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Loss of RE-1 silencing transcription factor accelerates exocrine damage from pancreatic injury.

Bray JK, Elgamal OA, Jiang J, Wright LS, Sutaria DS, Badawi M, Borcyk MG, Liu X, Fredenburg KM, Campbell-Thompson ML, Schmittgen TD.

Cell Death Dis. 2020 Feb 20;11(2):138. doi: 10.1038/s41419-020-2269-7.


Human Colon Mucosal Biofilms and Murine Host Communicate via Altered mRNA and microRNA Expression during Cancer.

Tomkovich S, Gharaibeh RZ, Dejea CM, Pope JL, Jiang J, Winglee K, Gauthier J, Newsome RC, Yang Y, Fodor AA, Schmittgen TD, Sears CL, Jobin C.

mSystems. 2020 Jan 14;5(1). pii: e00451-19. doi: 10.1128/mSystems.00451-19.


Knockout of Acinar Enriched microRNAs in Mice Promote Duct Formation But Not Pancreatic Cancer.

Sutaria DS, Jiang J, Azevedo-Pouly AC, Wright L, Bray JA, Fredenburg K, Liu X, Lu J, Torres C, Mancinelli G, Grippo PJ, Coppola V, Schmittgen TD.

Sci Rep. 2019 Jul 31;9(1):11147. doi: 10.1038/s41598-019-47566-x.


Exosomal miRNA Cargo as Mediator of Immune Escape Mechanisms in Neuroblastoma.

Schmittgen TD.

Cancer Res. 2019 Apr 1;79(7):1293-1294. doi: 10.1158/0008-5472.CAN-19-0021.


Pancreatic Cancer Related Health Disparities: A Commentary.

Scarton L, Yoon S, Oh S, Agyare E, Trevino J, Han B, Lee E, Setiawan VW, Permuth JB, Schmittgen TD, Odedina FG, Wilkie DJ.

Cancers (Basel). 2018 Jul 18;10(7). pii: E235. doi: 10.3390/cancers10070235.


CD44 positive and sorafenib insensitive hepatocellular carcinomas respond to the ATP-competitive mTOR inhibitor INK128.

Badawi M, Kim J, Dauki A, Sutaria D, Motiwala T, Reyes R, Wani N, Kolli S, Jiang J, Coss CC, Jacob ST, Phelps MA, Schmittgen TD.

Oncotarget. 2018 May 25;9(40):26032-26045. doi: 10.18632/oncotarget.25430. eCollection 2018 May 25.


MicroRNAs Targeting Caspase-3 and -7 in PANC-1 Cells.

Park JK, Doseff AI, Schmittgen TD.

Int J Mol Sci. 2018 Apr 16;19(4). pii: E1206. doi: 10.3390/ijms19041206.


Expression Profiling Identifies the Noncoding Processed Transcript of HNRNPU with Proliferative Properties in Pancreatic Ductal Adenocarcinoma.

Sutaria DS, Jiang J, Azevedo-Pouly ACP, Lee EJ, Lerner MR, Brackett DJ, Vandesompele J, Mestdagh P, Schmittgen TD.

Noncoding RNA. 2017 Aug 25;3(3). pii: E24. doi: 10.3390/ncrna3030024.


Correction for Pandharkar et al., "Studies on the Antileishmanial Mechanism of Action of the Arylimidamide DB766: Azole Interactions and Role of CYP5122A1".

Pandharkar T, Zhu X, Mathur R, Jiang J, Schmittgen TD, Shaha C, Werbovetz KA.

Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01124-17. doi: 10.1128/AAC.01124-17. Print 2018 Jan. No abstract available.


Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery.

Sutaria DS, Jiang J, Elgamal OA, Pomeroy SM, Badawi M, Zhu X, Pavlovicz R, Azevedo-Pouly ACP, Chalmers J, Li C, Phelps MA, Schmittgen TD.

J Extracell Vesicles. 2017 Jun 14;6(1):1333882. doi: 10.1080/20013078.2017.1333882. eCollection 2017.


Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells.

Zhu X, Badawi M, Pomeroy S, Sutaria DS, Xie Z, Baek A, Jiang J, Elgamal OA, Mo X, Perle K, Chalmers J, Schmittgen TD, Phelps MA.

J Extracell Vesicles. 2017 Jun 6;6(1):1324730. doi: 10.1080/20013078.2017.1324730. eCollection 2017.


miR-221 regulates CD44 in hepatocellular carcinoma through the PI3K-AKT-mTOR pathway.

Kim J, Jiang J, Badawi M, Schmittgen TD.

