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Items: 1 to 50 of 121

1.

Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer's disease hallmarks.

Reinhardt S, Stoye N, Luderer M, Kiefer F, Schmitt U, Lieb K, Endres K.

Sci Rep. 2018 Jan 22;8(1):1329. doi: 10.1038/s41598-018-19577-7.

2.

Statistical control of peptide and protein error rates in large-scale targeted data-independent acquisition analyses.

Rosenberger G, Bludau I, Schmitt U, Heusel M, Hunter CL, Liu Y, MacCoss MJ, MacLean BX, Nesvizhskii AI, Pedrioli PGA, Reiter L, Röst HL, Tate S, Ting YS, Collins BC, Aebersold R.

Nat Methods. 2017 Sep;14(9):921-927. doi: 10.1038/nmeth.4398. Epub 2017 Aug 21.

3.

Annual Cambial Rhythm in Pinus halepensis and Pinus sylvestris as Indicator for Climate Adaptation.

Prislan P, Gričar J, de Luis M, Novak K, Martinez Del Castillo E, Schmitt U, Koch G, Štrus J, Mrak P, Žnidarič MT, Čufar K.

Front Plant Sci. 2016 Dec 26;7:1923. doi: 10.3389/fpls.2016.01923. eCollection 2016.

4.

OpenMS: a flexible open-source software platform for mass spectrometry data analysis.

Röst HL, Sachsenberg T, Aiche S, Bielow C, Weisser H, Aicheler F, Andreotti S, Ehrlich HC, Gutenbrunner P, Kenar E, Liang X, Nahnsen S, Nilse L, Pfeuffer J, Rosenberger G, Rurik M, Schmitt U, Veit J, Walzer M, Wojnar D, Wolski WE, Schilling O, Choudhary JS, Malmström L, Aebersold R, Reinert K, Kohlbacher O.

Nat Methods. 2016 Aug 30;13(9):741-8. doi: 10.1038/nmeth.3959.

PMID:
27575624
5.

PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/β1-Integrin Signaling.

Liu X, Huai J, Endle H, Schlüter L, Fan W, Li Y, Richers S, Yurugi H, Rajalingam K, Ji H, Cheng H, Rister B, Horta G, Baumgart J, Berger H, Laube G, Schmitt U, Schmeisser MJ, Boeckers TM, Tenzer S, Vlachos A, Deller T, Nitsch R, Vogt J.

Dev Cell. 2016 Aug 8;38(3):275-90. doi: 10.1016/j.devcel.2016.06.019. Epub 2016 Jul 21.

6.

Transnasal delivery of human A-beta peptides elicits impaired learning and memory performance in wild type mice.

Endres K, Reinhardt S, Geladaris A, Knies J, Grimm M, Hartmann T, Schmitt U.

BMC Neurosci. 2016 Jul 4;17(1):44. doi: 10.1186/s12868-016-0280-9.

7.

Amphiphilic Copolymers Shuttle Drugs Across the Blood-Brain Barrier.

Clemens-Hemmelmann M, Kuffner C, Metz V, Kircher L, Schmitt U, Hiemke C, Postina R, Zentel R.

Macromol Biosci. 2016 May;16(5):655-65. doi: 10.1002/mabi.201500388. Epub 2016 Jan 13.

PMID:
26766666
8.

A novel fibrinogen γ chain frameshift deletion (c.637delT) in a patient with hypodysfibrinogenemia associated with thrombosis.

Ivaškevičius V, Thomas A, Biswas A, Ensikat H, Schmitt U, Horneff S, Pavlova A, Poetzsch B, Oldenburg J.

Hamostaseologie. 2015;35 Suppl 1:S27-31.

PMID:
26540127
9.

Extract of Caragana sinica as a potential therapeutic option for increasing alpha-secretase gene expression.

Schuck F, Schmitt U, Reinhardt S, Freese C, Lee IS, Thines E, Efferth T, Endres K.

Phytomedicine. 2015 Oct 15;22(11):1027-36. doi: 10.1016/j.phymed.2015.08.001. Epub 2015 Aug 14.

PMID:
26407945
10.

DynaMet: a fully automated pipeline for dynamic LC-MS data.

Kiefer P, Schmitt U, Müller JE, Hartl J, Meyer F, Ryffel F, Vorholt JA.

Anal Chem. 2015 Oct 6;87(19):9679-86. doi: 10.1021/acs.analchem.5b01660.

PMID:
26366644
11.

Fast and Efficient XML Data Access for Next-Generation Mass Spectrometry.

Röst HL, Schmitt U, Aebersold R, Malmström L.

