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Items: 1 to 50 of 285

1.

Knockdown of Atg7 Induces Nuclear-LC3 Dependent Apoptosis and Augments Chemotherapy in Colorectal Cancer Cells.

Scherr AL, Jassowicz A, Pató A, Elssner C, Ismail L, Schmitt N, Hoffmeister P, Neukirch L, Gdynia G, Goeppert B, Schulze-Bergkamen H, Jäger D, Köhler BC.

Int J Mol Sci. 2020 Feb 7;21(3). pii: E1099. doi: 10.3390/ijms21031099.

2.

ASTX660, an antagonist of cIAP1/2 and XIAP, increases antigen processing machinery and can enhance radiation-induced immunogenic cell death in preclinical models of head and neck cancer.

Ye W, Gunti S, Allen CT, Hong Y, Clavijo PE, Van Waes C, Schmitt NC.

Oncoimmunology. 2020 Jan 9;9(1):1710398. doi: 10.1080/2162402X.2019.1710398. eCollection 2020.

3.

A Novel Loss-of-Function Variant in the Chloride Ion Channel Gene Clcn2 Associates with Atrial Fibrillation.

Hansen TH, Yan Y, Ahlberg G, Vad OB, Refsgaard L, Dos Santos JL, Mutsaers N, Svendsen JH, Olesen MS, Bentzen BH, Schmitt N.

Sci Rep. 2020 Jan 29;10(1):1453. doi: 10.1038/s41598-020-58475-9.

4.

Functional phenotype variations of two novel KV 7.1 mutations identified in patients with Long QT syndrome.

Hammami Bomholtz S, Refaat M, Buur Steffensen A, David JP, Espinosa K, Nussbaum R, Wojciak J, Hjorth Bentzen B, Scheinman M, Schmitt N.

Pacing Clin Electrophysiol. 2020 Feb;43(2):210-216. doi: 10.1111/pace.13870. Epub 2020 Jan 11.

PMID:
31899541
5.

Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models.

Greene S, Robbins Y, Mydlarz WK, Huynh AP, Schmitt NC, Friedman J, Horn LA, Palena C, Schlom J, Maeda DY, Zebala JA, Clavijo PE, Allen C.

Clin Cancer Res. 2019 Dec 17. doi: 10.1158/1078-0432.CCR-19-2625. [Epub ahead of print]

PMID:
31848188
6.

Dysregulation of very-long-chain fatty acid metabolism causes membrane saturation and induction of the unfolded protein response.

Micoogullari Y, Basu SS, Ang J, Weisshaar N, Schmitt ND, Abdelmoula WM, Lopez B, Agar JN, Agar N, Hanna J.

Mol Biol Cell. 2020 Jan 1;31(1):7-17. doi: 10.1091/mbc.E19-07-0392. Epub 2019 Nov 20.

PMID:
31746669
7.

Neoadjuvant PD-1 Immune Checkpoint Blockade Reverses Functional Immunodominance among Tumor Antigen-Specific T Cells.

Friedman J, Moore EC, Zolkind P, Robbins Y, Clavijo PE, Sun L, Greene S, Morisada MV, Mydlarz WK, Schmitt N, Hodge JW, Schreiber H, Van Waes C, Uppaluri R, Allen C.

Clin Cancer Res. 2020 Feb 1;26(3):679-689. doi: 10.1158/1078-0432.CCR-19-2209. Epub 2019 Oct 23.

PMID:
31645352
8.

Effect of Ionic Liquid Modification on the ORR Performance and Degradation Mechanism of Trimetallic PtNiMo/C Catalysts.

George M, Zhang GR, Schmitt N, Brunnengräber K, Sandbeck DJS, Mayrhofer KJJ, Cherevko S, Etzold BJM.

ACS Catal. 2019 Sep 6;9(9):8682-8692. doi: 10.1021/acscatal.9b01772. Epub 2019 Aug 12.

9.

Minimal n-noids in hyperbolic and anti-de Sitter 3-space.

Bobenko AI, Heller S, Schmitt N.

Proc Math Phys Eng Sci. 2019 Jul;475(2227):20190173. doi: 10.1098/rspa.2019.0173. Epub 2019 Jul 17.

PMID:
31423097
10.

Cisplatin and oxaliplatin induce similar immunogenic changes in preclinical models of head and neck cancer.