Biochem Biophys Res Commun. 2017 Jun 3;487(3):709-715. doi: 10.1016/j.bbrc.2017.04.121. Epub 2017 Apr 23.


MiRNA199a-3p suppresses tumor growth, migration, invasion and angiogenesis in hepatocellular carcinoma by targeting VEGFA, VEGFR1, VEGFR2, HGF and MMP2.

Ghosh A, Dasgupta D, Ghosh A, Roychoudhury S, Kumar D, Gorain M, Butti R, Datta S, Agarwal S, Gupta S, Krishna Dhali G, Chowdhury A, Schmittgen TD, Kundu GC, Banerjee S.

Cell Death Dis. 2017 Mar 30;8(3):e2706. doi: 10.1038/cddis.2017.123.


Achieving the Promise of Therapeutic Extracellular Vesicles: The Devil is in Details of Therapeutic Loading.

Sutaria DS, Badawi M, Phelps MA, Schmittgen TD.

Pharm Res. 2017 May;34(5):1053-1066. doi: 10.1007/s11095-017-2123-5. Epub 2017 Mar 17. Review.


Anti-invasion and anti-migration effects of miR-199a-3p in hepatocellular carcinoma are due in part to targeting CD151.

Kim JH, Badawi M, Park JK, Jiang J, Mo X, Roberts LR, Schmittgen TD.

Int J Oncol. 2016 Nov;49(5):2037-2045. doi: 10.3892/ijo.2016.3677. Epub 2016 Sep 2.


miR-216 and miR-217 expression is reduced in transgenic mouse models of pancreatic adenocarcinoma, knockout of miR-216/miR-217 host gene is embryonic lethal.

Azevedo-Pouly AC, Sutaria DS, Jiang J, Elgamal OA, Amari F, Allard D, Grippo PJ, Coppola V, Schmittgen TD.

Funct Integr Genomics. 2017 May;17(2-3):203-212. doi: 10.1007/s10142-016-0512-1. Epub 2016 Aug 19.


The pancreatic tumor microenvironment drives changes in miRNA expression that promote cytokine production and inhibit migration by the tumor associated stroma.

Han S, Gonzalo DH, Feely M, Delitto D, Behrns KE, Beveridge M, Zhang D, Thomas R, Trevino JG, Schmittgen TD, Hughes SJ.

Oncotarget. 2016 Jul 20;8(33):54054-54067. doi: 10.18632/oncotarget.10722. eCollection 2017 Aug 15.


Globally increased ultraconserved noncoding RNA expression in pancreatic adenocarcinoma.

Jiang J, Azevedo-Pouly AC, Redis RS, Lee EJ, Gusev Y, Allard D, Sutaria DS, Badawi M, Elgamal OA, Lerner MR, Brackett DJ, Calin GA, Schmittgen TD.

Oncotarget. 2016 Aug 16;7(33):53165-53177. doi: 10.18632/oncotarget.10242.


In vitro immunotoxicity assessment of culture-derived extracellular vesicles in human monocytes.

Rosas LE, Elgamal OA, Mo X, Phelps MA, Schmittgen TD, Papenfuss TL.

J Immunotoxicol. 2016 Sep;13(5):652-65. doi: 10.3109/1547691X.2016.1148089. Epub 2016 Apr 14.


Effects of local structural transformation of lipid-like compounds on delivery of messenger RNA.

Li B, Luo X, Deng B, Giancola JB, McComb DW, Schmittgen TD, Dong Y.

Sci Rep. 2016 Feb 26;6:22137. doi: 10.1038/srep22137.


Dietary apigenin reduces LPS-induced expression of miR-155 restoring immune balance during inflammation.

Arango D, Diosa-Toro M, Rojas-Hernandez LS, Cooperstone JL, Schwartz SJ, Mo X, Jiang J, Schmittgen TD, Doseff AI.

Mol Nutr Food Res. 2015 Apr;59(4):763-72. doi: 10.1002/mnfr.201400705. Epub 2015 Feb 23.


RNA isolation from mouse pancreas: a ribonuclease-rich tissue.

Azevedo-Pouly AC, Elgamal OA, Schmittgen TD.

J Vis Exp. 2014 Aug 2;(90):e51779. doi: 10.3791/51779.


Studies on the antileishmanial mechanism of action of the arylimidamide DB766: azole interactions and role of CYP5122A1.

Pandharkar T, Zhu X, Mathur R, Jiang J, Schmittgen TD, Shaha C, Werbovetz KA.

Antimicrob Agents Chemother. 2014 Aug;58(8):4682-9. doi: 10.1128/AAC.02405-14. Epub 2014 Jun 2. Erratum in: Antimicrob Agents Chemother. 2017 Dec 21;62(1):.