PLoS One. 2015 Apr 30;10(4):e0125108. doi: 10.1371/journal.pone.0125108. eCollection 2015.

12.

Identification of trichlormethiazide as a Mdr1a/b gene expression enhancer via a dual secretion-based promoter assay.

Schulze S, Reinhardt S, Freese C, Schmitt U, Endres K.

Pharmacol Res Perspect. 2015 Feb;3(1):e00109. doi: 10.1002/prp2.109. Epub 2015 Jan 5.

13.

DIANA--algorithmic improvements for analysis of data-independent acquisition MS data.

Teleman J, Röst HL, Rosenberger G, Schmitt U, Malmström L, Malmström J, Levander F.

Bioinformatics. 2015 Feb 15;31(4):555-62. doi: 10.1093/bioinformatics/btu686. Epub 2014 Oct 27.

14.

pyOpenMS: a Python-based interface to the OpenMS mass-spectrometry algorithm library.

Röst HL, Schmitt U, Aebersold R, Malmström L.

Proteomics. 2014 Jan;14(1):74-7. doi: 10.1002/pmic.201300246.

PMID:
24420968
15.

Evaluation of P-glycoprotein (abcb1a/b) modulation of [(18)F]fallypride in MicroPET imaging studies.

Piel M, Schmitt U, Bausbacher N, Buchholz HG, Gründer G, Hiemke C, Rösch F.

Neuropharmacology. 2014 Sep;84:152-8. doi: 10.1016/j.neuropharm.2013.04.062. Epub 2013 Aug 29.

PMID:
23994301
16.

LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype.

Maier W, Bednorz M, Meister S, Roebroek A, Weggen S, Schmitt U, Pietrzik CU.

Mol Neurodegener. 2013 Jul 17;8:25. doi: 10.1186/1750-1326-8-25.

17.

Pharmacodynamic effects of aripiprazole and ziprasidone with respect to p-glycoprotein substrate properties.

Holthoewer D, Kirschbaum KM, Frisch J, Hiemke C, Schmitt U.

Pharmacopsychiatry. 2013 Jul;46(5):175-80. doi: 10.1055/s-0033-1347176. Epub 2013 Jun 4.

PMID:
23737243
18.

Altered brain concentrations of citalopram and escitalopram in P-glycoprotein deficient mice after acute and chronic treatment.

Karlsson L, Carlsson B, Hiemke C, Ahlner J, Bengtsson F, Schmitt U, Kugelberg FC.

Eur Neuropsychopharmacol. 2013 Nov;23(11):1636-44. doi: 10.1016/j.euroneuro.2013.01.003. Epub 2013 Feb 19.

PMID:
23428338
19.

eMZed: an open source framework in Python for rapid and interactive development of LC/MS data analysis workflows.

Kiefer P, Schmitt U, Vorholt JA.

Bioinformatics. 2013 Apr 1;29(7):963-4. doi: 10.1093/bioinformatics/btt080. Epub 2013 Feb 15.

20.

Topochemical and transmission electron microscopic studies of bacterial decay in pine (Pinus sylvestris L.) harbour foundation piles.

Rehbein M, Koch G, Schmitt U, Huckfeldt T.

Micron. 2013 Jan;44:150-8. doi: 10.1016/j.micron.2012.05.012. Epub 2012 Jun 9.

PMID:
22743130
21.

In vitro P-glycoprotein efflux inhibition by atypical antipsychotics is in vivo nicely reflected by pharmacodynamic but less by pharmacokinetic changes.

Schmitt U, Kirschbaum KM, Poller B, Kusch-Poddar M, Drewe J, Hiemke C, Gutmann H.

Pharmacol Biochem Behav. 2012 Aug;102(2):312-20. doi: 10.1016/j.pbb.2012.04.002. Epub 2012 Apr 15.

PMID:
22525746
22.

Behavioural consequences of p-glycoprotein deficiency in mice, with special focus on stress-related mechanisms.

Schoenfelder Y, Hiemke C, Schmitt U.

J Neuroendocrinol. 2012 May;24(5):809-17. doi: 10.1111/j.1365-2826.2012.02278.x.

PMID:
22339976
23.

Acitretin, an enhancer of alpha-secretase expression, crosses the blood-brain barrier and is not eliminated by P-glycoprotein.

Holthoewer D, Endres K, Schuck F, Hiemke C, Schmitt U, Fahrenholz F.

Neurodegener Dis. 2012;10(1-4):224-8. doi: 10.1159/000334300. Epub 2012 Feb 1.