Park SJ, Ye W, Xiao R, Silvin C, Padget M, Hodge JW, Van Waes C, Schmitt NC.

Oral Oncol. 2019 Aug;95:127-135. doi: 10.1016/j.oraloncology.2019.06.016. Epub 2019 Jun 20.

PMID:
31345380
11.

Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV- and HPV+ Head and Neck Cancers to TNFα, TRAIL, and Radiation Therapy.

Xiao R, An Y, Ye W, Derakhshan A, Cheng H, Yang X, Allen C, Chen Z, Schmitt NC, Van Waes C.

Clin Cancer Res. 2019 Nov 1;25(21):6463-6474. doi: 10.1158/1078-0432.CCR-18-3802. Epub 2019 Jul 2.

PMID:
31266830
12.

Gaps of care in patients with venous thrombotic embolism: a qualitative study.

Golemi I, Salazar Adum JP, Diaz Quintero L, Paz LH, Fuentes HE, Schmitt N, Tafur AJ.

Int Angiol. 2019 Aug;38(4):284-290. doi: 10.23736/S0392-9590.19.04130-0. Epub 2019 Jun 13.

PMID:
31203596
13.

Comparative analysis of clonal hematopoiesis of multipotent stem cells in healthy elderly in blood and bone marrow.

Jann JC, Nolte F, Mossner M, Flach J, Altrock E, Schmitt N, Röhl H, Jawhar A, Neumann U, Nowak V, Danner J, Obländer J, Palme I, Hofmann WK, Nowak D.

Leuk Res. 2019 Jul;82:15-18. doi: 10.1016/j.leukres.2019.05.005. Epub 2019 May 16. No abstract available.

PMID:
31132434
14.

Reappraisal of variants previously linked with sudden infant death syndrome: results from three population-based cohorts.

Paludan-Müller C, Ghouse J, Vad OB, Herfelt CB, Lundegaard P, Ahlberg G, Schmitt N, Svendsen JH, Haunsø S, Bundgaard H, Hansen T, Kanters JK, Olesen MS.

Eur J Hum Genet. 2019 Sep;27(9):1427-1435. doi: 10.1038/s41431-019-0416-3. Epub 2019 May 1.

PMID:
31043699
15.

Pembrolizumab for recurrent/metastatic head and neck cancer: equally promising for Asian patients?

Ye W, Schmitt NC.

Ann Transl Med. 2019 Mar;7(Suppl 1):S14. doi: 10.21037/atm.2019.01.46. No abstract available.

16.

Extraskeletal Osteosarcoma: A Rare Case Arising in Phthisis Bulbi with a Review of the Literature.

Salomão DR, Schmitt NJ, Wenger DE, Schlafmann S, Fritchie K.

Ocul Oncol Pathol. 2019 Feb;5(2):114-118. doi: 10.1159/000487544. Epub 2018 Jul 26.

17.

Genetically Encoded Fluorescent Proteins Enable High-Throughput Assignment of Cell Cohorts Directly from MALDI-MS Images.

Schmitt ND, Rawlins CM, Randall EC, Wang X, Koller A, Auclair JR, Kowalski JM, Kowalski PJ, Luther E, Ivanov AR, Agar NYR, Agar JN.

Anal Chem. 2019 Mar 19;91(6):3810-3817. doi: 10.1021/acs.analchem.8b03454. Epub 2019 Mar 6.

PMID:
30839199
18.

Exceptional responses to pertuzumab, trastuzumab, and docetaxel in human epidermal growth factor receptor-2 high expressing salivary duct carcinomas.

Park JC, Ma TM, Rooper L, Hembrough T, Foss RD, Schmitt NC, Sawhney R, Flanders A, Kang H.

Head Neck. 2018 Dec;40(12):E100-E106. doi: 10.1002/hed.25392. Epub 2018 Nov 26.

PMID:
30478962
19.

Nuclear Translocation of RELB Is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice.

Elßner C, Goeppert B, Longerich T, Scherr AL, Stindt J, Nanduri LK, Rupp C, Kather JN, Schmitt N, Kautz N, Breuhahn K, Ismail L, Heide D, Hetzer J, García-Beccaria M, Hövelmeyer N, Waisman A, Urbanik T, Mueller S, Gdynia G, Banales JM, Roessler S, Schirmacher P, Jäger D, Schölch S, Keitel V, Heikenwalder M, Schulze-Bergkamen H, Köhler BC.