Tumor suppressive function of mir-205 in breast cancer is linked to HMGB3 regulation.

Elgamal OA, Park JK, Gusev Y, Azevedo-Pouly AC, Jiang J, Roopra A, Schmittgen TD.

PLoS One. 2013 Oct 2;8(10):e76402. doi: 10.1371/journal.pone.0076402. eCollection 2013.


A differential microRNA profile distinguishes cholangiocarcinoma from pancreatic adenocarcinoma.

Collins AL, Wojcik S, Liu J, Frankel WL, Alder H, Yu L, Schmittgen TD, Croce CM, Bloomston M.

Ann Surg Oncol. 2014 Jan;21(1):133-8. doi: 10.1245/s10434-013-3240-y. Epub 2013 Sep 18.


HINCUTs in cancer: hypoxia-induced noncoding ultraconserved transcripts.

Ferdin J, Nishida N, Wu X, Nicoloso MS, Shah MY, Devlin C, Ling H, Shimizu M, Kumar K, Cortez MA, Ferracin M, Bi Y, Yang D, Czerniak B, Zhang W, Schmittgen TD, Voorhoeve MP, Reginato MJ, Negrini M, Davuluri RV, Kunej T, Ivan M, Calin GA.

Cell Death Differ. 2013 Dec;20(12):1675-87. doi: 10.1038/cdd.2013.119. Epub 2013 Sep 13.


Microbiomarkers with big impact in CLL.

Schmittgen TD.

Blood. 2013 Sep 12;122(11):1843-4. doi: 10.1182/blood-2013-08-514117. No abstract available.


miR-221 silencing blocks hepatocellular carcinoma and promotes survival.

Park JK, Kogure T, Nuovo GJ, Jiang J, He L, Kim JH, Phelps MA, Papenfuss TL, Croce CM, Patel T, Schmittgen TD.

Cancer Res. 2011 Dec 15;71(24):7608-16. doi: 10.1158/0008-5472.CAN-11-1144. Epub 2011 Oct 18.


MicroRNA replacement therapy for cancer.

Henry JC, Azevedo-Pouly AC, Schmittgen TD.

Pharm Res. 2011 Dec;28(12):3030-42. doi: 10.1007/s11095-011-0548-9. Epub 2011 Aug 31. Review.


miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor.

Park JK, Henry JC, Jiang J, Esau C, Gusev Y, Lerner MR, Postier RG, Brackett DJ, Schmittgen TD.

Biochem Biophys Res Commun. 2011 Mar 25;406(4):518-23. doi: 10.1016/j.bbrc.2011.02.065. Epub 2011 Feb 15.


miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines.

Henry JC, Park JK, Jiang J, Kim JH, Nagorney DM, Roberts LR, Banerjee S, Schmittgen TD.

Biochem Biophys Res Commun. 2010 Dec 3;403(1):120-5. doi: 10.1016/j.bbrc.2010.10.130. Epub 2010 Nov 3.


MicroRNAs are mediators of androgen action in prostate and muscle.

Narayanan R, Jiang J, Gusev Y, Jones A, Kearbey JD, Miller DD, Schmittgen TD, Dalton JT.

PLoS One. 2010 Oct 27;5(10):e13637. doi: 10.1371/journal.pone.0013637.


Strong inverse correlation between microRNA-125b and human papillomavirus DNA in productive infection.

Nuovo GJ, Wu X, Volinia S, Yan F, di Leva G, Chin N, Nicol AF, Jiang J, Otterson G, Schmittgen TD, Croce C.

Diagn Mol Pathol. 2010 Sep;19(3):135-43. doi: 10.1097/PDM.0b013e3181c4daaa.


miR-31: a master regulator of metastasis?

Schmittgen TD.

Future Oncol. 2010 Jan;6(1):17-20. doi: 10.2217/fon.09.150.


MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes.

Li Y, Guessous F, Zhang Y, Dipierro C, Kefas B, Johnson E, Marcinkiewicz L, Jiang J, Yang Y, Schmittgen TD, Lopes B, Schiff D, Purow B, Abounader R.

Cancer Res. 2009 Oct 1;69(19):7569-76. doi: 10.1158/0008-5472.CAN-09-0529. Epub 2009 Sep 22.


Antisense inhibition of microRNA-21 or -221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma.

Park JK, Lee EJ, Esau C, Schmittgen TD.

Pancreas. 2009 Oct;38(7):e190-9. doi: 10.1097/MPA.0b013e3181ba82e1.


Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice.

Wang B, Majumder S, Nuovo G, Kutay H, Volinia S, Patel T, Schmittgen TD, Croce C, Ghoshal K, Jacob ST.