PMID:
22301853
24.

Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice.

Rat D, Schmitt U, Tippmann F, Dewachter I, Theunis C, Wieczerzak E, Postina R, van Leuven F, Fahrenholz F, Kojro E.

FASEB J. 2011 Sep;25(9):3208-18. doi: 10.1096/fj.10-180133. Epub 2011 May 18.

25.

HPMA based amphiphilic copolymers mediate central nervous effects of domperidone.

Hemmelmann M, Knoth C, Schmitt U, Allmeroth M, Moderegger D, Barz M, Koynov K, Hiemke C, Rösch F, Zentel R.

Macromol Rapid Commun. 2011 May 18;32(9-10):712-7. doi: 10.1002/marc.201000810. Epub 2011 Apr 5.

PMID:
21469240
26.

P-glycoprotein influence on the brain uptake of a 5-HT(2A) ligand: [(18)F]MH.MZ.

Schmitt U, Lee DE, Herth MM, Piel M, Buchholz HG, Roesch F, Hiemke C, Lueddens H, Debus F.

Neuropsychobiology. 2011;63(3):183-90. doi: 10.1159/000321594. Epub 2011 Feb 8.

PMID:
21304228
27.

Ro 15-4513 Antagonizes Alcohol-Induced Sedation in Mice Through αβγ2-type GABA(A) Receptors.

Linden AM, Schmitt U, Leppä E, Wulff P, Wisden W, Lüddens H, Korpi ER.

Front Neurosci. 2011 Jan 20;5:3. doi: 10.3389/fnins.2011.00003. eCollection 2011.

28.

Effects on enantiomeric drug disposition and open-field behavior after chronic treatment with venlafaxine in the P-glycoprotein knockout mice model.

Karlsson L, Hiemke C, Carlsson B, Josefsson M, Ahlner J, Bengtsson F, Schmitt U, Kugelberg FC.

Psychopharmacology (Berl). 2011 May;215(2):367-77. doi: 10.1007/s00213-010-2148-5. Epub 2010 Dec 30.

29.

Pharmacokinetics of acute and sub-chronic aripiprazole in P-glycoprotein deficient mice.

Kirschbaum KM, Uhr M, Holthoewer D, Namendorf C, Pietrzik C, Hiemke C, Schmitt U.

Neuropharmacology. 2010 Nov;59(6):474-9. doi: 10.1016/j.neuropharm.2010.06.010. Epub 2010 Jul 3.

PMID:
20599439
30.

Induction of Drug Transporters Alters Disposition of Risperidone - A Study in Mice.

Holthoewer D, Hiemke C, Schmitt U.

Pharmaceutics. 2010 Jun 2;2(2):258-274.

31.

Blood-brain barrier penetration of the enantiomers of venlafaxine and its metabolites in mice lacking P-glycoprotein.

Karlsson L, Schmitt U, Josefsson M, Carlsson B, Ahlner J, Bengtsson F, Kugelberg FC, Hiemke C.

Eur Neuropsychopharmacol. 2010 Sep;20(9):632-40. doi: 10.1016/j.euroneuro.2010.04.004. Epub 2010 May 13.

32.

Spatial learning and expression patterns of PP1 mRNA in mouse hippocampus.

Haege S, Galetzka D, Zechner U, Haaf T, Gamerdinger M, Behl C, Hiemke C, Schmitt U.

Neuropsychobiology. 2010;61(4):188-96. doi: 10.1159/000297736. Epub 2010 Mar 19.

PMID:
20299813
33.

Rotarod impairment: catalepsy-like screening test for antipsychotic side effects.

Kirschbaum KM, Hiemke C, Schmitt U.

Int J Neurosci. 2009;119(10):1509-22.

PMID:
19922371
34.

The effects of GABA transporter inhibition on synaptophysin and synaptotagmin expression in diazepam tolerance.

Schmitt U, Conner AC, Rapp S, Kissling C, Jennen-Steinmetz C, Hünnerkopf R, Coogan AN, Thome J.

World J Biol Psychiatry. 2010 Mar;11(2 Pt 2):439-46. doi: 10.1080/15622970902874932.

PMID:
19452356
35.

Preliminary in vivo and ex vivo evaluation of the 5-HT2A imaging probe [(18)F]MH.MZ.

Herth MM, Piel M, Debus F, Schmitt U, Lüddens H, Rösch F.

Nucl Med Biol. 2009 May;36(4):447-54. doi: 10.1016/j.nucmedbio.2009.01.012. Epub 2009 Mar 26.

PMID:
19423013
36.