Gastroenterology. 2019 Mar;156(4):1190-1205.e14. doi: 10.1053/j.gastro.2018.11.018. Epub 2018 Nov 13.

PMID:
30445013
20.

Antagonist of cIAP1/2 and XIAP enhances anti-tumor immunity when combined with radiation and PD-1 blockade in a syngeneic model of head and neck cancer.

Xiao R, Allen CT, Tran L, Patel P, Park SJ, Chen Z, Van Waes C, Schmitt NC.

Oncoimmunology. 2018 Aug 1;7(9):e1471440. doi: 10.1080/2162402X.2018.1471440. eCollection 2018.

21.

T cell receptor richness in peripheral blood increases after cetuximab therapy and correlates with therapeutic response.

Kansy BA, Shayan G, Jie HB, Gibson SP, Lei YL, Brandau S, Lang S, Schmitt NC, Ding F, Lin Y, Ferris RL.

Oncoimmunology. 2018 Aug 24;7(11):e1494112. doi: 10.1080/2162402X.2018.1494112. eCollection 2018.

22.

Deletion in mice of X-linked, Brugada syndrome- and atrial fibrillation-associated Kcne5 augments ventricular KV currents and predisposes to ventricular arrhythmia.

David JP, Lisewski U, Crump SM, Jepps TA, Bocksteins E, Wilck N, Lossie J, Roepke TK, Schmitt N, Abbott GW.

FASEB J. 2019 Feb;33(2):2537-2552. doi: 10.1096/fj.201800502R. Epub 2018 Oct 5.

23.

Homozygosity for SCN4A Arg1142Gln causes congenital myopathy with variable disease expression.

Sloth CK, Denti F, Schmitt N, Bentzen BH, Fagerberg C, Vissing J, Gaist D.

Neurol Genet. 2018 Sep 19;4(5):e267. doi: 10.1212/NXG.0000000000000267. eCollection 2018 Oct. No abstract available.

24.

Humpback whale migrations to Antarctic summer foraging grounds through the southwest Pacific Ocean.

Andrews-Goff V, Bestley S, Gales NJ, Laverick SM, Paton D, Polanowski AM, Schmitt NT, Double MC.

Sci Rep. 2018 Aug 17;8(1):12333. doi: 10.1038/s41598-018-30748-4.

25.

Spinal dorsal horn astrocytes release GABA in response to synaptic activation.

Christensen RK, Delgado-Lezama R, Russo RE, Lind BL, Alcocer EL, Rath MF, Fabbiani G, Schmitt N, Lauritzen M, Petersen AV, Carlsen EM, Perrier JF.

J Physiol. 2018 Oct;596(20):4983-4994. doi: 10.1113/JP276562. Epub 2018 Aug 28.

26.

Radiation-Associated Sarcoma of the Neck: Case Series and Systematic Review.

Williams L, Tmanova L, Mydlarz WK, Page B, Richmon JD, Quon H, Schmitt NC.

Ann Otol Rhinol Laryngol. 2018 Oct;127(10):735-740. doi: 10.1177/0003489418789966. Epub 2018 Jul 26. Review.

PMID:
30047787
27.

PKD Phosphorylation as Novel Pathway of KV11.1 Regulation.

Steffensen AB, Bomholtz SH, Andersen MN, Olsen JV, Mutsaers N, Lundegaard PR, Lundby A, Schmitt N.

Cell Physiol Biochem. 2018;47(4):1742-1750. doi: 10.1159/000491007. Epub 2018 Jun 27.

28.

Functional consequences of genetic variation in sodium channel modifiers in early onset lone atrial fibrillation.

Denti F, Paludan-Müller C, Olesen SP, Haunsø S, Svendsen JH, Olesen MS, Bentzen BH, Schmitt N.

Per Med. 2018 Mar;15(2):93-102. doi: 10.2217/pme-2017-0076. Epub 2018 Jan 31.

PMID:
29714131
29.

Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis.

El-Demerdash A, Moriou C, Toullec J, Besson M, Soulet S, Schmitt N, Petek S, Lecchini D, Debitus C, Al-Mourabit A.

