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Items: 20

1.

Single-Molecule Sequencing Reveals Patterns of Preexisting Drug Resistance That Suggest Treatment Strategies in Philadelphia-Positive Leukemias.

Schmitt MW, Pritchard JR, Leighow SM, Aminov BI, Beppu L, Kim DS, Hodgson JG, Rivera VM, Loeb LA, Radich JP.

Clin Cancer Res. 2018 Nov 1;24(21):5321-5334. doi: 10.1158/1078-0432.CCR-18-0167. Epub 2018 Jul 24.

PMID:
30042204
2.

Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations.

Salk JJ, Schmitt MW, Loeb LA.

Nat Rev Genet. 2018 May;19(5):269-285. doi: 10.1038/nrg.2017.117. Epub 2018 Mar 26. Review.

PMID:
29576615
3.

Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues.

Krimmel JD, Schmitt MW, Harrell MI, Agnew KJ, Kennedy SR, Emond MJ, Loeb LA, Swisher EM, Risques RA.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):6005-10. doi: 10.1073/pnas.1601311113. Epub 2016 May 5.

4.

The influence of subclonal resistance mutations on targeted cancer therapy.

Schmitt MW, Loeb LA, Salk JJ.

Nat Rev Clin Oncol. 2016 Jun;13(6):335-47. doi: 10.1038/nrclinonc.2015.175. Epub 2015 Oct 20. Review.

5.

Sequencing small genomic targets with high efficiency and extreme accuracy.

Schmitt MW, Fox EJ, Prindle MJ, Reid-Bayliss KS, True LD, Radich JP, Loeb LA.

Nat Methods. 2015 May;12(5):423-5. doi: 10.1038/nmeth.3351. Epub 2015 Apr 6.

6.

Detecting ultralow-frequency mutations by Duplex Sequencing.

Kennedy SR, Schmitt MW, Fox EJ, Kohrn BF, Salk JJ, Ahn EH, Prindle MJ, Kuong KJ, Shen JC, Risques RA, Loeb LA.

Nat Protoc. 2014 Nov;9(11):2586-606. doi: 10.1038/nprot.2014.170. Epub 2014 Oct 9. Erratum in: Nat Protoc. 2014 Dec;9(12):2903.

7.

Risks of double-counting in deep sequencing.

Schmitt MW, Fox EJ, Salk JJ.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):E1560. doi: 10.1073/pnas.1400941111. Epub 2014 Mar 20. No abstract available.

8.

Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage.

Kennedy SR, Salk JJ, Schmitt MW, Loeb LA.

PLoS Genet. 2013;9(9):e1003794. doi: 10.1371/journal.pgen.1003794. Epub 2013 Sep 26.

9.

A substitution in the fingers domain of DNA polymerase δ reduces fidelity by altering nucleotide discrimination in the catalytic site.

Prindle MJ, Schmitt MW, Parmeggiani F, Loeb LA.

J Biol Chem. 2013 Feb 22;288(8):5572-80. doi: 10.1074/jbc.M112.436410. Epub 2013 Jan 2.

10.

Implications of genetic heterogeneity in cancer.

Schmitt MW, Prindle MJ, Loeb LA.

Ann N Y Acad Sci. 2012 Sep;1267:110-6. doi: 10.1111/j.1749-6632.2012.06590.x.

11.

Detection of ultra-rare mutations by next-generation sequencing.

Schmitt MW, Kennedy SR, Salk JJ, Fox EJ, Hiatt JB, Loeb LA.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14508-13. doi: 10.1073/pnas.1208715109. Epub 2012 Aug 1.

12.

The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase δ.

Kamath-Loeb AS, Shen JC, Schmitt MW, Loeb LA.

J Biol Chem. 2012 Apr 6;287(15):12480-90. doi: 10.1074/jbc.M111.332577. Epub 2012 Feb 17.

13.

The biochemistry and fidelity of synthesis by the apicoplast genome replication DNA polymerase Pfprex from the malaria parasite Plasmodium falciparum.

Kennedy SR, Chen CY, Schmitt MW, Bower CN, Loeb LA.

J Mol Biol. 2011 Jul 1;410(1):27-38. doi: 10.1016/j.jmb.2011.04.071. Epub 2011 May 5.

14.

Trends in suicide by carbon monoxide inhalation in King County, Washington: 1996-2009.

Schmitt MW, Williams TL, Woodard KR, Harruff RC.

J Forensic Sci. 2011 May;56(3):652-5. doi: 10.1111/j.1556-4029.2010.01688.x. Epub 2011 Feb 3.

PMID:
21291470
15.

Active site mutations in mammalian DNA polymerase delta alter accuracy and replication fork progression.

Schmitt MW, Venkatesan RN, Pillaire MJ, Hoffmann JS, Sidorova JM, Loeb LA.

J Biol Chem. 2010 Oct 15;285(42):32264-72. doi: 10.1074/jbc.M110.147017. Epub 2010 Jul 13.

16.

Molecularly evolved thymidylate synthase inhibits 5-fluorodeoxyuridine toxicity in human hematopoietic cells.

Bielas JH, Schmitt MW, Icreverzi A, Ericson NG, Loeb LA.

Hum Gene Ther. 2009 Dec;20(12):1703-7. doi: 10.1089/hum.2009.053.

17.

High fidelity and lesion bypass capability of human DNA polymerase delta.

Schmitt MW, Matsumoto Y, Loeb LA.

Biochimie. 2009 Sep;91(9):1163-72. doi: 10.1016/j.biochi.2009.06.007. Epub 2009 Jun 18.

18.

Simple-to-use, reference criteria for revealing drug-induced QT interval prolongation in conscious dogs.

Schmitt MW, Von Landenberg F, Poth H, Wimmer E, Goddemeier T, Cavero I.

Eur J Pharmacol. 2007 Jan 5;554(1):46-52. Epub 2006 Oct 10.

PMID:
17112506
19.
20.

Responses of isolator-derived Japanese quail and quail cell cultures to selected animal viruses.

Farrow WM, Schmitt MW, Groupé V.

J Clin Microbiol. 1975 Nov;2(5):419-24.

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