Detection of behavioral alterations and learning deficits in mice lacking synaptophysin.

Schmitt U, Tanimoto N, Seeliger M, Schaeffel F, Leube RE.

Neuroscience. 2009 Aug 18;162(2):234-43. doi: 10.1016/j.neuroscience.2009.04.046. Epub 2009 Apr 22.

PMID:
19393300
37.

Effect of a dominant-negative form of ADAM10 in a mouse model of Alzheimer's disease.

Schroeder A, Fahrenholz F, Schmitt U.

J Alzheimers Dis. 2009;16(2):309-14. doi: 10.3233/JAD-2009-0952.

PMID:
19221420
38.

Suppression of 4-coumarate-CoA ligase in the coniferous gymnosperm Pinus radiata.

Wagner A, Donaldson L, Kim H, Phillips L, Flint H, Steward D, Torr K, Koch G, Schmitt U, Ralph J.

Plant Physiol. 2009 Jan;149(1):370-83. doi: 10.1104/pp.108.125765. Epub 2008 Oct 29.

39.

Haloperidol and risperidone have specific effects on altered pain sensitivity in the ketamine model of schizophrenia.

Becker A, Grecksch G, Zernig G, Ladstaetter E, Hiemke C, Schmitt U.

Psychopharmacology (Berl). 2009 Mar;202(4):579-87. doi: 10.1007/s00213-008-1336-z. Epub 2008 Sep 23.

PMID:
18810393
40.
41.

Pharmacodynamic consequences of P-glycoprotein-dependent pharmacokinetics of risperidone and haloperidol in mice.

Kirschbaum KM, Henken S, Hiemke C, Schmitt U.

Behav Brain Res. 2008 Apr 9;188(2):298-303. doi: 10.1016/j.bbr.2007.11.009. Epub 2007 Nov 21.

PMID:
18164477
42.

Evaluation of a novel standardized system for collection and quantification of oral fluid.

Raggam RB, Santner BI, Kollroser M, Gössler W, Schmied B, Schmitt U, Stelzl E, Lackner A, Wagner J, Marth E, Kessler HH.

Clin Chem Lab Med. 2008;46(2):287-91.

PMID:
18076348
43.

Estimating the onset of cambial activity in Scots pine in northern Finland by means of the heat-sum approach.

Seo JW, Eckstein D, Jalkanen R, Rickebusch S, Schmitt U.

Tree Physiol. 2008 Jan;28(1):105-12.

PMID:
17938119
44.

Speeding up parallel GROMACS on high-latency networks.

Kutzner C, van der Spoel D, Fechner M, Lindahl E, Schmitt UW, de Groot BL, Grubmüller H.

J Comput Chem. 2007 Sep;28(12):2075-84.

PMID:
17405124
45.

Over-expression of two different forms of the alpha-secretase ADAM10 affects learning and memory in mice.

Schmitt U, Hiemke C, Fahrenholz F, Schroeder A.

Behav Brain Res. 2006 Dec 15;175(2):278-84. Epub 2006 Oct 2.

PMID:
17014917
46.

Effect of local heating and cooling on cambial activity and cell differentiation in the stem of Norway spruce (Picea abies).

Gricar J, Zupancic M, Cufar K, Koch G, Schmitt U, Oven P.

Ann Bot. 2006 Jun;97(6):943-51. Epub 2006 Apr 13.

47.

Lignification in cell cultures of Pinus radiata: activities of enzymes and lignin topochemistry.

Möller R, Koch G, Nanayakkara B, Schmitt U.

Tree Physiol. 2006 Feb;26(2):201-10.

PMID:
16356917
48.

Topochemical studies on modified lignin distribution in the xylem of Poplar (Populus spp.) after wounding.

Frankenstein C, Schmitt U, Koch G.

Ann Bot. 2006 Feb;97(2):195-204. Epub 2005 Dec 14.

49.

Cyclosporine A (CsA) affects the pharmacodynamics and pharmacokinetics of the atypical antipsychotic amisulpride probably via inhibition of P-glycoprotein (P-gp).

Schmitt U, Abou El-Ela A, Guo LJ, Glavinas H, Krajcsi P, Baron JM, Tillmann C, Hiemke C, Langguth P, Härtter S.

J Neural Transm (Vienna). 2006 Jul;113(7):787-801. Epub 2005 Oct 27.

PMID:
16252067
50.

Differentiation of terminal latewood tracheids in silver fir trees during autumn.

Gricar J, Cufar K, Oven P, Schmitt U.

Ann Bot. 2005 May;95(6):959-65. Epub 2005 Mar 10.

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