Mar Drugs. 2018 Apr 27;16(5). pii: E146. doi: 10.3390/md16050146.

30.

PD-1 Inhibition Minimally Affects Cisplatin-Induced Toxicities in a Murine Model.

Spielbauer K, Cunningham L, Schmitt N.

Otolaryngol Head Neck Surg. 2018 Aug;159(2):343-346. doi: 10.1177/0194599818767621. Epub 2018 Apr 3.

31.

In Vitro Liquid Extraction Surface Analysis Mass Spectrometry (ivLESA-MS) for Direct Metabolic Analysis of Adherent Cells in Culture.

Basu SS, Randall EC, Regan MS, Lopez BGC, Clark AR, Schmitt ND, Agar JN, Dillon DA, Agar NYR.

Anal Chem. 2018 Apr 17;90(8):4987-4991. doi: 10.1021/acs.analchem.8b00530. Epub 2018 Apr 2.

32.

Multiple genetic variations in sodium channel subunits in a case of sudden infant death syndrome.

Denti F, Bentzen BH, Wojciak J, Thomsen NM, Scheinman M, Schmitt N.

Pacing Clin Electrophysiol. 2018 Jun;41(6):620-626. doi: 10.1111/pace.13328. Epub 2018 Apr 25.

PMID:
29572929
33.

Lack of beta-arrestin signaling in the absence of active G proteins.

Grundmann M, Merten N, Malfacini D, Inoue A, Preis P, Simon K, Rüttiger N, Ziegler N, Benkel T, Schmitt NK, Ishida S, Müller I, Reher R, Kawakami K, Inoue A, Rick U, Kühl T, Imhof D, Aoki J, König GM, Hoffmann C, Gomeza J, Wess J, Kostenis E.

Nat Commun. 2018 Jan 23;9(1):341. doi: 10.1038/s41467-017-02661-3.

34.

Predicting effects of hearing-instrument signal processing on consonant perception.

Zaar J, Schmitt N, Derleth RP, DiNino M, Arenberg JG, Dau T.

J Acoust Soc Am. 2017 Nov;142(5):3216. doi: 10.1121/1.5011737.

PMID:
29195458
35.

Salivary duct carcinoma: An aggressive salivary gland malignancy with opportunities for targeted therapy.

Schmitt NC, Kang H, Sharma A.

Oral Oncol. 2017 Nov;74:40-48. doi: 10.1016/j.oraloncology.2017.09.008. Epub 2017 Sep 21. Review.

36.

Cisplatin Alters Antitumor Immunity and Synergizes with PD-1/PD-L1 Inhibition in Head and Neck Squamous Cell Carcinoma.

Tran L, Allen CT, Xiao R, Moore E, Davis R, Park SJ, Spielbauer K, Van Waes C, Schmitt NC.

Cancer Immunol Res. 2017 Dec;5(12):1141-1151. doi: 10.1158/2326-6066.CIR-17-0235. Epub 2017 Nov 2.

37.

Trafficking of Kv2.1 Channels to the Axon Initial Segment by a Novel Nonconventional Secretory Pathway.

Jensen CS, Watanabe S, Stas JI, Klaphaak J, Yamane A, Schmitt N, Olesen SP, Trimmer JS, Rasmussen HB, Misonou H.

J Neurosci. 2017 Nov 29;37(48):11523-11536. doi: 10.1523/JNEUROSCI.3510-16.2017. Epub 2017 Oct 17.

38.

Human papillomavirus 16 E6 antibodies are sensitive for human papillomavirus-driven oropharyngeal cancer and are associated with recurrence.

Lang Kuhs KA, Kreimer AR, Trivedi S, Holzinger D, Pawlita M, Pfeiffer RM, Gibson SP, Schmitt NC, Hildesheim A, Waterboer T, Ferris RL.

Cancer. 2017 Nov 15;123(22):4382-4390. doi: 10.1002/cncr.30966. Epub 2017 Sep 26.

39.

PD-1 Status in CD8+ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer.

Kansy BA, Concha-Benavente F, Srivastava RM, Jie HB, Shayan G, Lei Y, Moskovitz J, Moy J, Li J, Brandau S, Lang S, Schmitt NC, Freeman GJ, Gooding WE, Clump DA, Ferris RL.