Hepatology. 2009 Oct;50(4):1152-61. doi: 10.1002/hep.23100.


A methodology for the combined in situ analyses of the precursor and mature forms of microRNAs and correlation with their putative targets.

Nuovo GJ, Elton TS, Nana-Sinkam P, Volinia S, Croce CM, Schmittgen TD.

Nat Protoc. 2009;4(1):107-15. doi: 10.1038/nprot.2008.215. Epub 2009 Jan 8.


Detection of microRNA expression in human peripheral blood microvesicles.

Hunter MP, Ismail N, Zhang X, Aguda BD, Lee EJ, Yu L, Xiao T, Schafer J, Lee ML, Schmittgen TD, Nana-Sinkam SP, Jarjoura D, Marsh CB.

PLoS One. 2008;3(11):e3694. doi: 10.1371/journal.pone.0003694. Epub 2008 Nov 11. Erratum in: PLoS One. 2010;5(3) doi: 10.1371/annotation/b15ca816-7b62-4474-a568-6b60b8959742.


Integrating the MicroRNome into the study of lung disease.

Nana-Sinkam SP, Hunter MG, Nuovo GJ, Schmittgen TD, Gelinas R, Galas D, Marsh CB.

Am J Respir Crit Care Med. 2009 Jan 1;179(1):4-10. doi: 10.1164/rccm.200807-1042PP. Epub 2008 Sep 11. Review.


Regulation of microRNA processing in development, differentiation and cancer.

Schmittgen TD.

J Cell Mol Med. 2008 Oct;12(5B):1811-9. doi: 10.1111/j.1582-4934.2008.00483.x. Review.


High-throughput real-time PCR.

Schmittgen TD, Lee EJ, Jiang J.

Methods Mol Biol. 2008;429:89-98. doi: 10.1007/978-1-60327-040-3_7.


Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis.

Datta J, Kutay H, Nasser MW, Nuovo GJ, Wang B, Majumder S, Liu CG, Volinia S, Croce CM, Schmittgen TD, Ghoshal K, Jacob ST.

Cancer Res. 2008 Jul 1;68(13):5049-58. doi: 10.1158/0008-5472.CAN-07-6655.


Analyzing real-time PCR data by the comparative C(T) method.

Schmittgen TD, Livak KJ.

Nat Protoc. 2008;3(6):1101-8.


Epigenetic modification of CCAAT/enhancer binding protein alpha expression in acute myeloid leukemia.

Hackanson B, Bennett KL, Brena RM, Jiang J, Claus R, Chen SS, Blagitko-Dorfs N, Maharry K, Whitman SP, Schmittgen TD, L├╝bbert M, Marcucci G, Bloomfield CD, Plass C.

Cancer Res. 2008 May 1;68(9):3142-51. doi: 10.1158/0008-5472.CAN-08-0483.


Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts.

Kuhn DE, Nuovo GJ, Martin MM, Malana GE, Pleister AP, Jiang J, Schmittgen TD, Terry AV Jr, Gardiner K, Head E, Feldman DS, Elton TS.

Biochem Biophys Res Commun. 2008 Jun 6;370(3):473-7. doi: 10.1016/j.bbrc.2008.03.120. Epub 2008 Apr 1. Retraction in: Biochem Biophys Res Commun. 2013 Jul 5;436(3):564.


Benign metastasizing leiomyoma of the lung: clinicopathologic, immunohistochemical, and micro-RNA analyses.

Nuovo GJ, Schmittgen TD.

Diagn Mol Pathol. 2008 Sep;17(3):145-50. doi: 10.1097/PDM.0b013e31815aca19.


Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival.

Jiang J, Gusev Y, Aderca I, Mettler TA, Nagorney DM, Brackett DJ, Roberts LR, Schmittgen TD.

Clin Cancer Res. 2008 Jan 15;14(2):419-27. doi: 10.1158/1078-0432.CCR-07-0523.


MicroRNAs modulate the chemosensitivity of tumor cells.

Blower PE, Chung JH, Verducci JS, Lin S, Park JK, Dai Z, Liu CG, Schmittgen TD, Reinhold WC, Croce CM, Weinstein JN, Sadee W.

Mol Cancer Ther. 2008 Jan;7(1):1-9. doi: 10.1158/1535-7163.MCT-07-0573. Epub 2008 Jan 9.


Real-time PCR quantification of precursor and mature microRNA.

Schmittgen TD, Lee EJ, Jiang J, Sarkar A, Yang L, Elton TS, Chen C.

Methods. 2008 Jan;44(1):31-8. Review.

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