biophys Acta. 2014 Nov;1843(11):2754-2764. doi: 10.1016/j.bbamcr.2014.08.004. Epub 2014 Aug 10. Review.


Thrombin selectively induces transcription of genes in human monocytes involved in inflammation and wound healing.

López ML, Bruges G, Crespo G, Salazar V, Deglesne PA, Schneider H, Cabrera-Fuentes H, Schmitz ML, Preissner KT.

Thromb Haemost. 2014 Nov;112(5):992-1001. doi: 10.1160/TH14-01-0034. Epub 2014 Jul 24.


MRI before intraarterial therapy in ischemic stroke: feasibility, impact, and safety.

Simonsen CZ, Sørensen LH, Karabegovic S, Mikkelsen IK, Schmitz ML, Juul N, Yoo AJ, Andersen G.

J Cereb Blood Flow Metab. 2014 Jun;34(6):1076-81. doi: 10.1038/jcbfm.2014.57. Epub 2014 Apr 2.


Expression pattern of protease activated receptors in lymphoid cells.

López ML, Soriano-Sarabia N, Bruges G, Marquez ME, Preissner KT, Schmitz ML, Hackstein H.

Cell Immunol. 2014 Mar-Apr;288(1-2):47-52. doi: 10.1016/j.cellimm.2014.02.004. Epub 2014 Feb 28.


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