Cancer Res. 2017 Nov 15;77(22):6353-6364. doi: 10.1158/0008-5472.CAN-16-3167. Epub 2017 Sep 13.

40.

SUMO co-expression modifies KV 11.1 channel activity.

Steffensen AB, Andersen MN, Mutsaers N, Mujezinovic A, Schmitt N.

Acta Physiol (Oxf). 2018 Mar;222(3). doi: 10.1111/apha.12974. Epub 2017 Sep 26.

PMID:
28888063
41.

Chemoradiation-induced hearing loss remains a major concern for head and neck cancer patients.

Schmitt NC, Page BR.

Int J Audiol. 2018 Sep;57(sup4):S49-S54. doi: 10.1080/14992027.2017.1353710. Epub 2017 Jul 20. Review.

42.

Direct and Topoisomerase II Mediated DNA Damage by Bis-3-chloropiperidines: The Importance of Being an Earnest G.

Sosic A, Zuravka I, Schmitt NK, Miola A, Göttlich R, Fabris D, Gatto B.

ChemMedChem. 2017 Sep 7;12(17):1471-1479. doi: 10.1002/cmdc.201700368. Epub 2017 Aug 10.

PMID:
28724198
43.

Chromatin Accessibility Landscape of Cutaneous T Cell Lymphoma and Dynamic Response to HDAC Inhibitors.

Qu K, Zaba LC, Satpathy AT, Giresi PG, Li R, Jin Y, Armstrong R, Jin C, Schmitt N, Rahbar Z, Ueno H, Greenleaf WJ, Kim YH, Chang HY.

Cancer Cell. 2017 Jul 10;32(1):27-41.e4. doi: 10.1016/j.ccell.2017.05.008. Epub 2017 Jun 15.

44.

In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis.

Colman MA, Ni H, Liang B, Schmitt N, Zhang H.

PLoS Comput Biol. 2017 Jun 16;13(6):e1005587. doi: 10.1371/journal.pcbi.1005587. eCollection 2017 Jun.

45.
46.

Deep sequencing of atrial fibrillation patients with mitral valve regurgitation shows no evidence of mosaicism but reveals novel rare germline variants.

Gregers E, Ahlberg G, Christensen T, Jabbari J, Larsen KO, Herfelt CB, Henningsen KM, Andreasen L, Thiis JJ, Lund J, Holme S, Haunsø S, Bentzen BH, Schmitt N, Svendsen JH, Olesen MS.

Heart Rhythm. 2017 Oct;14(10):1531-1538. doi: 10.1016/j.hrthm.2017.05.027. Epub 2017 May 24.

PMID:
28549997
47.

Structural interplay of KV7.1 and KCNE1 is essential for normal repolarization and is compromised in short QT syndrome 2 (KV7.1-A287T).

Rothenberg I, Piccini I, Wrobel E, Stallmeyer B, Müller J, Greber B, Strutz-Seebohm N, Schulze-Bahr E, Schmitt N, Seebohm G.

HeartRhythm Case Rep. 2016 Sep 12;2(6):521-529. doi: 10.1016/j.hrcr.2016.08.015. eCollection 2016 Nov. No abstract available.

48.

The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes.

Simon K, Merten N, Schröder R, Hennen S, Preis P, Schmitt NK, Peters L, Schrage R, Vermeiren C, Gillard M, Mohr K, Gomeza J, Kostenis E.

Mol Pharmacol. 2017 May;91(5):518-532. doi: 10.1124/mol.116.107904. Epub 2017 Mar 2. Erratum in: Mol Pharmacol. 2017 Jul;92 (1):100.

PMID:
28254957
49.

Foxp1 expression is essential for sex-specific murine neonatal ultrasonic vocalization.

Fröhlich H, Rafiullah R, Schmitt N, Abele S, Rappold GA.

Hum Mol Genet. 2017 Apr 15;26(8):1511-1521. doi: 10.1093/hmg/ddx055.

PMID:
28204507
50.

Adaptive resistance to anti-PD1 therapy by Tim-3 upregulation is mediated by the PI3K-Akt pathway in head and neck cancer.

Shayan G, Srivastava R, Li J, Schmitt N, Kane LP, Ferris RL.

Oncoimmunology. 2016 Dec 23;6(1):e1261779. doi: 10.1080/2162402X.2016.1261779. eCollection 2017.

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